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Topic Review
Summaries of Product Characteristics
The Summary of Product Characteristics (SmPC) is a legal document, is one of the obligatory elements of the registration dossier of a medication, and is necessary to issue a marketing authorization for a medicinal product. The obligation to draw up a Summary of Product Characteristics is laid down in several European Parliament laws. The first documents were Directive 2001/83/EC of the European Parliament and the Council relating to medicinal products for human use, and Regulation 726/2004. The document was amended several times and finally replaced in 2004 by Directive 2004/27/EC.
  • 3.4K
  • 07 Mar 2022
Topic Review
Terpenes and Terpenoids for Bioplastics
This entry describes the most common types of bioplastics and biopolymers, and focuses specifically on the polymerization of terpenes and terpenoids, which represent a source of promising monomers to create bio-based polymers and copolymers.
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  • 25 Aug 2021
Topic Review
Mangiferin
Mangiferin is a naturally occurring C-glucosylxantone that has substantial potential for the treatment of various diseases. It possesses antioxidant, anti-infection, anti-cancer, anti-diabetic, cardiovascular, neuroprotective properties and it also increases immunity.
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  • 10 Jan 2022
Topic Review
Australian Modernism
Australian Modernism, similar to European and American Modernism was a social, political and cultural movement that was a reaction to rampant Industrialisation, associated moral panic of modernity and the death and trauma of the World Wars. This movement was predominately a reaction of female artists towards the male dominated art style of naturalism. It is also important to note the presence of Indigenous Art during this time of modernity. Indigenous Modernism refers to the unique experience of modernity of Aboriginal people that is vastly different to the White Australians experience of Modernity. The mainstream movement began in Australia approximately in 1914 and continued until 1948. Throughout these years tensions continued between the conservative and the Avant-garde schools of thought. The years following the Second World War is when Australian Modernism gained notability in the art world of Australia. Nationalistic pastoral painting of the Australian landscape were superseded by abstracted, colourful distorted images of Modernist works. After the World Wars the dynamics of society in Australia and overseas changed dramatically causing increased acceptance and attraction towards Modernism. Social and political unrest continued due to the devastation of war and increased immigration occurred. This caused a subsequent amount of European artists to travel to Australia to live. This contributed to the introduction of further art styles to Australia such as Surrealism, social realism and expressionism. Additionally, continued technological progress in the later 20th century contributed to an increase in cubism and print making. The first Indigenous Modernist or Modern Artist is said to be the Artists Albert Namatjira. He created art that aligned with the styles and techniques of western Modernism in Australia and Europe. It was not until the 1960s and 1970s that scholars began to call Indigenous Art Modern as there was a distinction made between Modern and Contemporary art to traditional Indigenous art. However, it is argued that all types of Indigenous Art is Modernist as it is all an aesthetic expression of Indigenous experiences of modernity.
  • 3.4K
  • 28 Sep 2022
Topic Review
Urban Land Management during 1979-2021
As the carrier of global urbanization, urban land is the basic means of productivity and life of urban residents. Urban land management is of great significance to global climate change mitigation, improving ecological quality, promoting economic development, and ensuring sustainable urban development. Although studies on urban land management have accumulated at the global level, the differences in research methods, objectives, and perspectives have led to the fragmentation and confusion of research conclusions. Combined with the annual change trend of scientific research output, urban land management research can be divided into three stages: the budding period, from 1979 to 1989, the development period, from 1990 to 2008, and the high-yield period, from 2009 to 2021. 
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  • 11 Nov 2022
Topic Review
Pisces
Pisces, the Latin term for "fishes," is a sprawling constellation in the northern celestial hemisphere, representing two fish tied together by a cord. Positioned between Aquarius and Aries along the ecliptic, Pisces is rich in mythology and serves as a prominent fixture in both ancient and modern astronomy.
