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Topic Review
MicroRNA Processing by Dicer
MicroRNAs (miRNAs) are small non-coding RNAs that are about 22 nucleotides in length. They regulate gene expression post-transcriptionally with the effector protein complex, containing Argonaute or trinucleotide repeat containing 6 (TNRC6) proteins, and target mRNAs in a sequence-dependent manner, causing the translational repression and destabilization of the target mRNAs. Both Drosha and Dicer, members of the RNase III family proteins, are essential components in the canonical miRNA biogenesis pathway. miRNA is transcribed into primary-miRNA (pri-miRNA) from genomic DNA. Drosha then cleaves the flanking regions of pri-miRNA into precursor-miRNA (pre-miRNA), while Dicer cleaves the loop region of the pre-miRNA to form a miRNA duplex. In this report, we summarized and discussed the current reports in which double-stranded RNA binding proteins (dsRBPs), such as TAR RNA binding protein (TRBP) or the adenosine deaminase acting on RNA (ADAR), modulate the processing of miRNA by Dicer in various manners. 
  • 3.5K
  • 01 Oct 2021
Topic Review
Social Media Addiction
Social media addiction is a kind of psycho-social issues in the context of the increasing use of social media. What can be effective in reducing social media addiction, which causes social and economic problems, is an important issue today. It was determined that satisfaction with life had a mediation role in the effect of self-esteem and education level on social media addiction. Self-esteem and education level improved satisfaction with life, and increased satisfaction with life resulted in less social media addiction. These results demonstrate the importance of implementing specific practices based on self-esteem and education, especially for vulnerable groups, to minimize the problems that may arise with the excessive use of digital apps and social media.
  • 3.5K
  • 29 Sep 2021
Topic Review
Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting the joints. It is characterized by a progressive symmetric inflammation of affected joints resulting in cartilage destruction, bone erosion, and disability. In rheumatoid arthritis (RA) chronic autoimmune responses result in destruction of joints in affected patients. 
  • 3.5K
  • 01 Nov 2020
Topic Review
Fourier Transform Infrared (FTIR) Spectroscopy
Fourier transform infrared (FTIR) spectroscopy studies the interactions between matter and electromagnetic radiation that appear in the form of a spectrum, and has undergone significant development over the past decade, promising easier, rapid, and more objective diagnostics.
  • 3.5K
  • 14 Feb 2022
Topic Review
Diet Coke and Mentos Eruption
A Diet Coke and Mentos eruption (also known as a soda geyser) is a reaction between the carbonated beverage Diet Coke and Mentos mints that causes the beverage to spray out of its container. The candies catalyze the release of gas from the beverage, which creates an eruption that pushes most of the liquid up and out of the bottle. Lee Marek and "Marek's Kid Scientists" were the first to publicly demonstrate the experiment on the Late Show with David Letterman in 1999. Steve Spangler's televised demonstration of the eruption in 2005 became popular on YouTube, launching a chain of several other Diet Coke and Mentos experiment viral videos.
  • 3.5K
  • 07 Nov 2022
Topic Review
Panzer I Variants
The Panzerkampfwagen I (PzKpfW I) was a light tank produced in Germany in the 1930s. The Panzer I was built in several variants and was the basis for a number of variants listed below.
  • 3.5K
  • 31 Oct 2022
Topic Review
Wireless Sensor Networks Architecture
Wireless sensor networks (WSNs) have taken a giant leap in scale, expanding their applicability to a large variety of technological domains and applications, ranging from the Internet of things (IoT) for smart cities and smart homes to wearable technology healthcare applications, underwater, agricultural and environmental monitoring and many more. This expansion is rapidly growing every passing day in terms of the variety, heterogeneity and the number of devices which such applications support. Data collection is commonly the core application in WSN and IoT networks, which are typically composed of a large variety of devices, some constrained by their resources (e.g., processing, storage, energy) and some by highly diverse demands. Many challenges span all the conceptual communication layers, from the Physical to the Applicational. In addition, the integrated unit architecture and the platform design can be subject to various stringent constraints. For example, size requirements can impose a strict constraint on the device design; low power consumption, low production cost, and self-operation can represent additional constraints.  Accordingly, the device architecture is fundamental and affects many other factors in the system. For example, power supply affects the life span; it also affects transmission range, memory, and processing unit, which in turn can affect the algorithms that can be executed on the device, etc.
  • 3.5K
  • 12 Apr 2022
Topic Review
List of Ant Genera
Ants (family Formicidae in the order Hymenoptera) are the most species-rich of all social insects, with more than 12,000 described species and many others awaiting description. Formicidae is divided into 21 subfamilies, of which 17 are extant and four subfamilies are extinct, described from fossils. In total more than 300 genera have been described. Ants have come to occupy virtually all major terrestrial habitats, with the exception of tundra and cold ever-wet forests. They display a wide range of social behaviors, foraging habits and associations with other organisms, which has generated scientific and public interest. The following is a list of worldwide ant genera organised by subfamily.
  • 3.5K
  • 09 Nov 2022
Topic Review
IBMPFD
Inclusion body myopathy with early-onset Paget disease and frontotemporal dementia (IBMPFD) is a condition that can affect the muscles, bones, and brain.
  • 3.5K
  • 04 Jan 2021
Topic Review
Cultural Additivity
This entry provides the conceptual development of “cultural additivity.” It reviews the three most relevant concepts namely syncretism, cultural hybridity, and creolization, and then makes a case for the usefulness of “cultural additivity” in explaining the adoption and rejection of emerging cultural values. The newly introduced concept utilizes a well-developed theory called mindsponge theory.
  • 3.5K
  • 02 Sep 2022
Topic Review
Magnitude
In astronomy, magnitude is a unitless measure of the brightness of an object in a defined passband, often in the visible or infrared spectrum, but sometimes across all wavelengths. An imprecise but systematic determination of the magnitude of objects was introduced in ancient times by Hipparchus. The scale is logarithmic and defined such that a magnitude 1 star is exactly 100 times brighter than a magnitude 6 star. Thus each step of one magnitude is [math]\displaystyle{ \sqrt{100} \approx 2.512 }[/math] times brighter than the next faintest. The brighter an object appears, the lower the value of its magnitude, with the brightest objects reaching negative values. Astronomers use two different definitions of magnitude: apparent magnitude and absolute magnitude. The apparent magnitude (m) is the brightness of an object as it appears in the night sky from Earth. Apparent magnitude depends on an object's intrinsic luminosity, its distance, and the extinction reducing its brightness. The absolute magnitude (M) describes the intrinsic luminosity emitted by an object and is defined to be equal to the apparent magnitude that the object would have if it were placed at a certain distance from Earth, 10 parsecs for stars. A more complex definition of absolute magnitude is used for planets and small Solar System bodies, based on its brightness at one astronomical unit from the observer and the Sun. The Sun has an apparent magnitude of −27 and Sirius, the brightest visible star in the night sky, −1.46. Venus at its brightest is -5. The International Space Station (ISS) sometimes reaches a magnitude of −6.
  • 3.5K
  • 28 Sep 2022
Topic Review Peer Reviewed
Developing Emotional Intelligence
Daniel Goleman perceptively and accurately noted that emotional intelligence is critical to leadership success, claiming that emotional intelligence is far more important to leadership emergence and effectiveness than intellectual capacity. