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Topic Review
VISTA, PDL-L1, and BRAF—Markers in Prognosis of Melanoma
Melanoma is currently known as one of the most aggressive malignant tumors. T cell Activation (VISTA) is a novel target that is considered to be highly important in determining the invasive potential and treatment response of a melanoma. Programmed death-ligand 1 (PD-L1) is a marker with whose importance has been revealed in multiple types of malignancies.
  • 784
  • 29 Mar 2022
Topic Review
Pathological Mechanisms of Mitochondria in Brain Disease
Mitochondria play a vital role in maintaining cellular energy homeostasis, regulating apoptosis, and controlling redox signaling. Dysfunction of mitochondria has been implicated in the pathogenesis of various brain diseases, including neurodegenerative disorders, stroke, and psychiatric illnesses.
  • 782
  • 24 Oct 2023
Topic Review
Predictors of Major Depressive Disorder in Older People
Major depressive disorder (MDD) is one of the most common mental disorders in older people. There are several biological, psychological, and social factors associated with this disorder.
  • 781
  • 01 Dec 2021
Topic Review
Taxonomy for Skeleton-GNN-Based Human Action Recognition
Human action recognition has been applied in many fields, such as video surveillance and human computer interaction, where it helps to improve performance. Connecting the skeleton joints as in the physical appearance can naturally generate a graph. A new taxonomy for skeleton-GNN-based methods is proposed according to current designs, and the merits and demerits are analyzed.
  • 778
  • 14 Mar 2022
Topic Review
Application for Food Plan Management Alzheimer Patients
Alzheimer’s disease is a type of dementia that affects many individuals, mainly in an older age group. Over time, it leads to other diseases that affect their autonomy and independence. The quality of food ingestion is a way to mitigate the disease and preserve the patient’s well-being, which substantially impacts their health.
  • 778
  • 15 May 2023
Topic Review
The Relationship between Personality Traits and COVID-19 Anxiety
The COVID-19 pandemic has created a lot of fear and anxiety globally. The current study attempted to investigate the association among the big five personality traits and the two factors of COVID-19 pandemic anxiety (fear and somatic concern). Further, sleep quality as a mediator between personality traits and pandemic anxiety was also assessed. The study involved a cross-sectional sample of 296 adult Indians who were administered the 10-item short version of BFI along with the COVID-19 Pandemic Anxiety Scale and Sleep Quality Scale. Path analysis was used to test the theoretical model that we proposed. The overall model has explained 6% and 36% of the variance, respectively, for the factors of fear and somatic concern of COVID-19 pandemic anxiety. The path analysis model indicated that only the trait of neuroticism showed a significant direct and indirect effect on pandemic anxiety in the sample. Those scoring high on neuroticism indicated high levels of fear as well as somatic concern. Neuroticism also showed partial mediation through sleep quality on the factor of somatic concern. Agreeableness was the only other personality trait that indicated a significantly negative relationship with the factor of somatic concern. These relationships were independent of age, gender, and occupational status. These findings provide a preliminary insight into the slightly different relationship which has emerged between personality and COVID-19 pandemic anxiety in comparison to general anxiety. 
  • 774
  • 27 Jan 2022
Topic Review
Sex Disparity in Cardiovascular Disease
Among cardiovascular diseases, acute myocardial infarction (AMI) shows significant differences in occurrence rate, prognosis and efficacy of treatment between male and female patients. Genomics and epigenomics approaches together with epidrugs design and drug repositioning could fill the sex-gap.
  • 773
  • 29 Mar 2022
Topic Review
Persons Experiencing Homelessness during COVID-19
Persons experiencing homelessness are at heightened risk for infection, morbidity, and mortality from COVID-19. However, health consequences of the pandemic extend far beyond those directly caused by the virus, including fear of infection, access to housing, hygiene, PPE, food, as well as mental health, substance use, other health-related outcomes and treatment services.
  • 773
  • 22 Mar 2022
Topic Review
Consequences on Family Informal Caregiving during COVID-19 Pandemic
The COVID-19 pandemic has deeply affected the quality of people’s social life, strongly impacting family dynamics, too, not only in the harshest periods of the pandemic but also afterwards. Pandemic-related measures led to a ‘stay-at-home’ approach that increased the mental and physical burdens of family caregivers, irrespective of whether they were living together with the person they were caring for or not. 
  • 773
  • 24 Mar 2023
Topic Review
Cardiometabolic-Based Chronic Disease in Czechia
Unlike the traditional adiposity and dysglycemia classifiers, which do not capture the complexity of cardiometabolic pathophysiology, the Cardiometabolic-Based Chronic Disease (CMBCD) model was proposed to incorporate the natural history of the cardiometabolic disease in four stages: 1—risk; 2—pre-disease; 3—diseases; and 4—complications. The CMBCD model combines the dysglycemia and abnormal adiposity drivers into the chronic care model as DBCD  and ABCD, with the presence of earlier primary drivers (genetics, environment, and behavior) and later metabolic drivers (hypertension and dyslipidemia) impacting the eventual cardiovascular disease phenotype. The CMBCD model triggers proactive detection and stratification of subjects at risk using a culturally adapted approach to improve successful implementation and precision. 