  • 3.4K
  • 15 Mar 2024
Topic Review
Analysis of Minimum Inhibitory Concentrations
In response to the threat presented by AMR, it is critically important to find methods for effectively interpreting minimum inhibitory concentration (MIC) tests. A wide array of techniques for analysis of MIC data exist, which require different ways of modifying the MIC data for use as the dependent variable in regression and analysis. For use as the outcome in logistic regression, MIC data is categorized using clinical breakpoints and epidemiological cutoff values (ECOFF). Clinical breakpoints classify isolates as susceptible (S), resistant (R), or an intermediate category based on expected clinical outcomes of treatment with a specific antimicrobial. The ECOFF classifies organisms as wild type (WT) or non-wild type (non-WT)  based on the absence or presence of phenotypically-detectable acquired resistance mechanisms to the specific antimicrobial. Dichotomization of MIC data results in information loss, as only changes in the proportions of WT/non-WT or S/R are observed in dichotomized data. As a result, changes in MIC distributions that do not cross the threshold may be unobserved using approaches with dichotomized outcomes. Other modeling approaches for MIC data may attempt to avoid information loss by not dichotomizing the outcome when using regression to analyze MIC data.
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  • 02 Sep 2020
Topic Review
Extraction Functional Ingredients from Jackfruit
Various studies in the literature showed the effect of conventional and non-conventional extraction methods to obtain jackfruit functional ingredients; among the non-conventional methods, some use emerging technologies to extract or as a pre-treatment. Among the studies using conventional extraction, applying solvents such as methanoland oxalic acidstands out, as well as the extraction with hot water. Regarding extraction by emerging technologies, radio frequency-assistedand supercritical fluid (SFE) with CO2extractions have attracted attention owing to their less negative impact on the environment and safety of the final product obtained in comparison with other methods using non-conventional technologies.
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  • 26 Aug 2021
Topic Review
Nonaqueous Titration
Nonaqueous titration is the titration of substances dissolved in solvents other than water. It is the most common titrimetric procedure used in pharmacopoeial assays and serves a double purpose: it is suitable for the titration of very weak acids and very weak bases, and it provides a solvent in which organic compounds are soluble. The most commonly used procedure is the titration of organic bases with perchloric acid in anhydrous acetic acid. These assays sometimes take some perfecting in terms of being able to judge the endpoint precisely. The Karl Fischer titration for water content is another nonaqueous titration, usually done in methanol or sometimes in ethanol. Since water is the analyte in this method, it cannot also be used as the solvent.
  • 3.4K
  • 14 Oct 2022
Topic Review
Classical Plant Breeding
Classical plant breeding uses deliberate interbreeding (crossing) of closely or distantly related species to produce new crops with desirable properties. Plants are crossed to introduce traits/genes from a particular variety into a new genetic background. For example, a mildew resistant pea may be crossed with a high-yielding but susceptible pea, the goal of the cross being to introduce mildew resistance without losing the high-yield characteristics. Progeny from the cross would then be crossed with the high-yielding parent to ensure that the progeny were most like the high-yielding parent, (backcrossing), the progeny from that cross would be tested for yield and mildew resistance and high-yielding resistant plants would be further developed. Plants may also be crossed with themselves to produce inbred varieties for breeding. Germplasm resources from genebanks have invaluable for classical breeding. Classical breeding relies heavily on the naturally occuring plant life-cycle and homologous recombination to generate genetic diversity and to eliminate undesirable traits. It may also makes use of a variety of artificial laboratory procedures to overcome obstacles to introduction of useful traits from wild species that do not usually exchange genes with the domesticated line. These approaches include in vitro techniques such as protoplast fusion, embryo rescue or mutagenisis (see below) to generate genetic alterations and produce transgenic plants that would not exist in nature. Traits that breeders' have tried to incorporate into crop plants in the last 100 years include: Intraspecific hybridization within a plant species was demonstrated by Charles Darwin and Gregor Mendel, and was further developed by geneticists and plant breeders. In the early 20th century, plant breeders realized that Mendel's findings on the non-random nature of inheritance could be applied to seedling populations produced through deliberate pollinations to predict the frequencies of different types. In 1908, George Harrison Shull described heterosis, also known as hybrid vigor. Heterosis describes the tendency of the progeny of a specific cross to outperform both parents. The detection of the usefulness of heterosis for plant breeding has lead to the development of inbred lines that reveal a heterotic yield advantage when they are crossed. Maize was the first species where