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Topic Review
Project Medishare
Project Medishare is a 501(c)(3), non-profit organization registered in the State of Florida. It was founded by Dr. Barth Green and Arthur Fournier from the University of Miami School of Medicine. The organization was created in 1994 to improve healthcare in Haiti. Since then, it has been committed to help its Haitian partners by establishing and funding sustainable programs, providing technology and equipment to hospitals, clinics, and other affiliated programs and training of Haitian physicians, nurses, and allied health professionals. Project Medishare’s focus program include Community Health, Maternal Health, Child Health and Nutrition, and Medical Training and Education. The geographic areas served by the organization include Port-au-Prince and the Central Plateau in Haiti. The organization provides direct beneficiaries for more than 80,000 people every year.
  • 1.1K
  • 25 Oct 2022
Topic Review
Traditional Uses, Phytochemistry, and Pharmacology of Elegia Species
This review provides constructive and extensive information about the botanical characterization, distribution, traditional uses, phytochemistry and pharmacology of the genus Elegia. The genus Elegia L. is the second largest of the Restionaceae family, comprising 52 species, which are mainly used as materials for thatching. A comprehensive search of previously published literature was performed for studies on this genus, using databases with different key search words. This survey documented 52 Elegia species summarizing their previous taxonomic classification. In addition, 14 species were found to be studied for their phytochemical profile, revealing 14 chemical compounds. Concerning their biological activities, only one species (E. tectorum (L.f.) Moline and H.P.Linder) is reported for its anti-wrinkle activity. Moreover, two species are locally used for thatching and as materials for brooms. The present review highlights the Elegia genus as an important source of bioactive phytochemicals with flavonol glycosides being the main metabolites and reveals the uncharted territory of this genus for new research studies.
  • 1.1K
  • 23 Jan 2022
Topic Review
Tuberculosis Meningitis
Worldwide, Tuberculosis (TB) remains the most important infectious disease in causing morbidity and death. About one-third of the population worldwide has currently contracted TB infection through Mycobacterium tuberculosis. The human host serves as the natural reservoir for M tuberculosis. The underlying mechanisms responsible for successful dissemination of M tuberculosis to the meninges to cause TB meningitis remains poorly understood. Given the magnitude of the health problem and the emergence of drug-resistant strains of the organism, a better understanding of the protective immunity and pathogenesis of TB meningitis, development of reliable rapid laboratory diagnosis, therapeutics and effective vaccine are highly desirable.
  • 1.1K
  • 27 Oct 2020
Topic Review
Marshall-Marchetti-Krantz
Urinary incontinence (UI), also known as involuntary urination, is any uncontrolled leakage of urine. It is a common and distressing problem, which may have a large impact on quality of life. It has been identified as an important issue in geriatric health care. The term enuresis is often used to refer to urinary incontinence primarily in children, such as nocturnal enuresis (bed wetting). UI is an example of a stigmatized medical condition, which creates barriers to successful management and makes the problem worse. People may be too embarrassed to seek medical help, and attempt to self-manage the symptom in secrecy from others. Pelvic surgery, pregnancy, childbirth, and menopause are major risk factors. Urinary incontinence is often a result of an underlying medical condition but is under-reported to medical practitioners. There are four main types of incontinence: Treatments include pelvic floor muscle training, bladder training, surgery, and electrical stimulation. Behavioral therapy generally works better than medication for stress and urge incontinence. The benefit of medications is small and long term safety is unclear. Urinary incontinence is more common in older women.
  • 1.1K
  • 19 Oct 2022
Topic Review
Conjugated Linoleic Acids
Conjugated linoleic acids (CLA) are distinctive polyunsaturated fatty acids. They are present in food produced by ruminant animals and they are accumulated in seeds of certain plants. These naturally occurring substances have demonstrated to have anti-carcinogenic activity. Their potential effect to inhibit cancer has been shown in vivo and in vitro studies. In this study, we present the multiple effects of CLA isomers on cancer development such as anti-tumor efficiency, anti-mutagenic and anti-oxidant activity. 
