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Topic Review
Features in Interdigitated Electrode Array
The electrical double layer (EDL) and crucial parameters such as sensitivity, selectivity, specificity, and limit of detection (LOD) are prominent to determine the interdigitated electrode array (IDEA)-based electrochemical sensor. The design of IDEA focuses on controlling the width and gap measurements between the adjacent fingers and increases the IDEA’s height are crucial because all the design measurement and parameters affected the IDEA-based electrochemical sensor functionality according to the application usage.
  • 1.2K
  • 08 Dec 2022
Topic Review
Protein L
Protein L is a surface protein of Peptostreptococcus magnus, showing binding activity against IgGs. Therefore, protein L can be used as affinity ligand in the purification process of antibodies and antibody fragments. Furthermore, analytical tools based on this specific interaction are applied in industry and research.
  • 1.2K
  • 28 May 2021
Topic Review
Confocal Microscopy
Confocal microscopy, most frequently Confocal Laser Scanning Microscopy (CLSM) or Laser Confocal Scanning Microscopy (LCSM), is an optical imaging technique for increasing the optical resolution and contrast of a micrograph by means of using a spatial pinhole to block out-of-focus light or glare in image formation.
  • 1.2K
  • 18 Mar 2021
Topic Review
3D Bioprinting of Musculoskeletal Tissue
The musculoskeletal system is a vital body system that protects internal organs, supports locomotion, and maintains homeostatic function. Unfortunately, musculoskeletal disorders are the leading cause of disability worldwide. Although implant surgeries using autografts, allografts, and xenografts have been conducted, several adverse effects, including donor site morbidity and immunoreaction, exist. To overcome these limitations, various biomedical engineering approaches have been proposed based on an understanding of the complexity of human musculoskeletal tissue. In this review, the leading edge of musculoskeletal tissue engineering using 3D bioprinting technology and musculoskeletal tissue-derived decellularized extracellular matrix bioink is described. In particular, studies on in vivo regeneration and in vitro modeling of musculoskeletal tissue have been focused on. Lastly, the current breakthroughs, limitations, and future perspectives are described.
  • 1.2K
  • 03 Mar 2022
Topic Review
Thermosensitive Polymers
Temperature excursions within a biological milieu can be effectively used to induce drug release from thermosensitive drug-encapsulating nanoparticles. Oncological hyperthermia is of particular interest, as it is proven to synergistically act to arrest tumor growth when combined with optimally-designed smart drug delivery systems (DDSs). Thermoresponsive DDSs aid in making the drugs more bioavailable, enhance the therapeutic index and pharmacokinetic trends, and provide the spatial placement and temporal delivery of the drug into localized anatomical sites.
  • 1.2K
  • 09 Mar 2022
Topic Review
Applications of Smart Drug Delivery Devices
The internet of things (IoT) plays a vital role in smart drug delivery systems. It is an emerging field that offers promising solutions for improving the efficacy, safety, and patient compliance of drug therapies. IoT-based drug delivery systems leverage advanced devices, sophisticated sensors, and smart tools to monitor and analyse the health matrices of the patient in real-time, allowing for personalised and targeted drug delivery. This technology is implemented through various types of devices, including wearable and implantable devices such as infusion pumps, smart pens, inhalers, and auto-injectors. However, the development and implementation of IoT-based drug delivery systems pose several challenges, such as ensuring data security and privacy, regulatory compliance, compatibility, and reliability.
  • 1.2K
  • 10 Jul 2023
Topic Review
Coatings Empowering Antiviral/Viricidal Properties
In the surge of the current, alarming scenario of SARS-CoV-2 infections, there is a immediate necessity for developing highly-innovative antiviral agents to work against the viruses with a broad spectrum of antiviral activity. Here-in, science-based methods, mechanisms, and procedures are implemented in obtaining resultant antiviral coated substrates, used in the destruction of the strains of the different viruses are presented. we pay particular attention to recent examples from the materials science and engineering field that highlight how some classes of antiviral drug candidates, such as polymeric materials, metal ions/metal oxides and functional nanomaterials result in acting against the viral spread. Based on the available literature and data, we also disclose some of the strategies for development of a universal and reusable virus deactivation system against the emerging COVID-19.
