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Topic Review
Enzyme-Mediated Wastewater Remediation
Several additional treatments that could potentially supplement existing wastewater treatment plants (WWTPs) to eliminate pollutants include a range of physicochemical and biological methods. The use of enzymes, specifically, oxidoreductases, are increasingly being studied for their ability to degrade different classes of organic compounds. These enzymes have been immobilized on different supports to promote their adoption as a cost-effective and recyclable remediation approach. Unfortunately, some of these techniques have shown a negative effect on the enzyme, including denaturation and loss of catalytic activity.
  • 2.3K
  • 02 Dec 2021
Topic Review Peer Reviewed
Korean Division Films
As one half of what is currently the only divided country in the world, the phenomenon of the so-called “division film” in South Korea has developed as a reflection of the social changes associated with its divided national background. The divided Korean Peninsula, the cause of military confrontation between the two Koreas, the Korean War, and espionage activities, is the background for Korean division films. As a result, the divided state serves as a narrative element and can be explored as a theme. Since the release of the first division films in 1949, a year after the Korean Peninsula was split into two countries, division films have been produced constantly. This entry analyzes major political changes, focusing on the regime changes represented in division films and, based on this approach, explores the cinematic illustrations of modern Korean history in three distinct periods. In a bid to reflect the characteristics of the times, division films portray historical elements while acting successfully as an advanced form of art. Herein, I will examine the definition and the range of these division films. This entry thus aims to discuss, in depth, the origin and history of Korea’s division films. 
  • 2.3K
  • 27 Apr 2022
Topic Review
Clinical Applications of MR Spectroscopy in Pediatrics
In vivo MR spectroscopy is a non-invasive methodology that provides information about the biochemistry of tissues. It is available as a “push-button” application on state-of-the-art clinical MR scanners. MR spectroscopy has been used to study various brain diseases including tumors, stroke, trauma, degenerative disorders, epilepsy/seizures, inborn errors, neuropsychiatric disorders, and others.
  • 2.3K
  • 01 Jul 2022
Topic Review
Cannabis Sativa Revisited
Critically ill patients with sepsis require a multidisciplinary approach, as this situation implies multiorgan distress, with most of the bodily biochemical and cellular systems being affected by the condition. Moreover, sepsis is characterized by a multitude of biochemical interactions and by dynamic changes of the immune system. At the moment, there is a gap in our understanding of the cellular, genetic, and molecular mechanisms involved in sepsis. One of the systems intensely studied in recent years is the endocannabinoid signaling pathway, as light was shed over a series of important interactions of cannabinoid receptors with biochemical pathways, specifically for sepsis. Furthermore, a series of important implications on inflammation and the immune system that are induced by the activity of cannabinoid receptors stimulated by the delta-9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) have been noticed. One of the most important is their ability to reduce the biosynthesis of pro-inflammatory mediators and the modulation of immune mechanisms. Different studies have reported that cannabinoids can reduce oxidative stress at mitochondrial and cellular levels. In detail, the entry shows the important mechanisms modulated by the endocannabinoid signaling pathway, as well as of the molecular and cellular links it has with sepsis. At the same time, the possible implications of cannabinoids in the most important biological pathways involved in sepsis, such as inflammation, redox activity, immune system, and epigenetic expression will be presented.
  • 2.3K
  • 04 Jul 2022
Topic Review
Technocrat
Technocracy is an ideological system of governance in which a decision-maker or makers are elected by the population or appointed on the basis of their expertise in a given area of responsibility, particularly with regard to scientific or technical knowledge. This system explicitly contrasts with Representative Democracy, the notion that elected representatives should be the primary decision-makers in government, though it does not necessarily imply eliminating elected representatives. Leadership skills for decision-makers are selected on the basis of specialized knowledge and performance, rather than political affiliations or parliamentary skills. The term technocracy was originally used to advocate the application of the scientific method to solving social problems. Concern could be given to sustainability within the resource base, instead of monetary profitability, so as to ensure continued operation of all social-industrial functions. In its most extreme sense technocracy is an entire government running as a technical or engineering problem and is mostly hypothetical. In more practical use, technocracy is any portion of a bureaucracy that is run by technologists. A government in which elected officials appoint experts and professionals to administer individual government functions and recommend legislation can be considered technocratic. Some uses of the word refer to a form of meritocracy, where the ablest are in charge, ostensibly without the influence of special interest groups. Critics have suggested that a "technocratic divide" challenges more participatory models of democracy, describing these divides as "efficacy gaps that persist between governing bodies employing technocratic principles and members of the general public aiming to contribute to government decision making".
  • 2.3K
  • 17 Oct 2022
Topic Review
SAP Converged Cloud
SAP Converged Cloud is a private managed cloud developed and marketed by SAP. It is a set of cloud computing services that offers managed private cloud, based on the OpenStack technology-based public cloud. It is used by SAP's organization for their own internal IT resources to create a mix of different cloud computing environments made up of the Openstack services. It offers compute, storage, and platform services that are accessible to SAP.