  • 1.1K
  • 10 Mar 2021
Topic Review
Red Eye
A red eye is an eye that appears red due to illness or injury. It is usually injection and prominence of the superficial blood vessels of the conjunctiva, which may be caused by disorders of these or adjacent structures. Conjunctivitis and subconjunctival hemorrhage are two of the less serious but more common causes. Management includes assessing whether emergency action (including referral) is needed, or whether treatment can be accomplished without additional resources. Slit lamp examination is invaluable in diagnosis but initial assessment can be performed using a careful history, testing vision (visual acuity), and carrying out a penlight examination.
  • 1.1K
  • 27 Oct 2022
Topic Review
Hybrid Systems for Tissue Engineering
Biomimetic Hybrid Systems for Tissue Engineering: New Materials and Fabrication Techniques. Tissue engineering approaches appear nowadays highly promising for the regeneration of injured/diseased tissues. Biomimetic scaffolds are continuously been developed to act as structural support for cell growth and proliferation as well as for the delivery of cells able to be differentiated, and also of bioactive molecules like growth factors and even signaling cues. The current research concerns materials employed to develop biological scaffolds with improved features as well as complex preparation techniques. In this work, hybrid systems based on natural polymers are discussed and the efforts focused to provide new polymers able to mimic proteins and DNA are extensively explained.
  • 1.1K
  • 28 Oct 2020
Topic Review
Cyclosporine CsA
The bioavailability of CsA was matched and enhanced with nanoparticles in the context of the physicochemical properties and the character of its interactions with lipid membranes. This study can suggest the suitability of liposome/microemulsion as promising vehicles for CsA oral or injection delivery. As the most hopeful proved to be formulation with the smaller particle size because can facilitating absorption, but none of the formulations is flawless. However, when safety of the product is assessed, relying on just the particle size cannot be the only criteria.
  • 1.1K
  • 18 Nov 2020
Topic Review
Osteoporotic Bone Tissue Engineering
Bone tissue engineering aims at delivering novel methods for treating bone tissue deficiencies of-ten resulting from polytrauma, pathological fractures, and osteonecrosis as there is an increasing need to provide functional replacement grafts for the patients.
  • 1.1K
  • 26 Jan 2021
Topic Review
Stinger
In medicine, a stinger, also called a burner or nerve pinch injury, is a neurological injury suffered by athletes, mostly in high-contact sports such as ice hockey, rugby, American football, and wrestling. The spine injury is characterized by a shooting or stinging pain that travels down one arm, followed by numbness and weakness in the parts of the arms, including the biceps, deltoid, and spinati muscles. Many athletes in contact sports have suffered stingers, but they are often unreported to medical professionals. Anyone who experiences significant trauma to his or her head or neck needs immediate medical evaluation for the possibility of a spinal injury. In fact, it's safest to assume that trauma victims have a spinal injury until proven otherwise because: (1) The time between injury and treatment can be critical in determining the extent of complications and the amount of recovery. (2) A serious spinal injury is not always immediately obvious. If it is not recognized, more severe injury may occur. (3) Numbness or paralysis may develop immediately or come on gradually as bleeding or swelling occurs in or around the spinal cord.
  • 1.1K
  • 27 Oct 2022
Topic Review
Hepatic Arterial Infusion Chemotherapy
HAIC involves two procedures as follows: as scheduled, chemotherapeutic regimens are administered through a reservoir port connected to a catheter, which is implanted under the skin, and a catheter is inserted each time without implantation of the reservoir port. As HAIC is expected to accumulate drug concentrations in the local liver and reduce systemic toxicity of anti-cancer drugs, it is considered to have a more favorable antitumor effect and less influence on other organs than systemic chemotherapy.  The clinical benefits of HAIC are as follows: (1) even a patient with Child–Pugh B HCC (7 or 8 points) is a candidate for HAIC (2) Child–Pugh scores barely decline with the use of HAIC compared with sorafenib (3) HAIC is highly effective in patients with vascular invasion compared with sorafenib; and (4) survival in patients receiving HAIC may not be associated with skeletal muscle volume. In contrast, the disadvantages are problems related with the reservoir system. HAIC has clinical benefits in a subpopulation of patients without extrahepatic metastasis with Child–Pugh A HCC and vascular invasion (especially primary branch invasion or main portal vein invasion) or with Child–Pugh B HCC.
