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Topic Review
Plastic Food Packaging: Consumer Perspective
The use of plastics for packaging has some advantages, since they are flexible and inexpensive. However, most plastics are of single use, which, combined with low recycling or reuse ratios, contributes substantially to environmental pollution. This work is part of a project studying the habits of Portuguese citizens concerning plastic food packaging and focuses on aspects related to sustainability. The survey was carried out via an online questionnaire about sustainability, recycling, and knowledge of the effects of plastic materials or their residues on the environment. The results were obtained based on a statistical analysis of the data. The participants tend to think about the negative impact of plastic packages on the environment; 39% sometimes do not buy plastic; and 30% try to look for alternatives. A substantial fraction, 81%, support the avoidance of plastic utensils and reduction in the use of plastic bags. Most participants have a good knowledge of recycling and strongly agree with the use of recycled materials, and 87% of respondents practice separation of different types of waste for recycling. Changing plastic consumption habits has not been an easy task. Nevertheless, it is expected that society will increasingly move toward sustainable habits, questioning its actions and considering their impact on the environment.
  • 1.8K
  • 13 Sep 2021
Topic Review
Physical Exercise and the Hallmarks of Breast Cancer
Growing evidence suggests that, among the different molecular/cellular pathophysiological mechanisms associated with cancer, there are 14 hallmarks that play a major role, including: (i) sustaining proliferative signaling, (ii) evading growth suppressors, (iii) activating invasion and metastasis, (iv) enabling replicative immortality, (v) inducing angiogenesis, (vi) resisting cell death, (vii) reprogramming energy metabolism, (viii) evading immune destruction, (ix) genome instability and mutations, (x) tumor-promoting inflammation, (xi) unlocking phenotypic plasticity, (xii) nonmutational epigenetic reprogramming, (xiii) polymorphic microbiomes, and (xiv) senescent cells. These hallmarks are also associated with the development of breast cancer, which represents the most prevalent tumor type in the world. For the first time, the effects of physical activity/exercise on these hallmarks are described. In summary, an active lifestyle, and particularly regular physical exercise, provides beneficial effects on all major hallmarks associated with breast cancer, and might therefore help to counteract the progression of the disease or its associated burden.
  • 1.8K
  • 01 Feb 2023
Topic Review
Hadron Therapy Achievements and Challenges
Protons and carbon ions (hadrons) have useful properties for the treatments of patients affected by oncological pathologies. They are more precise than conventional X-rays and possess radiobiological characteristics suited for treating radio-resistant or inoperable tumours. 
  • 1.8K
  • 07 Mar 2022
Topic Review
Azoospermia
Azoospermia (a-, without + –zoo– » Greek zôion, animal + –spermia– » Greek sperma, sperm/seed) is defined by the absence of sperm in the ejaculate.
  • 1.8K
  • 04 Aug 2021
Topic Review
Retinoic Acid and Retinaldehyde Dehydrogenase
Retinoic acid (RA) is an important biological metabolite synthesized from the retinol content (known as “vitamin A”) via a sequential cellular process in the retinoid signaling pathway (RSP). RSP-mediated RA biosynthesis is a vital physiological process in chordates, since RA interacts with the nuclear receptor superfamily, namely nuclear RA receptors (RARs) and retinoid X receptors (RXRs), bound to the RA response elements (RAREs) in the promoter region of RA target genes. Retinaldehyde dehydrogenases (RALDH) belongs to the oxidoreductase family and plays a critical role in RA synthesis from the retinaldehyde content; therefore, this enzyme is considered to be one of the key regulators of RA-related retinol metabolism and embryonic development.
  • 1.8K
  • 27 Oct 2021
Topic Review
Cellular Neurobiology of Psychedelics
Psychedelic substances have gained significant attention in recent years for their potential therapeutic effects on various psychiatric disorders.
  • 1.8K
  • 07 Nov 2023
Topic Review
Post-SARS-CoV-2 Acute Telogen Effluvium
Telogen effluvium (TE) is a scalp disorder characterized by diffuse, non-scarring hair shedding. The term “telogen effluvium” was proposed to differentiate the disorder from the excessive shedding of normal club hair. It affects both males and females, with a higher incidence rate in females. Various hypotheses have been proposed for the pathophysiology of TE, based on abnormalities in the normal hair cycle, triggered by different factors. 
