Your browser does not fully support modern features. Please upgrade for a smoother experience.
Subject:
All Disciplines Arts & Humanities Biology & Life Sciences Business & Economics Chemistry & Materials Science Computer Science & Mathematics Engineering Environmental & Earth Sciences Medicine & Pharmacology Physical Sciences Public Health & Healthcare Social Sciences
Sort by:
Most Viewed Latest Alphabetical (A-Z) Alphabetical (Z-A)
Filter:
All Topic Review Biography Peer Reviewed Entry Video Entry
Topic Review
Uremic Toxins Control in CKD
Uremic toxins (UTs) are mainly produced by protein metabolized by the intestinal microbiota and converted in the liver or by mitochondria or other enzymes. The accumulation of UTs can damage the intestinal barrier integrity and cause vascular damage and progressive kidney damage. Together, these factors lead to metabolic imbalances, which in turn increase oxidative stress and inflammation and then produce uremia that affects many organs and causes diseases including renal fibrosis, vascular disease, and renal osteodystrophy. This article is based on the theory of the intestinal–renal axis, from bench to bedside, and it discusses nonextracorporeal therapies for UTs, which are classified into three categories: medication, diet and supplement therapy, and complementary and alternative medicine (CAM) and other therapies. The effects of medications such as AST-120 and meclofenamate are described. Diet and supplement therapies include plant-based diet, very low-protein diet, probiotics, prebiotics, synbiotics, and nutraceuticals. The research status of Chinese herbal medicine is discussed for CAM and other therapies. This review can provide some treatment recommendations for the reduction of UTs in patients with chronic kidney disease.
  • 2.9K
  • 10 Sep 2021
Topic Review
Streptavidin
Streptavidin /ˌstrɛpˈtævɪdɪn/ is a 52.8 kDa protein purified from the bacterium Streptomyces avidinii. Streptavidin homo-tetramers have an extraordinarily high affinity for biotin (also known as vitamin B7 or vitamin H). With a dissociation constant (Kd) on the order of ≈10−14 mol/L, the binding of biotin to streptavidin is one of the strongest non-covalent interactions known in nature. Streptavidin is used extensively in molecular biology and bionanotechnology due to the streptavidin-biotin complex's resistance to organic solvents, denaturants (e.g. guanidinium chloride), detergents (e.g. SDS, Triton), proteolytic enzymes, and extremes of temperature and pH.
  • 2.9K
  • 25 Oct 2022
Topic Review
Abecedarian: An Impossible Model Preschool Program
The primary goal of pre- and early-school programs is to prevent young children from socioeconomically disadvantaged backgrounds to start school already with educational delays. The programs offer compensatory stimulation activities which are supposed to be not available in the home situation; the focus is on language development. Proponents claim that such programs can be effective, provided they are of high quality. The belief in their success is very much based on the outcomes of a few so-called model programs from the 1960s and 1970s. One of these programs is the Carolina Abecedarian Project, a small single-site project started in 1972. Four cohorts of in total 111 children and their poor, Black parents participated in this experiment with a random allocated treatment and control group. The children were followed from 6 weeks after birth to 6 years of age, that is, when they entered school. They were regularly tested and observed, and then after the program had ended again until they were 40 years of age.
  • 2.9K
  • 14 Jan 2024
Topic Review
Experimental Studies of PCM Building Applications
The use of phase change material (PCM) as a thermal energy storage system integrated in new buildings, and as retrofits in old buildings, proved its merit as promising renewable energy source. Experimental investigations for the use of PCM in buildings gained attention where the experimental setups used are classified as: Large-scale, small-scale, retrofitting, and laboratory-based test facilities.
  • 2.9K
  • 22 Mar 2022
Topic Review
Human Satellite DNA Families
Going back to the 1960s, the discovery and classification of three clearly distinguishable human genomic DNA fractions in CsSO4 gradients established the identity of the corresponding classical satellite DNAs I, II, and III. More precisely, a set of repetitive sequences with analogous buoyant densities was found to compose each gradient fraction. These DNA fractions presented a characteristic inter-sequence heterogeneity, which led to a new classification in 1987, as a prime family of simple repeats was identified for each fraction. The three families were described as satellite DNA families I, II, and III and were first reported to be present in all acrocentric chromosomes, as well as in chromosomes 3 and 4. Additionally, the centromeric alpha (α) satellite DNA family was also identified and described, soon becoming the most intensively studied human satDNA sequence. Later on, gamma (γ) and beta (β) satellites were likewise found among the diverse families of human satellite DNAs.
  • 2.9K
  • 13 May 2021
Topic Review
E-Consumers in the E-Services Market
In economics, the “consumer” is considered in terms of choice theory, representing the entity that consumes and creates demand. Typically, the term is identified with the purchaser who consumes the products bought and enjoys their use value. In marketing theory, the consumer is the starting point of marketing activities that are undertaken in the market for goods and services. The purpose of these activities is to direct the marketing strategy of producers and sellers to identify the requirements of consumers.
