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Topic Review
Antioxidant Activity of Natural Products
Natural products identified with potential antioxidant activity need to be further evaluated in the cellular model. Antioxidant activity of a large number of natural products will not extrapolate its performance in the biological system, either in vitro as cellular assays or in vivo as animal model studies. Thus, it is necessary to examine the bioavailability, metabolism and mechanism of action in a living system to prove potential antioxidant activities of new natural products.
  • 2.5K
  • 09 Dec 2021
Topic Review
Hollywood Indian
The Hollywood Indian is a fictitious stock character, a stereotype and representation of Native Americans used in television and movies, especially in the Western genre. The image of the Hollywood Indian reflects contemporary and historical Native American popular culture. Closely connected to myths and images created about Native Americans and the Wild West, the stereotype has undergone significant changes from the beginning of cinema to the present day.
  • 2.5K
  • 13 Nov 2022
Topic Review
TLR4
Toll-like receptor 4 is a protein that in humans is encoded by the TLR4 gene. TLR4 is a transmembrane protein, member of the toll-like receptor family, which belongs to the pattern recognition receptor (PRR) family. Its activation leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system. TRL4 expressing cells are myeloid (erythrocytes, granulocytes, macrophages) rather than lymphoid (T-cells, B-cells, NK cells). Most myeloid cells also express high levels of CD14, which facilitates activation of TLR4 by LPS. It is most well known for recognizing lipopolysaccharide (LPS), a component present in many Gram-negative bacteria (e.g. Neisseria spp.) and selected Gram-positive bacteria. Its ligands also include several viral proteins, polysaccharide, and a variety of endogenous proteins such as low-density lipoprotein, beta-defensins, and heat shock protein. Palmitic acid is also a TLR4 agonist. TLR4 has also been designated as CD284 (cluster of differentiation 284). The molecular weight of TLR4 is approximately 95 kDa.
  • 2.5K
  • 29 Nov 2022
Topic Review
{001} Faceted Anatase TiO2-Based Composites
For anatase TiO2, the {001} crystal facets are the most reactive because they exhibit unique surface characteristics such as visible light responsiveness, dissociative adsorption, efficient charge separation capabilities and photocatalytic selectivity. In this review, a concise survey of the literature in the field of {001} dominated anatase TiO2 crystals and their composites is presented. Even though the design and morphologically controlled synthesis of TiO2-001 is considered to be a hot spot in scientific research, it still has some drawbacks like its wide band gap and high recombination rate. These drawbacks can easily be overcome by coupling them with other materials to form TiO2-001-based composites. This review focusses on the synthesis, properties and applications of TiO2-001-based composites. 
  • 2.5K
  • 12 Nov 2021
Topic Review
Two-Line Hybrid Rice Breeding
This entry enlightens a deep understanding of the molecular control of MF in EGMS liens and exploring the regulatory driving forces that function efficiently during plant adaptation under a changing environment. 
  • 2.5K
  • 11 Nov 2020
Topic Review
Standard for Automated ECG Interpretation
Diagnostic statements for automated ECG interpretation algorithms are the fundamental output, and the accuracy of these statements should be well characterized by algorithm testing, including both ECG contour and ECG rhythm diagnostic statements. The methods for measuring accuracy have been consistently and well defined, and previously included in ECG standards. However, the current industry ECG standards have omitted these historical requirements to test the accuracy of diagnostic statements, which is a gap that is being addressed in 80601-2-86.
  • 2.5K
  • 17 Sep 2021
Topic Review
Apple Bandai Pippin
The Apple Bandai Pippin, stylized PiP P!N, is a multimedia technology console, designed by Apple Computer. The console is based on the Apple Pippin platform – a derivative of the Apple Macintosh platform. Bandai produced the ATMARK and @WORLD consoles between 1996 and 1997. It was sold at $599. The goal of the Bandai Pippin was to create an inexpensive computer system aimed mostly at playing CD-based multimedia software, especially games, but also functioning as a thin client. The operating system is a version of System 7.5.2, and is based on a 66 MHz PowerPC 603 processor and a 14.4 kb/s modem. It features a 4×-speed CD-ROM drive and a video output that can connect to a standard television display.
  • 2.5K
  • 27 Oct 2022
Topic Review
PDE4 as Therapeutic Targets in Different Diseases
Cyclic nucleotides (cAMP, cGMP) play a major role in normal and pathologic signaling. Beyond receptors, cyclic nucleotide phosphodiesterases; (PDEs) rapidly convert the cyclic nucleotide in its respective 5′-nucleotide to control intracellular cAMP and/or cGMP levels to maintain a normal physiological state. However, in many pathologies, dysregulations of various PDEs (PDE1-PDE11) contribute mainly to organs and tissue failures related to uncontrolled phosphorylation cascade. Among these, PDE4 represents the greatest family, since it is constituted by 4 genes with multiple variants differently distributed at tissue, cellular and subcellular levels, allowing different fine-tuned regulations.
