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Topic Review
TRPV1 in Skin Diseases
TRPV1 is a nonspecific ion channel highly expressed by cutaneous sensory nerves and other skin cells, including circulating and skin resident immune cells. Understanding the role of TRPV1 in wound healing may inform future TRPV1-targeted therapies to improve healing in impaired and chronic wounds. Many factors contribute to the polymodal nature of TRPV1 channel activation including tetrameric composition, splice variant, accessory protein sensitization or desensitization, activator concentration/coupling, etc.
  • 1.9K
  • 28 Jun 2021
Topic Review
Shot Peening and Cavitation Peening
Shot peening is a dynamically developing surface treatment used to improve the surface properties modified by tool, impact, microblasting, or shot action.
  • 1.9K
  • 08 Apr 2022
Topic Review
Floral Scents in Roses
Floral scents possess high ornamental and economic values to rose production in the floricultural industry. The floral scent is one of the most important traits in plants, which is essential to the fertilization of angiosperm plants by attracting and guiding pollinators. Molecular bases of floral scent production have been studied in the rose as well as their genetic inheritance. Some significant achievements have been acquired, such as the comprehensive rose genome and the finding of a novel geraniol synthase in plants.
  • 1.9K
  • 05 Aug 2022
Topic Review
Semiconductor Device
Semiconductor devices are electronic components that exploit the electronic properties of semiconductor materials, principally silicon, germanium, and gallium arsenide, as well as organic semiconductors. Semiconductor devices have replaced thermionic devices (vacuum tubes) in most applications. They use electronic conduction in the solid state as opposed to the gaseous state or thermionic emission in a high vacuum. Semiconductor devices are manufactured both as single discrete devices and as integrated circuits (ICs), which consist of a number—from a few (as low as two) to billions—of devices manufactured and interconnected on a single semiconductor substrate, or wafer. Semiconductor materials are useful because their behavior can be easily manipulated by the addition of impurities, known as doping. Semiconductor conductivity can be controlled by the introduction of an electric or magnetic field, by exposure to light or heat, or by the mechanical deformation of a doped monocrystalline grid; thus, semiconductors can make excellent sensors. Current conduction in a semiconductor occurs via mobile or "free" electrons and holes, collectively known as charge carriers. Doping a semiconductor such as silicon with a small proportion of an atomic impurity, such as phosphorus or boron, greatly increases the number of free electrons or holes within the semiconductor. When a doped semiconductor contains excess holes it is called "p-type", and when it contains excess free electrons it is known as "n-type", where p (positive for holes) or n (negative for electrons) is the sign of the charge of the majority mobile charge carriers. The semiconductor material used in devices is doped under highly controlled conditions in a fabrication facility, or fab, to control precisely the location and concentration of p- and n-type dopants. The junctions which form where n-type and p-type semiconductors join together are called p–n junctions. Semiconductor devices made per year have been growing by 9.1% on average since 1978 and shipments in 2018 are predicted for the first time to exceed 1 trillion, meaning well over 7 trillion has been made to date, in just in the decade prior.
  • 1.9K
  • 26 Oct 2022
Topic Review
Discovery and Development of Non-nucleoside Reverse-transcriptase Inhibitors
Non-nucleoside reverse-transcriptase inhibitors (NNRTIs) are antiretroviral drugs used in the treatment of human immunodeficiency virus (HIV). NNRTIs inhibit reverse transcriptase (RT), an enzyme that controls the replication of the genetic material of HIV. RT is one of the most popular targets in the field of antiretroviral drug development. Discovery and development of NNRTIs began in the late 1980s and in the end of 2009 four NNRTI had been approved by regulatory authorities and several others were undergoing clinical development. Drug resistance develops quickly if NNRTIs are administered as monotherapy and therefore NNRTIs are always given as part of combination therapy, the highly active antiretroviral therapy (HAART).
  • 1.9K
  • 09 Nov 2022
Topic Review
Methods to Remediate Arsenic-Contaminated Soils
Arsenic is a metalloid widely distributed in the environment and of global concern for human health. In a promising breakthrough for sustainable arsenic soil remediation, a fern, Pteris vittata L., was discovered to take up arsenic from the soil and accumulate it in its fronds at up to ~100 times soil concentrations. Successively harvesting the fronds removes, or phytoextracts, arsenic from the soil with potential environmental and economic benefits including low site disturbance and low cost. 
