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Topic Review
Anterior Chamber Angle Assessment Techniques
This review summarizes the last findings in Anterior Chamber Angle evaluation, focusing on new instruments and their application to the clinical practice. Special attention will be given to the comparison between these new techniques and traditional slit-lamp gonioscopy.
  • 2.1K
  • 11 Dec 2020
Topic Review
Enzymatic Biofuel Cells
Enzymatic biofuel cells can be considered as a promising solution to generate electricity from biological catalytic reactions. Indeed, enzymes show very good results as biocatalysts thanks to their excellent intrinsic properties, such as specificity toward substrate, high catalytic activity with low overvoltage for substrate conversion, mild operating conditions like ambient temperature and near-neutral pH. Furthermore, enzymes present low cost, renewability and biodegradability. The wide range of applications moves from miniaturized portable electronic equipment and sensors to integrated lab-on-chip power supplies, advanced in vivo diagnostic medical devices to wearable devices. Nevertheless, enzymatic biofuel cells show great concerns in terms of long-term stability and high power output nowadays, highlighting that this particular technology is still at early stage of development. 
  • 2.1K
  • 22 Mar 2021
Topic Review
Single Ventricle
In this paper, the author enumerates cardiac defects with a functionally single ventricle, summarizes single ventricle physiology, presents a summary of management strategies to address the single ventricle defects, goes over the steps of staged total cavo-pulmonary connection, cites the prevalence of inter-stage mortality, names the causes of inter-stage mortality, discusses strategies to address the inter-stage mortality, reviews post-Fontan issues, and introduces alternative approaches to Fontan circulation. 
  • 2.1K
  • 10 Jun 2021
Topic Review
Delivery Platforms for miRNA-Based Cancer Therapeutics
Restoration of microRNA (miRNA) expression or downregulation of aberrantly expressed miRNAs using miRNA mimics or anti-miRNA inhibitors (anti-miRs/antimiRs), respectively, continues to show therapeutic potential for the treatment of cancer. Although the manipulation of miRNA expression presents a promising therapeutic strategy for cancer treatment, it is predominantly reliant on nucleic acid-based molecules for their application, which introduces an array of hurdles, with respect to in vivo delivery. Because naked nucleic acids are quickly degraded and/or removed from the body, they require delivery vectors that can help overcome the many barriers presented upon their administration into the bloodstream.
  • 2.1K
  • 25 Aug 2022
Topic Review
Applications of Fucoidan from Marine Macroalgae
According to the International Union of Pure and Applied Chemistry (IUPAC) nomenclature system, fucoidan specifically designates the heterogeneous marine sulfated polysaccharides which are copiously found in the cell wall matrix of various species of brown algae. The cell walls of brown algae consist of an amorphous matrix of acid polysaccharides, such as fucoidan and alginic acid, which are linked to each other by proteins, giving structural integrity and flexibility to the seaweed. Generally, fucoidan constitutes about 5–10% of the dry algal biomass, which varies based on the species and the seasons. The fucoidan is used in regenerative medicine, drug delivery systems and the food industry.
  • 2.1K
  • 14 Oct 2022
Topic Review
Here It Goes Again
"Here It Goes Again" is a song by OK Go and is the third released single (the fifth including radio-only singles) from the album Oh No. It was the band's only single to chart on the Billboard Hot 100 until "I Won't Let You Down" entered the Hot 100 in November 2014. Featuring the band dancing on treadmills, the video became a staple on YouTube; at one time being one of their most watched videos, with over 53 million views. In addition, the single peaked at number 36 on the UK Singles Chart on October 1, 2006, hence marking their second UK Top 40 single and their third UK Top 75 single. Its B-side, "The Lovecats", a cover of The Cure's single, was previously released on the band's Do What You Want EP and the single "A Million Ways". An alternate version was nicknamed "UK Surf".
  • 2.1K
  • 01 Nov 2022
Topic Review
Nuances of Emirati Identity
Identity, as a complex and multifaceted concept, has been a subject of exploration among various sociologists and theorists. Dual-identity Emiratis have long been a topic of discussion and introspection within Emirati communities. 