  • 2.3K
  • 15 Nov 2022
Topic Review
Performance-Enhancing Drugs (PEDs)
Performance-enhancing drugs (PEDs) are substances used to improve athletic ability, endurance, strength, or recovery beyond the body’s natural limits. While some PEDs have legitimate medical applications, their use in competitive sports is controversial due to ethical concerns, health risks, and violations of fair play principles. Anti-doping agencies and sports governing bodies have established strict regulations and testing protocols to detect and deter PED use in both amateur and professional athletics.
  • 2.3K
  • 25 Sep 2025
Topic Review
Open Space Design
Open space design, as an integral part of urban design, is the art of relationship.
  • 2.3K
  • 26 Jul 2021
Topic Review
Removal of Pharmaceuticals from Water
It is important to consider and characterize the efficiency of pharmaceutical removal during wastewater and drinking-water treatment processes. Various treatment options have been investigated for the removal/reduction of drugs (e.g., antibiotics, NSAIDs, analgesics) using conventional or biological treatments, such as activated sludge processes or bio-filtration, respectively. The efficiency of these processes ranges from 20–90%.
  • 2.3K
  • 02 Aug 2021
Topic Review
Developing Resilience to Disinformation through Media Literacy Programs
Disinformation and false information, often referred to as fake news do not constitute a novel phenomenon. Media literacy initiatives to enable the general public to critically evaluate media messages formally date back to UNESCO’s declaration of 1982, known as the Grünwald Declaration on Media Education. More recently (2020), UNESCO reiterated its position, drawing attention that in the age of ‘post-truth’, ‘fake news’ and ‘alternative facts’ disinformation and misinformation can and should be countered through media and information literacy (MIL) programs.
  • 2.3K
  • 16 May 2022
Topic Review
Automated Driving System
An automated driving system is a complex combination of various components that can be defined as systems where perception, decision making, and operation of the automobile are performed by electronics and machinery instead of a human driver, and as introduction of automation into road traffic. This includes handling of the vehicle, destination, as well as awareness of surroundings. While the automated system has control over the vehicle, it allows the human operator to leave all responsibilities to the system.
  • 2.3K
  • 28 Sep 2022
Topic Review
Macchi C.200
The Macchi C.200 Saetta (Italian: Lightning), or MC.200, was a fighter aircraft developed and manufactured by Aeronautica Macchi in Italy. It was operated in various forms by the Regia Aeronautica (Italian Air Force) who used the type throughout the Second World War. The C.200 was designed by Mario Castoldi, Macchi's lead designer, to serve as a modern monoplane fighter aircraft, furnished with retractable landing gear and powered by a radial engine. It possessed excellent maneuverability and the C.200's general flying characteristics left little to be desired. Stability in a high-speed dive was exceptional, but it was underpowered and underarmed in comparison to its contemporaries. Early on, there were a number of crashes caused by stability problems, nearly resulting in the grounding of the type, which was ultimately addressed via aerodynamic modifications to the wing. From the time Italy entered the Second World War on 10 June 1940, until the signing of the armistice of 8 September 1943, the C. 200 flew more operational sorties than any other Italian aircraft. The Saetta saw operational service in Greece, North Africa, Yugoslavia, across the Mediterranean and the Soviet Union (where it obtained an excellent kill to loss ratio of 88 to 15). Its very strong all-metal construction and air-cooled engine made the aircraft ideal for conducting ground attack missions; several units flew it as a fighter-bomber. Over 1,000 aircraft had been constructed by the end of the war.
  • 2.3K
  • 31 Oct 2022
Topic Review
Timeline of Typhoid Fever
This is a Timeline of typhoid fever, describing major events such as scientific/medical developments and notable epidemics.
  • 2.3K
  • 14 Nov 2022
Topic Review
Beta Lactams and Products
Discovery and synthesis of penicillin and other beta-lactam antibiotics have received sustained attention. The use of β-lactam antibiotics is extensively documented in several thousand of publications. In modern times, microwave-induced reactions are also used extensively for the synthesis and stereochemical studies of diverse β-lactams. In this paper, the author describes a few crucial reactions that are performed toward the synthesis of β-lactams and products obtained from them under classical conditions as well as by domestic or automated microwave oven.
  • 2.3K
  • 28 Oct 2020
Topic Review
Bone Tissue Engineering
Tissue engineering has promoted structures that can simulate the extracellular matrix and are capable of guiding natural bone repair using signaling molecules to promote osteoinduction and angiogenesis essential in the formation of new bone tissues.