  • 1.9K
  • 16 Jan 2023
Topic Review
Foodborne Diseases
Foodborne diseases (FBDs) comprise a broad spectrum of illnesses that result from the ingestion of contaminated foodstuffs or water. FBDs can occur at any stage, from production to food consumption, and contamination may be the result of environmental contamination, such as pollution of water, soil, or air [1]. FBDs represent one of the most critical public health problems in the world, especially in developing countries that present serious shortcomings in infrastructure and basic sanitation [2–5]. With the knowledge to prevent FBDs, and the concerns about the increase in FBD cases arising in households, it is essential to evaluate homes’ good food preparation practices.
  • 1.9K
  • 10 Nov 2020
Topic Review
Hyaluronic Acid for Tissue Engineering
Polysaccharides such as hyaluronic acid (HA) which is omnipresent in the human body and exert pleiotropic biological functions such as tissue repair and tissue regeneration, may be exploited for cosmetics development, esthetic medicine, tissue engineering and regenerative medicine. In this work, the authors describe the excellent biocompatibility and biodegradability of HA-derived hydrogels with make them ideal materials for tissue engineering applications.
  • 1.9K
  • 27 May 2021
Topic Review
Insulin-Degrading Enzyme
Insulin-degrading enzyme (IDE) is a highly conserved and ubiquitously expressed metalloprotease that degrades insulin and several other intermediate-size peptides. For many decades, IDE had been assumed to be involved primarily in hepatic insulin clearance, a key process that regulates availability of circulating insulin levels for peripheral tissues. Emerging evidence, however, suggests that IDE has several other important physiological functions relevant to glucose and insulin homeostasis, including the regulation of insulin secretion from pancreatic β-cells. Investigation of mice with tissue-specific genetic deletion of Ide in the liver and pancreatic β-cells (L-IDE-KO and B-IDE-KO mice, respectively) has revealed additional roles for IDE in the regulation of hepatic insulin action and sensitivity.
  • 1.9K
  • 21 Feb 2021
Topic Review
Sodium Metabisulfite on Selective Flotation of Chalcopyrite/Molybdenite
Sodium metabisulfite (MBS) was used in this study for selective flotation of chalcopyrite and molybdenite. Microflotation tests of single and mixed minerals were performed to assess the floatability of chalcopyrite and molybdenite. The results of microflotation of single minerals showed that MBS treatment significantly depressed the floatability of chalcopyrite and slightly reduced the floatability of molybdenite. The results of microflotation of mixed minerals demonstrated that the MBS treatment could be used as a selective chalcopyrite depressant in the selective flotation of chalcopyrite and molybdenite. Furthermore, the addition of diesel oil or kerosene could significantly improve the separation efficiency of selective flotation of chalcopyrite and molybdenite using MBS treatment.
  • 1.9K
  • 20 Dec 2021
Topic Review
Abusive Domain Names by Internet Entities
A large number of domains are abused every day for cybercrime. At the same time, the fight against abusive domains is not the fight of one person or organization but a battle that requires the cooperation of the entire community.  A large number of domain names on the Internet are misused daily for cybercriminal activities, ranging from spoofing victims’ private information (phishing), to maliciously installing software onto end-users’ devices (malware attacks), to distributing illegal obscene videos. Internet abuse continues to victimize millions of people each year, reducing trust in the Internet as a place to conduct business and non-business activities. This decline in confidence has a detrimental effect on all stakeholders in the Internet ecosystem, from end-users to infrastructure service providers.
  • 1.9K
  • 06 May 2022
Topic Review
Cell-Based Therapies to Promote Lung Regeneration in IPF
The lung epithelium is constantly exposed to harmful agents present in the air that we breathe making it highly susceptible to damage. However, in instances of injury to the lung, it exhibits a remarkable capacity to regenerate injured tissue thanks to the presence of distinct stem and progenitor cell populations along the airway and alveolar epithelium. Mechanisms of repair are affected in chronic lung diseases such as idiopathic pulmonary fibrosis (IPF), a progressive life-threatening disorder characterized by the loss of alveolar structures, wherein excessive deposition of extracellular matrix components cause the distortion of tissue architecture that limits lung function and impairs tissue repair. cell therapy has been investigated for the treatment of IPF, including the use of a variety of cell types such as lung epithelial cells, specifically AT2 cells, induced pluripotent stem cells (iPSCs), and mesenchymal stem cells (MSCs) isolated from bone marrow stroma and those from adipose tissue or from other tissues.
