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Topic Review
Toxicity and Physicochemical Properties of Trifluoroacetic Acid
Trifluoroacetic acid (TFA) is a known and persistent pollutant in the environment. Although several direct anthropogenic sources exist, production from the atmospheric degradation of fluorocarbons such as some hydrofluorocarbons (HFCs) has been a known source for some time. The current transition from HFCs to HFOs (hydrofluoroolefins) is beneficial from a global warming viewpoint because HFOs are much shorter-lived and pose a much smaller threat in terms of warming, but the fraction of HFOs converted into TFA is higher than seen for the corresponding HFCs and the region in which TFA is produced is close to the source. Therefore, it is timely to review the role of TFA in the Earth’s environment.
  • 1.9K
  • 27 Mar 2024
Topic Review
Slow-Release Urea
Slow-release urea (SRU) is a coated non-protein nitrogen (NPN) source for ruminant nutrition. This study applied a meta-analytic technique to quantify the effect of a commercial SRU (Optigen®, Alltech Inc., Nicholasville, KY, USA) on the performance of beef cattle. Data were extracted from 17 experiments and analysed using the random-effects model to estimate the effect size of SRU on dry matter intake (DMI), crude protein intake (CPI), live weight gain (LWG) and feed efficiency (FE) of growing and finishing beef cattle. There was no effect of feeding SRU on the overall DMI and CPI of beef cattle. Dietary inclusion of SRU improved the overall LWG (+92 g/d/head) and FE (+12 g LWG/kg DMI/head) of beef cattle. Notably, SRU supplementation in growing cattle exhibited a better improvement on LWG (130 vs. 60 g/d/head) and FE (18 vs. 8 g LWG/kg DMI/head) compared with finishing cattle. Moreover, SRU showed consistent improvements on the LWG and FE of beef cattle under several study factors. Simulation analysis indicated that positive effects of SRU on LWG and FE improved profitability through reduction in feed cost and reduced the emission intensity of beef production. These results indicate that SRU is a sustainable NPN solution in beef cattle production.
  • 1.9K
  • 30 Oct 2020
Topic Review
Vitamin K2 and Alzheimer’s Disease
Recent studies have highlighted the importance of vitamin K2 (VK2) in human health. However, there have been no clinical studies investigating the role of VK2 in the prevention or treatment of Alzheimer’s disease (AD), a debilitating disease for which currently there is no cure. In reviewing basic science research and clinical studies that have connected VK2 to factors involved in AD pathogenesis, we have found a growing body of evidence demonstrating that VK2 has the potential to slow the progression of AD and contribute to its prevention. In our review, we consider the antiapoptotic and antioxidant effects of VK2 and its impact on neuroinflammation, mitochondrial dysfunction, cognition, cardiovascular health, and comorbidities in AD. We also examine the link between dysbiosis and VK2 in the context of the microbiome’s role in AD pathogenesis.
  • 1.9K
  • 22 Sep 2021
Topic Review
Oxidation Protection of High-Temperature Oxidation-Resistant Coatings
Molybdenum and its alloys, with high melting points, excellent corrosion resistance and high temperature creep resistance, are a vital high-temperature structural material. However, the poor oxidation resistance at high temperatures is a major barrier to their application. 
  • 1.9K
  • 28 Feb 2022
Topic Review
Brain Trauma, Glucocorticoids and Neuroinflammation
Brain injury is a common cause of death and disability for people of all ages worldwide. Depending on the biomechanics, brain lesions may occur both in areas of the brain directly adjacent to the place of force application and in remote areas. The mechanisms of hippocampal damage are of particular importance, since they underlie late complications of traumatic brain injury (TBI), such as epilepsy, depression and cognitive impairment. The mechanisms of reorganization of neuronal networks in the hippocampus include long-lasting chronic neuroinflammation and secondary damage to the nervous tissue. Responses and disturbances of the hypothalamic–pituitary–adrenal (HPA) axis may play a critical role in late post-traumatic pathology, in particular by modulation of synaptic activity and neuroinflammation in the hippocampus.
