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Topic Review
General Characteristics of Chitosan
Chitosan is a naturally occurring compound that can be obtained from deacetylated chitin, which is obtained from various sources such as fungi, crustaceans, and insects. Commercially, chitosan is produced from crustaceans. Based on the range of its molecular weight, chitosan can be classified into three different types, namely, high molecular weight chitosan (HMWC, >700 kDa), medium molecular weight chitosan (MMWC, 150–700 kDa), and low molecular weight chitosan (LMWC, less than 150 kDa).
  • 2.1K
  • 14 Jul 2023
Topic Review
Dysregulation of Microbiome–Immunity Interaction in Various Diseases
Gut microbes and their metabolites are actively involved in the development and regulation of host immunity, which can influence disease susceptibility. The role of the microbiome as a protective force is supported by research indicating that immature microbiomes of neonates are more susceptible to invasion by pathobionts. During early years of development, exposure to various microbes shapes the immune system for a lifetime. The gut microbiome has a wide range of metabolic activities, including metabolizing lipids, carbohydrates, and proteins, and participates in maintaining host homeostasis. Therefore, disruption of gut microbiome can lead to conditions as severe as cancer.
  • 2.1K
  • 06 Feb 2023
Topic Review
Gastroschisis
The International Clearinghouse for Birth Defects Surveillance and Research defines gastroschisis as "a congenital malformation characterized by visceral herniation usually through a right side abdominal wall defect to an intact umbilical cord and not covered by a membrane". Approximately 10% of infants with gastroschisis have intestinal stenosis or atresia resulting from vascular insufficiency due to a volvulus or compression of vascular pedicle by a narrowing abdominal ring.
  • 2.1K
  • 30 Jan 2021
Topic Review
Toons Mag
Toons Mag is a cartoon magazine that offers a global online platform for publishing editorial cartoons, comics, caricatures, illustrations, and related news. It is a multilingual publication and organizer of an international cartoon contest and exhibitions. It was founded in 2009 by cartoonist Arifur Rahman, based in Drøbak, Norway.
  • 2.1K
  • 24 Oct 2022
Topic Review
Protein–Polysaccharide Complexes (Conjugates) as Delivery Systems
Due to their combination of featured properties, protein and polysaccharide-based carriers show promising potential in food bioactive ingredient encapsulation, protection, and delivery. The common types of protein–polysaccharide complex/conjugate-based bioactive ingredient delivery systems include emulsion (conventional emulsion, nanoemulsion, multiple emulsion, multilayered emulsion, and Pickering emulsion), microcapsule, hydrogel, and nanoparticle-based delivery systems. This entry highlights the applications of protein–polysaccharide-based delivery vehicles in common bioactive ingredients including polyphenols, food proteins, bioactive peptides, carotenoids, vitamins, and minerals. The loaded food bioactive ingredients exhibited enhanced physicochemical stability, bioaccessibility, and sustained release in simulated gastrointestinal digestion. 
  • 2.1K
  • 04 Mar 2022
Topic Review
Molecular Classification of Breast Cancer
Breast cancer is the most commonly occurring cancer in women. There were over two-million new cases in world in 2018. It is the second leading cause of death from cancer in western countries. At the molecular level, breast cancer is a heterogeneous disease, which is characterized by high genomic instability evidenced by somatic gene mutations, copy number alterations, and chromosome structural rearrangements. The genomic instability is caused by defects in DNA damage repair, transcription, DNA replication, telomere maintenance and mitotic chromosome segregation. According to molecular features, breast cancers are subdivided in subtypes, according to activation of hormone receptors (estrogen receptor and progesterone receptor), of human epidermal growth factors receptor 2 (HER2), and or BRCA mutations. 
  • 2.1K
  • 26 May 2022
Topic Review
In Vivo Methods for Measuring the Glycemic Index
The concept of Glycemic Index (GI) was suggested by Jenkins to classify carbohydrate-containing foods. GI is “an expression of the percentage of the area under the blood glucose response curve when taking the same amount of carbohydrate as glucose”. It is a physiological way to explain how dietary carbohydrate impacts blood glucose. The GI value has a range between 1 and 100. Glucose, as the reference material, has a GI value of 100. A food with a lower GI value (≤54) raises blood glucose more slowly.
