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Topic Review
Billing (Performing Arts)
Billing is a performing arts term used in referring to the order and other aspects of how credits are presented for plays, films, television, or other creative works. Information given in billing usually consists of the companies, actors, directors, producers, and other crew members.
  • 2.5K
  • 14 Oct 2022
Topic Review
Boeing CST-100 Starliner
The Boeing Starliner (CST-100 - Crew Space Transportation-100) is a crew capsule manufactured by Boeing as its participation in NASA's Commercial Crew Development (CCDev) program. Its primary purpose is to transport crew to the International Space Station (ISS) and to private space stations such as the proposed Bigelow Aerospace Commercial Space Station. The capsule has a diameter of 4.56 meters (15.0 ft), which is slightly larger than the Apollo command module and smaller than the Orion capsule. The Boeing Starliner is to support larger crews of up to seven people and is being designed to be able to remain in-orbit for up to seven months with reusability of up to ten missions. It is designed to be compatible with four launch vehicles: Atlas V, Delta IV, Falcon 9, and Vulcan. In the first phase of its CCDev program NASA awarded Boeing US$18 million in 2010 for preliminary development of the spacecraft. In the second phase Boeing was awarded a $93 million contract in 2011 for further spacecraft development. On 3 August 2012, NASA announced the award of $460 million to Boeing to continue work on the CST-100 under the Commercial Crew Integrated Capability (CCiCap) Program. On 16 September 2014, NASA selected the Boeing CST-100, along with SpaceX's Crew Dragon, for the Commercial Crew Transportation Capability (CCtCap) program, with an award of $4.2 billion. On 30 July 2019, NASA had no specific dates for Commercial Crew launches, stating that this was under review pending a leadership change. The Boeing Starliner Orbital Flight Test (uncrewed test flight) launched with the Atlas V N22, on 20 December 2019 from SLC-41 at Cape Canaveral Air Force Station , Florida. During the test, the Starliner experienced an anomaly that precluded a docking with the International Space Station. Two days after launch, on 22 December 2019 at 07:58 EST (12:58 UTC), with the successful landing at White Sands, New Mexico, the Boeing Starliner Calypso became the first-ever, crew-capable space capsule to make a land-based touchdown in the United States.
  • 2.5K
  • 30 Nov 2022
Topic Review
Antioxidant Assays
Antioxidant assay methods are essential tools for evaluating the ability of substances to combat oxidative stress, a process linked to aging and various diseases. These methods assess different aspects of antioxidant activity, helping researchers quantify and compare the antioxidant potential of compounds. They contribute to our understanding of how antioxidants protect cells and guide the development of health-promoting products. These assays are integral to advancing research on oxidative stress and antioxidants' roles in maintaining cellular health and reducing disease risk.
  • 2.5K
  • 11 Sep 2023
Topic Review
Statistical Analysis of Intensive Care Unit COVID-19 Data
COVID-19 caused a pandemic, due to its ease of transmission and high number of infections. The evolution of the pandemic and its consequences for the mortality and morbidity of populations, especially the elderly, generated several scientific studies and many research projects. Among them, researchers have the Predictive Models of COVID-19 Outcomes for Higher Risk Patients Towards a Precision Medicine (PREMO) research project. For such a project with many data records, it is necessary to provide a smooth graphical analysis to extract value from it.
  • 2.5K
  • 10 Apr 2024
Topic Review
Early Childhood Education
Early Childhood Education (ECE) often is part of a broader educational disadvantage policy and offers institutional compensatory programs to young children who lack specific educational stimulation in the home environment. ECE typically aims at children from deprived socioeconomic backgrounds and those of immigrant origin. Although ECE nowadays is widespread and accepted as perhaps the most important means of preventing and combating educational disadvantage, the controversy surrounding the evidence of effects and thus the justification and foundation of ECE provisions still is not solved. This article focuses on the basis (or lack of it) of ECE in the Netherlands.
  • 2.5K
  • 03 Nov 2020
Topic Review
Vaccine Technology in Bovine Theileriosis
Theileriosis is a blood piroplasmic disease that adversely affects the livestock industry, especially in tropical and sub-tropical countries. It is caused by haemoprotozoan of the Theileria genus, transmitted by hard ticks and which possesses a complex life cycle. The infection and treatment method (ITM) is currently used in the control and prevention of T. parva infection, and recombinant vaccines are still under evaluation. The use of gene gun immunization against T. parva infection has been recently evaluated.
  • 2.5K
  • 26 Oct 2020
Topic Review
IFN Signaling in Neutrophils
Interferons (IFNs) are induced by viruses and are the main regulators of the host antiviral response. They balance tissue tolerance and immune resistance against viral challenges.