  • 1.9K
  • 25 May 2022
Topic Review
American Petroleum Institute
The American Petroleum Institute (API) is the largest U.S. trade association for the oil and natural gas industry. It claims to represent about 650 corporations involved in production, refinement, distribution, and many other aspects of the petroleum industry. The association describes its mission as to influence public policy in support of a strong, viable U.S. oil and natural gas industry. API's chief functions on behalf of the industry include advocacy, negotiation and lobbying with governmental, legal, and regulatory agencies; research into economic, toxicological, and environmental effects; establishment and certification of industry standards; and education outreach. API both funds and conducts research related to many aspects of the petroleum industry. The current CEO and president is Mike Sommers.
  • 1.9K
  • 10 Nov 2022
Topic Review
Scientist.com
Scientist.com (formerly known as Assay Depot) is a network of public and private e-commerce marketplaces that connect buyers and sellers of scientific research services. The company was founded in 2007 by Kevin Lustig, Chris Petersen and Andrew Martin and launched its first public research marketplace in September 2008.
  • 1.9K
  • 18 Nov 2022
Topic Review
C5 Complement Pathway
Complement 5 (C5) protein, the cleavage of which is mediated by the serine proteases C5 convertases to generate two different fragments: C5a, which is a potent chemoattractant and pro-inflammatory modulator, and C5b, which initiates the formation of MAC, mediating cell lysis and triggering inflammation.
  • 1.9K
  • 27 Apr 2021
Topic Review
Manganese and Manganese Oxide Nanoparticles
Manganese and its oxides in the form of nanoparticles could be a promising alternative for gadolinium-based contrast agents used in diagnostic imaging. Manganese, which is essential for living organisms as an enzyme cofactor, under excessive exposure—for example, due to water contamination or as an occupational hazard for welders—can lead to neurological disorders, including manganism—a condition similar to Parkinson’s disease. This review attempts to summarise the available literature data on the potential applications of manganese and manganese oxide nanoparticles.
  • 1.9K
  • 18 May 2021
Topic Review
Phenolic Compounds from Australian Grown Bananas
Bananas are an essential source of staple food and fruit worldwide and are widely regarded as the world’s largest fruit crop, with more than 100 million tons total annual production. Banana peel, a by-product that represents about 40% of the entire banana’s weight, and pulp are rich in bioactive compounds and have a high antioxidant capacity.
  • 1.9K
  • 22 Oct 2021
Topic Review
VR/AR in K-12 Science Education
virtual reality (VR) and augmented reality (AR) are increasingly capturing educators’ and learners’ attention. In particular, VR is defined as a real-time graphical simulation in which the user interacts with the system via analog control, within a spatial frame of reference and with user control of the viewpoint’s motion and view direction. It first appeared in 1966 and was used in the design of US Air Force Flight Simulator. Developed from VR, AR is a technology used for improving users’ perception of the real world by dynamically adding virtual elements to the physical environment. It made its debut in the 1990s, which was initially proposed by scientists from Boeing, an aircraft manufacturer, where they mixed virtual graphics with real environment displays to help aircraft electricians assemble cables.
  • 1.9K
  • 08 Dec 2021
Topic Review
Moist Rice Husk Smoldering for Silica Production
In order to assess the possibility of silica production via smoldering of moist rice husk, experiments of washed (moist) rice husk (7 kg with moisture content of 51%) in a newly designed smoldering apparatus was performed. The temperature inside the fuel bed during smoldering was recorded, and characteristics of ash were analyzed. Results showed that the highest temperature in the middle of the naturally piled fuel bed was about 560.0 °C, lower than those in most of combustors. Some volatiles from the lower part of the fuel bed adhere to its upper ash during piled smoldering. Silica content and specific surface area of ash from smoldering of washed (moist) rice husk were 86.4% and 84.9 m2/g, respectively.
  • 1.9K
  • 24 Jan 2022
Topic Review
Hypothermia Caused by Earthquakes
Natural disasters can destroy all personal belongings and infrastructure and can deprive humans of the possibility of protecting themselves from harsh environments. One consequence may be death from accidental hypothermia.