  • 1.2K
  • 25 Sep 2020
Topic Review
Applications of Magnetic Hydrogels
Magnetic hydrogels (MHGs) are a special class of hydrogel that contain at least one magnetic component in their composition. Generally, MNPs are dispersed in a polymer gel matrix to form MHGs. These hydrogels are special because they are prone to show fluctuations in their physical properties in the presence of an externally applied magnetic field.
  • 1.2K
  • 08 Dec 2021
Topic Review
Nanotechnology
Nanotechnology is opening new therapeutic possibilities of fighting against COVID-19 by enabling new prevention, diagnosis, drug delivery, and treatment methods. Nanomedicine is known as the branch of medicine involved in preventing and curing various diseases using nanoscale materials, such as biocompatible nanoparticles and nanorobots, for various applications, including diagnosis, delivery, and sensing. In addition, nanomedicines have exhibited important features, such as efficient transport through fine capillary blood vessels and lymphatic endothelium, longer circulation duration and blood concentration, higher binding capacity to biomolecules such as endogenous compounds including proteins, higher accumulation in target tissues, reduced inflammatory or immune responses, and oxidative stress in tissues.
  • 1.2K
  • 09 May 2024
Topic Review
Pluripotent Stem Cell
Pluripotent stem cells (PSC) such as embryonic stem cells (ESC) and induced PSCs (iPSC) are originated from embryos and induced from adult tissue cells, respectively. PSCs are capable of proliferating almost indefinitely, and differentiating into all somatic cells, through processes that mimic early embryogenesis. The resulting cells tend to carry embryonic characteristics.
  • 1.2K
  • 11 Oct 2021
Topic Review
Enzymatic Biofuel Cells
Enzymatic biofuel cells can be considered as a promising solution to generate electricity from biological catalytic reactions. Indeed, enzymes show very good results as biocatalysts thanks to their excellent intrinsic properties, such as specificity toward substrate, high catalytic activity with low overvoltage for substrate conversion, mild operating conditions like ambient temperature and near-neutral pH. Furthermore, enzymes present low cost, renewability and biodegradability. The wide range of applications moves from miniaturized portable electronic equipment and sensors to integrated lab-on-chip power supplies, advanced in vivo diagnostic medical devices to wearable devices. Nevertheless, enzymatic biofuel cells show great concerns in terms of long-term stability and high power output nowadays, highlighting that this particular technology is still at early stage of development. 
  • 1.2K
  • 22 Mar 2021
Topic Review
AI&ML for Medical Sector
This work represents a comprehensive analysis of the potential AI, ML, and IoT technologies for defending against the COVID-19 pandemic. The existing and potential applications of AI, ML, and IoT, along with a detailed analysis of the enabling tools and techniques are outlined. A critical discussion on the risks and limitations of the aforementioned technologies are also included.
  • 1.1K
  • 21 Jan 2021
Topic Review
Rhizopus oryzae Lipase
Lipases are biocatalysts with a significant potential to enable a shift from current pollutant manufacturing processes to environmentally sustainable approaches. The main reason of this prospect is their catalytic versatility as they carry out several industrially relevant reactions as hydrolysis of fats in water/lipid interface and synthesis reactions in solvent-free or non-aqueous media such as transesterification, interesterification and esterification. Because of the outstanding traits of Rhizopus oryzae lipase (ROL), 1,3-specificity, high enantioselectivity and stability in organic media, its application in energy, food and pharmaceutical industrial sector has been widely studied. Significant advances have been made in the biochemical characterisation of ROL particularly in how its activity and stability are affected by the presence of its prosequence. In addition, native and heterologous production of ROL, the latter in cell factories like Escherichia coli, Saccharomyces cerevisiae and Komagataella phaffii (Pichia pastoris), have been thoroughly described. Therefore, in this review, we summarise the current knowledge about R. oryzae lipase (i) biochemical characteristics, (ii) production strategies and (iii) potential industrial applications.
