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Topic Review
Knowledge Management for Fourth Industrial Revolution
The Fourth Industrial Revolution (4IR) offers optimum productivity and efficiency via automation, expert systems, and artificial intelligence. The Fourth Industrial Revolution deploys smart sensors, Cyber-Physical Systems (CPS), Internet of Things (IoT), Internet of Services (IoS), big data and analytics, Augmented Reality (AR), autonomous robots, additive manufacturing (3D Printing), and cloud computing for optimization purposes. Knowledge management (KM) is the process of acquiring, constructing, managing, and disseminating knowledge throughout an organization in order to improve project efficiency and effectiveness. In times of crisis, knowledge management has been shown to be a critical tool in healthcare, allowing people all over the world to cope with and manage massive amounts of data in the event of a pandemic.
  • 2.2K
  • 29 Jun 2022
Topic Review
Thermal Decomposition of Plastic Waste
The resources of fossil fuels, such as crude oil, natural gas, and coal, are depleting day by day due to increasing energy demands. Plastic items have witnessed a substantial surge in manufacturing due to their wide range of applications and low cost. Therefore, the amount of plastic waste is increasing rapidly. Hence, the proper management of plastic wastes for sustainable technologies is the need of the hour.
  • 2.2K
  • 24 Aug 2022
Topic Review
Traveler's Cheque
A traveler's cheque[lower-alpha 1] is a medium of exchange that can be used in place of hard currency. They can be denominated in one of a number of major world currencies and are preprinted, fixed-amount cheques designed to allow the person signing it to make an unconditional payment to someone else as a result of having paid the issuer for that privilege. They are generally used by people on vacation in foreign countries instead of cash, as many businesses used to accept traveler's cheques as currency. The incentive for merchants and other parties to accept them lies in the fact that as long as the original signature (which the buyer is supposed to place on the cheque in ink as soon as they receive the cheque) and the signature made at the time the cheque is used are the same, the cheque's issuer will unconditionally guarantee payment of the face amount even if the cheque was fraudulently issued, stolen, or lost. This means that a traveler's cheque can never 'bounce' unless the issuer goes bankrupt and out of business. If a traveler's cheque were lost or stolen, it could be replaced by the issuing financial institution. The financial institutions issuing traveler's cheques earn income in a number of ways. Firstly, they charge a fee on sale of such cheques. In addition, they can earn interest for the period that the cheques are uncashed, while not paying any interest to the cheque holder, making them effectively interest-free loans. Also, the foreign exchange rate commonly used on traveler's cheques (generally based on rates applicable at the time of purchase) is less favourable compared to other forms of obtaining foreign currency, especially those on credit card transactions (which use a rate applicable at the statement date). In addition, the setup cost and the cost of issuing and processing traveler's cheques is much higher than for credit card transactions. The cheque issuer carries the exchange rate risk, and normally pays a fee to hedge against the risk. Their use has been in decline since the 1990s, when a variety of more convenient alternatives, such as credit cards, debit cards, pre-paid currency cards and automated teller machines, became more widely available and easier for travelers to use. Traveler's cheques are no longer widely accepted and cannot easily be cashed, even at the banks that issued them. The alternatives to traveler's cheques are generally cheaper and more flexible. Travel money cards, for instance, provide features similar to traveler's cheques but offer greater ease and flexibility.
  • 2.2K
  • 10 Oct 2022
Topic Review
Components of Supercapacitors
The enormous demand for energy due to rapid technological developments pushes mankind to the limits in the exploration of high-performance energy devices. Among the two major energy storage devices (capacitors and batteries), electrochemical capacitors (known as ‘Supercapacitors’) play a crucial role in the storage and supply of conserved energy from various sustainable sources. The high power density and the ultra-high cyclic stability are the attractive characteristics of supercapacitors. However, the low energy density is a major downside of them, which is also responsible for the extensive research in this field to help the charge storage capabilities thrive to their limits. Discoveries of electrical double-layer formation, pseudocapacitive and intercalation-type (battery-type) behaviors drastically improved the electrochemical performances of supercapacitors. The introduction of nanostructured active materials (carbon-/metal-/redox-active-polymer/metal-organic/covalent-organic framework-based electrode materials), electrolytes (conventional aqueous and unconventional systems) with superior electrochemical stability and unprecedented device architectures further boosted their charge storage characteristics. 
  • 2.2K
  • 07 Apr 2023
Topic Review
Aquila
Aquila, a constellation in the northern celestial hemisphere, is renowned for its striking resemblance to an eagle soaring through the heavens. Designated by the International Astronomical Union (IAU), Aquila captivates observers with its prominent stars and rich astronomical history, making it a prominent feature in both ancient mythology and modern astronomy.
