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Topic Review
C-to-U RNA Editing
The restoration of genetic code by editing mutated genes is a potential method for the treatment of genetic diseases/disorders. Genetic disorders are caused by the point mutations of thymine (T) to cytidine (C) or guanosine (G) to adenine (A), for which gene editing (editing of mutated genes) is a promising therapeutic technique. In C-to-Uridine (U) RNA editing, it converts the base C-to-U in RNA molecules and leads to nonsynonymous changes when occurring in coding regions; for G-to-A mutations, A-to-I editing occurs. Editing of C-to-U is not as physiologically common as that of A-to-I editing.
  • 2.2K
  • 30 Sep 2022
Topic Review
Tokyō
Tokyō (斗栱・斗拱, more often 斗きょう)[note 1] (also called kumimono (組物) or masugumi (斗組)) is a system of supporting blocks (斗 or 大斗, masu or daito, lit. block or big block) and brackets (肘木, hijiki, lit. elbow wood) supporting the eaves of a Japanese building, usually part of a Buddhist temple or Shinto shrine. The use of tokyō is made necessary by the extent to which the eaves protrude, a functionally essential element of Japanese Buddhist architecture. The system has however always had also an important decorative function. Like most architectural elements in Japan, the system is Chinese in origin (on the subject, see the article Dougong) but has evolved since its arrival into several original forms. In its simplest configuration, the bracket system has a single projecting bracket and a single block, and is called hitotesaki. If the first bracket and block group support a second similar one, the whole system is called futatesaki, if three brackets are present it is called mitesaki, and so on until a maximum of six brackets as in the photo to the right. Each supporting block in most cases supports, besides the next bracket, a U-shaped supporting bracket set at 90° to the first (see photos in the gallery below). The Protection of Cultural Properties logo (see gallery below) represents a tokyō, considered an element of Japanese architecture which stands for the continuity in time of cultural property protection.
  • 2.2K
  • 14 Oct 2022
Topic Review
4D Printable Smart Hydrogels for Drug Delivery
Hydrogels are three-dimensional crosslinked polymer network structures that can absorb and hold a large quantity of water while retaining a distinct shape. Among modern drug formulations, stimuli-responsive hydrogels, also known as "smart hydrogels," has attracted enormous attention. The fundamental characteristic of these systems is the capacity to change their mechanical properties, swelling capacity, hydrophilicity, permeability of bioactive molecules, etc., in response to a wide range of stimuli, including temperature, pH, light irradiation, magnetic field, biological factors, etc. On the other hand, the expeditious development of 3D printing technologies has revolutionized the fabrication of hydrogel systems for biomedical applications. By combining these two aspects, 4D printing (i.e., 3D printing of smart hydrogels) has emerged as a new promising platform for the development of novel drug delivery systems, which release active ingredients in response to internal or external stimuli.
  • 2.2K
  • 01 Nov 2022
Topic Review
Silver Nanoparticles for Conductive Ink
Nanoparticles, defined as having one of the dimensions in the 1–100 nm range, show unique and considerably different physical, chemical, and biological properties, compared to bulk materials, due to their large portion of surface atoms and the reduced area to volume ratio. 
  • 2.2K
  • 24 Feb 2022
Topic Review
Clipboard (Computing)
The clipboard is a buffer that some operating systems provide for short-term storage and transfer within and between application programs. The clipboard is usually temporary and unnamed, and its contents reside in the computer's RAM. The clipboard provides an application programming interface by which programs can specify cut, copy and paste operations. It is left to the program to define methods for the user to command these operations, which may include keybindings and menu selections. When an element is copied or cut, the clipboard must store enough information to enable a sensible result no matter where the element is pasted. Application programs may extend the clipboard functions that the operating system provides. A clipboard manager may give the user additional control over the clipboard. Specific clipboard semantics vary among operating systems, can also vary between versions of the same system, and can sometimes be changed by programs and by user preferences. Windows, Linux and macOS support a single clipboard transaction.
  • 2.2K
  • 19 Oct 2022
Topic Review
Microbial Mats: Extraterrestrial Life Models
Extant microbial mats already present on Earth provide useful working analog models for the exploration of life in extraterrestrial hydrospheres.
