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Topic Review
Secoiridoids from Olea europaea L.
Iridoids, which have beneficial health properties, include a wide group of cyclopentane [c] pyran monoterpenoids present in plants and insects. The cleavage of the cyclopentane ring leads to secoiridoids. Mainly, secoiridoids have shown a variety of pharmacological effects including anti-diabetic, antioxidant, anti-inflammatory, immunosuppressive, neuroprotective, anti-cancer, and anti-obesity, which increase the interest of studying these types of bioactive compounds in depth. Secoiridoids are thoroughly distributed in several families of plants such as Oleaceae, Valerianaceae, Gentianaceae and Pedialaceae, among others. Specifically, Olea europaea L. (Oleaceae) is rich in oleuropein (OL), dimethyl-OL, and ligstroside secoiridoids, and their hydrolysis derivatives are mostly OL-aglycone, oleocanthal (OLE), oleacein (OLA), elenolate, oleoside-11-methyl ester, elenoic acid, hydroxytyrosol (HTy), and tyrosol (Ty). These compounds have proved their efficacy in the management of diabetes, cardiovascular and neurodegenerative disorders, cancer, and viral and microbial infections. Particularly, the antioxidant, anti-inflammatory, and immunomodulatory properties of secoiridoids from the olive tree (Olea europaea L. (Oleaceae)) have been suggested as a potential application in a large number of inflammatory and reactive oxygen species (ROS)-mediated diseases.
  • 1.4K
  • 28 Jun 2021
Topic Review
DKK1 in Hair Regeneration
Dickkopf-related protein 1 (DKK1) is distinctly identified as an inhibitor of canonical Wnt/β-catenin signaling.
  • 1.3K
  • 22 Nov 2021
Topic Review
Synthetic Biology towards Flavonoid Pharmacokinetics
Flavonoids are a structurally diverse class of natural products that have been found to have a range of beneficial activities in humans. However, the clinical utilisation of these molecules has been limited due to their low solubility, chemical stability, bioavailability and extensive intestinal metabolism in vivo. Recently, the view has been formed that site-specific modification of flavonoids by methylation and/or glycosylation, processes that occur in plants endogenously, can be used to improve and adapt their biophysical and pharmacokinetic properties. The traditional source of flavonoids and their modified forms is from plants and is limited due to the low amounts present in biomass, intrinsic to the nature of secondary metabolite biosynthesis. Access to greater amounts of flavonoids, and understanding of the impact of modifications, requires a rethink in terms of production, more specifically towards the adoption of plant biosynthetic pathways into ex planta synthesis approaches. Advances in synthetic biology and metabolic engineering, aided by protein engineering and machine learning methods, offer attractive and exciting avenues for ex planta flavonoid synthesis.
  • 1.3K
  • 04 Jun 2021
Topic Review
Teak Allelopathy and Agroforestry
Teak (Tectona grandis L.f.) is one of the most valuable timber species, and is cultivated in agroforestry systems in many countries across the tropical and subtropical regions of the world.
  • 1.3K
  • 09 Jan 2022
Topic Review
Seaweed Cultivation and Its Applications in Colombia
Colombia has a diverse range of marine ecosystems in the coastal and insular areas of the Caribbean Sea and the Pacific Ocean. Seaweed research has focused mainly on the identification and taxonomic distribution of 628 species identified so far, mainly in the Caribbean Sea. Among the most widely cultivated genera of seaweeds in open-sea pilot systems in Colombia are Hydropuntia, Gracilaria, Hypnea, Kappaphycus, and Eucheuma. These genera have shown low yields as a consequence of high tissue fragility, epiphytism, sedimentation, and nitrogen deficiency. In addition, the evaluation of the biological activity of selected seaweed compounds has advanced considerably, focusing on their composition and their use for direct consumption by humans and animals. Despite the diversity of seaweeds, as well as certain technical and scientific advances, Colombia is still lagging behind other countries in seaweed exploitation, both in Latin America and worldwide.
