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Topic Review
Drug Reaction with Eosinophilia and Systemic Symptoms
Drug reaction with eosinophilia and systemic symptoms (DReSS), also known as drug-induced hypersensitivity syndrome (DiHS), is a severe, systemic, T cell mediated drug reaction with combinations of cutaneous, hematologic, and internal organ involvement. Pathogenesis of DReSS is multi-factorial, involving drug-exposure, genetic predisposition through specific human leukocyte antigen (HLA) alleles and metabolism defects, viral reactivation, and immune dysregulation. Clinical features of this condition are delayed, stepwise, and heterogenous, making this syndrome challenging to recognize and diagnose.
  • 848
  • 13 May 2022
Topic Review
Microbiome in Hidradenitis Suppurativa
Hidradenitis suppurativa is a chronic disease of the pilosebaceous unit. The name of the condition is a testament to the presumed relationship between the disease and the microbiome. The pathophysiology of hidradenitis suppurativa is, however, complex and believed to be the product of a multifactorial interplay between the interfollicular epithelium, pilosebaceous unit, microbiome, as well as genetic and environmental factors.
  • 839
  • 08 Oct 2021
Topic Review
Dermatan Sulfate in Tissue Development
The crucial roles of dermatan sulfate (DS) have been demonstrated in tissue development of the cutis, blood vessels, and bone through construction of the extracellular matrix and cell signaling. DS classically exerts physiological functions via interaction with collagens, growth factors, and heparin cofactor-II.
  • 834
  • 14 Jul 2022
Topic Review
Probiotics and the Enterocutaneous Axis
Probiotics are defined as those microorganisms that, when administered in sufficient quantities, confer a health benefit. Some pathologies in which dysbiosis is present and the therapeutic role of probiotics has been explored are atopic dermatitis, psoriasis and acne.
  • 832
  • 22 Sep 2021
Topic Review
Applications of Curcumin in Wound-Healing
Wound healing is an intricate process of tissue repair or remodeling that occurs in response to injury. Plants and plant-derived bioactive constituents are well explored in the treatment of various types of wounds. Curcumin is a natural polyphenolic substance that has been used since ancient times in Ayurveda for its healing properties, as it reduces inflammation and acts on several healing stages.
  • 828
  • 11 Nov 2022
Topic Review
Nanotechnology-Based Topical Delivery of Natural Products for AD
Atopic dermatitis (AD) is a chronic eczematous inflammatory disease that may arise from environmental, genetic, and immunological factors. Despite the efficacy of current treatment options such as corticosteroids, such approaches are mainly focused on symptom relief and may present certain undesirable side effects. Isolated natural compounds, oils, mixtures, and/or extracts have gained scientific attention because of their high efficiency and moderate to low toxicity.
  • 825
  • 07 Jul 2023
Topic Review
Preferentially Expressed Antigen in Melanoma and Malignant Melanoma
Preferentially expressed antigen in melanoma (PRAME) is a cancer testis antigen (CTA) identified in 1997 through analysis of the specificity of tumor-reactive T-cell clones derived from a patient with metastatic cutaneous melanoma. Although at first it seemed even more specific, various studies have shown that PRAME can also be expressed in the context of atypical lesions that do not correspond solely to the definition of malignant melanoma. Various studies have shown that PRAME can also be expressed in the context of atypical lesions apart from MM and, for this reason, the diagnostic sensitivity and specificity (hence accuracy) are clearly lower. 
  • 810
  • 28 Apr 2022
Topic Review
Cassia alata (Linnaeus) Roxburgh for Skin
Atopic dermatitis (AD) is an inflamed skin condition with relapsing pruritus and cutaneous physiological dysfunction. This skin disorder is widespread around the world and frequently affects infants, children and adults. Natural products with bioactive lead compounds are the source of natural medicines for complementary and alternative therapy in managing AD. Cassia alata (Senna alata) has been used traditionally as a remedy for a variety of health issues. Cassia alata is also known as ringworm cassia. This plant is perennial and is known as a ‘candle bush’ due to its shape and inflorescences. 
  • 808
  • 08 Feb 2023
Topic Review
Cytokines in Vitiligo
Vitiligo is a chronic autoimmune dermatosis of which the pathogenesis remains scarcely known. A wide variety of clinical studies have been proposed to investigate the immune mediators which have shown the most recurrency.
  • 807
  • 27 Oct 2021
Topic Review
Acne Syndromes and Mosaicism
Abnormal mosaicism is the coexistence of cells with at least two genotypes, by the time of birth, in an individual derived from a single zygote, which leads to a disease phenotype. Somatic mosaicism can be further categorized into segmental mosaicism and nonsegmental somatic mosaicism. Acne is a chronic illness characterized by inflammatory changes around and in the pilosebaceous units, commonly due to hormone- and inflammatory signaling-mediated factors. Several systemic disorders, such as congenital adrenal hyperplasia, polycystic ovarian syndrome, and seborrhoea-acne-hirsutism-androgenetic alopecia syndrome have classically been associated with acne. Autoinflammatory syndromes, including PAPA, PASH, PAPASH, PsAPASH, PsaPSASH, PASS, and SAPHO syndromes include acneiform lesions as a key manifestation. Mosaic germline mutations in the FGFR2 gene have been associated with Apert syndrome and nevus comedonicus, two illnesses that are accompanied by acneiform lesions.