  • 2.1K
  • 12 May 2022
Topic Review
Deep Learning for Robotic Vision Methods
Robotic vision algorithms serve three primary functions in visual perception. Pattern recognition in machine vision is the process of identifying and classifying objects or patterns in images or videos using machine learning algorithms. Deep learning in robotic vision reveals a plethora of promising approaches, each with its own unique strengths and characteristics. Robotic vision systems can leverage the strengths of each architecture to improve object detection, tracking, and the understanding of complex visual scenes in dynamic environments. Big data and federated learning play significant roles in advancing the field of computer vision. Big data provides a wealth of diverse visual information, which is essential for training deep learning models that power computer vision applications. These datasets enable more accurate object recognition, image segmentation, and scene understanding.
  • 2.1K
  • 07 Feb 2024
Topic Review
Biological Clocks as Biomarkers of Aging
A key objective in biological aging research is to identify biomarkers capable of predicting the biological age (B-age) of different tissues, as an alternative to relying solely on chronological age (C-age). Biological clock technologies are designed to assess the acceleration of biological age (B-age) in diverse cell types, offering a distinctive opportunity in toxicogenomic research to explore the impact of environmental stressors, social challenges, and unhealthy lifestyles on health impairment. These clocks also play a role in identifying factors that can hinder aging and promote a healthy lifestyle. 
  • 2.1K
  • 29 Dec 2023
Topic Review
Idiopathic Pulmonary Fibrosis
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease. Chronic lung inflammation is linked to the pathogenesis of IPF. DROSHA, a class 2 ribonuclease III enzyme, has an important role in the biogenesis of microRNA (miRNA). The function of miRNAs has been identified in the regulation of the target gene or protein related to inflammatory responses via degradation of mRNA or inhibition of translation. The absent-in-melanoma-2 (AIM2) inflammasome is critical for inflammatory responses against cytosolic double stranded DNA (dsDNA) from pathogen-associated molecular patterns (PAMPs) and self-DNA from danger-associated molecular patterns (DAMPs). The AIM2 inflammasome senses double strand DNA (dsDNA) and interacts with the adaptor apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), which recruits pro-caspase-1 and regulates the maturation and secretion of interleukin (IL)-1β and IL-18. A recent study showed that inflammasome activation contributes to lung inflammation and fibrogenesis during IPF. In the current review, we discuss recent advances in our understanding of the DROSHA–miRNA–AIM2 inflammasome axis in the pathogenesis of IPF.
  • 2.1K
  • 26 Oct 2020
Topic Review
The Pathology of Parkinson’s Disease
Parkinson’s disease (PD) is a progressive neurodegenerative disorder that is characterized by a loss of dopaminergic neurons, leading to bradykinesia, rigidity, tremor at rest, and postural instability, as well as non-motor symptoms such as olfactory impairment, pain, autonomic dysfunction, impaired sleep, fatigue, and behavioral changes. 
  • 2.1K
  • 23 Feb 2021
Topic Review
Phytosomes
Phytosomes are an innovative lipid-based delivery system that have a liposomes-related structure and can be used for the entrapment of different types of polyphenolic-based phytoconstituents to improve their absorption when administrated. The first phytosomes were developed by Indena company (Milan, Italy) in the late 1980s, which aimed to increase the bioavailability of drugs by complexing them to phospholipids. The structure of phytosomes is composed of standardized polyphenolic plant extract incorporated into phospholipids, mainly phosphatidylcholine (PC).
  • 2.1K
  • 19 Oct 2021
Topic Review
Project 75I-class Submarine
The Project 75 (India)-class submarines, or P-75I, for short, are a planned class of diesel-electric submarines, which are to be built for the Indian Navy. The P-75I class is a follow-on of the P-75 class submarines of the Indian Navy. Under this project, the Indian Navy intends to acquire six conventional, diesel-electric attack submarines, which will also feature advanced capabilities - including air-independent propulsion (AIP), ISR, special operations forces (SOF), anti-ship warfare (AShW), anti-submarine warfare (ASW), anti-surface warfare (ASuW), land-attack capabilities and other features. All six submarines are expected to be constructed in India, under the Make in India initiative.