  • 1.1K
  • 10 Dec 2020
Topic Review
Nanomaterials for Heavy Metal Removal
Nanomaterials are defined as materials that contain particles measuring between 1.0 and 100 nm in at least one dimension.
  • 1.1K
  • 01 Feb 2021
Topic Review
Carbon Dots-Mediated Fluorescent Scaffolds
Regeneration of damaged tissues or organs is one of the significant challenges in tissue engineering and regenerative medicine. Many researchers have fabricated various scaffolds to accelerate the tissue regeneration process. However, most of the scaffolds are limited in clinical trials due to scaffold inconsistency, non-biodegradability, and lack of non-invasive techniques to monitor tissue regeneration after implantation. Recently, carbon dots (CDs) mediated fluorescent scaffolds are widely explored for the application of image-guided tissue engineering due to their controlled architecture, light-emitting ability, higher chemical and photostability, excellent biocompatibility, and biodegradability.
  • 1.1K
  • 08 Jun 2021
Topic Review
Quantum Dots
Quantum dots (QDs) are an advanced nanomaterial technology deem to be useful in clinical and biomedical applications. QDs have given a big impact in biomedical application due to their imaging potential which significantly improved the clinical diagnostics test. Meanwhile, QDs also have the potential to become the nanocarrier for the drug.
  • 1.1K
  • 05 Feb 2021
Topic Review
Micro-Computed Tomography
Micro-computed tomography (micro-CT) is a consolidated imaging technology allowing non-destructive three-dimensional (3D) qualitative and quantitative analysis by the observation of microstructures with high resolution. This paper Ten Years of Micro-CT in Dentistry and Maxillofacial Surgery: A Literature Overview aims at delivering a structured overview of literature about studies performed using micro-CT in dentistry and maxillofacial surgery (MFS) by analyzing the entire set of articles to portray the state of the art of the last ten years of scientific publications on the topic. 
  • 1.1K
  • 23 Feb 2021
Topic Review
Design of Gold Nanoparticle Vertical Flow Assays
Vertical flow assays (VFAs) or flow-through assays have emerged as an alternate type of paper-based assay due to their faster detection time, larger sample volume capacity, and significantly higher multiplexing capabilities compared to lateral flow assays (LFAs).  VFA can be used for detecting important biomarkers in diagnostic medicine, particularly when VFA is paired with gold nanoparticle conjugation.
  • 1.1K
  • 10 May 2022
Topic Review
Low-Cost Thermal Cameras
Thermal imaging is a promising technology in the medical field, in which infrared (IR) sensors can be used in e-health applications. However, in order to make this technology more accessible, the suitability of low-cost devices for such applications has been evaluated. Low-cost sensors present reduced capabilities compared to more expensive high-end devices. Therefore, their characterization is of outmost interest, which is performed in terms of the following parameters: non-uniformity (NU) effects and correction as well as their dependence on room temperature, noise-equivalent temperature difference (NETD), and response curve stability with temperature. In this work, a good performance is shown for the selected low-cost sensor, especially when used in temperature-controlled environments. Thus, the suitability of such sensors for medical applications is confirmed, proving its efficiency for the particular application we are focused on, this is, the assessment of diabetic foot ulcers.
  • 1.1K
  • 29 Oct 2020
Topic Review
EPS Cyanobacterial Bioprocess Development
Cyanobacteria have the potential to become an industrially sustainable source of functional biopolymers. Their exopolysaccharides (EPS) harbor chemical complexity, which predicts bioactive potential. Cyanobacterial EPS, from the bioprocess point of view, is seen as a by-product of biomass and/or metabolite production such as proteins and to a lesser extent lipid. The slimy texture of culture medium after EPS production hinders handling while structure elucidation and productivities gave a tough reputation to these classes of polysaccharides within the industrial sector; however, the uniqueness of the few resolved structures has opened markets to these polysaccharides. To develop an EPS cyanobacterial bioprocess (Cyano-EPS) three steps are highlighted: the selection of the cyanobacterial host; optimization of production parameters; downstream processing. 
  • 1.1K
  • 27 Oct 2020
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