  • 2.2K
  • 29 Feb 2024
Topic Review Peer Reviewed
The Workplace Dynamic of People-Pleasing: Understanding Its Effects on Productivity and Well-Being
This entry explores the psychological, developmental, and organizational dynamics of people-pleasing behavior, analyzing its roots in childhood conditioning, cultural reinforcement, and evolutionary mechanisms. It highlights how chronic approval-seeking compromises authenticity, mental health, and workplace productivity, while proposing interventions for individuals and organizations to cultivate assertiveness and healthier relational patterns.
  • 2.2K
  • 04 Jul 2025
Topic Review
PARP Inhibitor-Induced Synthetic Lethality
The advanced development of synthetic lethality has opened the doors for specific anti-cancer medications of personalized medicine and efficient therapies against cancers. One of the most popular approaches being investigated is targeting DNA repair pathways as the implementation of the poly-ADP ribose polymerase 1 (PARP) inhibitor (PARPi) into individual or combinational therapeutic schemes. Such treatment has been effectively employed against homologous recombination-defective solid tumors as well as hematopoietic malignancies. In the most common aspect of precision medicine, PARPi triggers synthetic lethality in cancer cells harboring BRCA1/2 mutations/deficiencies. 
  • 2.2K
  • 05 Dec 2022
Topic Review
Warburg Effect
Otto Warburg discovered that cancer cells use a fermentative rather than oxidative metabolism even though the former is more inefficient in terms of energy production per molecule of glucose. Cancer cells increase the use of this fermentative metabolism even in the presence of oxygen, and this process is called aerobic glycolysis or the Warburg effect.
  • 2.2K
  • 14 Jun 2023
Topic Review
Action Sports
In the last two decades, non-traditional sports activities characterized by elements such as speed, height, and exposure to natural forces knew a rapid increase in global participation. They are generally referred to as action sports (AS), with the terms adventure sports or extreme sports that could be used as interchangeable synonyms.
  • 2.2K
  • 09 Dec 2020
Topic Review
Neutrophils in Obesity
Obesity is characterized by an increase in body weight associated with an exaggerated enlargement of the adipose tissue. Accumulation of fat in adipose tissue causes stress and malfunction of adipocytes, which then initiate inflammation. Next, adipose tissue is infiltrated by cells of the innate immune system. It has become evident that neutrophils, the most abundant leukocytes in blood, are the first immune cells infiltrating the adipose tissue. Neutrophils then get activated and release inflammatory factors that recruit macrophages and other immune cells. These immune cells, in turn, perpetuate the inflammation state by producing cytokines and chemokines that can reach other parts of the body, creating a systemic inflammatory condition.
  • 2.2K
  • 14 Jul 2022
Topic Review
Machine Learning-Based Network Anomaly Detection
Artificial intelligence (AI) techniques have been used to describe the characteristics of information, as they help in the process of data mining (DM) to analyze data and reveal rules and patterns. In DM, anomaly detection is an important area that helps discover hidden behavior within the data that is most vulnerable to attack. It also helps detect network intrusion. Algorithms such as hybrid K-mean array and sequential minimal optimization (SMO) rating can be used to improve the accuracy of the anomaly detection rate. 
  • 2.2K
  • 19 Aug 2022
Topic Review
Kuni-yuzuri
The kuni-yuzuri (国譲り) "Transfer of the land" was a mythological event in Japanese prehistory, related in sources such as the Kojiki and the Nihon Shoki. It relates the story of how the rulership of Japan passed from the earthly kami (kunitsukami) to the kami of Heaven (amatsukami) and their eventual descendants, the Imperial House of Japan.
  • 2.2K
  • 08 Oct 2022
Topic Review
Chitin and Chitosan in Ruminant Diets
The slow progress in the development of the subsector, particularly of alternative feed sources such as agro-industrial byproducts and unconventional feed resources, has deepened the gap in the availability of and accessibility to animal feed. Production of animal feed is highly resource demanding. It has been shown that increasing climate change, land degradation, and the recurrence of droughts have worsened the feed gap. In the backdrop of these challenges, there has been attention to food-not-feed components, which have great potential to substitute human-edible components in livestock feeding. Chitosan, a non-toxic polyglucosamine, is widely distributed in nature and used as a feed additive. Chitosan is obtained from the de-acetylation process of the chitin and is mostly present in shrimp, crabs, and insect exoskeletons, and has antimicrobial and anti-inflammatory, anti-oxidative, antitumor, and immune-stimulatory hypo-cholesterolemic properties.