  • 2.1K
  • 12 Dec 2023
Topic Review
Stationary Fuel Cell System
Fuel cell technologies have several applications in stationary power production, such as units for primary power generation, grid stabilization, systems adopted to generate backup power, and combined-heat-and-power configurations (CHP). The main sectors where stationary fuel cells have been employed are (a) micro-CHP, (b) large stationary applications, (c) UPS, and IPS. The fuel cell size for stationary applications is strongly related to the power needed from the load. Since this sector ranges from simple backup systems to large facilities, the stationary fuel cell market includes few kWs and less (micro-generation) to larger sizes of MWs. The design parameters for the stationary fuel cell system differ for fuel cell technology (PEM, AFC, PAFC, MCFC, and SOFC), as well as the fuel type and supply.
  • 2.1K
  • 09 Oct 2021
Topic Review
The Applications of Phlorotannins
Phlorotannins are a type of natural active substance extracted from brown algae, which belong to a type of important plant polyphenol. Phloroglucinol is the basic unit in its structure. Phlorotannins have a wide range of biological activities, such as antioxidant, antibacterial, antiviral, anti-tumor, anti-hypertensive, hypoglycemic, whitening, anti-allergic and anti-inflammatory, etc. Phlorotannins are mainly used in the fields of medicine, food and cosmetics. 
  • 2.1K
  • 12 Dec 2022
Topic Review
Miracle Berry
Miracle berry (MB) (Synsepalum dulcificum) is an indigenous fruit whose small, ellipsoid, and bright red berries have been described to transform a sour taste into a sweet one. MB is rich in terpenoids, phenolic compounds, and flavonoids, which are responsible for their described antioxidant activities. Moreover, MB has been reported to ameliorate insulin resistance and inhibit cancer cell proliferation and malignant transformation in vitro. Herein, we briefly summarize the current knowledge of MB to provide a scientific basis for its potential use as a supplement in the management of chronic diseases related to altered metabolism, including obesity and insulin resistance, which are well-known risk factors in cancer. First, we introduce cancer as a metabolic disease, highlighting the impact of systemic metabolic alterations, such as obesity and insulin resistance, in cancer initiation and progression. Next, as oxidative stress is closely associated with metabolic stress, we also evaluate the effect of phytochemicals in managing oxidative stress and its relationship with cancer. Finally, we summarize the main biological activities described for MB-derived extracts with a special focus on the ability of miraculin to transform a sour taste into a sweet one through its interaction with the sweet taste receptors. The identification of sweet taste receptors at the gastrointestinal level, with effects on the secretion of enterohormones, may provide an additional tool for managing chronic diseases, including cancer.
  • 2.1K
  • 21 Feb 2021
Topic Review
Phosphate
Phosphorous, in the form of phosphate, is a key element in the nutrition of all living beings. In nature, it is present in the form of phosphate salts, organophosphates, and phosphonates. 
  • 2.1K
  • 26 Feb 2021
Topic Review
Aerobic Granular Sludge–Membrane BioReactor (AGS–MBR)
Membrane-fouling represents a major drawback hampering the wider application of membrane bioreactor (MBR) technology. Fouling can be mitigated by applying aerobic granular sludge technology, a novel kind of biofilm technology characterized by high settleability, strong microbial structure, high resilience to toxic/recalcitrant compounds of industrial wastewater, and the possibility to simultaneously remove organic matter and nutrients. Different schemes can be foreseen for the AGS–MBR process. However, an updated literature review reveals that in the AGS–MBR process, granule breakage represents a critical problem in all configurations, which often causes an increase of pore-blocking.
  • 2.1K
  • 07 Apr 2021
Topic Review
Silk Fibroin as Contact Lenses
Fibroin is a fibrous protein that can be conveniently isolated from the silk cocoons produced by the larvae of Bombyx mori silk moth. In its form as a hydrogel, Bombyx mori silk fibroin (BMSF) has been employed in a variety of biomedical applications. When used as substrates for biomaterial-cells constructs in tissue engineering, the oxygen transport characteristics of the BMSF membranes have proved so far to be adequate. However, over the past three decades the BMSF hydrogels have been proposed episodically as materials for the manufacture of contact lenses, an application that depends on substantially elevated oxygen permeability.
