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Topic Review
Global Supply Chain Finance
Global supply chain finance refers to the set of solutions available for financing specific goods and/or products as they move from origin to destination along the supply chain. It is related to a quickly growing use of a battery of technologies and financial business practices that allow for discounting of Accounts Receivable and financing of companies' confirmed Accounts Payable. A global supply chain refers to the network created among different worldwide companies producing, handling, and distributing specific goods and/or products.
  • 2.1K
  • 21 Nov 2022
Topic Review
Theory of Everything
In philosophy, a theory of everything (ToE) is an ultimate, all-encompassing explanation or description of nature or reality. Adopting the term from physics, where the search for a theory of everything is ongoing, philosophers have discussed the viability of the concept and analyzed its properties and implications. Among the questions to be addressed by a philosophical theory of everything are: "Why is reality understandable?" – "Why are the laws of nature as they are?" – "Why is there anything at all?"
  • 2.1K
  • 30 Nov 2022
Topic Review
Gut Lymphatic Vessels
Lymphatic vessels play a distinctive role in draining fluid, molecules and even cells from interstitial and serosal spaces back to the blood circulation. Lymph vessels of the gut, and especially those located in the villi (called lacteals), not only serve this primary function, but are also responsible for the transport of lipid moieties absorbed by the intestinal mucosa and serve as a second line of defence against possible bacterial infections.
  • 2.1K
  • 15 Oct 2021
Topic Review
Prussian Blue and Its Analogues
Prussian blue analogues (PBAs)-based anode materials (oxides, sulfides, selenides, phosphides, borides, and carbides) have been extensively investigated in the field of energy conversion and storage. This is due to PBAs’ unique properties, including high theoretical specific capacity, environmental friendly, and low cost.
  • 2.1K
  • 02 Mar 2023
Topic Review
Post-Traumatic Stress Disorder and Thalamus
Post-traumatic stress disorder is a common mental disorder, with high lifetime prevalence approximately 6–10% . The prevalence of PTSD in trauma-exposed people has been approximately 20%. PTSD is induced by traumatic stress including life threatening, actual or threatened severe injury, and sexual violence. In DSM-V criteria, PTSD has the following symptoms: intrusion of unwanted memory updates related to traumatic stress, avoidance for reminders, negative alterations in mood, and hyper-arousal. Conservatively, fear-conditioned learning involving the amygdala has been considered one of the causative factors.
  • 2.1K
  • 03 Mar 2021
Topic Review
Pre-clinical Cerebral Perfusion MRI Techniques
Alterations to the cerebral microcirculation have been recognized to play a crucial role in the development of neurodegenerative disorders. However, the exact role of the microvascular alterations in the pathophysiological mechanisms often remains poorly understood. The early detection of changes in microcirculation and cerebral blood flow (CBF) can be used to get a better understanding of underlying disease mechanisms. This could be an important step towards the development of new treatment approaches. Animal models allow for the study of the disease mechanism at several stages of development, before the onset of clinical symptoms, and the verification with invasive imaging techniques. Specifically, pre-clinical magnetic resonance imaging (MRI) is an important tool for the development and validation of MRI sequences under clinically relevant conditions. This article reviews MRI strategies providing indirect non-invasive measurements of microvascular changes in the rodent brain that can be used for early detection and characterization of neurodegenerative disorders. The perfusion MRI techniques: Dynamic Contrast Enhanced (DCE), Dynamic Susceptibility Contrast Enhanced (DSC) and Arterial Spin Labeling (ASL), will be discussed, followed by less established imaging strategies used to analyze the cerebral microcirculation: Intravoxel Incoherent Motion (IVIM), Vascular Space Occupancy (VASO), Steady-State Susceptibility Contrast (SSC), Vessel size imaging, SAGE-based DSC, Phase Contrast Flow (PC) Quantitative Susceptibility Mapping (QSM) and quantitative Blood-Oxygenation-Level-Dependent (qBOLD). We will emphasize the advantages and limitations of each strategy, in particular on applications for high-field MRI in the rodent’s brain. 
  • 2.1K
  • 02 Jun 2021
Topic Review
Sleep Quantity and Sleep Quality
Sleep is one of the basic physiological processes for human survival. Both sleep quantity and sleep quality are fundamental components of sleep. We should pay more attention to obtaining sleep of good quality (restfulness, no sleepiness, no need for more sleep, sufficient objective sleep depth, etc.), although there have not been enough studies on the associations between sleep quality and health or disorders in children and adolescents.