  • 2.2K
  • 14 Nov 2022
Topic Review
Classification of Biostimulants
Biostimulants provide beneficial properties to plants by increasing plant metabolism, which promotes crop yield and improves the quality of crops; protecting plants against environmental stresses such as water shortage, soil salinization, and exposure to sub-optimal growth temperatures; and promoting plant growth via higher nutrient uptake. Biostimulants are classified as microbial, such as arbuscular mycorrhizae fungi (AMF), plant-growth-promoting rhizobacteria (PGPR), non-pathogenic fungi, protozoa, and nematodes, or non-microbial, such as seaweed extract, phosphite, humic acid, other inorganic salts, chitin and chitosan derivatives, protein hydrolysates and free amino acids, and complex organic materials.
  • 2.2K
  • 18 Sep 2023
Topic Review
Drug Delivery by Buccal/Sublingual Microenvironmental pH Modification
Many drug candidates are poorly water-soluble. Microenvironmental pH (pHM) modification in buccal/sublingual dosage forms has attracted increasing interest as a promising pharmaceutical strategy to enhance the oral mucosal absorption of drugs with pH-dependent solubility. Optimizing drug absorption at the oral mucosa using pHM modification is considered to be a compromise between drug solubility and drug lipophilicity (Log D)/permeation. To create a desired pHM around formulations during the dissolution process, a suitable amount of pH modifiers should be added in the formulations, and the appropriate methods of pHM measurement are required. 
  • 2.2K
  • 15 Mar 2023
Topic Review
Tipping Bucket Rain Gauges
Tipping bucket rain gauges (TBRs) continue to be one of the most widely used pieces of equipment for rainfall monitoring; they are frequently used for the calibration, validation, and downscaling of radar and remote sensing data, due to their major advantages—low cost, simplicity and low-energy consumption.
  • 2.2K
  • 20 Jun 2023
Topic Review
A Specialty Fiber for Distributed Acoustic Sensing Technology
Specialty fibers have introduced new levels of flexibility and variability in distributed fiber sensing applications. In particular, distributed acoustic sensing (DAS) systems utilized the unique functions of specialty fibers to achieve performance enhancements in various distributed sensing applications. 
  • 2.2K
  • 28 Apr 2022
Topic Review
Exosomes for Delivery of Biopharmaceuticals
Exosomes as nanosized vesicles are emerging as drug delivery systems for therapeutics owing to their natural origin, their ability to mediate intercellular communication, and their potential to encapsulate various biological molecules such as proteins and nucleic acids within the lipid bilayer membrane or in the lumen. Exosomes contain endogenous components (proteins, lipids, RNA) that could be used to deliver cargoes to target cells, offering an opportunity to diagnose and treat various diseases. Owing to their ability to travel safely in extracellular fluid and to transport cargoes to target cells with high efficacy, exosomes offer enhanced delivery of cargoes in vivo. However, several challenges related to the stabilization of the exosomes, the production of sufficient amounts of exosomes with safety and efficacy, the efficient loading of drugs into exosomes, the clearance of exosomes from circulation, and the transition from the bench scale to clinical production may limit their development and clinical use. For the clinical use of exosomes, it is important to understand the molecular mechanisms behind the transport and function of exosome vesicles.
  • 2.2K
  • 08 Jun 2021
Topic Review
Zinc
Zinc is an important micronutrient and is required for cell proliferation, differentiation, growth, and development. It takes part in the maintenance of homeostasis, DNA synthesis, RNA transcription, cell division, and activation. It is also involved in immune responses, oxidative stress, apoptosis, and aging. Its deficiency was found to increase the levels of lipid peroxidation in the mitochondrial and microsomal membrane and the osmotic fragility of the erythrocyte membrane.
  • 2.2K
  • 25 Dec 2020
Topic Review
Gastric Cancer in History
Gastric adenocarcinoma is the fourth most common type of cancer and the second leading cause of cancer death in the world. Despite abundant traces of an ancient history, the comprehension of its pathogenic mechanisms is rather recent and continuously updated. We investigated about how the ancient civilizations tried to understand the exactly physiopathology of gastric cancer, from the time when they could not examine deeply the histological and pathophysiologic aspects of the disease, but they just based their knowledge on a visual analysis of the signs and consequences of such disease. We examined the historical evolving knowledge of the disease along the centuries on the gastroenterological, pharmacological, and surgical fields, defining how gastric cancer became an increasingly curable disease.
  • 2.2K
  • 30 Jun 2021
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