  • 2.2K
  • 08 Sep 2021
Topic Review
FGCaMP7 Genetically Encoded Calcium Indicator
Genetically encoded calcium indicators (GECIs) have become a widespread tool for the visualization of neuronal activity. As compared to popular GCaMP GECIs, the FGCaMP indicator benefits from calmodulin from the Aspergillus niger fungus, which prevent its interaction with the intracellular environment. However, FGCaMP exhibits a two-phase fluorescence behavior with the variation of calcium ion concentration, has moderate sensitivity in neurons (as compared to the GCaMP6s indicator), and has not been fully characterized in vitro and in vivo. To address these limitations, we developed an enhanced version of FGCaMP, called FGCaMP7. FGCaMP7 preserves the ratiometric phenotype of FGCaMP, with a 3.1-fold larger ratiometric dynamic range in vitro. FGCaMP7 demonstrates 2.7- and 8.7-fold greater photostability compared to mEGFP and mTagBFP2 fluorescent proteins in vitro, respectively. The ratiometric response of FGCaMP7 is 1.6- and 1.4-fold higher, compared to the intensiometric response of GCaMP6s, in non-stimulated and stimulated neuronal cultures, respectively. We reveal the inertness of FGCaMP7 to the intracellular environment of HeLa cells using its truncated version with a deleted M13-like peptide; in contrast to the similarly truncated variant of GCaMP6s. We characterize the crystal structure of the parental FGCaMP indicator. Finally, we test the in vivo performance of FGCaMP7 in mouse brain using a two-photon microscope and an NVista miniscope; and in zebrafish using two-color ratiometric confocal imaging.
  • 2.1K
  • 29 Oct 2020
Topic Review
Anti-Cancer Quinone
Natural quinones are secondary metabolites of plant and are categorized as benzoquinone, naphthoquinone, phenanthrenequinone, and anthraquinone according to their aromatic carbon skeleton [3]. Quinones are highly electrophilic molecules that accept one- or two-electrons from flavoenzymes and iron-sulfur proteins to form semiquinone or hydroquinone. They exert cytotoxic effects through alkylating proteins or DNA and affect the redox cycle with their semiquinone radicals to generate reactive oxygen species.
  • 2.1K
  • 27 Oct 2020
Topic Review
NLRP3 Inflammasome Regulatory Mechanisms
The inflammasome is an intracellular molecular complex, which is mainly involved in innate immunity. Inflammasomes are formed in response to danger signals, associated with infection and injury, and mainly regulate the secretion of interleukin-1β and interleukin-18. Inflammasome dysregulation is known to be associated with various diseases and conditions, and its regulatory mechanisms have become of great interest in recent years. In the colon, inflammasomes have been reported to be associated with autophagy and the microbiota, and their dysregulation contributes to colitis and. However, the detailed role of inflammasomes in inflammatory bowel disease is still under debate because the mechanisms that regulate the inflammasome are complex and the inflammasome components and cytokines show seemingly contradictory multiple effects. 
  • 2.1K
  • 18 Jan 2021
Topic Review
Nanotechnology in Soilless/Microgreen Farming
Global food demand has increased in tandem with the world’s growing population, prompting calls for a new sustainable agricultural method. The scarcity of fertile soil and the world’s agricultural land have also become major concerns. Soilless and microgreen farming combined with nanotechnology may provide a revolutionary solution as well as a more sustainable and productive alternative to conventional farming. In this review, we look at the potential of nanotechnology in soilless and microgreen farming. The available but limited nanotechnology approaches in soilless farming include: (1) Nutrients nanoparticles to minimize nutrient losses and improve nutrient uptake and bioavailability in crops; (2) nano-sensing to provide real-time detection of p H, temperature, as well as quantifying the amount of the nutrient, allowing desired conditions control; and (3) incorporation of nanoparticles to improve the quality of substrate culture as crop cultivation growing medium. Meanwhile, potential nanotechnology applications in soilless and microgreen farming include: (1) Plant trait improvement against environmental disease and stress through nanomaterial application; (2) plant nanobionics to alter or improve the function of the plant tissue or organelle; and (3) extending the shelf life of microgreens by impregnating nanoparticles on the packaging or other preservation method.
  • 2.1K
  • 29 Jun 2021
Topic Review
Applications for Nanotechnology in Endodontics
Nanotechnology has been utilized in several different parts of dentistry. Nanomaterials can be employed as irrigation, intracanal medicament, obturation materials and sealers.
  • 2.1K
  • 11 Aug 2022
Topic Review
Cyclodextrins Modified/Coated Metal–Organic Frameworks
The introduction of cyclodextrins (CDs) via noncovalent bonds could improve various physiochemical properties of metal-organic frameworks (MOFs) and expand their practical applications in aqueous solutions, for example, biocompatible CDs could improve the solubility of CDs-coated MOFs as a hybrid delivery system. And external-stimuli responsiveness of CDs-coated MOFs is key for widening applications in controlled drug releasing system, catalysis, detection, extraction and separation.
  • 2.1K
  • 27 Oct 2020
Topic Review
Bio-catalysis in Multicomponent Reactions
Enzyme catalysis is a very active research area in organic chemistry, because biocatalysts are compatible with and can be adjusted to many reaction conditions, as well as substrates. Their integration in multicomponent reactions (MCRs) allows for simple protocols to be implemented in the diversity-oriented synthesis of complex molecules in chemo-, regio-, stereoselective or even specific modes without the need for the protection/deprotection of functional groups.
