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Topic Review
Pleiotropic Effects of Aldosterone in Diabetic Kidney Disease
Diabetic kidney disease (DKD) represents a major public health issue, currently posing an important burden on healthcare systems. Renin–angiotensin system (RAS) blockers are considered the cornerstone of treatment of albuminuric DKD. Aldosterone is a steroid hormone that is produced by the adrenal cortex and acts, together with other members of the steroid hormone family (cortisol and corticosterone), as a ligand of MRs. 
  • 2.4K
  • 05 May 2022
Biography
Gustave Trouvé
Gustave Pierre Trouvé (2 January 1839 – 27 July 1902) was a France electrical engineer and inventor in the 19th century. Trouvé was born on 2 January 1839 in La Haye-Descartes (Indre-et-Loire, France) and died on 27 July 1902 in Paris. A polymath, he was highly respected for his innovative skill in miniaturization. Gustave Trouvé was born into a modest family, his father, Jacques Trouv
  • 2.4K
  • 11 Nov 2022
Topic Review
Plant-Based Natural Coagulants for Water and Wastewater Treatment
Plant-based natural coagulants (PBNCs) have been shown to be a promising alternative to the conventional coagulants used in water treatment. PBNCs’ advantages include excellent biodegradability, biocompatibility, sustainable production, low cost, and high availability. Problems associated with using PBNC have hindered the progression of their practical applications and commercialisation. However, several modification methods have been employed to enhance the performance of various plant polysaccharides to overcome these disadvantages.
  • 2.4K
  • 09 Mar 2023
Topic Review
Effect of Licorice in Different Diseases
There are more than 30 species of Glycyrrhiza genus extensively spread worldwide. It was the most prescribed herb in Ancient Egyptian, Roman, Greek, East China, and the West from the Former Han era. There are various beneficial effects of licorice root extracts, such as treating throat infections, tuberculosis, respiratory, liver diseases, antibacterial, anti-inflammatory, and immunodeficiency. On the other hand, traditional medicines are getting the attraction to treat many diseases. Therefore, it is vital to screen the medicinal plants to find the potential of new compounds to treat chronic diseases such as respiratory, cardiovascular, anticancer, hepatoprotective, etc.
  • 2.4K
  • 07 Jan 2022
Topic Review
Entrepreneurship and Agribusiness in Agro-Economy in Nigeria
Since most scholars have agreed that there is a positive relationship between the growth of agricultural (agribusiness) and entrepreneurship, this has given a clear understanding that achieving high entrepreneurship development is critical to the transformation agenda of Nigeria’s agro-economy. Nigeria’s current demography reveals that the youth population may continue to rise in the coming decades, with more teenagers coming into the youth age. The implication of this for the already stressed economy could be devastating if these human resources are not properly harnessed. Efforts to managing these energetic individuals without cutting edge employment and/or entrepreneurship policy structure will not yield a desirable economic outcome.
  • 2.4K
  • 27 May 2022
Topic Review
Life
Life is the characteristic state of organisms. Properties common to terrestrial organisms (plants, animals, fungi, protists and bacteria) are that they are cellular, carbon-and-water-based with complex organization, having a metabolism, a capacity to grow, respond to stimuli, reproduce and—through natural selection—adapt. An entity with the above properties is considered to be organic life. However, not every definition of life considers all of these properties to be essential. For example, the capacity for descent with modification is often taken as the only essential property of life. This definition notably includes viruses, which do not qualify under narrower definitions as they are acellular and do not metabolise. Broader definitions of life may also include theoretical non-carbon-based life and other alternative biology. The entire Earth contains about 75 billion tons of biomass (life), which lives within various environments within the biosphere.