  • 2.1K
  • 13 Oct 2022
Topic Review
Cellulosic Ethanol Commercialization
Cellulosic ethanol commercialization is the process of building an industry out of methods of turning cellulose-containing organic matter into cellulosic ethanol for use as a biofuel. Companies, such as Iogen, POET, DuPont, and Abengoa, are building refineries that can process biomass and turn it into bioethanol. Companies, such as Diversa, Novozymes, and Dyadic, are producing enzymes that could enable a cellulosic ethanol future. The shift from food crop feedstocks to waste residues and native grasses offers significant opportunities for a range of players, from farmers to biotechnology firms, and from project developers to investors. As of 2013, the first commercial-scale plants to produce cellulosic biofuels have begun operating. Multiple pathways for the conversion of different biofuel feedstocks are being used. In the next few years, the cost data of these technologies operating at commercial scale, and their relative performance, will become available. Lessons learnt will lower the costs of the industrial processes involved.
  • 2.1K
  • 26 Oct 2022
Topic Review
History of Human-Powered Aircraft
HPAs are aircraft belonging to the class of vehicles known as human-powered vehicles. Early attempts at human-powered flight were unsuccessful because of the difficulty of achieving the high power-to-weight ratio. Prototypes often used ornithopter principles which were not only too heavy to meet this requirement but aerodynamically unsatisfactory. Human-powered aircraft have been successfully flown over considerable distances. However, they are still primarily constructed as engineering challenges rather than for any kind of recreational or utilitarian purpose.
  • 2.1K
  • 31 Oct 2022
Topic Review
Pedestrian Violations
Pedestrians are a vulnerable group of road users. Worldwide, the number of pedestrian deaths annually in road traffic accidents is about 270,000, which exceeds 22% of all traffic mortalities. This rate reveals its critical role in traffic safety research. Of these, pedestrian accidents mainly occur at signalized intersections when pedestrians illegally pass-through crosswalks, which are highly dangerous due to the high risk of pedestrian–vehicle interactions. Illegal crossings mainly include pedestrians crossing at red lights or outside of marked crosswalks, and the former usually causes severe harm. This risky behavior may raise traffic safety issues between pedestrians and driving vehicles. As such, it is necessary to analyze pedestrian red-light violations at signalized intersections and to reduce the risk of pedestrian crossing violations.
  • 2.1K
  • 14 Nov 2022
Topic Review
Homophile
The words homophile and homophilia are dated terms for homosexuality. The use of the word began to disappear with the emergence of the gay liberation movement of the late 1960s and early 1970s, replaced by a new set of terminology such as gay, lesbian, and bisexual.
  • 2.1K
  • 21 Nov 2022
Topic Review
Carbon Sequestration by Biofuel Crop Switchgrass
Under the macroenvironmental background of global warming, all countries are working to limit climate change. Internationally, biofuel plants are considered to have great potential in carbon neutralization. Several countries have begun using biofuel crops as energy sources to neutralize carbon emissions. Switchgrass (Panicum virgatum) is considered a resource-efficient low-input crop that produces bioenergy. 
  • 2.1K
  • 30 Dec 2022
Topic Review
Knowledge Management in Agriculture
Achieving global food security requires better use of natural, genetic, and importantly, human resources—knowledge. Technology must be created, and existing and new technology and knowledge deployed, and adopted by farmers and others engaged in agriculture. This requires collaboration amongst many professional communities world-wide including farmers, agribusinesses, policymakers, and multi-disciplinary scientific groups. Each community having its own knowledge-associated terminology, techniques, and types of data, collectively forms a barrier to collaboration. Knowledge management (KM) approaches are being implemented to capture knowledge from all communities and make it interoperable and accessible as a “group memory” to create a multi-professional, multidisciplinary knowledge economy.
  • 2.1K
  • 25 Apr 2023
Topic Review
North American River Otter
The North American River Otter (Lontra canadensis) is a charismatic and highly adaptable semi-aquatic mammal native to freshwater habitats across North America. Recognizable for its sleek, streamlined body, webbed feet, and playful behavior, this otter species is well-suited to its aquatic lifestyle. As a top predator in freshwater ecosystems, the North American River Otter plays a vital role in maintaining the health and balance of aquatic food webs.
  • 2.1K
  • 08 Feb 2024
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