  • 2.1K
  • 28 Dec 2020
Topic Review
Two Medicine Formation
The Two Medicine Formation is a geological formation, or rock body, in northwestern Montana and southern Alberta that was deposited between 83.5 ± 0.7 Ma and 70.6 ± 3.4 Ma (million years ago), during Campanian (Late Cretaceous) time. It crops out to the east of the Rocky Mountain Overthrust Belt, and the western portion (about 600 metres or 2,000 feet thick) of this formation is folded and faulted while the eastern part, which thins out into the Sweetgrass Arch, is mostly undeformed plains. Below the formation are the nearshore (beach and tidal zone) deposits of the Virgelle Sandstone, and above it is the marine Bearpaw Shale. Throughout the Campanian, the Two Medicine Formation was deposited between the western shoreline of the Late Cretaceous Interior Seaway and the eastward advancing margin of the Cordilleran Overthrust Belt. The Two Medicine Formation is mostly sandstone, deposited by rivers and deltas.
  • 2.1K
  • 10 Oct 2022
Topic Review
Biodegradable Materials and Polymer Composites with Natural Fillers
Biodegradable materials are natural materials and their properties are relatively inferior to those of non-biodegradable materials. Biofibre reinforcement or blending with other biodegradable products has proven to be an effective way to reduce the cost and brittleness of some commonly used polymers to produce a fully biodegradable composite. PLA and ABS polymers are standard materials used as base materials in composites due to their low cost, easy availability and good mechanical properties. Inorganic or organic materials such as glass, carbon fibres, silicon, ceramics or metals have been used in research to date. 
  • 2.1K
  • 08 Sep 2023
Topic Review
Opportunistic Premise Plumbing Pathogens
Opportunistic premise plumbing pathogens (OPPP) are microorganisms that are native to the plumbing environment and that present an emerging infectious disease problem. They share characteristics, such as disinfectant resistance, thermal tolerance, and biofilm formation. The colonisation of domestic water systems presents an elevated health risk for immune-compromised individuals who receive healthcare at home.
  • 2.1K
  • 29 Apr 2022
Topic Review
Near-Infrared Spectroscopy
Near-infrared spectroscopy (NIRS) is a spectroscopic method that uses the near-infrared region of the electromagnetic spectrum (from 780 nm to 2500 nm). Typical applications include medical and physiological diagnostics and research including blood sugar, pulse oximetry, functional neuroimaging, sports medicine, elite sports training, ergonomics, rehabilitation, neonatal research, brain computer interface, urology (bladder contraction), and neurology (neurovascular coupling). There are also applications in other areas as well such as pharmaceutical, food and agrochemical quality control, atmospheric chemistry, combustion research and astronomy.
  • 2.1K
  • 15 Nov 2022
Topic Review
Business Process Reengineering
Business process re-engineering (BPR) is a business management strategy, originally pioneered in the early 1990s, focusing on the analysis and design of workflows and business processes within an organization. BPR aimed to help organizations fundamentally rethink how they do their work in order to dramatically improve customer service, cut operational costs, and become world-class competitors. BPR seeks to help companies radically restructure their organizations by focusing on the ground-up design of their business processes. According to early BPR proponent Thomas Davenport (1990), a business process is a set of logically related tasks performed to achieve a defined business outcome. Re-engineering emphasized a holistic focus on business objectives and how processes related to them, encouraging full-scale recreation of processes rather than iterative optimization of sub-processes. Business process reengineering is also known as business process redesign, business transformation, or business process change management.
  • 2.1K
  • 12 Oct 2022
Topic Review
Src and Hippo/YAP in NSCLC
The advancement of new therapies, including targeted therapies and immunotherapies, has improved the survival of non-small-cell lung cancer (NSCLC) patients in the last decade. Some NSCLC patients still do not benefit from therapies or encounter progressive disease during the course of treatment because they have intrinsic resistance, acquired resistance, or lack a targetable driver mutation. More investigations on the molecular biology of NSCLC are needed to find useful biomarkers for current therapies and to develop novel therapeutic strategies. Src is a non-receptor tyrosine kinase protein that interacts with cell surface growth factor receptors and the intracellular signaling pathway to maintain cell survival tumorigenesis in NSCLC. The Yes-associated protein (YAP) is one of the main effectors of the Hippo pathway and has been identified as a promoter of drug resistance, cancer progression, and metastasis in NSCLC. Here, we review studies that have investigated the activation of YAP as mediated by Src kinases and demonstrate that Src regulates YAP through three main mechanisms: (1) direct phosphorylation; (2) the activation of pathways repressing Hippo kinases; and (3) Hippo-independent mechanisms. Further work should focus on the efficacy of Src inhibitors in inhibiting YAP activity in NSCLC. In addition, future efforts toward developing potentially reasonable combinations of therapy targeting the Src–YAP axis using other therapies, including targeted therapies and/or immunotherapies, are warranted.
  • 2.1K
  • 15 Oct 2020
Topic Review
Sustainability Assessment Methodologies
Sustainability assessment tools were the most commonly applied methodologies towards measuring sustainability performance. There are a number of assessment tools and techniques for sustainable development.
  • 2.1K
  • 20 Aug 2021
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