  • 2.1K
  • 30 Sep 2021
Topic Review
Hybrid Sol-Gel Materials
Microorganism-cell-based biohybrid materials have attracted considerable attention over the last several decades. They are applied in a broad spectrum of areas, such as nanotechnologies, environmental biotechnology, biomedicine, synthetic chemistry, and bioelectronics. Sol-gel technology allows to obtain a wide range of high-purity materials from nanopowders to thin-film coatings with high efficiency and low cost, which makes it one of the preferred techniques for creating organic-inorganic matrices for biocomponent immobilization.
  • 2.1K
  • 06 Apr 2022
Topic Review
Beneficial Microorganisms in Soil Quality and Plant Health
The practice of agriculture has always been a source of food production. The increase in the global population leads to improvements in agriculture, increasing crop quality and yield. Plant growth results from the interaction between roots and their environment, which is the soil or planting medium that provides structural support as well as water and nutrients to the plant. Therefore, good soil management is necessary to prevent problems that will directly affect plant health. Integrated crop management is a pragmatic approach to crop production, which includes integrated pest management focusing on crop protection. Currently, there is an extended idea that many microorganisms, such as fungi or bacteria, are useful in agriculture since they are attractive eco-friendly alternatives to mineral fertilizers and chemical pesticides. The microbes that interact with the plants supply nutrients to crops, control phytopathogens and stimulate plant growth. These actions have beneficial implications in agriculture.
  • 2.1K
  • 23 May 2022
Topic Review
Innovative Uses of Polyhydroxyalkanoates
Polyhydroxyalkanoate (PHA), a biodegradable polymer obtained from microorganisms and plants, have been widely used in biomedical applications and devices, such as sutures, cardiac valves, bone scaffold, and drug delivery of compounds with pharmaceutical interests, as well as in food packaging. The novel applications are based on the production and composition of the polymer, which can be modified by genetic engineering, a semi-synthetic approach, by changing feeding carbon sources and/or supplement addition, among others. The future of PHA is promising, and despite its production costs being higher than petroleum-based plastics, tools given by synthetic biology, bioinformatics, and machine learning, among others, have allowed for great production yields, monomer and polymer functionalization, stability, and versatility, a key feature to increase the uses of this interesting family of polymers.
  • 2.1K
  • 13 Dec 2022
Topic Review
Current Role of Immunotherapy in Lung Cancer
Immunotherapy is an ever-expanding field in lung cancer treatment research. The lung cancer treatment paradigm has been completely changed by immunotherapy; however, less than half of the treated patients obtain a response, and an even smaller proportion achieve a long survival.
  • 2.1K
  • 27 Dec 2022
Topic Review
Graphene
Graphene is the new generation material, which finds potential and practical applications in a vast range of research areas. It has unrivalled characteristics, chiefly in terms of electronic conductivity, mechanical robustness and large surface area, which allow the attainment of outstanding performances in many fields of materials science.
  • 2.1K
  • 09 Oct 2020
Topic Review
Fatigue Crack Growth
The development of crack patterns is a serious problem affecting the durability of orthopedic implants and the prognosis of patients. This issue has gained considerable attention in the medical community in recent years. This literature focuses on the five primary aspects relevant to the evaluation of the surface cracking patterns, i.e., inappropriate use, design flaws, inconsistent elastic modulus, allergic reaction, poor compatibility, and anti-corrosiveness. The hope is that increased understanding will open doors to optimize fabrication for biomedical applications. The latest technological issues and potential capabilities of implants that combine absorbable materials and shape memory alloys are also discussed. 
  • 2.1K
  • 18 Jan 2021
Topic Review
Spatter in Laser Powder Bed Fusion Additive Manufacturing
Spatter is an inherent, unpreventable, and undesired phenomenon in laser powder bed fusion (L-PBF) additive manufacturing. Spatter, metal vapor and molten pool are important physical phenomena in laser-matter interaction. During L-PBF, the spatter formation mechanism can be demonstrated as the hot spatter ejection mainly driven by the instability of the molten pool due to the vapor-induced recoil pressure, and the cold spatter ejection mainly driven by the vapor-induced entrainment of the shielding gas. Spatter behavior has an intrinsic correlation with the forming quality in L-PBF because it leads to metallurgical defects and the degradation of mechanical properties. This impact becomes more severe in the fabrication of large-sized parts during the multi-laser L-PBF process. Therefore, investigations of spatter generation and countermeasures have become more urgent. 