  • 1.3K
  • 16 Feb 2022
Topic Review
Osteocyte
Osteocytes are the most abundant bone cells, entrapped inside the mineralized bone matrix. They derive from osteoblasts through a complex series of morpho-functional modifications; such modifications not only concern the cell shape (from prismatic to dendritic) and location (along the vascular bone surfaces or enclosed inside the lacuno-canalicular cavities, respectively) but also their role in bone processes (secretion/mineralization of preosseous matrix and/or regulation of bone remodeling). Osteocytes are connected with each other by means of different types of junctions, among which the gap junctions enable osteocytes inside the matrix to act in a neuronal-like manner, as a functional syncytium together with the cells placed on the vascular bone surfaces (osteoblasts or bone lining cells), the stromal cells and the endothelial cells, i.e., the bone basic cellular system (BBCS). Within the BBCS, osteocytes can communicate in two ways: by means of volume transmission and wiring transmission, depending on the type of signals (metabolic or mechanical, respectively) received and/or to be forwarded. The capability of osteocytes in maintaining skeletal and mineral homeostasis is due to the fact that it acts as a mechano-sensor, able to transduce mechanical strains into biological signals and to trigger/modulate the bone remodeling, also because of the relevant role of sclerostin secreted by osteocytes, thus regulating different bone cell signaling pathways.
  • 1.3K
  • 09 Apr 2021
Topic Review
Methionine Dependence of Cancer
Tumorigenesis is accompanied by the reprogramming of cellular metabolism. The shift from oxidative phosphorylation to predominantly glycolytic pathways to support rapid growth is well known and is often referred to as the Warburg effect. However, other metabolic changes and acquired needs that distinguish cancer cells from normal cells have also been discovered. The dependence of cancer cells on exogenous methionine is one of them and is known as methionine dependence or the Hoffman effect. This phenomenon describes the inability of cancer cells to proliferate when methionine is replaced with its metabolic precursor, homocysteine, while proliferation of non-tumor cells is unaffected by these conditions. Surprisingly, cancer cells can readily synthesize methionine from homocysteine, so their dependency on exogenous methionine reflects a general need for altered metabolic flux through pathways linked to methionine.
  • 1.3K
  • 30 Jun 2021
Topic Review
Cancer Biomarkers
Cancer is one of the major public health issues in the world. It has become the second leading cause of death, with approximately 75% of cancer deaths transpiring in low- or middle-income countries. It causes a heavy global economic cost estimated at more than a trillion dollars per year. The conventional diagnostic technologies such as MRI (magnetic resonance imaging), CT (computerized tomography) scan, ultrasound and biopsy were not effective for cancer detection at primary stages; this is because of their dependency on tumorigenic properties or phenotypic characters of a tumor. Cancer is a very complex disease, with many epigenetic as well as genetic modifications which might alter the cell signaling process, related to development and resulting in tumorigenic transformation and malignancy. For almost all cancer patients, researchers and clinicians expect tests or methods that might diagnose cancer significantly earlier, provide better prognosis, and that can allow for increased survival rates. Cancer markers have been used in the oncology field. Biomarkers are molecules of biologic emergence found in blood, tissues, various body fluids such as urine, cerebrospinal fluid, or different body tissues that are elevated is the indicative of an abnormal disease or condition with cancer. 
  • 1.3K
  • 24 Mar 2023
Topic Review
MitoQ
Mitoquinone (MitoQ) is a mitochondrial reactive oxygen species scavenger that is characterized by high bioavailability. Prior studies have demonstrated its neuroprotective potential. Indeed, the release of reactive oxygen species due to damage to mitochondrial components plays a pivotal role in the pathogenesis of several neurodegenerative diseases.
  • 1.3K
  • 11 May 2021
Topic Review
Milk Proteins
Milk and colostrum have high biological potential, and due to their natural origin and non-toxicity, they have many uses in cosmetics and dermatology. Research is ongoing on their potential application in other fields of medicine, but there are still few results; most of the published ones are included in this entry. These natural products are especially rich in proteins, such as casein, β-lactoglobulin, α-lactalbumin, lactoferrin, immunoglobulins, lactoperoxidase, lysozyme, and growth factors, and possess various antibacterial, antifungal, antiviral, anticancer, antioxidant, immunomodulatory properties, etc. 
  • 1.3K
  • 22 Jun 2021
Topic Review
Pectins and Olive Pectins
Pectins are a component of the complex heteropolysaccharide mixture present in the cell wall of higher plants. Structurally, the pectin backbone includes galacturonic acid to which neutral sugars are attached, resulting in functional regions in which the esterification of residues is crucial. Pectins influence many physiological processes in plants and are used industrially for both food and non-food applications. Pectin-based compounds are also a promising natural source of health-beneficial bioactive molecules. Olives, the fruit of the olive tree, are consumed as part of the healthy Mediterranean diet or processed into olive oil. Pectins from olives have recently emerged as promising compounds with health-beneficial effects. 