heterosis was widely used to produce hybrids. Heterosis made breeders aware of the broad practical value of many genes carried in plant chromosomes even when the identity and trait specified by the paticular genes is unknown - that is that diverse plant Germplasm is generally valuable to the breeder. By the 1920s, statistical methods were developed to analyze gene action and distinguish heritable variation from variation caused by environment. In 1933, another important breeding technique, cytoplasmic male sterility (CMS), developed in maize, was described by Marcus Morton Rhoades. CMS is a maternally inherited trait that makes the plant produce sterile pollen, enabling the production of hybrids and removing the need for detasseling maize plants. The scientific use of Transgenic plants in farming gained impetus in the 1930s when a transgenic wheat variety named Hope bred by E. S. McFadden with a transgene originating in a wild grass saved American wheat growers from devastating stem rust outbreaks. These early breeding techniques resulted in large yield increase in the United States in the early 20th century. Similar yield increases were not produced elsewhere until after World War II, the Green Revolution increased crop production in the developing world in the 1960s. Success stories like Hope and hybrid-vigor made it clear that genetic divesity present in wild-species was of great potential value to plant breeders, and eventially lead to the establisment of Germplasm collections consisting of seed-banks devoted to preservation of potentially useful uncharacterised traits for posterity. Following World War II a number of techniques were developed that allowed plant breeders to hybridize distantly related species, and artificially induce genetic diversity. When distantly related species are crossed, plant breeders make use of a number of plant tissue culture techniques to produce progeny from other wise fruitless mating. Interspecific and intergeneric hybrids are produced from a cross of related species or genera that do not normally sexually reproduce with each other. These crosses are referred to as Wide crosses. The cereal triticale is a wheat and rye hybrid. The first generation created from the cross was sterile, so the cell division inhibitor colchicine was used to double the number of chromosomes in the cell. Cells with an uneven number of chromosomes are sterile. Failure to produce a hybrid may be due to pre- or post-fertilization incompatibility. If fertilization is possible between two species or genera, the hybrid embryo may abort before maturation. If this does occur the embryo resulting from an interspecific or intergeneric cross can sometimes be rescued and cultured to produce a whole plant. Such a method is referred to as Embryo Rescue. This technique has been used to produce new rice for Africa, an interspecific cross of Asian rice (Oryza sativa) and African rice (Oryza glaberrima). Hybrids may also be produced by a technique called protoplast fusion. In this case protoplasts are fused, usually in an electric field. Viable recombinants can be regenerated in culture. Chemical mutagens like EMS and DMSO, radiation and transposons are used to generate mutants with desirable traits to be bred with other cultivars. Classical plant breeders also generate genetic diversity within a species by exploiting a process called somaclonal variation, which occurs in plants produced from tissue culture, particularly plants derived from callus. Induced polyploidy, and the addition or removal of chromosomes using a technique called chromosome engineering also found uses. When a desirable trait has been bred into a species, a number of crosses to the favoured parent are made to make the new plant as similar as the parent as possible. Returning to the example of the mildew resistant pea being crossed with a high-yielding but susceptible pea, to make the mildew resistant progeny of the cross most like the high-yielding parent, the progeny will be crossed back to that parent for several generations (See backcrossing ). This process removes most of the genetic contribution of the mildew resistant parent. Classical breeding is therefore a cyclical process. It should be noted that with classical breeding techniques, the breeder does not know exactly what genes have been introduced to the new cultivars. Some scientists therefore argue that plants produced by classical breeding methods should undergo the same safety testing regime as genetically modified plants. There have been instances where plants bred using classical techniques have been unsuitable for human consumption, for example the poison solanine was accidentally re-introduced into varieties of potato through plant breeding.
  • 3.4K
  • 14 Oct 2022
Topic Review
Grandiosity
In the field of psychology, the term grandiosity refers to an unrealistic sense of superiority, characterized by a sustained view of one's self as better than others, which is expressed by disdainfully criticising them, overinflating one's own capability and belittling them as inferior; and refers to a sense of personal uniqueness, the belief that few other people have anything in common with oneself, and that one can only be understood by a few, very special people. The personality trait of grandiosity is principally associated with narcissistic personality disorder (NPD), but also is a feature in the occurrence and expression of antisocial personality disorder, and the manic and hypomanic episodes of bipolar disorder.