  • 2.1K
  • 26 May 2021
Topic Review
Volunteers Nature Conservation Motivational Factors
Global biodiversity is under pressure from human activities, and the effort for nature conservation and restoration and the allocation of economic resources for biodiversity policies remain insufficient. In such a context, volunteers can play an important role as a resource in nature conservation projects if their recreational activities interact with the objectives of nature management. Ensuring that volunteers remain motivated and engaged is crucial for the success of conservation projects. Five motivational factors determine the engagement of the volunteers, namely social, nature value, instrumental, identification, and personal benefit.
  • 2.1K
  • 23 Aug 2021
Topic Review
Best Estimate Plus Uncertainty Analysis in LBLOCA
As one of the Deterministic safety analysis (DSA) methodologies, best estimate plus uncertainty (BEPU) generates more realistic results that can be used in the license application of nuclear power plants (NPPs). However, uncertainty evaluation of parameters is needed in BEPU. The safety regulatory focuses on the large break loss of coolant accident (LBLOCA) of an advanced PWR. The BEPU analysis is mainly performed by TRACE V5.0 patch 4 code, and the uncertainty analysis is conducted based on DAKOTA code. 
  • 2.1K
  • 18 Feb 2022
Topic Review
Soyombo Alphabet
The Soyombo alphabet (Mongolian: Соёмбо бичиг, Soyombo biçig) is an abugida developed by the monk and scholar Zanabazar in 1686 to write Mongolian. It can also be used to write Tibetan and Sanskrit. A special character of the script, the Soyombo symbol, became a national symbol of Mongolia, and has appeared on the national flag since 1921, and on the Emblem of Mongolia since 1960, as well as money, stamps, etc.
  • 2.1K
  • 08 Oct 2022
Topic Review
Preservation (Library and Archival Science)
In library and archival science, preservation is a set of activities aimed at prolonging the life of a record, book, or object while making as few changes as possible. Preservation activities vary widely and may include monitoring the condition of items, maintaining the temperature and humidity in collection storage areas, writing a plan in case of emergencies, digitizing items, writing relevant metadata, and increasing accessibility. Preservation, in this definition, is practiced in a library or an archive by a librarian, archivist, or other professional when they perceive a record is in need of care. Preservation should be distinguished from conservation-restoration of cultural heritage, which refers to the treatment and repair of individual items to slow the process of decay, or restore them to a usable state. Because preservation covers a wide range of efforts aimed at prolonging the life of a record, conservation can be thought of as one of those efforts under the umbrella of preservation. Conservation is occasionally used interchangeably with preservation, particularly outside the professional literature.
  • 2.1K
  • 14 Nov 2022
Topic Review
Endogenous Enzyme during Meat Processing
Meat aging is a combination of transformations that originate in the animal’s muscle after slaughter, resulting in changes in colour, tenderness and aroma. The biochemical processes that occur during meat aging are mainly caused by endogenous enzymes, leading to glycolysis, proteolysis and lipolysis.
  • 2.1K
  • 12 Jun 2023
Topic Review Peer Reviewed
Person-Centered Care: Learning from the Evolution of Mental Health Care
A health care approach that involves service users in decisions concerning their own health. It considers service users’ beliefs, values, support system, and experiences in co-creating an action plan to address their distinct health care goal [this is de novo based on diverse publications about person-centered care].
  • 2.1K
  • 10 Mar 2025
Topic Review
Marine Cyclic Peptides
Oceans are a rich source of structurally unique bioactive compounds from the perspective of potential therapeutic agents. Marine peptides are a particularly interesting group of secondary metabolites because of their chemistry and wide range of biological activities. Among them, cyclic peptides exhibit a broad spectrum of antimicrobial activities, including against bacteria, protozoa, fungi, and viruses. Moreover, there are several examples of marine cyclic peptides revealing interesting antimicrobial activities against numerous drug-resistant bacteria and fungi, making these compounds a very promising resource in the search for novel antimicrobial agents to revert multidrug-resistance.
  • 2.1K
  • 04 Jul 2022
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