  • 1.3K
  • 14 Sep 2021
Topic Review
Resveratrol in Autism Spectrum Disorders
Resveratrol (RSV) is a polyphenolic stillbenoid with significant anti-oxidative and anti-inflammatory properties recently tested in animal models of several neurological diseases. Altered immune alteration and oxidative stress have also been found in patients with autism spectrum disorders (ASD), and these alterations could add to the pathophysiology associated with ASD. 
  • 1.3K
  • 27 May 2021
Topic Review Peer Reviewed
β-Glucans
β-glucans are complex polysaccharides that are found in several plants and foods, including mushrooms. β-glucans display an array of potentially therapeutic properties.
  • 1.3K
  • 13 Apr 2022
Topic Review
Ascorbate-Glutathione Pathway
The Ascorbate-Glutathione (AsA-GSH) pathway, also known as Asada–Halliwell pathway comprises of AsA, GSH, and four enzymes viz. ascorbate peroxidase, monodehydroascorbate reductase, dehydroascorbate reductase, and glutathione reductase, play a vital role in detoxifying ROS. Apart from ROS detoxification, they also interact with other defense systems in plants and protect the plants from various abiotic stress-induced damages. Several plant studies revealed that the upregulation or overexpression of AsA-GSH pathway enzymes and the enhancement of the AsA and GSH levels conferred plants better tolerance to abiotic stresses by reducing the ROS. 
  • 1.2K
  • 29 Jul 2021
Topic Review
Acremonium Strictum
Acremonium strictum is an environmentally widespread saprotroph species found in soil, plant debris, and rotting mushrooms. Isolates have been collected in North and Central America, Asia, Europe and Egypt. A. strictum is an agent of hyalohyphomycosis and has been identified as an increasingly frequent human pathogen in immunosuppressed individuals, causing localized, disseminated and invasive infections. Although extremely rare, A. strictum can infect immunocompetent individuals, as well as neonates. Due to the growing number of infections caused by A. strictum in the past few years, the need for new medical techniques in the identification of the fungus as well as for the treatment of human infections has risen considerably. A. strictum has been shown to be involved in some myoparasitic relationships, as well as a wide range of plant endophytic and parasitic relationships, and further studies are required to determine A. strictum's use as a biological control agent and role as a parasite that reduces crop yields. A. strictum exhibits metabolism of many products that imply future agricultural and pharmaceutical significance.
  • 1.2K
  • 27 Oct 2022
Topic Review
Proteomics in Forensic Analysis
Proteomics is in the early stages of development for forensic applications. It has been used in forensics for identification of tissue and body fluid, identification and quantification of protein toxins, human individualization, detection of protein drugs and hormones in sports, and estimation of post-mortem intervals.
  • 1.2K
  • 19 Apr 2021
Topic Review
Operon
The term operon was first coined by Jacob and Monod in 1961 to describe a cluster of genes whose expression was regulated by an operator.
  • 1.2K
  • 04 May 2023
Topic Review
Microglial Staining
Neuroinflammation has recently been identified as a fundamentally important pathological process in most, if not all, CNS diseases. The main contributor to neuroinflammation is the microglia, which constitute the innate immune response system. Accurate identification of microglia and their reactivity state is therefore essential to further understanding of CNS pathophysiology. Many staining techniques have been used to visualise microglia in rodent and human tissue, and immunostaining is currently the most frequently used.
  • 1.2K
  • 29 Apr 2022
Topic Review
Sensogenomics and the Biological Background Underlying Musical Stimuli
The impact of musical stimulus in the human genome opens a new era of research. We hereby introduce and develop the term Sensogenomics, referring to the still unexplored field of research focused on the response of our genome to sensorial stimuli.
  • 1.2K
  • 21 Jan 2022
Topic Review
Persea americana
Persea americana, commonly known as avocado, has recently gained substantial popularity and is often marketed as a “superfood” because of its unique nutritional composition, antioxidant content, and biochemical profile. However, the term “superfood” can be vague and misleading, as it is often associated with unrealistic health claims. This article provides a comprehensive summary and assessment of the studies performed in the literature to understand the nutritional and therapeutic properties of avocado and its bioactive compounds. 
  • 1.2K
  • 13 Aug 2021
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