  • 1.8K
  • 08 Mar 2022
Topic Review
2LARTH® Micro-Immunotherapy Treatment
Tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) are two cytokines involved in the perpetuation of the chronic inflammation state characterizing rheumatoid arthritis (RA). Significant advances in the treatment of this pathology have been made over the past ten years, partially through the development of anti-TNF and anti-IL-1 therapies. However, major side effects still persist and new alternative therapies should be considered.
  • 1.8K
  • 19 Nov 2021
Topic Review
Avian Orthoavulavirus Type-1
Avian orthoavulaviruses type-1 (AOaV-1) have transitioned from animal vaccine vector to a bona fide vaccine delivery vehicle in human. Owing to induction of robust innate and adaptive immune responses in mucus membranes in both birds and mammals, AOaVs offer an attractive vaccine against respiratory pathogens. The unique features of AOaVs include over 50 years of safety profile, stable expression of foreign genes, high infectivity rates in avian and mammalian hosts, broad host spectrum, limited possibility of recombination and lack of pre-existing immunity in humans. Additionally, AOaVs vectors allow the production of economical and high quantities of vaccine antigen in chicken embryonated eggs and several GMP-grade mammalian cell lines.
  • 1.8K
  • 18 Feb 2022
Topic Review
Human Signal Sources
Different signals are generated from different parts of the human body.
  • 1.8K
  • 18 Jan 2023
Topic Review
The Banyan (NGO)
The Banyan is an non-governmental organization based in Chennai, India was founded in 1993 by Vandana Gopikumar and Vaishnavi Jayakumar to cater to the mentally ill and homeless women in the city. Over the past two decades, has expanded to offer a range of comprehensive mental health solutions for men and women who are either homeless, or living in a state of abject poverty. This includes emergency care and critical time interventions offered across 2 hospital based settings, and one shelter for homeless persons with psychosocial disabilities, operated in collaboration with the Corporation of Chennai under the National Urban Livelihoods Mission (NULM), reaching out to 162 individuals in distress at any given point of time. Over 3400 individuals have accessed these services since 1993. The Banyan's NALAM programme offers well-being oriented outpatient clinics and community based mental health care in both urban and rural areas. These clinics provide free of charge and mental health and social care services, address distress, common mental disorders and severe mental disorders. They are offered across 15 service access points, reaching out to a population of approximately 7 lakhs. NALAM has reached out to over 10,000 individuals and has a current active registry of 2000 individuals. For those who experience high support needs, The Banyan offers a range of inclusive living options, over 200 individuals with moderate to severe mental health issues, today live in communities & homelike environments with supportive services across 6 districts in 3 States (Tamil Nadu, Kerala, Maharashtra). The Banyan's sister organisation - The Banyan Academy of Leadership in Mental Health (BALM), was founded in 2007, and works towards consolidating findings and experiences from The Banyan, and disseminating it across multiple stakeholders within the mental health and development spaces. BALM works on building practice based evidence and contributing to a knowledge base, that aids in addressing treatment and care gaps, particularly in the context of vulnerable individuals and groups. It uses capacity building, education programmes (diploma, masters’, and PhD programmes) in collaboration with the Tata Institute of Social Sciences (TISS), research, collaborative work (with civil society organisations, local governments, disability movements, mental health user-caregiver groups, and Central and State Government) and construction of think tanks, as strategies to influence progressive policies and plans.
  • 1.8K
  • 10 Oct 2022
Topic Review
Resveratrol in Autism Spectrum Disorders
Resveratrol (RSV) is a polyphenolic stillbenoid with significant anti-oxidative and anti-inflammatory properties recently tested in animal models of several neurological diseases. Altered immune alteration and oxidative stress have also been found in patients with autism spectrum disorders (ASD), and these alterations could add to the pathophysiology associated with ASD. 
  • 1.8K
  • 27 May 2021
Topic Review
Sleep Health Promotion Interventions
Sleep health promotion is the public health field that is concerned with improving sleep health in primarily healthy populations. Good sleep health is characterized by subjective satisfaction, appropriate timing, adequate duration, high efficiency, and sustained alertness during waking hours (Buysse,2014). As in the last decade evidence has been mounting that good sleep is crucial for health, sleep health promotion is receiving increasing attention in public health. In this contribution, an overview is provided of the sleep health promotion interventions that have been described in reviews. 
  • 1.8K
  • 31 May 2021
Topic Review
Physical Activity among Children with Intellectual Disabilities
Children and adolescents with intellectual disabilities (ID) have low levels of physical activity (PA). Understanding factors influencing the PA participation of this population is essential to the design of effective interventions. Continued exploration of factors influencing PA participation is required among children and adolescents with ID. Future interventions should involve families, schools, and wider support network in promoting their PA participation together. 