  • 2.5K
  • 26 May 2021
Topic Review
Hydra
Hydra, known as the Water Snake, is a prominent constellation located in the southern celestial hemisphere. It is the largest of the 88 modern constellations in terms of area and is best observed from the Southern Hemisphere during the months of February and March. 
  • 2.5K
  • 15 Mar 2024
Topic Review
Social Sequence Analysis
Social sequence analysis is a special application of sequence analysis, a set of methods that were originally designed in bioinformatics to analyze DNA, RNA, and peptide sequences. Social sequence analysis involves the examination of ordered social processes, ranging from microsocial interaction patterns (for example, turn-taking dynamics in conversations) and interpersonal contact dynamics to the development of social hierarchies and macrosocial temporal patterns. The analysis of such patterns can involve descriptive accounts of sequence patterns, statistical event history analysis, optimal matching analysis, narrative or event structure analysis, and dynamic social network sequencing. After being introduced to the social sciences in the 1980s and a period of slow growth during the 1990s, social sequence methods have become increasingly prevalent.
  • 2.5K
  • 01 Nov 2022
Topic Review
Bongkrekic Acid as a Threat to Food Safety
Bongkrekic acid (BKA) poisoning, induced by the contamination of Burkholderia gladioli pathovar cocovenenans, has a long-standing history of causing severe outbreaks of foodborne illness. It has emerged as a lethal food safety concern, presenting significant challenges to public health. 
  • 2.5K
  • 08 Nov 2023
Topic Review
Fog and Edge Computing
The fourth industrial revolution heralds a paradigm shift in how people, processes, things, data and networks communicate and connect with each other. Conventional computing infrastructures are struggling to satisfy dramatic growth in demand from a deluge of connected heterogeneous end points located at the edge of networks while, at the same time, meeting quality of service levels. The complexity of computing at the edge makes it increasingly difficult for infrastructure providers to plan for and provision resources to meet this demand. While simulation frameworks are used extensively in the modelling of cloud computing environments in order to test and validate technical solutions, they are at a nascent stage of development and adoption for fog and edge computing. This paper provides an overview of challenges posed by fog and edge computing in relation to simulation.
  • 2.5K
  • 23 Dec 2020
Topic Review
Metal Ions as Signaling Agents
Metal ions can be involved in signaling processes within the cell in both physiological and pathological conditions. Magnesium and calcium are the most recognized signaling agents among metals. Zinc, copper, and iron can also play key roles in signaling pathways. There are many systems in which changes in intra- and extra-cellular zinc and copper concentrations have been linked to important downstream events, especially in nervous signal transduction. Iron signaling is mostly related with its homeostasis. However, it is also involved in a recently discovered type of programmed cell death, ferroptosis.
  • 2.5K
  • 06 Nov 2020
Topic Review
Caesars Rewards
Caesars Rewards (Europe/North Africa: Player Rewards and South Africa: Emerald Rewards; formerly Total Gold and Total Rewards) is a casino loyalty program at nearly all Caesars Entertainment Corporation (formerly Harrah's Entertainment) locations.
  • 2.5K
  • 22 Nov 2022
Topic Review
Boron-Silicon Junction
The discovery of the extremely shallow amorphous boron-crystalline silicon heterojunction occurred during the development of highly sensitive, hard and robust detectors for low-penetration-depth ionizing radiation, such as ultraviolet photons and low-energy electrons (below 1 keV). For many years it was believed that the junction created by the chemical vapor deposition of amorphous boron on n-type crystalline silicon was a shallow p-n junction, although experimental results could not provide evidence for such a conclusion. Only recently, quantum-mechanics based modelling revealed the unique nature and the formation mechanism of this new junction. Here, the entry reviews the initiation and the history of understanding the a-B/c-Si interface (henceforth called the “boron-silicon junction”).
  • 2.5K
  • 17 Jun 2021
Topic Review
Cyclophane-Modified AgNPs
Silver nanoparticles (AgNPs) are an attractive alternative to plasmonic gold nanoparticles. The relative cheapness and redox stability determine the growing interest of researchers in obtaining selective plasmonic and electrochemical (bio)sensors based on silver nanoparticles. Cyclophanes are well known for their great receptor properties and are of particular interest in the creation of metal nanoparticles due to a variety of cyclophane 3D structures and unique redox abilities. The chemistry of cyclophanes offers a whole arsenal of approaches: exocyclic ion coordination, association, stabilization of the growth centers of metal nanoparticles, as well as in reduction of silver ions.