  • 772
  • 23 Jul 2021
Topic Review
Intradural Pediatric Spinal Tumors
Pediatric spinal tumors are rare and account for 10% of all central nervous system tumors in children. Onset usually occurs with chronic nonspecific symptoms and may depend on the intra- or extradural neoplastic location. Meningiomas, schwannomas, and neurofibromas are the most common intradural-extramedullary lesions, while astrocytomas and ependymomas represent the majority of intramedullary tumors.
  • 771
  • 08 Oct 2021
Topic Review
Falsified Medicines Directive in European Union
The Falsified Medicines Directive (FMD) and the Delegated Regulation (DR) impact the pharmaceutical supply chain. The European Union published the Falsified Medicines Directive, introducing a safety feature on the packages of drugs, ensuring the verification of a drug’s authenticity before supplying it to the patient. The details of implementing a Europe-wide system for authentication of medicines is included in the Delegated Regulation, published in February 2016. The deadline for DR implementation was 9 February 2019, with the authentication systems required to be operational and running before this deadline. The FMD impacts the entire pharmaceutical supply chain.
  • 769
  • 24 Mar 2022
Topic Review
School gardening activities and Obesity
School gardening activities (SGA) combined with physical activities (PA) may improve childhood dietary intake and prevent overweight and obesity. This study aims to evaluate the effect of SGA combined with PA on children’s dietary intake and anthropometric outcomes. We searched studies containing randomized controlled trials up to January 2021 in Web of Science, PubMed, Cochrane Library, and the EBSCO database on this topic for children aged 7 to 12 years.
  • 768
  • 13 Aug 2021
Topic Review
Impact of Virtual Nature Therapy on Stress Responses
Previous research has found that virtual reality (VR) experiences affect socio-affective behavior, indicating the potential of using VR for cognitive and psychological stress therapy. However, evidence for the impacts of virtual forest therapy as a stress-reduction technique is lacking, and the usefulness of these techniques has yet to be determined. 
  • 767
  • 17 Jan 2022
Topic Review
Home-Based Devices for Detecting Obstructive Sleep Apnea
Obstructive Sleep Apnea (OSA) is a respiratory disorder characterized by frequent breathing pauses during sleep. The apnea–hypopnea index is a measure used to assess the severity of sleep apnea and the hourly rate of respiratory events. Despite numerous commercial devices available for apnea diagnosis and early detection, accessibility remains challenging for the general population, leading to lengthy wait times in sleep clinics. Consequently, research on monitoring and predicting OSA has surged. 
  • 767
  • 20 Feb 2024
Topic Review
Genetic Counselling for Rare Diseases in Spain
Genetic Counseling is essential for providing personalized information and support to patients with Rare Diseases (RD). Unlike most other developed countries, Spain does not recognize geneticists or genetic counsellors as healthcare professionals. Thus, patients with RD face not only challenges associated with their own disease but also deal with lack of knowledge, uncertainty, and other psychosocial issues arising as a consequence of diagnostic delay.
  • 766
  • 24 Jan 2022
Topic Review
Healthcare Safety Nets during COVID-19
Healthcare safety net is an important concept during covid-19 infectious diseases. In the case of covid-19, the healthcare safety net meets the safety requirements, improves the quality of life, and reduces the turnover rate and mortality of patients.
  • 765
  • 10 Aug 2021
Topic Review
Human Milk Microbiota on Maternal and Child Health
Human milk (HM) is considered the most complete food for infants as its nutritional composition is specifically designed to meet infant nutritional requirements during early life. HM also provides numerous biologically active components, such as polyunsaturated fatty acids, milk fat globules, IgA, gangliosides or polyamines, among others; in addition, HM has a “bifidogenic effect”, a prebiotic effect, as a result of the low concentration of proteins and phosphates, as well as the presence of lactoferrin, lactose, nucleotides and oligosaccharides. Recently, has been a growing interest in HM as a potential source of probiotics and commensal bacteria to the infant gut, which might, in turn, influence both the gut colonization and maturation of infant immune system. Our review aims to address practical approaches to the detection of microbial communities in human breast milk samples, delving into their origin, composition and functions. Furthermore, we will summarize the current knowledge of how HM microbiota dysbiosis acts as a short- and long-term predictor of maternal and infant health. Finally, we also provide a critical view of the role of breast milk-related bacteria as a novel probiotic strategy in the prevention and treatment of maternal and offspring diseases.
  • 765
  • 11 Nov 2021
Topic Review
Social Media for Health Service Design and Quality
Health organisations and stakeholders use social media for a range of functions, including engaging stakeholders in the design and quality improvement (QI) of services. Social media may help overcome some of the limitations of traditional stakeholder engagement methods. Risks/limitations included low quality of engagement and harms to users. Limited access and familiarity with social media were frequently reported barriers. Making discussions safe and facilitating access were common enablers. 
  • 765
  • 08 Dec 2022
Topic Review
Outpatient Antibiotic Use in Canadian Provinces
Antimicrobials are among the most prescribed medications in Canada, with over 90% of antibiotics prescribed in outpatient settings. Seniors prescribed antimicrobials are particularly vulnerable to adverse drug events and antimicrobial resistance. The extent of inappropriate antibiotic prescribing in outpatient Canadian medical practice, and the potential long-term trends in this practice, are unknown.
  • 763
  • 23 Dec 2021
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