  • 1.8K
  • 22 Feb 2022
Topic Review
Sustainable Buildings in Saudi Arabia
Sustainable building practices are a response to environmental issues. Businesses and industries are assessing how their activities affect the environment. The architecture, engineering and construction (AEC) industries have significant impacts on the environment and economy, while the industry is considered one of the largest contributors to greenhouse gas (GHG) emissions and has, therefore, been highlighted by researchers as a key area of intervention with a great potential to reduce environmental impacts. 
  • 1.7K
  • 01 Sep 2022
Topic Review
Mediterranean Diet and Potential Drug-Food Interactions
There is a growing interest among people in western countries for adoption of healthier lifestyle habits and diet behaviors with one of the most known ones to be Mediterranean diet (Med-D). Med-D is linked with daily consumption of food products such as vegetables, fruits, whole grains, seafood, beans, nuts, olive oil, low-fat food derivatives and limited consumption of meat or full fat food products. Med-D is well-known to promote well-being and lower the risk of chronic conditions such as cardiovascular diseases, diabetes, and metabolic syndrome. On the other hand, bioactive constituents in foods may interfere with drugs’ pharmacological mechanisms, modulating the clinical outcome leading to drug-food interactions (DFIs). This text discusses current evidence for food products that are included within the Med-D and available scientific data suggest a potential contribution in DFIs with impact on therapeutic outcome. Proper patient education and consultation from healthcare providers is important to avoid any conflicts and side effects due to clinically significant DFIs.
  • 1.7K
  • 08 Nov 2022
Topic Review
Lactose Intolerance and Personalized Nutrition
Recent discoveries in the “omics” field and the growing focus on preventive health have opened new avenues for personalized nutrition (PN), which is becoming an important theme in the strategic plans of organizations that are active in healthcare, food, and nutrition research. PN holds great potential for individual health optimization, disease management, public health interventions, and product innovation. However, there are still multiple challenges to overcome before PN can be truly embraced by the public and healthcare stakeholders. The diagnosis and management of lactose intolerance (LI), a common condition with a strong inter-individual component, is explored as an interesting example for the potential role of these technologies and the challenges of PN. From the development of genetic and metabolomic LI diagnostic tests that can be carried out in the home, to advances in the understanding of LI pathology and individualized treatment optimization, PN in LI care has shown substantial progress. However, there are still many research gaps to address, including the understanding of epigenetic regulation of lactase expression and how lactose is metabolized by the gut microbiota, in order to achieve better LI detection and effective therapeutic interventions to reverse the potential health consequences of LI.
  • 1.7K
  • 20 May 2021
Topic Review
Diffusion Weighted Imaging in Neuro-Oncology
Diffusion weighted imaging (DWI) is an imaging technique commonly used for the assessment of acute ischemia, inflammatory disorders, and CNS neoplasia. It has several benefits since it is a quick, easily replicable sequence that is widely used on many standard scanners. In addition to its normal clinical purpose, DWI offers crucial functional and physiological information regarding brain neoplasia and the surrounding milieu.
  • 1.7K
  • 24 Apr 2023
Topic Review
Bezold’s Abscess
Bezold’s abscess is a deep neck abscess related to otomastoiditis. Due to the insidious clinical presentation, diagnosis can be extremely challenging, leading to delays in treatment and possible life-threatening complications. Bezold’s abscess is found at any age, with overt male prevalence among adults. The clinical presentation, as well as the causative pathogens, are strikingly heterogeneous. Otomastoiditis and cholesteatoma are major risk factors.
  • 1.7K
  • 23 Jun 2022
Topic Review
Edible Mushrooms for Major Depressive Disorder
Major depressive disorder (MDD) is still defined as a unitary entity characterized by decontextualized symptoms, which include either: (1) depressed mood or (2) loss of interest or pleasure (anhedonia); and at least five out of nine other symptoms (e.g., fatigue, insomnia, suicidal thoughts, diminished concentration, and psychomotor delay). To qualify as a major depressive episode, the symptoms have to persist for a minimum of 2 weeks and cause significant distress and disturbances in initiating and performing daily activities. Individuals with recurrent episodes are diagnosed with MDD. Edible medicinal mushrooms may be an adjunctive treatment for MDD.
  • 1.7K
  • 10 Jan 2023
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