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Topic Review
Clinical Psychology
Clinical psychology is an integration of science, theory, and clinical knowledge for the purpose of understanding, preventing, and relieving psychologically-based distress or dysfunction and to promote subjective well-being and personal development. Central to its practice are psychological assessment, clinical formulation, and psychotherapy, although clinical psychologists also engage in research, teaching, consultation, forensic testimony, and program development and administration. In many countries, clinical psychology is a regulated mental health profession. The field is generally considered to have begun in 1896 with the opening of the first psychological clinic at the University of Pennsylvania by Lightner Witmer. In the first half of the 20th century, clinical psychology was focused on psychological assessment, with little attention given to treatment. This changed after the 1940s when World War II resulted in the need for a large increase in the number of trained clinicians. Since that time, three main educational models have developed in the USA—the Ph.D. Clinical Science model (heavily focused on research), the Ph.D. science-practitioner model (integrating scientific research and practice), and the Psy.D. practitioner-scholar model (focusing on clinical theory and practice). In the UK and the Republic of Ireland, the Clinical Psychology Doctorate falls between the latter two of these models, whilst in much of mainland Europe, the training is at the masters level and predominantly psychotherapeutic. Clinical psychologists are expert in providing psychotherapy, and generally train within four primary theoretical orientations—psychodynamic, humanistic, cognitive behavioral therapy (CBT), and systems or family therapy. Clinical psychology is distinguished from psychiatry. Although practitioners in both fields are mental health professionals, clinical psychologists treat mental disorders through talk therapy and have a doctorate in Psychology or a Doctor of Psychology degree but cannot prescribe medicine. Psychiatrists are medical doctors who treat mental disorders through medication and have a medical degree. Five states, Louisiana, New Mexico, Illinois, Iowa, and Idaho, allow clinical psychologists to prescribe certain medications with completion of medical training, whereas most states only allow psychiatrists to prescribe medicine.
  • 3.9K
  • 01 Nov 2022
Topic Review
Compartmental Models in Epidemiology
Compartmental models are a very general modelling technique. They are often applied to the mathematical modelling of infectious diseases. The population is assigned to compartments with labels – for example, S, I, or R, (Susceptible, Infectious, or Recovered). People may progress between compartments. The order of the labels usually shows the flow patterns between the compartments; for example SEIS means susceptible, exposed, infectious, then susceptible again. The origin of such models is the early 20th century, with important works being that of Ross in 1916, Ross and Hudson in 1917, Kermack and McKendrick in 1927 and Kendall in 1956 The models are most often run with ordinary differential equations (which are deterministic), but can also be used with a stochastic (random) framework, which is more realistic but much more complicated to analyze. Models try to predict things such as how a disease spreads, or the total number infected, or the duration of an epidemic, and to estimate various epidemiological parameters such as the reproductive number. Such models can show how different public health interventions may affect the outcome of the epidemic, e.g., what the most efficient technique is for issuing a limited number of vaccines in a given population.
  • 3.8K
  • 02 Dec 2022
Topic Review
Soft Gelatin Capsules
The development of soft gelatin capsules (SGCs) dosage forms has attracted a great deal of interest in the oral delivery of poorly water-soluble drugs. This is attributed to the increased number of poorly soluble drugs in the pipeline, and hence the challenges of finding innovative ways of developing bioavailable and stable dosage forms. Encapsulation of these drugs into SGCs is one of the approaches that is utilized to deliver the active ingredients to the systemic circulation to overcome certain formulation hurdles. Once formulated, encapsulated drugs in the form of SGCs require suitable in vitro dissolution test methods to ensure drug product quality and performance.
  • 3.8K
  • 04 Mar 2021
Topic Review
Positive Psychology
Positive psychology is the scientific study of what makes life most worth living, focusing on both individual and societal well-being. It studies "positive subjective experience, positive individual traits, and positive institutions...it aims to improve quality of life." It is a field of study that has been growing steadily throughout the years as individuals and researchers look for common ground on better well-being. Positive psychology began as a new domain of psychology in 1998 when Martin Seligman chose it as the theme for his term as president of the American Psychological Association. It is a reaction against past practices, which have tended to focus on mental illness and emphasized maladaptive behavior and negative thinking. It builds on the humanistic movement by Abraham Maslow, Rollo May, James Bugental and Carl Rogers, which encourages an emphasis on happiness, well-being, and positivity, thus creating the foundation for what is now known as positive psychology. Positive psychology focuses on eudaimonia, an Ancient Greek term for "the good life" and the concept for reflection on the factors that contribute the most to a well-lived and fulfilling life. Positive psychologists often use the terms subjective well-being and happiness interchangeably. Positive psychologists have suggested a number of factors may contribute to happiness and subjective well-being. For example, social ties with a spouse, family, friends, colleagues, and wider networks; membership in clubs or social organizations; physical exercise, and the practice of meditation. Spirituality can also be considered a factor that leads to increased individual happiness and well-being. Spiritual practice and religious commitment is a topic researchers have been studying as another possible source for increased well-being and an added part of positive psychology. Happiness may rise with increasing financial income, though it may plateau or even fall when no further gains are made or after a certain cut-off amount.