  • 2.5K
  • 29 Oct 2020
Topic Review
Green Production from BSFL
The purpose of this entry is to reveal the lipid and protein contents in black soldier fly larvae (BSFL) for the sustainable production of protein and energy sources. It has been observed from studies in the literature that the larval lipid and protein contents vary with the rearing conditions as well as the downstream processing employed. The homogenous, heterogenous and microbial-treated substrates via fermentation are used to rear BSFL and are compared in this review for the simultaneous production of larval protein and biodiesel. Moreover, the best moisture content and the aeration rate of larval feeding substrates are also reported in this review to enhance the growth of BSFL. As the downstream process after harvesting starts with larval inactivation, various related methods have also been reviewed in relation to its impact on the quality/quantity of larval protein and lipids. Subsequently, the other downstream processes, namely, extraction and transesterification to biodiesel, are finally epitomized from the literature to provide a comprehensive review for the production of unconventional protein and lipid sources from BSFL feedstock. Incontrovertibly, the review accentuates the great potential use of BSFL biomass as a green source of protein and lipids for energy production in the form of biodiesel. The traditional protein and energy sources, preponderantly fishmeal, are unsustainable naturally, pressingly calling for immediate substitutions to cater for the rising demands. Accordingly, this review stresses the benefits of using BSFL biomass in detailing its production from upstream all the way to downstream processes which are green and economical at the same time.
  • 2.5K
  • 09 Sep 2020
Topic Review
Bioethanol Production Using Seawater
  Bioethanol has many environmental and practical benefits as a transportation fuel. It is one of the best alternatives to replace fossil fuels due to its liquid nature, which is similar to the gasoline and diesel fuels traditionally used in transportation. In addition, bioethanol production technology has the capacity for negative carbon emissions, which is vital for solving the current global warming dilemma. However, conventional bioethanol production takes place based on an inland site and relies on freshwater and edible crops (or land suitable for edible crop production) for production, which has led to the food vs. fuel debate. Establishing a coastal marine biorefinery (CMB) system for bioethanol production that is based on coastal sites and relies on marine resources (seawater, marine biomass and marine yeast) could be the ultimate solution. In this paper, we aim to evaluate the environmental impact of using seawater for bioethanol production at coastal locations as a step toward the evaluation of a CMB system. Hence, a life cycle assessment for bioethanol production was conducted using the proposed scenario, named Coastal Seawater, and compared to the conventional scenario, named Inland Freshwater (IF). The impact of each scenario in relation to climate change, water depletion, land use and fossil depletion was studied for comparison. The Coastal Seawater scenario demonstrated an improvement upon the conventional scenario in all the selected impact categories. In particular, the use of seawater in the process had a significant effect on water depletion, showing an impact reduction of 31.2%. Furthermore, reductions were demonstrated in natural land transformation, climate change and fossil depletion of 5.5%, 3.5% and 4.2%, respectively. This indicates the positive impact of using seawater and coastal locations for bioethanol production and encourages research to investigate the CMB system.
  • 2.5K
  • 21 Aug 2021
Topic Review
Pharmacologic and Clinical Considerations of Nalmefene
Nalmefene is a pure opioid antagonist structurally similar to naltrexone that can serve as an alternative antidote for reversing respiratory depression associated with acute opioid overdose. Nalmefene is also known as 6-methylene naltrexone. Its main features of interest are its prolonged duration of action that surpasses most opioids and its ability to serve as an antidote for acute opioid overdose.
  • 2.5K
  • 29 Mar 2022
Topic Review
Endocytic Pathways
Endocytosis is a shared process by which molecules, proteins, lipids, and liquids are sorted inside the cell via formation of intermediate vesicles. Vesicle formation occurs at the plasma membrane, where ligand receptors, binding proteins, and structural proteins are localized. After their internalization, the vesicles containing protein receptors or soluble molecules undergo a round of recycling, eventually leading to the fusion of the vesicle with an intracellular organelle. Such a process is an essential hallmark in all cell types—it regulates major cellular functions such as antigen presentation, intracellular signaling cascades, cell polarity, and synaptic transmission. Moreover, it is required to remove aged and dead cells from the body and is part of the defense against microbes. Given its importance, it is not surprising that even subtle perturbations affecting the endocytic machinery often impair cell function and cause several pathological conditions, such as cancer, and neurological and storage diseases. Finally, endocytosis represents an important cellular route for targeted drug-delivery in many diseases.
  • 2.5K
  • 15 Apr 2022
Biography
Harvey Fletcher
Harvey Fletcher (September 11, 1884 – July 23, 1981) was an American physicist.[1] Known as the "father of stereophonic sound," he is credited with the invention of the 2-A audiometer[2] and an early electronic hearing aid.[3][4] He was an investigator into the nature of speech and hearing, and made contributions in acoustics, electrical engineering, speech, medicine, music, atomic physics, so
  • 2.5K
  • 25 Nov 2022
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