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Topic Review
Reducing Phosphorus Loads
The wide application of fertilizers in tile-drained agricultural systems commonly results in the loss of phosphorus (P) to the underground tile drains during precipitation events and emission to downstream surface waters. As different catchments are subject to local geological and climatic conditions, among other factors, it is observed a large spatiotemporal variation in the dynamics of P emissions, including the load and dominant form (i.e., particulate or dissolved). In-farm practices may be able to mitigate this problem to some extent (e.g. by optimizing the P application), but may not suffice in areas saturated with P. Therefore, systems designed to reduce the excess P loads at relatively low costs and located at the edge of tile-drained catchments have been tested and implemented. This has been done by increasing the hydraulic residence time of the drainage discharge, allowing sedimentation of particles and biogeochemical processes between the water, soil/sediments and biota to occur; by trapping P at the bank of watercourses; and by enhancing the retention of dissolved P with filters rich in P sorbents. The retention of P by these measures, however, can be rather variable and largely depends on the catchment conditions. Thus, a series of considerations, e.g., in regards to design parameters, long-term stability of the P retained and retention of different P forms, must be taken into account, including major constraints (e.g., use of agricultural land), to ensure successful application of edge-of-field measures and achieve the desired cost-efficiency.
  • 2.1K
  • 01 Nov 2020
Topic Review
TikTok in Contemporary Arts Market
During the COVID-19 pandemic, TikTok attracted many artists, who used the platform to take their practice, and thereby their self-marketing, into their own hands. At the same time, a new generation of collectors use TikTok to discover art under popular hashtag #feministartists. When artists label their work with #feministartists, they insert themselves into the gatekeeping process, and use opportunities and restrictions bounded to that specific hashtag. The study examines this process of professional self-positioning by using interviews with contemporary artists, curators, and observations on TikTok, artist talks, and secondary interviews with artists on online platforms. The findings suggest a variation in how one trades in or trades on “feminist artist”, accessing resources, and gaining exposure. A focus on “feminist artists” is restrictive for consolidating artists’ efforts to pursue specific professional, social, political, and economic agendas through art. 
  • 2.1K
  • 23 Aug 2021
Topic Review
Heterocyclic Anticancer Compounds
Heterocyclic organic compounds are designated as integral components on a wide array of structures with both pharmacological and biological importance. They constitute a large cohort of structures with immense importance in the life sciences. 
  • 2.1K
  • 29 Mar 2022
Topic Review
Biological Activities of Paper Mulberry
Paper mulberry (Broussonetia papyrifera) is one of the most common skin-lightening agents in the beauty industry due to its strong anti-tyrosinase activity. It consists of various components, including flavonoids, tannins, alkaloids, phenols, saponins, coumarins, glycosides, and polysaccharides, which possess a wide range of pharmacological properties. Apart from its anti-tyrosinase activity, paper mulberry and its compounds exhibited anti-inflammatory, antioxidant, antimicrobial, antiviral, anticancer, antidiabetic, anticholinesterase, antigout, antinociceptive, and hepatoprotective effects. Phenols and flavonoids were demonstrated to be the main contributors to the biological activities of paper mulberry. Paper mulberry is widely applied in cosmetics for skin lightening and skin moisturizing purposes and shows potential for application in hair care products due to the hair nourishing effects. The safety of paper mulberry for topical application was proven in clinical studies.
  • 2.1K
  • 18 Nov 2022
Topic Review
Purification Strategies of Microbial Lipases
Lipases are versatile biocatalysts and are used in different bioconversion reactions. Microbial lipases are attracting a great amount of attention due to the rapid advancement of enzyme technology and its practical application in a variety of industrial processes. Lipase purification is a meticulous technique that requires great care to retain the bioactive state of the lipase.
  • 2.1K
  • 27 Feb 2023
Topic Review
Congenital Heart Disease
The use of next-generation sequencing has provided new insights into the causes and mechanisms of congenital heart disease (CHD). Examinations of the whole exome sequence have detected detrimental gene variations modifying single or contiguous nucleotides, which are characterised as pathogenic based on statistical assessments of families and correlations with congenital heart disease, elevated expression during heart development, and reductions in harmful protein-coding mutations in the general population.
