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Topic Review
Dendrimers
Today, dendrimers are the main nanoparticle applied to drug delivery systems. The physicochemical characteristics of dendrimers and their versatility structural modification make them attractive to applied as a platform to bioactive molecules transport. Nanoformulations based on dendrimers enhance low solubility drugs, arrival to the target tissue, drugs bioavailability, and controlled release. This review describes the latter approaches on the transport of bioactive molecules based on dendrimers. The review focus is on the last therapeutic strategies addressed by dendrimers conjugated with bioactive molecules. A brief review of the latest studies in therapies against cancer and cardiovascular diseases, as well as future projections in the area, are addressed.
  • 2.4K
  • 17 Sep 2020
Topic Review
Deep Eutectic Solvents (DESs)
Deep eutectic solvents (DESs) are promising green solvents, due to their versatility and properties such as high biodegradability, inexpensiveness, ease of preparation and negligible vapor pressure. They have been employed as green catalysts in biomass transformations and its upgrading into valuable chemicals. 
  • 2.4K
  • 18 Mar 2021
Topic Review
Application of Ketamine in Depression in Alzheimer’s Disease
Depression is a leading cause of disability globally, with a prevalence of 3.8% among the whole population, 5% of the adult population, and 5.7% of the elderly population over 60 years of age. There is evidence that depression is linked to certain neurodegenerative diseases, one being Alzheimer’s disease (AD). The efficacy of conventional antidepressants to treat depression in AD is conflicting, especially regarding selective serotonin reuptake inhibitors (SSRIs). However, ketamine, a nonselective N-methyl-D-aspartate (NMDA) receptor antagonist, can mediate a wide range of pharmacological effects, including neuroprotection, anti-inflammatory and anticancer properties, multimodal analgesia, and treatment of depression, suicidal attempts, and status epilepticus. Recent clinical findings suggest that ketamine may provide neuroprotection and reduce neuropsychiatric symptoms associated with AD. 
  • 2.4K
  • 31 Mar 2022
Topic Review
The Honey Bee Apis mellifera
The honey bee Apis mellifera Linnaeus (1758) provides many benefits to humans and ecosystems. This species is an important pollinator in natural environments, which may help to preserve and restore the biodiversity of wild plants. On the other hand, pollination in agro-ecosystems by managed honey bee colonies may enhance crop yield and quality, meeting the increasing food demand. Beekeeping is also a high-valued and income-generating activity, which provides humans with honey as high-quality food as well as substances used as raw materials and in pharmaceuticals. In addition, the honey bee and its products are valuable bioindicators and bioaccumulators of environmental pollution: they provide valuable information on the impact of human activities, enabling the implementation of measures to mitigate risks to human and ecosystem health. The honey bee is also linked to many cultural ecosystem services and has a longstanding tradition in human culture, mysticism, and religion. Its popularity may be therefore used for educational purposes and to raise public awareness of important issues, such as the conservation of pollinator habitats and biodiversity.
  • 2.4K
  • 22 Jun 2022
Topic Review
Unsaturated Fat
An unsaturated fat is a fat or fatty acid in which there is at least one double bond within the fatty acid chain. A fatty acid chain is monounsaturated if it contains one double bond, and polyunsaturated if it contains more than one double bond. Where double bonds are formed, hydrogen atoms are subtracted from the carbon chain. Thus, a saturated fat has no double bonds, has the maximum number of hydrogens bonded to the carbons, and therefore is "saturated" with hydrogen atoms. In cellular metabolism, unsaturated fat molecules contain somewhat less energy (i.e., fewer calories) than an equivalent amount of saturated fat. The greater the degree of unsaturation in a fatty acid (i.e., the more double bonds in the fatty acid) the more vulnerable it is to lipid peroxidation (rancidity). Antioxidants can protect unsaturated fat from lipid peroxidation.
  • 2.4K
  • 28 Sep 2022
Topic Review
Domain Hack
A domain hack is a domain name that suggests a word, phrase, or name when concatenating two or more adjacent levels of that domain. For example, "bir.ds" and "examp.le", using the fictitious country-code domains .ds and .le, suggest the words birds and example respectively. In this context, the word hack denotes a clever trick (as in programming), not an exploit or break-in (as in security). Domain hacks offer the ability to produce short domain names. This makes them potentially valuable as redirectors, pastebins, base domains from which to delegate subdomains and URL shortening services.