  • 2.5K
  • 11 Oct 2022
Topic Review
CD4 T Helper Cells
CD4 T helper cells, including Th1, Th2, Th17, Treg and Tfh, play a central role in orchestrating adaptive immune responses.
  • 2.5K
  • 16 Nov 2020
Topic Review
Bioactive Lipids in Food Applications
Bioactive lipids, such as fat-soluble vitamins, omega-3 fatty acids, conjugated linoleic acids, carotenoids and phytosterols play an important role in boosting human health and wellbeing. These lipophilic substances cannot be synthesized within the human body, and so people must include them in their diet. There is increasing interest in incorporating these bioactive lipids into functional foods designed to produce certain health benefits, such as anti-inflammatory, antioxidant, anticancer and cholesterol-lowering properties. However, many of these lipids have poor compatibility with food matrices and low bioavailability because of their extremely low water solubility. Nanotechnology is a promising technology that can be used to overcome many of these limitations. Different kinds of nanoscale delivery systems have been designed to encapsulate and protect bioactive lipids, thereby facilitating their handling, stability, food matrix compatibility, and bioavailability.
  • 2.5K
  • 27 Mar 2021
Topic Review
Metal Oxide Nanoparticles
Metal oxide nanoparticles (NPs) have received a great deal of attention as potential theranostic agents. Despite extensive work on a wide variety of metal oxide NPs, few chemically active metal oxide NPs have received Food and Drug Administration (FDA) clearance. The clinical translation of metal oxide NP activity, which often looks so promising in preclinical studies, has not progressed as rapidly as one might expect. The lack of FDA approval for metal oxide NPs appears to be a consequence of the complex transformation of NP chemistry as any given NP passes through multiple extra- and intracellular environments and interacts with a variety of proteins and transport processes that may degrade or transform the chemical properties of the metal oxide NP. Moreover, the translational models frequently used to study these materials do not represent the final therapeutic environment well, and studies in reduced preparations have, all too frequently, predicted fundamentally different physico-chemical properties from the biological activity observed in intact organisms. Understanding the evolving pharmacology of metal oxide NPs as they interact with biological systems is critical to establish translational test systems that effectively predict future theranostic activity. 
  • 2.5K
  • 20 Apr 2021
Topic Review
Career Plateau
Career plateau is a situation in which an employee has less to no possibility of a vertical promotion or a horizontal movement. Ze can feel to be stuck in your current position without room to develop.
  • 2.5K
  • 20 Apr 2022
Topic Review
Social Engineering (Security)
In the context of information security, social engineering is the psychological manipulation of people into performing actions or divulging confidential information. This differs from social engineering within the social sciences, which does not concern the divulging of confidential information. A type of confidence trick for the purpose of information gathering, fraud, or system access, it differs from a traditional "con" in that it is often one of many steps in a more complex fraud scheme. It has also been defined as "any act that influences a person to take an action that may or may not be in their best interests." An example of social engineering is the use of the "forgot password" function on most websites which require login. An improperly-secured password-recovery system can be used to grant a malicious attacker full access to a user's account, while the original user will lose access to the account.
  • 2.5K
  • 08 Nov 2022
Topic Review
MRNA Vaccine
An mRNA vaccine is a type of vaccine that uses a copy of a molecule called messenger RNA (mRNA) to produce an immune response. The vaccine delivers molecules of antigen-encoding mRNA into immune cells, which use the designed mRNA as a blueprint to build foreign protein that would normally be produced by a pathogen (such as a virus) or by a cancer cell. These protein molecules stimulate an adaptive immune response that teaches the body to identify and destroy the corresponding pathogen or cancer cells. The mRNA is delivered by a co-formulation of the RNA encapsulated in lipid nanoparticles that protect the RNA strands and help their absorption into the cells. File:MRNA vaccines against the coronavirus.webm Reactogenicity, the tendency of a vaccine to produce adverse reactions, is similar to that of conventional non-RNA vaccines. People susceptible to an autoimmune response may have an adverse reaction to messenger RNA vaccines. The advantages of mRNA vaccines over traditional vaccines are ease of design, speed and lower cost of production, the induction of both cellular and humoral immunity, and lack of interaction with the genomic DNA. While some messenger RNA vaccines, such as the Pfizer–BioNTech COVID-19 vaccine, have the disadvantage of requiring ultracold storage before distribution, other mRNA vaccines, such as the Moderna, CureVac, and Walvax COVID-19 vaccines, do not have such requirements. In RNA therapeutics, messenger RNA vaccines have attracted considerable interest as COVID-19 vaccines. In December 2020, Pfizer–BioNTech and Moderna obtained authorization for their mRNA-based COVID-19 vaccines. On 2 December, the UK Medicines and Healthcare products Regulatory Agency (MHRA) became the first medicines regulator to approve an mRNA vaccine, authorizing the Pfizer–BioNTech vaccine for widespread use. On 11 December, the US Food and Drug Administration (FDA) issued an emergency use authorization for the Pfizer–BioNTech vaccine and a week later similarly authorized the Moderna vaccine.