  • 1.1K
  • 12 Oct 2021
Topic Review
Epidemiology of Diabetes Mellitus
Globally, an estimated 422 million adults are living with diabetes mellitus, according to the latest 2016 data from the World Health Organization (WHO). Diabetes prevalence is increasing rapidly; previous 2013 estimates from the International Diabetes Federation put the number at 381 million people having diabetes. The number is projected to almost double by 2030. Type 2 diabetes makes up about 85-90% of all cases. Increases in the overall diabetes prevalence rates largely reflect an increase in risk factors for type 2, notably greater longevity and being overweight or obese. Diabetes mellitus occurs throughout the world, but is more common (especially type 2) in the more developed countries. The greatest increase in prevalence is, however, occurring in low- and middle-income countries including in Asia and Africa, where most patients will probably be found by 2030. The increase in incidence in developing countries follows the trend of urbanization and lifestyle changes, including increasingly sedentary lifestyles, less physically demanding work and the global nutrition transition, marked by increased intake of foods that are high energy-dense but nutrient-poor (often high in sugar and saturated fats, sometimes referred to as the Western pattern diet). The risk of getting type 2 diabetes has been widely found to be associated with lower socio-economic position across countries. The WHO estimates that diabetes resulted in 1.5 million deaths in 2012, making it the 8th leading cause of death. However another 2.2 million deaths worldwide were attributable to high blood glucose and the increased risks of associated complications (e.g. heart disease, stroke, kidney failure), which often result in premature death and are often listed as the underlying cause on death certificates rather than diabetes.
  • 1.1K
  • 23 Nov 2022
Topic Review
Impact of Chemical Endocrine Disruptors on Endocrine System
Endocrine disruptors may be derived from natural animal, human, or plant (phytoestrogen) sources. However, the best-known are chemical endocrine disruptors (EDCs). EDCs include industrial ones (dioxins, polychlorinated biphenyls (PCBs) and alkyphenols), agricultural ones (pesticides, herbicides, fungicides, and insecticides), phthalates, bisphenol A (BPA), drugs (mitotane, ketoconazole, cardiac glycosides, nitrofurans, carbamazepine, and astazene), and heavy metals.
  • 1.1K
  • 27 May 2022
Topic Review
Renin-Angiotensin System in Liver Fibrosis
There is considerable experimental evidence that the renin angiotensin system (RAS) plays a central role in both hepatic fibrogenesis and portal hypertension. Angiotensin converting enzyme (ACE), a key enzyme of the classical RAS, converts angiotensin I (Ang I) to angiotensin II (Ang II), which acts via the Ang II type 1 receptor (AT1R) to stimulate hepatic fibrosis and increase intrahepatic vascular tone and portal pressure. Inhibitors of the classical RAS, drugs which are widely used in clinical practice in patients with hypertension, have been shown to inhibit liver fibrosis in animal models but their efficacy in human liver disease is yet to be tested in adequately powered clinical trials. Small trials in cirrhotic patients have demonstrated that these drugs may lower portal pressure but produce off-target complications such as systemic hypotension and renal failure. More recently, the alternate RAS, comprising its key enzyme, ACE2, the effector peptide angiotensin-(1–7) (Ang-(1–7)) which mediates its effects via the putative receptor Mas (MasR), and Mas related G protein-coupled receptor type-D (MrgD) has also been implicated in the pathogenesis of liver fibrosis and portal hypertension. This system is activated in both preclinical animal models and human chronic liver disease and it is now well established that the alternate RAS counter-regulates many of the deleterious effects of the ACE-dependent classical RAS. Work from our laboratory has demonstrated that liver-specific ACE2 overexpression reduces hepatic fibrosis and liver perfusion pressure without producing off-target effects. On the other hand, activation of the alternate RAS aggravates portal hypertension in cirrhosis via increasing splanchnic vasodilatation and elevating portal blood flow into the liver. Recent studies suggest that the blockers of the receptors of alternate RAS, such as the MasR and MrgD, increase splanchnic vascular resistance in cirrhotic animals, and thus drugs targeting the alternate RAS may be useful in the treatment of portal hypertension.
