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Topic Review
Plant Heat Shock Proteins
Plant heat shock proteins (HSPs), as chaperones, play a pivotal role in conferring biotic and abiotic stress tolerance. Moreover, HSP also enhances membrane stability and detoxifies the reactive oxygen species (ROS) by positively regulating the antioxidant enzymes system. 
  • 2.1K
  • 29 Oct 2021
Topic Review
Applications of Humanized Mice in Oncology
While chemotherapies remain the mainstay treatments for many cancers, the advent of new molecular techniques has opened doors for more targeted modalities towards cancer cells. Although immune checkpoint inhibitors (ICIs) have demonstrated therapeutic efficacy in treating cancer, adverse side effects related to excessive inflammation are often reported. There is a lack of clinically relevant animal models to probe the human immune response towards ICI-based interventions. Humanized mouse models have emerged as valuable tools for pre-clinical research to evaluate the efficacy and safety of immunotherapy. 
  • 2.1K
  • 05 Jun 2023
Topic Review
Life Quality in Smart Destinations
The objective of this research is to propose a theoretical model based on studies on residents’ quality of life in smart tourism destinations. Smart tourism destinations are territories based on information and communication technologies (ICT), which improve travelers’ tourist experiences as well as affect the quality of life of residents. To know the context of the relationships between tourism and quality of life, main studies and theories regarding these two phenomena are analyzed. Likewise, the relationship between smart places and quality of life is also studied.
  • 2.1K
  • 22 Oct 2020
Topic Review
Synthetic Biology towards Flavonoid Pharmacokinetics
Flavonoids are a structurally diverse class of natural products that have been found to have a range of beneficial activities in humans. However, the clinical utilisation of these molecules has been limited due to their low solubility, chemical stability, bioavailability and extensive intestinal metabolism in vivo. Recently, the view has been formed that site-specific modification of flavonoids by methylation and/or glycosylation, processes that occur in plants endogenously, can be used to improve and adapt their biophysical and pharmacokinetic properties. The traditional source of flavonoids and their modified forms is from plants and is limited due to the low amounts present in biomass, intrinsic to the nature of secondary metabolite biosynthesis. Access to greater amounts of flavonoids, and understanding of the impact of modifications, requires a rethink in terms of production, more specifically towards the adoption of plant biosynthetic pathways into ex planta synthesis approaches. Advances in synthetic biology and metabolic engineering, aided by protein engineering and machine learning methods, offer attractive and exciting avenues for ex planta flavonoid synthesis.
  • 2.1K
  • 04 Jun 2021
Topic Review
NKT Cells
Natural killer T (NKT) cells, a small population of T cells, are capable of influencing a wide range of the immune cells, including T cells, B cells, dendritic cells and macrophages. NKT cells can influence the status of the innate and adaptive immune systems because they secrete huge amounts of Th1 and Th2 cytokines. Earlier, the NKT cells were characterized by the NK and T cell properties as they express the natural killer (NK) cell lineage markers and αβ T-cell receptor (TCR). NKT cells are more appropriately defined as “CD1d-restricted and TCR-αβ positive T cells”. In mice, the NKT cells constitute about 0.2–2.0% of lymphocytes in the blood, spleen, bone marrow and thymus, and about 15–35% of total lymphocytes in the liver. On the other hand, the levels of NKT cells are lower in humans, comprising about 0.04–1.3% of circulating lymphocytes in the blood, spleen and bone marrow. They make up about 0.001–0.01% of lymphocytes in the thymus and about 1% in the liver. The greater part of the NKT cells, called canonical or invariant NKT cells (iNKT cells) or type I NKT cells have a specific TCR α-chain rearrangement (Vα14-Jα18 in mice; Vα24-Jα18 in humans), associated with limited diverse Vβ chains. Type II NKT cells, also called non-classical NKT cells, are more diverse in TCR α-chain (but some Vα3.2-Jα9, Vα8 in mice) and TCR-β chains (but some Vβ8.2 in mice).