  • 3.7K
  • 24 Nov 2022
Topic Review
Generalizing the Local Average Treatment Effect
The local average treatment effect (LATE), also known as the complier average causal effect (CACE), refers to the treatment effect among compliers. The LATE may not be of the same value as the average treatment effect (ATE), so extrapolating the LATE directly should be done cautiously. In addition, the LATE retrieved from an experiment may not immediately be externally valid, especially when there is a case for treatment effect heterogeneity (i.e. the treatment effect varies across individuals).  However, generalizing the LATE through reweighting can be attempted, given certain key assumptions.
  • 3.7K
  • 30 Oct 2022
Topic Review
Dynamic-Maturational Model of Attachment and Adaptation
The dynamic-maturational model of attachment and adaptation (DMM) is a transdisciplinary model describing the effect attachment relationships can have on human development and functioning. It is especially focused on the effects of relationships between children and parents and between romantic/reproductive couples. It developed initially from attachment theory as developed by John Bowlby and Mary Ainsworth, and incorporated many other theories into a comprehensive model of adaptation to life's many dangers. The DMM was initially created by developmental psychologist Patricia McKinsey Crittenden and her colleagues including David DiLalla, Angelika Claussen, Andrea Landini, Steve Farnfield, and Susan Spieker. A main tenant of the DMM is that exposure to danger drives neural development and adaptation to promote survival. Danger includes relationship danger. In DMM-attachment theory, when a person needs protection or comfort from danger from a person with whom they have a protective relationship, the nature of the relationship generates relation-specific self-protective strategies. These are patterns of behavior which include the underlying neural processing. The DMM protective strategies describe aspects of the parent-child relationship, romantic relationships, and to a degree, relationships between patients/clients and long-term helping professionals.
  • 3.6K
  • 22 Nov 2022
Topic Review
Xanthine Oxidoreductase Activities
Xanthine oxidoreductase (XOR) is the enzyme that catalyzes the oxidation of hypoxanthine to xanthine and xanthine to uric acid. XOR is widely distributed throughout living organisms and is highly conserved in prokaryotic, plant, and animal species. XOR activity is very versatile, generating both pro-oxidant (primarily within the cell) and anti-oxidant (primarily in plasma) products.
  • 3.5K
  • 21 Sep 2020
Topic Review
Applications of Nanocellulose/Nanocarbon Composites: Focus on Biotechnology and Medicine
Nanocellulose/nanocarbon composites are newly-emerging smart hybrid materials containing cellulose nanoparticles, such as nanofibrils and nanocrystals, and carbon nanoparticles, such as “classical” carbon allotropes (fullerenes, graphene, nanotubes and nanodiamonds), or other carbon nanostructures (carbon nanofibers, carbon quantum dots, activated carbon and carbon black). The nanocellulose component acts as a dispersing agent and homogeneously distribute the carbon nanoparticles in aqueous environment. Nanocellulose/nanocarbon composites can be prepared with many advantageous properties, such as high mechanical strength, flexibility, stretchability, tunable thermal and electrical conductivity, tunable optical transparency, photodynamic and photothermal activity, nanoporous character and high adsorption capacity. They are therefore promising for a wide range of industrial applications, such as energy generation, storage and conversion, water purification, food packaging, construction of fire retardants and shape memory devices. They also hold great promise for biomedical applications, such as radical scavenging, photodynamic and photothermal therapy of tumors and microbial infections, drug delivery, biosensorics, isolation of various biomolecules, electrical stimulation of damaged tissues (e.g. cardiac, neural), neural and bone tissue engineering, engineering of blood vessels and advanced wound dressing, e.g. with antimicrobial and antitumor activity. However, the potential cytotoxicity and immunogenicity of the composites and their components must also be taken into account.
  • 3.5K
  • 01 Nov 2020
Topic Review
Oppositional Defiant Disorder
Oppositional defiant disorder (ODD) is listed in the DSM-5 under Disruptive, impulse-control, and conduct disorders and defined as "a pattern of angry/irritable mood, argumentative/defiant behavior, or vindictiveness". This behavior is usually targeted toward peers, parents, teachers, and other authority figures. Unlike with conduct disorder (CD), those with oppositional defiant disorder are not aggressive towards people or animals, do not destroy property, and do not show a pattern of theft or deceit. It has certain links to ADHD (Attention Deficit Hyperactivity Disorder) and as much as one half of children with ODD will also diagnose as having ADHD as well.