  • 798
  • 03 Dec 2021
Topic Review
Cutaneous Findings in NF1
Neurofibromatosis type 1 (NF1) is a complex autosomal dominant disorder associated with germline mutations in the NF1 tumor suppressor gene. NF1 belongs to a class of congenital anomaly syndromes called RASopathies, a group of rare genetic conditions caused by mutations in the Ras/mitogen-activated protein kinase pathway. Generally, NF1 patients present with dermatologic manifestations.
  • 789
  • 02 Feb 2021
Topic Review
Factors Contributing to Atopic Dermatitis Development
Atopic dermatitis (AD) or atopic eczema is an increasingly manifested inflammatory skin disorder of complex etiology which is modulated by both extrinsic and intrinsic factors. Immune dysregulation, barrier dysfunction, hormonal fluctuations, and skin microbiome dysbiosis are important factors contributing to AD development, and their in-depth understanding is crucial not only for AD treatment but also for similar inflammatory disorders.
  • 786
  • 29 Jun 2023
Topic Review
Atopic Dermatitis (AD)
The skin harbors a huge number of different microorganisms such as bacteria, fungi and viruses, and it acts as a protective shield to prevent the invasion of pathogens and to maintain the health of the commensal microbiota. Several studies, in fact, have shown the importance of the skin microbiota for healthy skin. This balance can be altered by intrinsic and extrinsic factors, leading to the development of skin disease, such as acne vulgaris (AV), atopic dermatitis (AD) and rosacea (RS).
  • 785
  • 27 Oct 2022
Topic Review
Substances/Receptors Inducing Itch in AD
Itch or pruritus is the hallmark of atopic dermatitis and is defined as an unpleasant sensation that evokes the desire to scratch. It is also believed that itch is a signal of danger from various environmental factors or physiological abnormalities. Because histamine is a well-known substance inducing itch, H1-antihistamines are the most frequently used drugs to treat pruritus.
  • 782
  • 09 Jun 2021
Topic Review
Aberrant Expression of Immunohistochemical Markers
Malignant melanoma can rarely present with unusual staining patterns. This includes aberrant expression of non-melanocytic markers and/ or lack of expression of specific melanocytic markers. 
  • 781
  • 24 Nov 2021
Topic Review
Innovative Strategies for Wound Healing
Wound healing is highly specialized dynamic multiple phase process for the repair of damaged/injured tissues through an intricate mechanism. Various emerging and innovative strategies for promoting quality wound healing have been discussed. 
  • 779
  • 15 Aug 2022
Topic Review
HDPs in Skin Wound Healing
Cutaneous wound healing is a vital biological process that aids skin regeneration upon injury. Wound healing failure results from persistent inflammatory conditions observed in diabetes, or autoimmune diseases like psoriasis. Chronic wounds are incurable due to factors like poor oxygenation, aberrant function of peripheral sensory nervature, inadequate nutrients and blood tissue supply. The most significant hallmark of chronic wounds is heavily aberrant immune skin function. As the first line of defence against pathogenic bacterial infection, host defence peptides (HDPs) are a critical element in preventing biofilm-associated infections. A decline in sufficiently effective antibiotic treatments due to growing problems with antibiotic resistance may be ameliorated with alternatives to conventional antibiotics like peptides with antimicrobial properties. Aside from bacterial pathogen inactivation by disrupting their cell membranes, host defence peptides also have immunomodulatory properties, due to their ability to stimulate the cross-talk between immune cells promoting cutaneous wound healing in a healthier manner.
  • 775
  • 13 Jul 2021
Topic Review
Types of Indigenous Skin Bacteria and Their Effects
The skin is inhabited by about 102–107 cells/cm2 and 1000 species of commensal bacteria, fungi, viruses, and other microorganisms. In particular, metabolites such as fatty acids and glycerol released by indigenous skin bacteria have been reported to have functional properties for the health of the skin. Therefore, skin-domesticating bacteria and the metabolites derived from those bacteria are used in many skincare product ingredients and function as probiotic cosmetics. 
  • 774
  • 12 Dec 2022
Topic Review
Pharmacological Wound Healing Evidence of Iberian Lamiaceae
The traditional use of the family Lamiaceae has been highlighted in several ethnobotanical assays carried out within the Iberian Peninsula. Usually, Lamiaceae species are rich essential oil-bearing plants with a great diversity of phenolic compounds, polyphenols, iridoids, diterpenoids, triterpenoids, saponins and, in some restricted cases, pyridine and pyrrolidine alkaloids.
  • 774
  • 01 Mar 2023
Topic Review
The Involvement of Oxidative Stress in Psoriasis
Psoriasis is a chronic, immune-mediated inflammatory dermatosis characterized by the appearance of erythematous plaques, covered by white scales, occasionally pruritogenic, and distributed mainly on the extensor areas. Oxidative stress is defined as an imbalance or a transient or chronic increase in the levels of free oxygen/nitrogen radicals, either as a result of the exaggerated elevation in their production or the decrease in their ability to be eliminated by antioxidant systems. Although the pathogenesis of psoriasis remains far from elucidated, there are studies that delineate an involvement of oxidative stress in this skin disorder.
  • 771
  • 10 Feb 2022
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