  • 2.9K
  • 25 Feb 2022
Topic Review
Travel Website
A travel website is a website on the world wide web that is dedicated to travel. The site may be focused on travel reviews, trip fares, or a combination of both. Approximately 587.3 million consumers are expected to book travel plans online in 2018.
  • 2.9K
  • 25 Nov 2022
Topic Review
Methods for Obtaining Titanium and Its Alloys
Titanium and its alloys are widely employed in the aerospace industry, and their use will increase in the future. Titanium is mainly produced by the Kroll method, but this is expensive and energy-intensive. Therefore, the research of efficient and sustainable methods for its production has become relevant. 
  • 2.9K
  • 05 Jan 2024
Topic Review
Vertebrate Cutaneous Sensory Corpuscles
Vertebrate cutaneous sensory corpuscles are specialized sensory nerve formations located in the skin of all vertebrates and responsible for tactile sensation. Functionally, they are mechanoreceptors transducing external mechanical stimuli into electrical signals which will be later led to the Central Nervous System. The afferent innervation of vertebrate skin is supplied by nerve fibers (Aβ, Aδ, C) which are originated from peripheral neurons localized in the dorsal root ganglia (DRG). Aβ nerve fibers end at the dermis level forming several morphotypes of sensory corpuscles with capacity of detecting different stimuli: Merkel cell–neurite complexes, Ruffini corpuscles, Meissner’s corpuscles and Pacinian corpuscles are present in the glabrous skin; while pilo-neural complexes are found in hairy skin. The structure of sensory corpuscles is formed by an axon, non-myelinating Schwann-like cells, a capsule of endoneurial and/or perineurial origin and extracelullar matrix molecules.  The vertebrate skin contains sensory corpuscles that are receptors for different qualities of mechanosensitivity like light brush, touch, pressure, stretch or vibration. These specialized sensory organs are linked anatomically and functionally to mechanosensory neurons, which function as low-threshold mechanoreceptors connected to peripheral skin through Aβ nerve fibers. Furthermore, low-threshold mechanoreceptors associated with Aδ and C nerve fibers have been identified in hairy skin. The process of mechanotransduction requires the conversion of a mechanical stimulus into electrical signals (action potentials) through the activation of mechanosensible ion channels present both in the axon and the periaxonal cells of sensory corpuscles (i.e., Schwann-, endoneurial- and perineurial-related cells). Most of those putative ion channels belong to the degenerin/epithelial sodium channel (especially the family of acid-sensing ion channels), the transient receptor potential channel superfamilies, and the Piezo family.
  • 2.9K
  • 07 Sep 2020
Topic Review
Lung Cancer
Currently, lung cancer is a disease that acquired an impressive change in the clinical manangement due to the recent inovations regarding targeted therapies and immunne check point inhibitors.
  • 2.9K
  • 17 Apr 2021
Topic Review
Illegal Toxic Waste Dumping
Poor management of hazardous waste can lead to environmental pollution, injuries, and adverse health risks. Children’s exposure to hazardous waste may cause serious acute and chronic health problems due to their higher vulnerability to the toxic effects of chemicals. 
  • 2.9K
  • 24 Mar 2021
Topic Review
Soil and Food Crops Irrigated with Wastewater
Wastewater is actively used for irrigation of vegetable and forage crops in arid lands due to water scarcity and cost advantages. The objective of this review was to assess the effect of wastewater (mixture sources) reuse in irrigation on soil, crop (vegetable and forage crops), animal products, and human health. 
  • 2.9K
  • 31 Dec 2021
Topic Review
A2 Milk
Although milk consumption is increasing worldwide, in some geographical regions, its consumption has persistently declined. This fact, together with the increase in milk production prices, has caused both milk producers and the dairy industry to be immersed in a major crisis. Some possible solutions to this problem are to get people who do not currently consume milk to start drinking it again, or to market milk and dairy products with a higher added value. In this context, a type of milk called A2 has recently received attention from the industry. This type of milk, characterized by a difference in an amino acid at position 67 of the β-casein polypeptide chain, releases much smaller amounts of bioactive opioid peptide β-casomorphin 7 upon digestion, which has been linked to harmful effects on human health. Additionally, A2 milk has been attributed worse technological properties in the production of some dairy products. Thus, doubts exist about the convenience for the dairy industry to bet on this product. 
  • 2.9K
  • 30 Aug 2022
Topic Review
Burmese Amber
Burmese amber, also known as Burmite or Kachin amber, is amber from the Hukawng Valley in northern Myanmar. The amber is dated to around 99 million years old, during the earliest part of the Cenomanian age of the Late Cretaceous. The amber is of significant palaeontological interest due to the diversity of flora and fauna contained as inclusions, particularly arthropods including insects and arachnids but also birds, lizards, snakes, frogs and fragmentary dinosaur remains. The amber has been known and commercially exploited since the first century AD, and has been known to science since the mid-nineteenth century. Research on the deposit has attracted controversy due to its role in funding internal conflict in Myanmar and hazardous working conditions in the mines where it is collected.
