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HandWiki. Streptavidin. Encyclopedia. Available online: https://encyclopedia.pub/entry/31236 (accessed on 23 September 2026).
HandWiki. Streptavidin. Encyclopedia. Available at: https://encyclopedia.pub/entry/31236. Accessed September 23, 2026.
HandWiki. "Streptavidin" Encyclopedia, https://encyclopedia.pub/entry/31236 (accessed September 23, 2026).
HandWiki. (2022, October 25). Streptavidin. In Encyclopedia. https://encyclopedia.pub/entry/31236
HandWiki. "Streptavidin." Encyclopedia. Web. 25 October, 2022.
Streptavidin
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The content is sourced from: https://handwiki.org/wiki/Biology:Streptavidin

Streptavidin /ˌstrɛpˈtævɪdɪn/ is a 52.8 kDa protein purified from the bacterium Streptomyces avidinii. Streptavidin homo-tetramers have an extraordinarily high affinity for biotin (also known as vitamin B7 or vitamin H). With a dissociation constant (Kd) on the order of ≈10−14 mol/L, the binding of biotin to streptavidin is one of the strongest non-covalent interactions known in nature. Streptavidin is used extensively in molecular biology and bionanotechnology due to the streptavidin-biotin complex's resistance to organic solvents, denaturants (e.g. guanidinium chloride), detergents (e.g. SDS, Triton), proteolytic enzymes, and extremes of temperature and pH.

molecular biology streptavidin bionanotechnology

References

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  2. "Structural origins of high-affinity biotin binding to streptavidin". Science 243 (4887): 85–8. January 1989. doi:10.1126/science.2911722. PMID 2911722.  https://dx.doi.org/10.1126%2Fscience.2911722
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