  • 3.5K
  • 06 Oct 2022
Topic Review
Disinformation
Disinformation is false or misleading information that is spread deliberately to deceive. This is a subset of misinformation, which may also be unintentional. The English word disinformation is a loan translation of the Russian dezinformatsiya, derived from the title of a KGB black propaganda department. Joseph Stalin coined the term, giving it a French-sounding name to claim it had a Western origin. Russian use began with a "special disinformation office" in 1923. Disinformation was defined in Great Soviet Encyclopedia (1952) as "false information with the intention to deceive public opinion". Operation INFEKTION was a Soviet disinformation campaign to influence opinion that the U.S. invented AIDS. The U.S. did not actively counter disinformation until 1980, when a fake document reported that the U.S. supported apartheid. The word disinformation did not appear in English dictionaries until the late-1980s. English use increased in 1986, after revelations that the Reagan Administration engaged in disinformation against Libyan leader Muammar Gaddafi. By 1990, it was pervasive in U.S. politics; and by 2001 referred generally to lying and propaganda.
  • 3.5K
  • 14 Oct 2022
Topic Review
Nonparametric Limits of Agreement
The assessment of agreement in method comparison and observer variability analysis of quantitative measurements is usually done by the Bland-Altman Limits of Agreement, where the paired differences are implicitly assumed to follow a normal distribution. Whenever this assumption does not hold, the 2.5% and 97.5% percentiles are obtained by quantile estimation. In the literature, empirical quantiles have been used for this purpose. In this simulation study, we applied both sample, subsampling, and kernel quantile estimators as well as other methods for quantile estimation to sample sizes between 30 and 150 and different distributions of the paired differences. The performance of 15 estimators in generating prediction intervals was measured by their respective coverage probability for one newly generated observation. Our results indicated that sample quantile estimators based on one or two order statistics outperformed all the other estimators and can be used for deriving nonparametric Limits of Agreement. For sample sizes exceeding 80 observations, more advanced quantile estimators, such as the Harrell-Davis and estimators of Sfakianakis-Verginis type, which use all the observed differences, performed likewise well, but may be considered intuitively more appealing than simple sample quantile estimators that are based on only two observations per quantile.
  • 3.4K
  • 27 Oct 2020
Topic Review
Sexual Fetishism
Sexual fetishism or erotic fetishism is a sexual fixation on a nonliving object or nongenital body part. The object of interest is called the fetish; the person who has a fetish for that object is a fetishist. A sexual fetish may be regarded as a non-pathological aid to sexual excitement, or as a mental disorder if it causes significant psychosocial distress for the person or has detrimental effects on important areas of their life. Sexual arousal from a particular body part can be further classified as partialism. While medical definitions restrict the term sexual fetishism to objects or body parts, fetish can, in common discourse, also refer to sexual interest in specific activities.
  • 3.4K
  • 14 Oct 2022
Topic Review
DESCRIPTION OF THE MITOCHONDRIAL PORIN VDAC1 AND ITS DISEASE RELEVANCE
Mitochondrial porins or voltage-dependent anionic channels (VDAC) are nonspecific channels that determine the permeability of the mitochondrial outer membrane (MEM). Its molecular mass oscillates around 28 to 36 kDa. These channels represent the most abundant proteins of the MEM. They are freely permeable to hydrophilic solutes and the limit of exclusion of metabolites is 3 to 6 kDa. These channels are the main route for the diffusion of ions such as pyruvate and ATP, among others. It has been proposed that the transport of these metabolites regulates the cellular energy supply. This review focus on some of the main aspects of the VDAC porins and its relevance in some physiological processes related with cancer and neurodegeneration diseases. 
  • 3.4K
  • 30 Oct 2020
Topic Review
Vascular Endothelial Growth Factors
Vascular endothelial growth factors (VEGFs) are primary regulators of blood and lymphatic vessels. Hemangiogenic VEGFs (VEGF-A, PlGF, and VEGF-B) target mostly blood vessels, while the lymphangiogenic VEGFs (VEGF-C and VEGF-D) target mostly lymphatic vessels. Blocking VEGF-A is used today to treat several types of cancer (“antiangiogenic therapy”). However, in other diseases, it would be beneficial to do the opposite, namely to increase the activity of VEGFs. For example, VEGF-A could generate new blood vessels to protect from heart disease, and VEGF-C could generate new lymphatics to counteract lymphedema. Clinical trials that tried to stimulate blood vessel growth in ischemic diseases have been disappointing so far, and the first clinical trials targeting the lymphatic vasculature have progressed to phase II. Antiangiogenic drugs targeting VEGF-A such as bevacizumab or aflibercept neutralize the growth factor directly. However, since VEGF-C and VEGF-D are produced as inactive precursors, novel drugs against the lymphangiogenic VEGFs could also target the enzymatic activation of VEGF-C and VEGF-D. Because of the delicate balance between too much and too little vascular growth, a detailed understanding of the activation of the VEGF-C and VEGF-D is needed before such concepts can be converted into safe and efficacious therapies.