  • 2.4K
  • 26 Oct 2022
Topic Review
Economic Policy of the Indira Gandhi Premiership
The economic policy of the Indira Gandhi premiership was characterized by moderate tax increases on higher income Indians, bank nationalisation, green revolution. Gandhi presided over three Five-Year Plans as Prime Minister, two of which succeeded in meeting the targeted growth. There is considerable debate regarding whether Gandhi was a socialist on principle or out of political expediency. Sunanda K. Datta-Ray described her as "a master of rhetoric...often more posture than policy", while The Times journalist, Peter Hazelhurst, famously quipped that Gandhi's socialism was "slightly left of self-interest." Critics have focused on the contradictions in the evolution of her stance towards communism; Gandhi being known for her anti-communist stance in the 1950s with Meghnad Desai even describing her as "the scourge of [India's] Communist Party." Yet, she later forged close relations with Indian communists even while using the army to break the Naxalites. In this context, Gandhi was accused of formulating populist policies to suit her political needs; being seemingly against the rich and big business while preserving the status quo in order to manipulate the support of the left at times of political insecurity, such as the late 1960s. Although Gandhi came to be viewed in time as the scourge of the right-wing and reactionary political elements of India, leftist opposition to her policies emerged. As early as 1969, critics had begun accusing her of insincerity and machiavellianism. The Indian Libertarian wrote that: "it would be difficult to find a more machiavellian leftist than Mrs Indira Gandhi...for here is Machiavelli at its best in the person of a suave, charming and astute politician." Rosser wrote that "some have even seen the declaration of emergency rule in 1975 as a move to suppress [leftist] dissent against Gandhi's policy shift to the right." In the 1980s, Gandhi was accused of "betraying socialism" after the beginning of Operation Forward, an attempt at economic reform. Nevertheless, others were more convinced of Gandhi's sincerity and devotion to socialism. Pankaj Vohra noted that "even the late prime minister's critics would concede that the maximum number of legislations of social significance was brought about during her tenure...[and that] she lives in the hearts of millions of Indians who shared her concern for the poor and weaker sections and who supported her politics." In summarizing the biographical works on Gandhi, Blema S. Steinberg concluded she was decidedly non-ideological. Only 7.4% (24) of the total 330 biographical extractions posit ideology as a reason for her policy choices. Steinberg noted Gandhi's association with socialism was superficial; only having a general and traditional commitment to the ideology, by way of her political and family ties. Gandhi personally had a fuzzy concept of socialism. In one of the early interviews she had given as Prime Minister, Gandhi had ruminated: "I suppose you could call me a socialist, but you have understand what we mean by that term...we used the word [socialism] because it came closest to what we wanted to do here – which is to eradicate poverty. You can call it socialism; but if by using that word we arouse controversy, I don't see why we should use it. I don't believe in words at all." Regardless of the debate over her ideology or lack of thereof, Gandhi remains a left-wing icon. She has been described by Hindustan Times columnist, Pankaj Vohra as "arguably the greatest mass leader of the last century." Her campaign slogan, Garibi Hatao ('Remove Poverty'), has become the iconic motto of the Indian National Congress. To the rural and urban poor, untouchables, minorities and women in India, Gandhi was "Indira Amma or Mother Indira."
  • 2.4K
  • 24 Nov 2022
Topic Review
Hydrogen Energy in Russian
Solving production problems in the field of hydrogen energy, as well as ensuring the transportation of hydrogen raw materials with minimal losses, will allow in the foreseeable future to overcome the local scale of its capabilities and bring hydrogen energy to the international level, including replacing traditional gas or using it as a resource. In line with global trends, the development of hydrogen energy in the Russian Federation is taking place.
  • 2.4K
  • 06 Dec 2022
Topic Review
Mechanism of Heterogeneous Alkaline Deacetylation of Chitin
Chitosan can be obtained from chitin chemically or by using enzymatic preparations. From a chemical point of view, both acids and alkalis can be used to deacetylate chitin. However, alkaline deacetylation is used more often since glycosidic bonds are very sensitive to an acidic environment, in which they are destroyed. A mechanism for the chitin deacetylation reaction is proposed, taking into account its kinetic features in which the decisive role is assigned to the effects of hydration. It has been shown that the rate of chitin deacetylation increases with a decrease in the degree of hydration of hydroxide ions in a concentrated alkali solution. When the alkali concentration is less than the limit of complete hydration, the reaction practically does not occur. Hypotheses have been put forward to explain the decrease in the rate of the reaction in the second flat portion of the kinetic curve. The first hypothesis is the formation of “free” water, leading to the hydration of chitin molecules and a decrease in the reaction rate. The second hypothesis postulates the formation of a stable amide anion of chitosan, which prevents the nucleophilic attack of the chitin macromolecule by hydroxide ions.
  • 2.4K
  • 19 Jun 2023
Topic Review
ROS-Responsive Cell Harvesting Methods
Cell sheet engineering has evolved rapidly over the last few years and as a new approach for cell-based therapy. Cell sheet harvest technology is important for producing viable, transplantable cell sheets and applying them to tissue engineering. To date, various approaches have been reported for harvesting cell sheets by inducing property changes of the culture surface such as wettability, pH, electricity, and magnetism. This section provides a comprehensive introduction to reactive oxygen species (ROS) and the progress of new strategies for applying ROS in cell sheet detachment.
  • 2.4K
  • 13 Oct 2021
Topic Review
Reconfigurable Vectorial Thrusters
The reconfigurable vectorial thruster (RVT) is a propulsion element that changes not only the intensity of the thrust vector but also its direction. This vector reorientation by a servomotor, for example, is usually faster than the intensity change. Thus, the possibility of fast vehicle reconfiguration allows the optimized choice of the reconfigured propulsion architecture according to different tasks, minimizing the trajectory tracking error and energy consumption. Moreover, the use of RVTs can significantly reduce the total number of needed thrusters in a vehicle.
  • 2.4K
  • 19 Mar 2021
Topic Review
Intelligent Battery Systems
Intelligent Battery Systems (IBSs) represent a promising but also a challenging approach to significantly improve the reliability, safety, and efficiency of Battery Electric Vehicles (BEVs). The essential features of Intelligent Battery Systems are the accurate and robust determination of cell individual states and the ability to control the current of each cell by reconfiguration. They enable high-level functions like fault diagnostics, multi-objective balancing strategies, multilevel inverters, and hybrid energy storage systems. 