  • 3.4K
  • 25 Nov 2022
Topic Review
The Use of Green Laser in LiDAR Bathymetry
Bathymetric LiDAR technology is a technology used for simultaneous data acquisition regarding the morphology of the bottom of water reservoirs and the surrounding coastal zone, realized from the air, e.g., by plane or drone. Contrary to the air topographic LiDAR, which uses an infrared wavelength of 1064 nm, bathymetric LiDAR systems additionally use a green wavelength of 532 nm. The green laser can penetrate the water, which makes it possible to measure the depth of shallow water reservoirs, rivers, and coastal sea waters within three Secchi depths.
  • 3.4K
  • 13 Jan 2023
Topic Review
Dan Role
Dan is the general name for female roles in Chinese opera, often referring to leading roles. They may be played by male or female actors. In the early years of Peking opera, all dan roles were played by men, but this practice is no longer common in any Chinese opera genre.
  • 3.4K
  • 21 Oct 2022
Topic Review
Cassava Value Chain in Thailand
Population growth and urbanization in Thailand has generated negative environmental externalities and the underuse of agricultural materials. Plastics from cassava present an alternative that helps reduce the use of non-biodegradable petroleum-based plastics and can reshape a sustainable cassava value chain. The development of cassava-based bioplastic not only positively contributes to economic aspects but also generates beneficial long-term impacts on social and environmental aspects. Considering cassava supply, bioplastic production, and potential consumer acceptance, the development of bioplastics from cassava in Thailand faces several barriers and is growing slowly, but is needed to drive the sustainable cassava value chain.
  • 3.4K
  • 26 Oct 2023
Topic Review
Virtual Reality for Rehabilitation
Virtual reality (VR) is a trending, widely accessible, contemporary technology of increasing utility to biomedical and health applications. VR is the technological experience that allows for a full immersion in virtual spaces with which you can interact via specific wearable or using only your hand. A key feature of all VR applications is interaction. VR ranges from non-immersive to fully immersive, depending on the degree to which the user is isolated from the physical surroundings when interacting with the virtual environment. Non-immersive virtual reality allows for interacting with the environment through mouse or joystick; immersive virtual reality, instead, uses tools that are connected to the human body in order to perform the same motor task. Despite the growing evidence of the positive effects of VR in rehabilitation of functional and cognitive abilities, some systems still raised concerns regarding their acceptability with complex clinical populations, as, for example, the older people. In particular, during trials with immersive systems, few adverse events have been described by participants, including headache and dizziness. Finally, little is known about the perceived effect of the exposure at multisensory input during a complex activity, such as treadmill walking with VR in patients during post-stroke rehabilitation to improve balance and gait ability.
  • 3.4K
  • 30 Jul 2020
Topic Review
Evolution of Domestic Goats
Goat evolution is the process by which domestic goats came to exist through evolution by natural selection. Wild goats — medium-sized mammals which are found in noticeably harsh environments, particularly forests and mountains, in the Middle East and Central Asia — were one of the first species domesticated by modern humans, with the date of domestication generally considered to be 8,000 BCE. Goats are part of the family Bovidae, a broad and populous group which includes a variety of ruminants such as bison, cows and sheep. Bovids all share many traits, such as hooves and a herbivorous diet and all males, along with many females, have horns. Bovids began to diverge from deer and giraffids during the early Miocene epoch. The subfamily Caprinae, which includes goats, ibex and sheep, are considered to have diverged from the rest of Bovidae as early as the late Miocene, with the group reaching its greatest diversity in the ice ages. The tribe Caprini would subsequently develop from Caprids who arrived in the mountainous areas of Eurasia and split into goats and sheep in response to a further geographic separation. The ancestors of sheep remained in the foothills and the ancestors of goats went to higher altitudes. This divergence resulted in the adaption of the ancestors of goats to a mountainous environment, producing many of the traits considered peculiar to the species. During the ice ages a genus called Capri evolved which would then diverge into the modern goat species, along with several species of ibex. It is commonly held that the earliest domestication was of the bezoar ibex in the Zagros Mountains. These earliest domesticated goats were used to produce meat and milk for Neolithic farmers, along with providing many of the materials required to built residences and tools. Following the domestication of goats over 300 breeds have been established for a variety of purposes, including for the maximation of milk production and for meat. Domestication and the selective breeding which resulted had a significant effect on the direction of goat evolution, with goats developing behaviour which is considered to have been influenced by consistent proximity to humans. Selective breeding also significantly increased the physical diversity of modern goats, producing characteristics not seen in wild goats.