  • 2.4K
  • 30 Sep 2022
Topic Review
Self-confrontation Psychology
Self-Confrontation psychology is a technique for examining people's behavior modification. This process can be called Self-Confrontation Method(SCM). It relies on people's inconsistent knowledge and dissatisfaction with their own values, motivation, behaviors, or with their personal systems and those of significant others to make a change that patient needs to change. Self-Confrontation Psychology is based on two theories which are Valuation Theory and Dialogical-Self Theory.
  • 2.4K
  • 03 Nov 2022
Topic Review
Fabrication Techniques of Perovskite Solar Cells
Perovskite solar cells (PSCs) are gaining popularity due to their high efficiency and low-cost fabrication. Researchers are exploring new materials and fabrication techniques to enhance the performance of PSCs under various environmental conditions. The mechanical stability of flexible PSCs is another area of research that has gained significant attention. 
  • 2.4K
  • 22 Feb 2024
Topic Review Peer Reviewed
Educational Technologies
Educational technologies refer to the set of digital tools, resources, applications, and methodologies used to facilitate the teaching–learning process. These technologies include software, online platforms, hardware devices (such as tablets, computers, and interactive whiteboards), and, if one wants to give special relevance, as it should be these days, to the issue of inclusion in education, assistive technologies, all aimed at improving access to education, personalizing learning paths, and fostering a more dynamic interaction between students and teachers. This entry explores the integration of educational technologies, highlighting their role in enhancing the teaching–learning process, promoting inclusive and personalized education. It analyses the pedagogical implications of the use of digital technologies, including assistive technologies (which foster learning in a Universal Design for Learning perspective), and the need to train competent teachers to adopt innovative teaching practices. This entry concludes by emphasizing the importance of a shared commitment to prepare future generations for a technologically changing world by creating more dynamic and accessible learning environments, including through virtual reality, augmented reality, and artificial intelligence.
  • 2.4K
  • 26 Feb 2025
Topic Review
Shtrafbat
Shtrafbats (Russian: штрафбат, штрафной батальон) were Union of Soviet Socialist Republics penal battalions that fought on the Eastern Front in World War II. The shtrafbats were greatly increased in number by Joseph Stalin in July 1942 via Order No. 227 (Директива Ставки ВГК №227). Order No. 227 was a desperate effort to re-instill discipline after the panicked routs of the first year of combat with Germany. The order—popularized as the "Not one step back!" (Ни шагу назад!, Ni shagu nazad!) Order—introduced severe punishments, including summary execution, for unauthorized retreats. In his order, Stalin also mentioned Hitler's successful use of penal battalions (known as Strafbataillon) as a means to ensure obedience among regular Wehrmacht units.
  • 2.4K
  • 19 Oct 2022
Topic Review
Remote Sensing and Deep Learning
The advances in remote sensing technologies, hence the fast-growing volume of timely data available at the global scale, offer new opportunities for a variety of applications. Deep learning being significantly successful in dealing with Big Data, is a great candidate for exploiting the potentials of such complex massive data. However, with remote sensing, there are some challenges related to the ground-truth, resolution, and the nature of data that require further efforts and adaptions of deep learning techniques.
  • 2.4K
  • 26 Jan 2021
Topic Review
Soybean Isoflavones
Soybeans are rich in proteins and lipids and have become a staple part of the human diet. Besides their nutritional excellence, they have also been shown to contain various functional components, including isoflavones, and have consequently received increasing attention as a functional food item. Isoflavones are structurally similar to 17-β-estradiol and bind to estrogen receptors (ERα and ERβ). The estrogenic activity of isoflavones ranges from a hundredth to a thousandth of that of estrogen itself. Isoflavones play a role in regulating the effects of estrogen in the human body, depending on the situation. Thus, when estrogen is insufficient, isoflavones perform the functions of estrogen, and when estrogen is excessive, isoflavones block the estrogen receptors to which estrogen binds, thus acting as an estrogen antagonist. In particular, estrogen antagonistic activity is important in the breast, endometrium, and prostate, and such antagonistic activity suppresses cancer occurrence. 