  • 2.1K
  • 13 Sep 2021
Topic Review
Racing Thoughts
Racing thoughts refers to the rapid thought patterns that often occur in manic, hypomanic, or mixed episodes. While racing thoughts are most commonly described in people with bipolar disorder and sleep apnea, they are also common with anxiety disorders, OCD, and other psychiatric disorders such as attention deficit hyperactivity disorder. Racing thoughts are also associated with sleep deprivation, hyperthyroidism. and the use of amphetamines.
  • 2.1K
  • 10 Oct 2022
Topic Review
Neuroarchaeology
Neuroarchaeology refers to a field of study that records neuroscientific history through archaeological methods of investigation. The term was first suggested and thus coined by Colin Renfrew and Lambros Malafouris first individually in 2004 and then collaboratively in 2008.It is a combination of the words "neuro-" from 'neuroscience' indicating its connection with the brain sciences and "archaeology" meaning study of human history and prehistory through excavations and other tools. Significant leaps in brain and cognitive sciences in the 21st century have opened up new areas of partnership between archaeology and neuroscience. This collaboration can help an archaeologist figure out biological and neural substrates of human cognitive abilities present in the archaeological objects. The knowledge of neuroscience can also be applied to critically review and challenge existing theories and assumptions about the inception of modern human cognition. The term implies a new area of research that could investigate issues relating to the collaboration between the brain and culture over the long term development of humans. So far, the goals of neuroscience and archaeology are the same- to understand human nature. But their disciplinary approaches diverge significantly. Neuroarchaeology aims at building the analytical bridge between brain and culture ""by putting material culture, embodiment, time and long-term change at centre stage in mind".
  • 2.1K
  • 21 Nov 2022
Topic Review
Deep Eutectic Solvents in Pharmaceutical Industry
Neoteric solvents emerged as an alternative to organic solvents and are commonly called green solvents, since they have low toxicity, are biodegradable, are made with accessible and low-cost materials, and are quite easy to produce. Deep eutectic solvents (DESs) are defined as a mixture of two or more pure compounds, which, when combined in an appropriate ratio, give rise to a eutectic mixture that deviates from the ideal thermodynamic behaviour. This deviation is due to strong interactions between the initial components that act as hydrogen bond donors (HBDs) and hydrogen bond acceptors (HBAs). The HBDs and HBAs interact in the DESs to form a dense network of molecules that give them remarkably interesting physical and chemical properties. 
  • 2.1K
  • 23 Jan 2024
Topic Review
Hybrid Fibre-Coaxial
Hybrid fiber-coaxial (HFC) is a telecommunications industry term for a broadband network that combines optical fiber and coaxial cable. It has been commonly employed globally by cable television operators since the early 1990s. In a hybrid fiber-coaxial cable system, the television channels are sent from the cable system's distribution facility, the headend, to local communities through optical fiber subscriber lines. At the local community, a box called an optical node translates the signal from a light beam to radio frequency (RF), and sends it over coaxial cable lines for distribution to subscriber residences. The fiberoptic trunk lines provide adequate bandwidth[weasel words] to allow future expansion and new bandwidth-intensive services.
  • 2.1K
  • 07 Nov 2022
Topic Review
Concentrating Photovoltaic—Thermal Systems
Numerous numerical and experimental studies have been conducted regarding the Concentrated Photovoltaic Thermal (CPVT) system because of its significant potential for efficient conversion of solar energy. The overall efficiency of the CPVT system is strongly dependent on the device, which extracts excess heat from photovoltaic cells. The most efficient cooling technology involves active cooling, which means that heat is collected from the photovoltaic (PV) cell via the forced flow of heat transfer fluid.
  • 2.1K
  • 14 Sep 2022
Topic Review
Thyroid Cancer
Thyroid cancer represents a heterogenous disease whose incidence has increased in the last decades. Although three main different subtypes have been described, molecular characterization is progressively being included in the diagnostic and therapeutic algorithm of these patients. In fact, thyroid cancer is a landmark in the oncological approach to solid tumors as it harbors key genetic alterations driving tumor progression that have been demonstrated to be potential actionable targets. Within this promising and rapid changing scenario, current efforts are directed to improve tumor characterization for an accurate guidance in the therapeutic management. In this sense, it is strongly recommended to perform tissue genotyping to patients that are going to be considered for systemic therapy in order to select the adequate treatment, according to recent clinical trials data.