  • 3.4K
  • 30 Mar 2021
Topic Review
Health-Promoting Beverages
Tea, a beverage made from the processed leaves of the tea plant, Camellia sinensis, and herbal infusions, were primarily consumed to their pleasant taste. Nowadays, are also consumed due to the existence of nutraceutical compounds in the herbs used, such as polyphenols.
  • 3.3K
  • 30 Oct 2020
Topic Review
Transgender Hormone Therapy (Male-to-female)
Transgender hormone therapy of the male-to-female (MTF) type, also known as transfeminine hormone therapy, is hormone therapy and sex reassignment therapy to change the secondary sexual characteristics of transgender people from masculine or androgynous to feminine. It is one of two types of transgender hormone therapy (the other being female-to-male) and is predominantly used to treat transgender women and other transfeminine individuals. Some intersex people also take this form of therapy, according to their personal needs and preferences. The purpose of the therapy is to cause the development of the secondary sex characteristics of the desired sex, such as breasts and a feminine pattern of hair, fat, and muscle distribution. It cannot undo many of the changes produced by naturally occurring puberty, which may necessitate surgery and other treatments to reverse (see below). The medications used for the MTF therapy include estrogens, antiandrogens, progestogens, and gonadotropin-releasing hormone modulators (GnRH modulators). While the therapy cannot undo the effects of a person's first puberty, developing secondary sex characteristics associated with a different gender has been shown to relieve some or all of the distress and discomfort associated with gender dysphoria, and can help the person to "pass" or be seen as the gender they identify with. Introducing exogenous hormones into the body impacts it at every level and many patients report changes in energy levels, mood, appetite, etc. The goal of the therapy is to provide patients with a more satisfying body that is more congruent with their gender identity.
  • 3.3K
  • 06 Oct 2022
Topic Review
Scopophobia
Scopophobia, scoptophobia, or ophthalmophobia is an anxiety disorder characterized by a morbid fear of being seen in public or stared at by others. Similar phobias include erythrophobia, the fear of blushing, and an epileptic's fear of being looked at, which may itself precipitate such an attack. Scopophobia is also commonly associated with schizophrenia and other psychiatric disorders. Often scopophobia will result in symptoms common with other anxiety disorders. Scopophobia is unique among phobias in that the fear of being looked at is considered both a social phobia and a specific phobia.
  • 3.3K
  • 10 Oct 2022
Topic Review
Will
Will, generally, is a faculty of the mind - within philosophy, will is important as one of the parts of the mind, along with reason and understanding. It is considered central to the field of ethics because of its role in enabling deliberate action. One of the recurring questions discussed in the Western philosophical tradition is that of free will - and the related, but more general notion of fate - which asks how the will can be truly free if a person's actions have either natural or divine causes which determine them. In turn, this is directly connected to discussions on the nature of freedom and to the problem of evil.
  • 3.3K
  • 11 Oct 2022
Topic Review
Histopathology of Colorectal Carcinoma
The histopathology of colorectal carcinoma involves analysis of tissue taken from a biopsy or surgery. A pathology report contains a description of the microscopical characteristics of the tumor tissue, including both tumor cells and how the tumor invades into healthy tissues and finally if the tumor appears to be completely removed. The most common form of colon cancer is adenocarcinoma, constituting between 95% to 98% of all cases of colorectal cancer. Other, rarer types include lymphoma, adenosquamous and squamous cell carcinoma. Some subtypes have been found to be more aggressive.
  • 3.2K
  • 09 Nov 2022
Topic Review
Self-Amplifying mRNA Vaccine
The core principle behind mRNA vaccines is to encode the antigen in the mRNA and then to deliver the transcript to the host cell cytoplasm using a non-viral delivery system, allowing antigen expression and induction of an antigen-specific immune response. Self-amplifying RNA (saRNA) is a type of mRNA that also encodes viral replicase, which enables the RNA to self-replicate upon delivery into the cell.
  • 3.2K
  • 13 Feb 2021
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