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Topic Review
Microbial Reprogramming in Obsessive–Compulsive Disorders
Obsessive–compulsive disorder (OCD) is a debilitating mental health disorder characterized by intrusive thoughts (obsessions) and repetitive behaviors (compulsions). Dysbiosis, an imbalance in the gut microbial composition, has been associated with various health conditions, including mental health disorders, autism, and inflammatory diseases. While the exact mechanisms underlying OCD remain unclear, researchers present a growing body of evidence suggesting a potential link between dysbiosis and the multifaceted etiology of OCD, interacting with genetic, neurobiological, immunological, and environmental factors.
  • 1.2K
  • 24 Aug 2023
Topic Review
Aeromonas spp.
Aeromonas a Gram-negative bacillus, positive for oxidase and catalase tests, a glucose fermenter, and it is resistant to vibriostatic O/129 (2,4-diamino-6,7-diisopropylpteridine). In humans, it can cause intestinal and extra-intestinal infections. It is important in the medical area, mainly in patients with diarrhea, or with infections in the skin and soft tissue; moreover, it can cause bacteremia, which progresses to sepsis, or endocarditis.
  • 1.2K
  • 26 Jun 2021
Topic Review
Antibiofilm Therapeutics Strategies to Overcome Antimicrobial Drug Resistance
Biofilms embrace the capability to resist and survive harsh environmental conditions and defeat the host immune system, so there is a desire for exploring new antibiofilm agents. Antibiofilm agents that can abet the process of dismantling the biofilm has provided research strategies for designing new biofilm dispersal inducers.
  • 1.2K
  • 10 Mar 2022
Topic Review
Post-Translational Modifications of Proliferating Cell Nuclear Antigen
The sliding clamp proliferating cell nuclear antigen (PCNA) is a multifunctional homotrimer mainly linked to DNA replication. During this process, cells must ensure an accurate and complete genome replication when constantly challenged by the presence of DNA lesions. Post-translational modifications of PCNA play a crucial role in channeling DNA damage tolerance (DDT) and repair mechanisms to bypass unrepaired lesions and promote optimal fork replication restart. PCNA ubiquitination processes trigger the following two main DDT sub-pathways: Rad6/Rad18-dependent PCNA monoubiquitination and Ubc13-Mms2/Rad5-mediated PCNA polyubiquitination, promoting error-prone translation synthesis (TLS) or error-free template switch (TS) pathways, respectively. However, the fork protection mechanism leading to TS during fork reversal is still poorly understood. In contrast, PCNA sumoylation impedes the homologous recombination (HR)-mediated salvage recombination (SR) repair pathway. 
  • 1.2K
  • 01 Sep 2022
Topic Review
Human Trimethylamine N-Oxide-Associated Diseases
Trimethylamine N-oxide (TMAO) is a metabolite produced by the gut microbiota and has been mainly associated with an increased incidence of cardiovascular diseases (CVDs) in humans. TMAO is a biomolecule capable of providing relevant information on the metabolic and immunological state of the human body. Having been linked to the pathogenesis and progression of several diseases, it could be a potential biomarker for diagnosis, prognosis, and therapeutic intervention.
  • 1.2K
  • 14 Feb 2023
Topic Review
Heme-Copper Oxidases with Nitrite and Nitric Oxide
Nitrite and nitric oxide (NO), two active and critical nitrogen oxides linking nitrate to dinitrogen gas in the broad nitrogen biogeochemical cycle, are capable of interacting with redox-sensitive proteins. The interactions of both with heme-copper oxidases (HCOs) serve as the foundation not only for the enzymatic interconversion of nitrogen oxides but also for the inhibitory activity.
  • 1.2K
  • 26 Jan 2022
Topic Review
Co-Inoculation of three species
The adoption of multi-species starter cultures is highly considered in modern winemaking to enhance the complexity and wine attributes. However, the valuation of strains compatibility at the industrial-scale is essential to guarantee the quality and the safety during the process. This concept is particularly important when the starter is composed of non-Saccharomyces, Saccharomyces spp. and malolactic bacteria, three organisms with dissimilar biological properties and oenological implication.
  • 1.2K
  • 28 Oct 2020
Topic Review
Carbapenem-Resistant Enterobacterales
Improper use of antimicrobials has resulted in the emergence of antimicrobial resistance (AMR), including multi-drug resistance (MDR) among bacteria. Recently, a sudden increase in Carbapenem-resistant Enterobacterales (CRE) has been observed. This presents a substantial challenge in the treatment of CRE-infected individuals. Bacterial plasmids include the genes for carbapenem resistance, which can also spread to other bacteria to make them resistant. The incidence of CRE is rising significantly despite the efforts of health authorities, clinicians, and scientists. Many genotypic and phenotypic techniques are available to identify CRE. However, effective identification requires the integration of two or more methods. Whole genome sequencing (WGS), an advanced molecular approach, helps identify new strains of CRE and screening of the patient population; however, WGS is challenging to apply in clinical settings due to the complexity and high expense involved with this technique.
  • 1.2K
  • 29 Nov 2022
Topic Review
Viral Enteritis in Cattle
Livestock products supply about 13 percent of energy and 28 percent of protein in diets consumed worldwide. Diarrhea is a leading cause of sickness and death of beef and dairy calves in their first month of life and also affecting adult cattle, resulting in large economic losses and a negative impact on animal welfare. Despite the usual multifactorial origin, viruses are generally involved, being among the most important causes of diarrhea. There are several viruses that have been confirmed as etiological agents (i.e., rotavirus and coronavirus), and some viruses that are not yet confirmed as etiological agents. 