  • 2.1K
  • 21 Jul 2020
Topic Review
Smart Sanitation
The Toilet Board Coalition defines Smart Sanitation as a way to build resilience in cities, communities and sectors by utilizing Fourth Industrial Revolution technologies to improve the collection and monitoring of wastewater for both individualized and aggregate-level preventative health surveillance. 
  • 2.1K
  • 09 Nov 2020
Topic Review
Denial of Service Attacks in the Smart Grid
The smart grid is the current energy management and distribution trend: it merges cyber–physical systems (CPS) infrastructure with information and communication technologies (ICT) to ensure efficient power generation, smart energy distribution in real-time, and optimisation. It also allows for greater integration of alternative energy sources such as solar and wind power, which are heavily reliant on weather patterns. Smart grid applications include extraction of business value, smart charging of electric vehicles, smart distribution, generation and storage of energy, grid optimization, grid self-healing with fault protection technology, and many others. Denial-of-Service (DoS) attacks, in particular, have become critical threats to the smart grid because they target the availability of the grid infrastructure and services: in the context of smart grids, this includes both “ensuring timely and reliable access to and use of information” and “ensuring access to enough power”.
  • 2.1K
  • 28 Jan 2023
Topic Review
Circular RNAs in Metastasis in Breast Cancer
Circular RNAs (circRNAs) are single-stranded closed non-coding RNA molecules that are aberrantly expressed and produce tumor-specific gene signatures in human cancers. They exert biological functions by acting as transcriptional regulators, microRNA sponges, and protein scaffolds, regulating the formation of protein–RNA complexes and, ultimately, regulating gene expression. Triple-negative breast cancer (TNBC) is one of the most aggressive cancers of the mammary gland and has a poor prognosis. Studies of circRNAs in TNBC are limited but have demonstrated these molecules’ pivotal roles in cell proliferation, invasion, metastasis, and resistance to chemo/radiotherapy, suggesting that they could be potential prognostic biomarkers and novel therapeutic targets. 
  • 2.1K
  • 20 Nov 2023
Topic Review
Sulfur Compounds in Garlic for Asthma Treatment
Asthma is a chronic inflammatory disease in the airways with a multifactorial origin but with inflammation and oxidative stress as related pathogenic mechanisms. Garlic (Allium sativum) is a nutraceutical with different biological properties due to sulfur-containing natural compounds. Studies have shown that several compounds in garlic may have beneficial effects on cardiovascular diseases, including those related to the lungs. Therefore, it is possible to take advantage of the compounds from garlic as nutraceuticals for treating lung diseases.
  • 2.1K
  • 14 Dec 2022
Topic Review
Cognition-Based Evolution
Cognition-Based Evolution (CBE) asserts a comprehensive alternative approach to phenotypic variation and the generation of biological novelty. In CBE, evolutionary variation is the product of natural cellular engineering that permits purposive genetic adjustments as cellular problem-solving. CBE upholds that the cornerstone of biology is the intelligent measuring cell. Since all biological information that is available to cells is ambiguous, multicellularity arises from the cellular requirement to maximize the validity of available environmental information. This is best accomplished through collective measurement purposed towards maintaining and optimizing individual cellular states of homeorhesis as dynamic flux that sustains cellular equipoise. The collective action of the multicellular measurement and assessment of information and its collaborative communication is natural cellular engineering. Its yield is linked cellular ecologies and mutualized niche constructions that comprise biofilms and holobionts. In this context, biological variation is the product of collective differential assessment of ambiguous environmental cues by networking intelligent cells. Such concerted action is enabled by non-random natural genomic editing in response to epigenetic impacts and environmental stresses. Random genetic activity can be either constrained or deployed as a ‘harnessing of stochasticity’. Therefore, genes are cellular tools. Selection filters cellular solutions to environmental stresses to assure continuous cellular-organismal-environmental complementarity. Since all multicellular eukaryotes are holobionts as vast assemblages of participants of each of the three cellular domains (Prokaryota, Archaea, Eukaryota) and the virome, multicellular variation is necessarily a product of co-engineering among them. 