  • 2.3K
  • 08 Mar 2021
Topic Review
Materials for Solar Cells and Supercapacitors
Hybrid systems have gained significant attention among researchers and scientists worldwide due to their ability to integrate solar cells and supercapacitors. Subsequently, this has led to rising demands for green energy, miniaturization and mini-electronic wearable devices. These hybrid devices will lead to sustainable energy becoming viable and fossil-fuel-based sources of energy gradually being replaced. A solar photovoltaic (SPV) system is an electronic device that mainly functions to convert photon energy to electrical energy using a solar power source. 
  • 2.3K
  • 14 Mar 2022
Topic Review
The HD-Domain Metalloprotein Superfamily
The histidine–aspartate (HD)-domain protein superfamily contains metalloproteins that share common structural features but catalyze vastly different reactions ranging from oxygenation to hydrolysis. This chemical diversion is afforded by (i) their ability to coordinate most biologically relevant transition metals in mono-, di-, and trinuclear configurations, (ii) sequence insertions or the addition of supernumerary ligands to their active sites, (iii) auxiliary substrate specificity residues vicinal to the catalytic site, (iv) additional protein domains that allosterically regulate their activities or have catalytic and sensory roles, and (v) their ability to work with protein partners. More than 500 structures of HD-domain proteins are available to date that lay out unique structural features which may be indicative of function. In this respect, we describe the three known classes of HD-domain proteins (hydrolases, oxygenases, and lyases) and identify their apparent traits with the aim to portray differences in the molecular details responsible for their functional divergence and reconcile existing notions that will help assign functions to yet-to-be characterized proteins.
  • 2.3K
  • 29 Oct 2020
Topic Review
RFID Sensors for IoT
Abstract: Radio-frequency identification (RFID) sensors are one of the fundamental components of the Internet of Things.  Within this framework, chipless RFIDs are a breakthrough technology because, removing the cost associated with the chip, are at the same time printable, passive, low-power and suitable for harsh environments. For this reason, there is a clear motivation and interest to extend the chipless sensing functionality to physical, chemical, structural and environmental parameters. Temperature and humidity sensors, as well as localization, proximity, and structural health prototypes, have already been produced, and many other sensing applications are on the way. In this review, architectural approaches and requirements related to the materials employed for chipless RFID sensing are summarized. The state-of-the-art of many categories of sensors and their applications is reported and an analysis of the current limitations and possible solution strategies are given, together with an overview of expected future developments.
  • 2.3K
  • 29 Oct 2020
Topic Review
Classification of Waste Biomass and Biogenic Materials
Waste biomasses such as oil seed crops, lignocellulosic materials (e.g., agricultural and forest residues), microalgae, energy crops, manure, food waste and organic fraction of municipal solid waste have a huge potential to provide energy and value-added products via different conversion technologies.
  • 2.3K
  • 16 Sep 2022
Topic Review
Pressure Ulcer
Pressure ulcers, also known as pressure sores, bed sores or pressure injuries, are localised damage to the skin and/or underlying tissue that usually occur over a bony prominence as a result of usually long-term pressure, or pressure in combination with shear or friction. The most common sites are the skin overlying the sacrum, coccyx, heels, and hips, though other sites can be affected, such as the elbows, knees, ankles, back of shoulders, or the back of the cranium. Pressure ulcers occur due to pressure applied to soft tissue resulting in completely or partially obstructed blood flow to the soft tissue. Shear is also a cause, as it can pull on blood vessels that feed the skin. Pressure ulcers most commonly develop in individuals who are not moving about, such as those who are on chronic bedrest or consistently use a wheelchair. It is widely believed that other factors can influence the tolerance of skin for pressure and shear, thereby increasing the risk of pressure ulcer development. These factors are protein-calorie malnutrition, microclimate (skin wetness caused by sweating or incontinence), diseases that reduce blood flow to the skin, such as arteriosclerosis, or diseases that reduce the sensation in the skin, such as paralysis or neuropathy. The healing of pressure ulcers may be slowed by the age of the person, medical conditions (such as arteriosclerosis, diabetes or infection), smoking or medications such as anti-inflammatory drugs. Although often prevented and treatable if detected early, pressure ulcers can be very difficult to prevent in critically ill people, frail elders and individuals with impaired mobility such as wheelchair users (especially where spinal injury is involved). Primary prevention is to redistribute pressure by regularly turning the person. The benefit of turning to avoid further sores is well documented since at least the 19th century. In addition to turning and re-positioning the person in the bed or wheelchair, eating a balanced diet with adequate protein and keeping the skin free from exposure to urine and stool is important. The rate of pressure ulcers in hospital settings is high; the prevalence in European hospitals ranges from 8.3% to 23%, and the prevalence was 26% in Canadian healthcare settings from 1990 to 2003. In 2013, there were 29,000 documented deaths from pressure ulcers globally, up from 14,000 deaths in 1990.
  • 2.3K
  • 25 Oct 2022
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