  • 2.4K
  • 06 Jul 2021
Topic Review
Humani Generis
Humani generis is a papal encyclical that Pope Pius XII promulgated on 12 August 1950 "concerning some false opinions threatening to undermine the foundations of Catholic Doctrine". Theological opinions and doctrines known as Nouvelle Théologie or neo-modernism and their consequences on the Church were its primary subject. Reginald Garrigou-Lagrange (1877–1964), professor of the Pontifical University of Saint Thomas Aquinas Angelicum, is said to have been a dominant influence on the content of the encyclical.
  • 2.4K
  • 27 Oct 2022
Topic Review
Hybrid Convolutional Neural Network–Bidirectional Long Short-Term Memory
Recognition of lying is a more complex cognitive process than truth-telling because of the presence of involuntary cognitive cues that are useful to lie recognition. Researchers have proposed different approaches in the literature to solve the problem of lie recognition from either handcrafted and/or automatic lie features during court trials and police interrogations.
  • 2.4K
  • 04 Dec 2025
Topic Review
Apis mellifera
The current knowledge about viruses of the Western honey bee, Apis mellifera.
  • 2.4K
  • 02 Nov 2020
Topic Review
Halide Perovskites
Halide perovskites (HPs), with an excellent photoactive nature, dielectric, piezoelectric, ferroelectric, and pyroelectric properties, have been potential candidates for obtaining flexible nanogenerator-based self-powered sensors including light, pressure, and temperature. Additionally, the photo-stimulated dielectric, piezoelectric, and triboelectric properties of HPs make them efficient entrants for developing bimodal and multimode sensors to sense multi-physical signals individually or simultaneously. 
  • 2.4K
  • 30 Jul 2021
Topic Review
Phycobiliproteins
Phycobiliproteins are gaining popularity as long term, high value natural products which can be alternative to synthetic products. This study analyzed research trends of phycobiliproteins from 1909 to 2020 using a bibliometric approach based on the Scopus database. 
  • 2.4K
  • 19 Nov 2021
Topic Review
Metaverse Concept
The global market is experiencing stagnation and recession in the “untact era”, and the emergence of the metaverse provides platform support and presents a new paradigm. The “metaverse” platform services combine 5G network technology, advanced lightweight graphic technology, and cutting-edge display device technology. The emergence of the metaverse platform presents a new global market paradigm in the ongoing recession caused by COVID-19 and has attracted attention as a new growth engine that connects industry and content. The metaverse is not bound by time and space, which is conducive to a contactless era, and provides a virtual experience with a high degree of immersion and connectivity, resulting in increased user value. The metaverse can be based on PCs and mobile devices, and is characterized by access at anytime and anywhere.
  • 2.4K
  • 19 Apr 2022
Topic Review
Nurses' Health Study
The Nurses' Health Study is a series of prospective studies that examine epidemiology and the long-term effects of nutrition, hormones, environment, and nurses' work-life on health and disease development. The studies have been among the largest investigations into risk factors for major chronic diseases ever conducted. The Nurses' Health Studies have led to many insights on health and well-being, including cancer prevention, cardiovascular disease, and type 2 diabetes. They have included clinicians, epidemiologists, and statisticians at the Channing Laboratory (of Brigham and Women's Hospital), Harvard Medical School, Harvard School of Public Health, and several Harvard-affiliated hospitals, including Brigham and Women's Hospital, Dana–Farber Cancer Institute, Children's Hospital Boston, and Beth Israel Deaconess Medical Center.
  • 2.4K
  • 30 Oct 2022
Topic Review
Media Coverage of Global Warming
Media coverage of global warming has had effects on public opinion on climate change, as it mediates the scientific opinion on climate change that the global temperature has increased in recent decades and that the trend is mainly caused by human-induced emissions of greenhouse gases. Almost all scientific bodies of national or international standing agree with this view, although a few organisations hold non-committal positions. Climate change communication research frequently studies the effectiveness of that media. Some researchers and journalists believe that media coverage of political issues is adequate and fair, while a few feel that it is biased. However, most studies on media coverage of the topic are neither recent nor concerned with coverage of environmental issues. Moreover, they are only rarely concerned specifically with the question of bias. Despite recent trends in increased coverage on climate change, media coverage is not constant, and researchers wonder if the current increase in attention will be sustained.
  • 2.4K
  • 11 Nov 2022
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