  • 2.1K
  • 19 Feb 2024
Topic Review
HDAC6
Histone deacetylase (HDAC) 6 is a zinc-dependent enzyme of HDAC class IIb. HDAC6 is unique within the HDAC family due to a particular structure giving it unique biological functions implicated in all major cell pathways. This isoenzyme is mainly active in the cytoplasm and possesses two functional catalytic sites and an ubiquitin-binding domain. The deacetylase functions of HDAC6 targets multiple substrates including essentially α-tubulin and heat shock protein (HSP)90α which are key factors in cell regulatory networks through the regulation of the microtubule network and many protein functions, respectively. Accordingly, several studies have highlighted the role of HDAC6 in various pathological conditions. For instance HDAC6 overexpression frequently correlates with tumorigenesis and favor cell survival and metastasis. Therefore, HDAC6 represents an interesting potential therapeutic target.
  • 2.1K
  • 15 Jul 2021
Topic Review
Amygdalin
Bioactive amygdalin, found in high concentrations in bitter almonds, has been recognized as a symbol of the cyanogenic glycoside chemical organic substance, which was initially developed as a pharmaceutical for treating cancer after being hydrolyzed to hydrogen cyanide (HCN).
  • 2.1K
  • 25 Oct 2022
Topic Review
Ionic Liquid Membranes
Heightened levels of carbon dioxide (CO2) and other greenhouse gases (GHGs) have prompted research into techniques for their capture and separation, including membrane separation, chemical looping, and cryogenic distillation. Ionic liquids, due to their negligible vapour pressure, thermal stability, and broad electrochemical stability have expanded their application in gas separations.
  • 2.1K
  • 12 Oct 2020
Topic Review
Immunologic Adverse Reactions to Food
Adverse food reactions include immune-mediated food allergies and non-immune-mediated intolerances. However, this distinction and the involvement of different pathogenetic mechanisms are often confused. Furthermore, there is a discrepancy between the perceived vs. actual prevalence of immune-mediated food allergies and non-immune reactions to food that are extremely common. The risk of an inappropriate approach to their correct identification can lead to inappropriate diets with severe nutritional deficiencies.
  • 2.1K
  • 23 Jun 2021
Topic Review
Mouth Pain in Horses
Mouth pain in horses, specifically that caused by bits, is evaluated as a significant welfare issue. The conscious experiences of pain generated within the body generally, its roles, and its assessment using behaviour, as well as the sensory functionality of the horse’s mouth, are outlined as background to a more detailed evaluation of mouth pain. Bit-induced mouth pain elicited by compression, laceration, inflammation, impeded blood flow, and the stretching of tissues is considered. Observable signs of mouth pain are behaviours that are present in bitted horses and absent or much less prevalent when they are bit-free. It is noted that many equestrians do not recognise that these behaviours indicate mouth pain, so that the magnitude of the problem is often underestimated. 
  • 2.1K
  • 19 Jan 2022
Topic Review
Processing of Fab Fragments in E. coli
Monoclonal antibody fragments (Fab) are a rising class of biotherapeutics and their production has been optimised using coexpression of molecular chaperones such as DsbC or DnaK–DnaJ–GrpE, as well as strain engineering for post-translational modifications such as disulphide bridging. Different media systems such as EnBase and combining nitrogen source supplementation with low-temperature cultivation have resulted in improvement in cell integrity, protein expression, and protein refolding. The recovery of native proteins from insoluble inclusion bodies can be improved by adjusting refolding conditions, as well as by incorporating multimodal and affinity chromatography for achieving high product yields in purification.
  • 2.1K
  • 27 Apr 2022
Topic Review
Climate Change and Agriculture
Climate change and agriculture are interrelated processes, both of which take place on a global scale. Global warming affects agriculture in a number of ways, including through changes in average temperatures, rainfall, and climate extremes (e.g., heat waves); changes in pests and diseases; changes in atmospheric carbon dioxide and ground-level ozone concentrations; changes in the nutritional quality of some foods; and changes in sea level. Climate change is already affecting agriculture, with effects unevenly distributed across the world. Future climate change will likely negatively affect crop production in low latitude countries, while effects in northern latitudes may be positive or negative. Animal agriculture, although lesser than vehicles, is also responsible for CO2 greenhouse gas production and a percentage of the world's methane, and future land infertility, and the displacement of local species. Agriculture contributes to climate change both by anthropogenic emissions of greenhouse gases and by the conversion of non-agricultural land such as forests into agricultural land. In 2010, agriculture, forestry and land-use change were estimated to contribute 20–25% of global annual emissions.. In 2020, the European Union's Scientific Advice Mechanism estimated that the food system as a whole contributed 37% of total greenhouse gas emissions, and that this figure was on course to increase by 30–40% by 2050 due to population growth and dietary change. A range of policies can reduce the risk of negative climate change impacts on agriculture and greenhouse gas emissions from the agriculture sector.