  • 1.9K
  • 11 Mar 2022
Topic Review
Early Life Stress, Oxytocin System, and Obesity
Obesity disease results from a dysfunctional modulation of the energy balance whose master regulator is the central nervous system. Consistently, the prevalence of obesity is higher among individuals who experienced early life stress (ELS). Oxytocin, a hypothalamic neurohormone, regulates the energy balance and modulates social, emotional, and eating behaviors, exerting both central and peripheral actions. Oxytocin closely cooperates with leptin in regulating energy homeostasis. Based on the available data, alterations in the oxytocin system may in part mediate the ELS-induced susceptibility to obesity. 
  • 1.9K
  • 05 Aug 2022
Topic Review
Metal Oxide Nanoparticles for Food Packaging
Metal oxide nanoparticles have a higher surface area due to their smaller size, which makes them useful in various applications such as biosensors, bio-nanotechnology, and nanomedicine. These nanoparticles have many atoms on their surfaces, making them highly reactive.  There is a huge demand for packaging materials that can keep food fresher for extended periods of time. The incorporation of nanoscale fillers in the polymer matrix would assists in the alleviation of packaging material challenges while also improving functional qualities.
  • 1.9K
  • 20 Jun 2022
Topic Review
Fsutil
As the next version of Windows NT after Windows 2000, as well as the successor to Windows Me, Windows XP introduced many new features but it also removed some others.
  • 1.9K
  • 08 Nov 2022
Topic Review
HP Series 80
The Hewlett-Packard series 80 of small scientific desktop computers was introduced in 1980, beginning with the popular HP-85 targeted at engineering and control applications. They provided the capability of the HP 9800 series desktop computers with an integrated monitor in a smaller package including storage and printer, at half the price.
  • 1.9K
  • 30 Nov 2022
Topic Review
Extracellular Hemoglobin
Hemoglobin is essential for maintaining cellular bioenergetic homeostasis through its ability to bind and transport oxygen to the tissues. Besides its ability to transport oxygen, hemoglobin within erythrocytes plays an important role in cellular signaling and modulation of the inflammatory response either directly by binding gas molecules (NO, CO, and CO2) or indirectly by acting as their source. Once hemoglobin reaches the extracellular environment, it acquires several secondary functions affecting surrounding cells and tissues. By modulating the cell functions, this macromolecule becomes involved in the etiology and pathophysiology of various diseases. The up-to-date results disclose the impact of extracellular hemoglobin on (i) redox status, (ii) inflammatory state of cells, (iii) proliferation and chemotaxis, (iv) mitochondrial dynamic, (v) chemoresistance and (vi) differentiation.
  • 1.9K
  • 06 Dec 2022
Topic Review
Plant Biostimulants
Modern agriculture is being challenged by deteriorating edaphoclimatic conditions and increasing anthropogenic pressure. This necessitates the development of innovative crop production systems that can sustainably meet the demands of a growing world population while minimizing the environmental impact. The use of plant biostimulants is gaining ground as a safe and ecologically sound approach to improving crop yields.
  • 1.9K
  • 12 Mar 2024
Topic Review
Iron Deficiency
Iron deficiency (ID) is the most frequent nutritional deficiency in the whole population worldwide, and the second most common cause of anemia in the elderly. Anemia in aged subjects impacts health and quality of life, and it is associated with several negative outcomes, such as longer time of hospitalization and a higher risk of disability. Furthermore, it is an independent risk factor of increased morbidity and mortality. Even though iron deficiency anemia is a common disorder in older adults, it should be not considered as a normal ageing consequence, but a sign of underlying dysfunction. Relating to the pathophysiology in Iron Deficiency Anemia (IDA), hepcidin has a key role in iron homeostasis. It downregulates the iron exporter ferroportin, inhibiting both iron absorption and release. Furthermore, IDA at old age is frequently dependent on blood loss, especially caused by gastrointestinal lesions. Thus, a diagnostic algorithm for IDA should include invasive investigation such as endoscopic procedures. The treatment choice is influenced by the severity of anemia, underlying conditions, comorbidities, and the clinical state of the patient. Correction of anemia and iron supplementation should be associated with the treatment of the causal disease.
  • 1.9K
  • 27 Oct 2020
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