  • 3.4K
  • 08 Oct 2023
Topic Review
Virtual Currency
Virtual currency, or virtual money, is a type of unregulated, digital money, which is issued and usually controlled by its developers and used and accepted among the members of a specific virtual community. The U.S. Commodity Futures Trading Commission has warned investors against pump and dump schemes that use virtual currencies. The Financial Crimes Enforcement Network (FinCEN), a bureau of the US Treasury, defined virtual currency in its guidance published in 2013. In 2014, the European Banking Authority defined virtual currency as "a digital representation of value that is neither issued by a central bank or a public authority, nor necessarily attached to a fiat currency, but is accepted by natural or legal persons as a means of payment and can be transferred, stored or traded electronically". By contrast, a digital currency that is issued by a central bank is defined as "central bank digital currency".
  • 3.4K
  • 20 Oct 2022
Topic Review
Root Name Server
A root name server is a name server for the root zone of the Domain Name System (DNS) of the Internet. It directly answers requests for records in the root zone and answers other requests by returning a list of the authoritative name servers for the appropriate top-level domain (TLD). The root name servers are a critical part of the Internet infrastructure because they are the first step in translating (resolving) human readable host names into IP addresses that are used in communication between Internet hosts. A combination of limits in the DNS and certain protocols, namely the practical size of unfragmented User Datagram Protocol (UDP) packets, resulted in a decision to limit the number of root servers to thirteen server addresses. The use of anycast addressing permits the actual number of root server instances to be much larger, and is 1,086 (As of July 2020).
  • 3.4K
  • 03 Nov 2022
Topic Review
Kodi
Kodi (formerly XBMC) is a free and open-source media player software application developed by the XBMC Foundation, a non-profit technology consortium. Kodi is available for multiple operating systems and hardware platforms, with a software 10-foot user interface for use with televisions and remote controls. It allows users to play and view most streaming media, such as videos, music, podcasts, and videos from the Internet, as well as all common digital media files from local and network storage media. It is a multi-platform home-theater PC (HTPC) application. Kodi is customizable: skins can change its appearance, and plug-ins allow users to access streaming media content via online services such as Amazon Prime Instant Video, Crackle, Pandora Internet Radio, Rhapsody, Spotify, and YouTube. The later versions also have a personal video-recorder (PVR) graphical front end for receiving live television with electronic program guide (EPG) and high-definition digital video recorder (DVR) support. The software was created in 2002 as an independently developed homebrew media player application named Xbox Media Player for the first-generation Xbox game console, changing its name in 2004 to Xbox Media Center (abbreviated as XBMC, which was adopted as the official name in 2008) and was later made available under the name XBMC as a native application for Android, Linux, BSD, macOS, iOS/tvOS, and Microsoft Windows-based operating systems. Because of its open source and cross-platform nature, with its core code written in C++, modified versions of Kodi-XBMC together with JeOS have been used as a software appliance suite or software framework in a variety of devices, including smart TVs, set-top boxes, digital signage, hotel television systems, network connected media players and embedded systems based on armhf platforms like Raspberry Pi. Derivative applications such as MediaPortal and Plex have been spun off from XBMC or Kodi, as well as just enough operating systems like LibreELEC. Kodi has attracted negative attention due to the availability of third-party plug-ins for the software that facilitate unauthorized access to copyrighted media content, as well as "fully loaded" digital media players that are pre-loaded with such add-ons; The XBMC Foundation has not endorsed any of these uses, and has taken steps to disassociate the Kodi project from these add-ons, including threatening legal action against those using its trademarks to promote them.
  • 3.4K
  • 10 Oct 2022
Topic Review
Anal Stenosis
Anal stenosis (AS) is defined as anatomical or functional narrowing of the anal canal, which can result from inflammatory bowel diseases, radiation therapy, congenital malformations, or excisional hemorrhoidectomy. The anatomical AS is related to the increased fibrous scar tissue forming, which disables stretching of the anal canal. The leading cause of the anatomical AS is excisional hemorrhoidectomy that is often the chosen treatment for grade III and IV hemorrhoidal disease.
  • 3.4K
  • 18 Apr 2022
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