  • 2.1K
  • 20 May 2021
Topic Review
The Moderating Role of e-WOM
Except for perceived fee, which has a negative effect on perceived value, the results demonstrate that all hypotheses of latent correlations in TAM and VAM were strongly significant. Furthermore, attitude and perceived value have a significant role in determining consumer adoption of e-learning. Consumers’ perceived value will be driven by the high and low levels of the moderating influence of e-word of mouth, influencing their intention toward e-learning. Since e-learning is an effective sustainable education system, the result of this study can provide a good solution to facilitate e-learning in current and future conditions.
  • 2.1K
  • 13 Jan 2022
Topic Review
Circadian Rhythms
Infertility represents a growing health problem in industrialized countries. Thus, a greater understanding of the molecular networks involved in this disease could be critical for the development of new therapies. A recent finding revealed that circadian rhythmicity disruption is one of the main causes of poor reproductive outcome. The circadian clock system beats circadian rhythms and modulates several physiological functions such as the sleep-wake cycle, body temperature, heart rate, and hormones secretion, all of which enable the body to function in response to a 24 h cycle. This intricated machinery is driven by specific genes, called “clock genes” that fine-tune body homeostasis. Stress of modern lifestyle can determine changes in hormone secretion, favoring the onset of infertility-related conditions that might reflect disfunctions within the hypothalamic–pituitary–gonadal axis. Consequently, the loss of rhythmicity in the suprachiasmatic nuclei might affect pulsatile sexual hormones release. Herein, we provide an overview of the recent findings, in both animal models and humans, about how fertility is influenced by circadian rhythm. In addition, we explore the complex interaction among hormones, fertility and the circadian clock. A deeper analysis of these interactions might lead to novel insights that could ameliorate the therapeutic management of infertility and related disorders.
  • 2.1K
  • 02 Feb 2021
Topic Review
Implementing Sustainable Irrigation
      The sustainability of irrigated agriculture is threatening due to adverse climate change, given future projections that every one in four people on Earth might be suffering from extreme water scarcity by the year 2025. Pressurized irrigation systems and appropriate irrigation schedules can increase water productivity (i.e., product yield per unit volume of water consumed by the crop) and reduce the evaporative or system loss of water as opposed to traditional surface irrigation methods. However, in water-scarce countries, irrigation management frequently becomes a complex task. Deficit irrigation and the use of non-conventional water resources (e.g., wastewater, brackish groundwater) has been adopted in many cases as part of a climate change mitigation measures to tackle the water poverty issue. Protected cultivation systems such as greenhouses or screenhouses equipped with artificial intelligence systems present another sustainable option for improving water productivity and may help to alleviate water scarcity in these countries. This article presents a comprehensive review of the literature, which deals with sustainable irrigation for open-field and protected cultivation systems under the impact of climatic change in vulnerable areas, including the Mediterranean region.
  • 2.1K
  • 27 Apr 2023
Topic Review
Oral Cancer and Diet
Oral cancer, included within head and neck cancer, is the sixth most common malignant neoplasm in the world. The main etiological factors are tobacco and alcohol, although currently, diet is considered an important determinant for its development. Several dietary nutrients have specific mechanisms of action, contributing to both protection against cancer and increasing the risk for development, growth, and spread. Foods such as fruits, vegetables, curcumin, and green tea can reduce the risk of oral cancer, while the so-called pro-inflammatory diet, rich in red meat and fried foods, can enhance the risk of occurrence. Dietary factors with a protective effect show different mechanisms that complement and overlap with antioxidant, anti-inflammatory, anti-angiogenic, and anti-proliferative effects. 
  • 2.1K
  • 29 Apr 2021
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