  • 2.4K
  • 15 Oct 2021
Topic Review
Eton College Controversies
There have been many controversies concerning Eton College, including those listed below. Eton College is a well-known independent boarding school for boys in Berkshire, England, United Kingdom, sometimes called the most famous school in the world. The Guardian claimed that 'Eton is no stranger to scandalous allegations, nor to claims that it tries to prevent them leaking out.'
  • 2.4K
  • 17 Oct 2022
Topic Review
Valorization of Bread Waste into Value-Added Products
Bread is a universal food that is sold and consumed across the entire social and geographical spectrum. Bread waste is currently of increasing interest, as it is considered a huge global issue with serious environmental impacts and significant economic losses that have become even greater in the post-pandemic years due to an increase in cereal prices, which has led to higher production costs and bread prices. Meanwhile, many efforts have been initiated in the past decades to investigate methods of repurposing bread residues into fuel and chemicals such as bioethanol, biohydrogen, succinic acid, and various added-value products that can be exploited in versatile industries.
  • 2.4K
  • 09 Dec 2022
Topic Review
Modes of Nanofertilizer Application
There are three primary methods of nanofertilizer application: foliar, seed nanopriming, and soil treatment. The appropriate method of nanofertilizer application is crucial for optimal plant growth, as it varies depending on the soil and climate type. The choice depends on soil quality, nutrient availability, and climate, which affect nutrient uptake and utilization. Understanding these factors and selecting the appropriate method can improve crop yield, reduce environmental impact, and create more sustainable agricultural practices.
  • 2.4K
  • 30 Jun 2023
Topic Review
Vidya
Vidya (Sanskrit: विद्या, IAST: vidyā) figures prominently in all texts pertaining to Indian philosophy – meaning science, learning, knowledge, and scholarship. Most importantly, it refers to valid knowledge, which cannot be contradicted, and true knowledge, which is the intuitively-gained knowledge of the self. Vidya is not mere intellectual knowledge, for the Vedas demand understanding.
  • 2.4K
  • 15 Nov 2022
Topic Review
Cetus
Cetus, known as the Whale, is a large constellation visible in the southern sky. In Greek mythology, Cetus represents the sea monster sent by Poseidon to terrorize the kingdom of Aethiopia, eventually slain by Perseus to rescue Andromeda. As one of the 88 recognized constellations, Cetus holds a special place in the realm of astronomy and mythology. 
  • 2.4K
  • 08 Mar 2024
Topic Review
Crop Domestication
In agriculture, domestication is the process of a selection of the best trait with increased adaptation or acclimatization of the plant. Driven by human activities, the domestication of plants has dramatically changed the development of the ecological condition. Domestication is the outcome of both phenotypic and genomics changes of a species conferred with classical plant breeding. Gradually, a wild plant changed to an elite high yielding cultivar. Domestication of orphan or underutilized crop plants using recently developed frontier technologies such as genome editing based on current and emerging knowledge generated by genomics and postgenomics approaches are thought to be one of the promising ways for the improvement of the smart crop for the future smart agriculture
  • 2.4K
  • 22 Dec 2020
Topic Review
Advanced Glycation End Products (AGEs)
The Maillard reaction is a simple but ubiquitous reaction that occurs both in vivo and ex vivo during the cooking or processing of foods under high-temperature conditions, such as baking, frying, or grilling. Glycation of proteins is a post-translational modification that forms temporary adducts, which, on further crosslinking and rearrangement, form permanent residues known as advanced glycation end products (AGEs). Cooking at high temperature results in various food products having high levels of AGEs. This review underlines the basis of AGE formation and their corresponding deleterious effects on the body. Glycated Maillard products have a direct association with the pathophysiology of some metabolic diseases, such as diabetes mellitus type 2 (DM2), acute renal failure (ARF), Alzheimer’s disease, dental health, allergies, and polycystic ovary syndrome (PCOS). The most glycated and structurally abundant protein is collagen, which acts as a marker for diabetes and aging, where decreased levels indicate reduced skin elasticity. In diabetes, high levels of AGEs are associated with carotid thickening, ischemic heart disease, uremic cardiomyopathy, and kidney failure. AGEs also mimic hormones or regulate/modify their receptor mechanisms at the DNA level. In women, a high AGE diet directly correlates with high levels of androgens, anti-Müllerian hormone, insulin, and androstenedione, promoting ovarian dysfunction and/or infertility. Vitamin D3 is well-associated with the pathogenesis of PCOS and modulates steroidogenesis. It also exhibits a protective mechanism against the harmful effects of AGEs.
  • 2.4K
  • 28 Jul 2021
Topic Review
Low-Temperature SCR Catalyst Development
In recent years, low-temperature SCR (Selective Catalytic Reduction) denitrification technology has been popularized in non-power industries and has played an important role in the control of industrial flue gas NOx emissions in China. Currently, the most commonly used catalysts in industry are V2O5-WO3(MoO3)/TiO2, MnO2-based catalysts, CeO2-based catalysts, MnO2-CeO2 catalysts and zeolite SCR catalysts. The flue gas emitted during industrial combustion usually contains SO2, moisture and alkali metals, which can affect the service life of SCR catalysts.
  • 2.4K
  • 31 Mar 2022
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