  • 1.9K
  • 06 Sep 2022
Topic Review
Excipients Used for Modified Nasal Drug Delivery
Intranasal absorption is a favored route because it avoids the gastrointestinal and hepatic metabolism, leading to an increase in drug bioavailability, and a reduction in the side effects and the required dose administered. The ongoing challenging task in the field of nasal drug delivery is the maintenance of an efficient concentration of the active substance in the target area for an adequate period of time. 
  • 1.9K
  • 27 Sep 2022
Topic Review
Tehachapi Energy Storage Project
The Tehachapi Energy Storage Project (TSP) is a lithium-ion battery-based grid energy storage system at the Monolith Substation of Southern California Edison (SCE) in Tehachapi, California. At the time of commissioning in 2014, it was the largest lithium-ion battery system operating in North America and one of the largest in the world. The TSP system can supply 32 megawatt-hours of energy, at a maximum rate of 8 megawatts. This is sufficient to power between 1,600 and 2,400 homes for four hours. TSP is considered to be a modern-day energy storage pioneer with significant accomplishments that have proven the viability of utility-scale energy storage using lithium-ion technology. While originally envisioned as a research and development project, TSP continues operation today as a distribution-level resource for SCE and for calendar year 2020, SCE reported that TSP operated in the wholesale energy market with revenue exceeding operating and maintenance costs.
  • 1.9K
  • 01 Nov 2022
Topic Review
XCore Architecture
The XCore Architecture is a 32-bit RISC microprocessor architecture designed by XMOS. The architecture is designed to be used in multi-core processors for embedded systems. Each XCore executes up to eight concurrent threads, each thread having its own register set, and the architecture directly supports inter-thread and inter-core communication and various forms of thread scheduling. Two versions of the XCore architecture exist: the XS1 architecture and the XS2 architecture. Processors with the XS1 architecture include the XCore XS1-G4 and XCore XS1-L1. Processors with the XS2 architecture include xCORE-200. The architecture encodes instructions compactly, using 16 bits for frequently used instructions (with up to three operands) and 32 bits for less frequently used instructions (with up to 6 operands). Almost all instructions execute in a single cycle, and the architecture is event-driven in order to decouple the timings that a program needs to make from the execution speed of the program. A program will normally perform its computations and then wait for an event (e.g. a message, time, or external I/O event) before continuing.
  • 1.9K
  • 24 Nov 2022
Topic Review
Graphene Field-Effect Transistor Biosensors in COVID-19 Detection Technology
Coronavirus disease 2019 (COVID-19) is a disease caused by the infectious agent of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). Graphene field-effect transistor (GFET) biosensors have become the most promising diagnostic technology for detecting SARS-CoV-2 due to their advantages of high sensitivity, fast-detection speed, label-free operation, and low detection limit.
  • 1.9K
  • 06 Nov 2023
Topic Review
Adolescent Sleep Deprivation
At this stage of adolescence, several environmental and biological factors may affect both circadian and homeostatic regulation of sleep. A large part of this population does not experience adequate sleep, leading to chronic sleep restriction and/or disrupted sleep-wake cycles.
  • 1.9K
  • 01 Feb 2021
Topic Review
Vision-Based Vibration Monitoring
Contactless structural monitoring has in recent years seen a growing number of applications in civil engineering. Indeed, the elimination of physical installations of sensors is very attractive, especially for structures that might not be easily or safely accessible, yet requiring the experimental evaluation of their conditions, for example following extreme events such as strong earthquakes, explosions, and floods. Among contactless technologies, vision-based monitoring is possibly the solution that has attracted most of the interest of civil engineers, given that the advantages of contactless monitoring can be potentially obtained thorough simple and low-cost consumer-grade instrumentations.
  • 1.9K
  • 07 Jan 2021
Topic Review
Liver Vessel Segmentation: A Review
The segmentation of liver blood vessels is of major importance as it is essential for formulating diagnoses, planning and delivering treatments, as well as evaluating the results of clinical procedures. Different imaging techniques are available for application in clinical practice, so the segmentation methods should take into account the characteristics of the imaging technique.
  • 1.9K
  • 18 Mar 2021
Topic Review
BRCA2 Variants of Uncertain Significance
Breast Cancer Susceptibility Gene 2 (BRCA2) is an essential protein that mediates the loading of RAD51 onto resected DNA breaks, a key step in HDR.
  • 1.9K
  • 07 Jun 2021
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