  • 2.1K
  • 15 Nov 2022
Biography
Nima Arkani-Hamed
Nima Arkani-Hamed (Persian: نیما ارکانی حامد‎; born April 5, 1972) is an Iranian-American-Canadian[1][2] theoretical physicist, with interests in high-energy physics, quantum field theory, string theory, cosmology and collider physics. Arkani-Hamed is a member of the permanent faculty at the Institute for Advanced Study in Princeton, New Jersey.[3] He is also director of The Cent
  • 2.1K
  • 01 Dec 2022
Topic Review
β-Ti Alloys for Orthopedic and Dental Applications
Ti and Ti alloys have charming comprehensive properties (high specific strength, strong corrosion resistance, and excellent biocompatibility) that make them the ideal choice in orthopedic and dental applications, especially in the particular fabrication of orthopedic and dental implants. However, these alloys present some shortcomings, specifically elastic modulus, wear, corrosion, and biological performance. Beta-titanium (β-Ti) alloys have been studied as low elastic modulus and low toxic or non-toxic elements.
  • 2.1K
  • 28 Mar 2022
Topic Review
Gynecological Problems in Newborns
Pediatric-adolescent or developmental gynecology has been separated from the general gynecology because of the unique issues that affect the development and anatomy of growing girls and young women. It deals with patients from the neonatal period until maturity. There are not many gynecological problems that can be diagnosed in newborns; however, some are typical for the neonatal period. This paper aimed to discuss the most frequent gynecological issues in the neonatal period.
  • 2.1K
  • 12 Mar 2021
Topic Review
Nosema locustae
Nosema locustae (Synonyms: Paranosema locustae, Antonospora locustae), a protozoan pathogen of locusts and grasshoppers, was developed as a biological control agent as early as the 1980s. 
  • 2.1K
  • 13 Apr 2021
Topic Review
Wave Energy in the Mediterranean
The installed power of the several deployed WECs in the Mediterranean Sea varies between 3–2500 kW. Ten project cases of deployed WECs in the basin are presented, with their analysis of the essential features. Five different types of WEC have already been tested under real environmental conditions in Italy, Greece, Israel and Gibraltar, with Italy being the Mediterranean country with the most deployed WECs. The main questions of the relevant studies were the ongoing trends, the examination of WECs in combination with other renewable sources, the utilising of WECs for desalination, and the prospects of wave energy in the Mediterranean islands and ports.
  • 2.1K
  • 12 Aug 2021
Topic Review
Suture Mesenchymal Stem Cells
Suture mesenchymal stem cells (SuSCs), a heterogeneous stem cell population, belong to mesenchymal stem cells (MSCs) or skeletal stem cells (SSCs), with the ability to self-renew and undergo multi-lineage differentiation. Unlike the well-established perivascular niche of SSCs in the long bone, stem cells of the cranial bone are generally located and confined within the cranial suture mesenchyme, subsequently defined as SuSCs. In the long bone, SSCs play an essential role in plenty of physiological processes, such as growth and development, life-long homeostasis, and fracture healing. Similarly, as the major stem cell population of cranial bones, the physiological significance of SuSCs is undoubted and self-evident. 
  • 2.1K
  • 22 Sep 2021
Topic Review
Aquatic Ecology of Southern African Watersheds
Southern Africa (SA) is rich in large river basin networks, from the over 1.4 million km2 Zambezi River Basin in the upper parts and extending further to the 0.4 million km2 Limpopo and 0.9 million km2 Orange River Basin systems southwards. Given that most SA river basins hold vast mineral deposits, the mining waste generated by artisanal and mechanised mining industries has significantly affected the health of its aquatic ecosystems.
  • 2.1K
  • 17 Feb 2022
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