  • 2.1K
  • 19 May 2023
Topic Review
A Review of Geometry, Construction and Modelling for Carbon Nanotori
After the discovery of circular formations of single walled carbon nanotubes called fullerene crop circles, their structure has become one of the most researched amongst carbon nanostructures due to their particular interesting physical properties. Several experiments and simulations have been conducted to understand these intriguing objects, including their formation and their hidden characteristics. It is scientifically conceivable that these crop circles, nowadays referred to as carbon nanotori, can be formed by experimentally bending carbon nanotubes into ring shaped structures or by connecting several sections of carbon nanotubes. Toroidal carbon nanotubes are likely to have many applications, especially in electricity and magnetism. In this review, geometry, construction, modelling and possible applications are discussed and the existing known analytical expressions, as obtained from the Lennard-Jones potential and the continuum approximation, for their interaction energies with other nanostructures are summarised.
  • 2.1K
  • 29 Oct 2020
Topic Review
Bland–Altman Agreement Analysis
The Bland–Altman Limits of Agreement is a popular and widespread means of analyzing the agreement of two methods, instruments, or raters in quantitative outcomes. An agreement analysis could be reported as a stand-alone research article but it is more often conducted as a minor quality assurance project in a subgroup of patients, as a part of a larger diagnostic accuracy study, clinical trial, or epidemiological survey. Consequently, such an analysis is often limited to brief descriptions in the main report. Therefore, in several medical fields, it has been recommended to report specific items related to the Bland–Altman analysis. Seven proposals were identified from a MEDLINE/PubMed search on March 03, 2020, three of which were derived by reviewing anesthesia journals. Broad consensus was seen for the a priori establishment of acceptability benchmarks, estimation of repeatability of measurements, description of the data structure, visual assessment of the normality and homogeneity assumption, and plotting and numerically reporting both bias and the Bland–Altman Limits of Agreement, including respective 95% confidence intervals. Abu-Arafeh et al. provided the most comprehensive and prudent list, identifying 13 key items for reporting (Br. J. Anaesth. 2016, 117, 569–575). The 13 key items should be applied by researchers, journal editors, and reviewers in the future, to increase the quality of reporting Bland–Altman agreement analyses.
  • 2.1K
  • 27 Oct 2020
Topic Review
Computer-Aided Drug Discovery for SMA
Spinal muscular atrophy (SMA), one of the leading inherited causes of child mortality, is a rare neuromuscular disease arising from loss-of-function mutations of the survival motor neuron 1 (SMN1) gene, which encodes the SMN protein. When lacking the SMN protein in neurons, patients suffer from muscle weakness and atrophy, and in the severe cases, respiratory failure and death. Several therapeutic approaches show promise with human testing and three medications have been approved by the U.S. Food and Drug Administration (FDA) to date. Despite the shown promise of these approved therapies, there are some crucial limitations, one of the most important being the cost. The FDA-approved drugs are high-priced and are shortlisted among the most expensive treatments in the world. The price is still far beyond affordable and may serve as a burden for patients. The blooming of the biomedical data and advancement of computational approaches have opened new possibilities for SMA therapeutic development. 
  • 2.1K
  • 09 Oct 2021
Topic Review
Pitahaya (Selenicereus Megalanthus Haw.)
The Dragon fruit, known as pitaya or pitahaya, belongs to the Cactaceae family, which originated from the southern and central regions of Mexico and America, and is separated in two genera: Hylocereus and Selenicereus. It is a nutritious and exotic fruit cultivated throughout the tropical and subtropical regions of the world. Pitahaya production has attracted interest in the United States, Australia, Southeast Asia, Israel and other regions. This fruit has gained considerable attention from consumers because it is a unique fruit that can tolerate drought stress and contains a considerable amount of nutrients. It is rich in polyphenols, vitamins, sugar, amino acids and betalain pigments.
  • 2.1K
  • 11 Nov 2021
Topic Review
Neuropharmacological Effects of Terpenoids
Terpenoids are widely distributed in nature, especially in the plant kingdom, and exhibit diverse pharmacological activities. In recent years, screening has revealed a wide variety of new terpenoids that are active against different psychiatric disorders.
  • 2.1K
  • 28 Sep 2022
Topic Review
Climate State
Climate state describes a state of climate on Earth and similar terrestrial planets based on a thermal energy budget, such as the greenhouse or icehouse climate state. The main climate state change is between periodical glacial and interglacial cycles in Earth history, studied from climate proxies. The climate system is responding to the current climate forcing and adjusts following climate sensitivity to reach a climate equilibrium, Earth's energy balance. Model simulations suggest that the current interglacial climate state will continue for at least another 100,000 years, due to CO2 emissions - including complete deglaciation of the Northern Hemisphere.
  • 2.1K
  • 16 Nov 2022
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