  • 1.1K
  • 03 Mar 2021
Topic Review
Chronic Spinal Cord Injury
Spinal cord injuries (SCI) are a devastating event and can lead to physical, psychosocial, and vocational implications for patients and their family. In the United States, approximately 288,000 individuals are estimated to suffer from symptoms caused by SCI, and a recent survey showed the annual incidence of SCI to be approximately 54 cases per one million people.
  • 1.1K
  • 14 Jul 2021
Topic Review
Journal Efficiency
Journal efficiency is determined by measuring the timelag in the acceptance and publication of scientific findings by a journal on behalf of the authors upon submission.
  • 1.1K
  • 29 Oct 2020
Topic Review
Immune Checkpoint Agents
Immune checkpoint inhibitors represent a promising treatment choice in many kind of tumours, including hepatocellular carcinoma (HCC). In this review, we provide an overview of the role of these new agents in the management of HCC according to the Barcelona staging system, alongside with a critical evaluation of the current status and future directions. Several clinical trials are focusing on the use of immunotherapy in HCC, alone or in combinations with antiangiogenetic agents as well as local treatment. However, the majority of those trials are still ongoing and, until now, only a few combinations were approved in the clinical practice from the regulatory authorities. Additionally, decisions about the choice of the right sequence of treatments in HCC patients in the light of the “continuum of care” principles, is still hard. In fact, it requires careful consideration in a multidisciplinary context in order to ensure a tailored treatment for each patient. 
  • 1.1K
  • 09 Nov 2020
Topic Review
Carbamazepine to Treat Bipolar Disorder
Carbamazepine and its derivatives all appear to have stronger efficacy in treating acute mania than depression, which also translates to better protection against manic than depressive relapses for carbamazepine. Still, there is a paucity of controlled acute studies on bipolar depression for all and, with the exception of carbamazepine, a lack of long-term monotherapy maintenance data. For eslicarbazepine, the efficacy in bipolar disorder remains largely unknown. Especially with carbamazepine, tolerability issues and drug–drug interactions need to be kept in mind.
  • 1.1K
  • 08 May 2021
Topic Review
Myelodysplastic Syndromes
The molecular pathogenesis of myelodysplastic syndrome (MDS) is complex due to high rate of genomic heterogeneity. Significant advances have been made in the last decade in elucidating the landscape of molecular alterations (cytogenetic abnormalities, gene mutations) in MDS. Seminal experimental studies have clarified the role of diverse gene mutations in the context of disease phenotypes, but the lack of faithful murine models and/ or cell lines spontaneously carrying certain gene mutations have hampered the knowledge on how and why specific pathways are associated with MDS pathogenesis.
  • 1.1K
  • 09 Dec 2020
Topic Review
Sesquiterpene Lactones in Medicine
Sesquiterpene lactones (SL), characterized by their high prevalence in the Asteraceae family, are one of the major groups of secondary metabolites found in plants. Researchers from distinct research fields, including pharmacology, medicine, and agriculture, are interested in their biological potential. With new SL discovered in the last years, new biological activities have been tested, different action mechanisms (synergistic and/or antagonistic effects), as well as molecular structure–activity relationships described.
  • 1.1K
  • 18 Feb 2022
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