  • 2.9K
  • 24 Nov 2022
Topic Review
Theophory in the Bible
Theophory refers to the practice of embedding the name of a god or a deity in, usually, a proper name. Much Hebrew theophory occurs in the Bible, particularly in the Old Testament. The most prominent theophory involves names referring to: El, a word meaning might, power and (a) god in general, and hence in Judaism, God and among the Canaanites the name of the god who was the father of Baal. Yah, a shortened form of Yahweh. Levantine deities (especially the storm god, Hadad) by the epithet baal, meaning lord. In later times, as the conflict between Yahwism and the more popular pagan practices became increasingly intense, these names were censored and baal was replaced with bosheth, meaning "shame".
  • 2.9K
  • 30 Nov 2022
Topic Review Peer Reviewed
Effects of in Utero SARS-CoV-2 Exposure on Newborn Health Outcomes
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected over 600 million people worldwide, including millions of pregnant women. While newborns exposed to other viruses in utero are sometimes at high risk for vertical transmission, a substantial body of literature since early 2020 has demonstrated that vertical transmission of SARS-CoV-2 from infected mother to neonate is rare, and that newborns who do become infected with SARS-CoV-2 generally have favorable outcomes. In this review, the authors evaluate the existing literature on vertical transmission of SARS-CoV-2 and its potential mechanisms and discuss short- and long-term health outcomes in newborns who were exposed to SARS-CoV-2 in utero. The authors conclude that vertical transmission and adverse neonatal and infant/child outcomes are unlikely, but that neonates exposed to prenatal maternal SARS-CoV-2 infection may be at slightly higher risk for preterm birth, possibly related to increased risk of severe COVID-19 disease in pregnant women, placental changes, or infection timing. Ultimately, the need for additional and longer-term follow-up data in this population is highlighted.
  • 2.9K
  • 12 Jan 2023
Topic Review
Alkaline–Surfactant–Polymer Flooding Mechanisms
Chemical flooding, expecially  alkali–surfactant–polymer (ASP) injection plays an important role in enhancing oil recovery under many synergetic mechanisms, in which there are four main mechanisms that have been widely used, including improving the mobility ratio between the heavy oil and the displacing phase, lowering the interfacial tension between oil and water (IFT), altering the rock wettability (oil-wet to water-wet) and emulsifying oil and water. Laboratory tests and pilot trials of ASP injection showed that the oil recovery of the emulsified system is 5% more than the cases where no emulsions existed. 
  • 2.9K
  • 28 Nov 2022
Topic Review
Tyrosinase and Melanogenesis Inhibition
Melanin is a widespread natural pigment that is responsible for color in hair, skin, and eyes. It provides protection against the deleterious effects of ultraviolet (UV) irradiation. Melanogenesis is the physiological process of melanin formation in which TYR, a copper-dependent enzyme, initiates the first step. Tyrosinase catalyzes the rate-limiting step where L-tyrosine is converted to L-3,4,-dihydroxyphenylalanine (L-DOPA), leading to the eventual formation of the pigment.
  • 2.9K
  • 27 Oct 2020
Topic Review
Rudolf Carnap
Rudolf Carnap (/ˈkɑːrnæp/; German: [ˈkaʁnaːp]; 18 May 1891 – 14 September 1970) was a German-language philosopher who was active in Europe before 1935 and in the United States thereafter. He was a major member of the Vienna Circle and an advocate of logical positivism. He is considered "one of the giants among twentieth-century philosophers."
  • 2.9K
  • 24 Nov 2022
Topic Review
Handfasting
Handfasting is a traditional practice that, depending on the term's usage, may correspond to an unofficiated wedding (in which a couple marries without an officiant, usually with the intent of later undergoing a second wedding with an officiant), a betrothal (an engagement in which a couple has formally promised to wed, and which can be broken only through divorce), or a temporary wedding (in which a couple makes an intentionally temporary marriage commitment). The phrase refers to the making fast of a pledge by the shaking or joining of hands. The terminology and practice is especially associated with Germanic peoples, including the English and Norse, as well as the Gaelic Scots. As a form of betrothal or unofficiated wedding, it was common up through Tudor England; as a form of temporary marriage, it was practiced in 17th-century Scotland and has been revived in Neopaganism. Sometimes the term is also used synonymously with "wedding" or "marriage" among Neopagans to avoid perceived non-Pagan religious connotations associated with those terms. It is also used, apparently ahistorically, to refer to an alleged pre-Christian practice of symbolically fastening or wrapping the hands of a couple together during the wedding ceremony.
  • 2.9K
  • 17 Oct 2022
  • Page
  • of
  • 2860
Featured Entry Collections
>>

Featured Reprints

>>
Encyclopedia of Digital Society, Industry 5.0 and Smart City
Encyclopedia of Engineering
Encyclopedia of Social Sciences
Encyclopedia of Medieval Royal Iconography
Academic Video Service
Feedback