  • 2.5K
  • 16 Nov 2022
Topic Review
Universal Priesthood
The universal priesthood or the priesthood of all believers is a principle in some branches of Christianity which abrogates the doctrine of holy orders found in some other branches, including the Roman Catholic and Eastern Orthodox. Derived from the Bible and elaborated in the theology of Martin Luther and John Calvin, the principle became prominent as a tenet of Protestant Christian doctrine, though the exact meaning of the belief and its implications vary widely among denominations.
  • 2.5K
  • 11 Nov 2022
Topic Review
Black-footed Cat
The Black-footed Cat (Felis nigripes) is a small and elusive wild cat species native to southern Africa. Renowned for its diminutive size and distinctive black markings on its legs and feet, this nocturnal predator is considered one of the smallest wild cats in Africa. Despite its small stature, the Black-footed Cat is a formidable hunter, preying on a variety of small mammals, birds, and insects in its arid savanna and scrubland habitats.
  • 2.5K
  • 08 Mar 2024
Topic Review
Effect of Potassium on Tea Plant Growth
Potassium is among the three essential macronutrients for tea plants, along with nitrogen and phosphorous, and plays important roles in growth and stress response. Potassium is absorbed by plants in larger amounts than any other mineral element except nitrogen and, in some cases, calcium. Potassium is positively correlated with the elements nitrogen, copper, and zinc. Sufficient potassium dramatically improves the yield and quality of tea: it accelerates metabolism, promotes synthesis of catechins, and strengthens biotic and abiotic resistance by activating and regulating different enzymes. Moderate application of potassium fertilizers, along with potassium-solubilizing bacteria, can regulate the ratio of different forms of potassium and increase available potassium in soils of tea gardens.
  • 2.5K
  • 06 Sep 2022
Topic Review
Fungal Endophytes and Their Benefits for Plants
Plant pathogens are responsible for causing economic and production losses in several crops worldwide, thus reducing the quality and quantity of agricultural supplies. To reduce the usage of chemically synthesized pesticides, strategies and approaches using endophytic microorganisms are being used in plant disease management. Although the term “endophyte” was originally introduced by de Bary in 1866, the most used definition of endophytes was proposed by Petrini in 1991. It refers to a group of organisms “inhabiting plant organs that at some time in their life can colonize internal plant tissues without causing apparent harm to the host”. These endophytes are usually fungi or bacteria that are present in the phyllosphere, endosphere or rhizosphere. These microorganisms live in the tissues of plants without causing any symptoms of disease, leading to beneficial effects for the hosts.
  • 2.5K
  • 21 Dec 2022
Topic Review
Video Game Engagement and Social Development in Children
Video games have rapidly emerged as a prevalent facet of children’s daily experiences globally. Their appeal to children can be attributed to features such as engaging content, immediate feedback, user interactivity, broad media accessibility, and applicability across a diverse age spectrum.
  • 2.5K
  • 20 Oct 2023
Topic Review
Wheat Blast and Food Security
Wheat blast is a fearsome fungal disease caused by a filamentous fungus, Magnaporthe oryzae Triticum pathotype. It was first detected in Brazil in 1985, then it spread to some neighboring South American countries such as Bolivia, Argentina and Paraguay. The outbreak of wheat blast was spotted in Bangladesh for the first time in 2016, which devastated 15,000 hectares of wheat with yield losses up to 100%. Recently, it was detected in Zambia (an African country). The disease spreads through seeds and airborne conidia. There is no resistant variety against wheat blast disease. Once the disease symptoms are expressed as the bleached or partially bleached spikes, fungicide application is ineffective to control it. A convenient and rapid molecular diagnostic tool is developed for surveillance and monitoring of the wheat blast. However, our understanding the biology of wheat blast fungus and its interactions with the host plant is limited. A globally concerted effort is needed to develop durable blast-resistant varieties to combat this killer of wheat before the spread to major wheat growing countries in the world.
  • 2.5K
  • 23 Oct 2020
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