  • 1.2K
  • 03 Sep 2021
Topic Review
General Overview of Klebsiella pneumonia
The opportunistic pathogen Klebsiella pneumoniae (K. pneumoniae) can colonize mucosal surfaces and spread from mucosae to other tissues, causing fatal infections. Medical equipment and the healthcare setting can become colonized by Klebsiella species, which are widely distributed in nature and can be found in water, soil, and animals. Moreover, a substantial number of community-acquired illnesses are also caused by this organism worldwide. These infections are characterized by a high rate of morbidity and mortality as well as the capacity to spread metastatically. Hypervirulent Klebsiella strains are thought to be connected to these infections. Four components are critical to this bacterium’s pathogenicity—the capsule, lipopolysaccharide, fimbriae, and siderophores. 
  • 1.2K
  • 01 Feb 2024
Topic Review
Bacteriophage-Mediated Control of Phytopathogenic Xanthomonads
Xanthomonads, members of the family Xanthomonadaceae, are economically important plant pathogenic bacteria responsible for infections of over 400 plant species. Bacteriophage-based biopesticides can provide an environmentally friendly, effective solution to control these bacteria. Bacteriophage-based biocontrol has important advantages over chemical pesticides, and treatment with these biopesticides is a minor intervention into the microflora. However, bacteriophages’ agricultural application has limitations rooted in these viruses’ biological properties as active substances. These disadvantageous features, together with the complicated registration process of bacteriophage-based biopesticides, means that there are few products available on the market. 
  • 1.2K
  • 04 Aug 2021
Topic Review
Thermotogae
The Thermotogae are a phylum of the domain Bacteria. The phylum Thermotogae is composed of Gram-negative staining, anaerobic, and mostly thermophilic and hyperthermophilic bacteria.
  • 1.2K
  • 28 Sep 2022
Topic Review
Microorganisms Improve Barley Salt Tolerance
As the global human population continues to increase, the use of saline–alkali land for food production is an important consideration for food security. In addition to breeding or cultivating salt-tolerant crop varieties, microorganisms are increasingly being evaluated for their ability to improve plant salt tolerance. Barley is one of the most important and salt-tolerant cereal crops and is a model system for investigating the roles of microorganisms in improving plant salt tolerance. 
  • 1.2K
  • 27 Dec 2023
Topic Review
Starvation-Induced Autophagy in Saccharomyces cerevisiae in Metabolomics Perspectives
The application of metabolomics has extended the scope of autophagy and provided newer intervention targets against cancer as well as neurodegenerative diseases in which autophagy is implicated. 
  • 1.2K
  • 02 Dec 2021
Topic Review
MDR Pumps as Crossroads of Resistance
The development of new antibiotics is either very expensive or ineffective due to rapidly developing bacterial resistance. The need to develop alternative approaches to the treatment of bacterial infections, such as phage therapy, is beyond doubt. The cornerstone of bacterial defense against antibiotics are multidrug resistance (MDR) pumps, which are involved in antibiotic resistance, toxin export, biofilm, and persister cell formation. MDR pumps are the primary non-specific defense of bacteria against antibiotics, while drug target modification, drug inactivation, target switching, and target sequestration are the second, specific line of their defense. All bacteria have MDR pumps, and bacteriophages have evolved along with them and use the bacteria’s need for MDR pumps to bind and penetrate into bacterial cells. 
  • 1.2K
  • 14 Jun 2022
Topic Review
Abyssomicins
Abyssomicins represent a new family of polycyclic macrolactones. The first described compounds of the abyssomicin family were abyssomicin B, C, atrop-C, and D, produced by the marine actinomycete strain Verrucosispora maris AB-18-032, which was isolated from a sediment collected in the Sea of Japan. Among the described abyssomicins, only abyssomicin C and atrop-abyssomicin C show a high antibiotic activity against Gram-positive bacteria, including multi-resistant and vancomycin-resistant strains. The inhibitory activity is caused by a selective inhibition of the enzyme 4-amino-4-deoxychorismate synthase, which catalyzes the transformation of chorismate to para-aminobenzoic acid, an intermediate in the folic acid pathway.
  • 1.2K
  • 04 Jun 2021
Topic Review
Borreliaceae Diagnostics
The acceleration of climate change has been associated with an alarming increase in the prevalence and geographic range of tick-borne diseases (TBD), many of which have severe and long-lasting effects—particularly when treatment is delayed principally due to inadequate diagnostics and lack of physician suspicion. Moreover, there is a paucity of treatment options for many TBDs that are complicated by diagnostic limitations for correctly identifying the offending pathogens. 
  • 1.2K
  • 30 Sep 2022
Topic Review
Bacteriocins
Las bacteriocinas son péptidos antimicrobianos termoestables, sintetizados ribosómicamente. Tanto las bacterias grampositivas como las gramnegativas y las arqueas liberan péptidos antimicrobianos extracelularmente en las fases de crecimiento exponencial tardía a estacionaria temprana.
  • 1.2K
  • 29 Apr 2021
Topic Review
Staphylococcus aureus Internalization
Bacterial internalization is a strategy that non-intracellular microorganisms use to escape the host immune system and survive inside the human body.
  • 1.2K
  • 05 Jul 2021
Topic Review
RNA Structure and RNA–RNA Interactions
Complex RNA–RNA interactions are increasingly known to play key roles in numerous biological processes from gene expression control to ribonucleoprotein granule formation. By contrast, the nature of these interactions and characteristics of their interfaces, especially those that involve partially or wholly structured RNAs, remain elusive. This entry describes different modalities of RNA–RNA interactions with an emphasis on those that depend on secondary, tertiary, or quaternary structure, and highlight a two-way relationship between RNA structure and interactions.
  • 1.2K
  • 12 Jan 2022
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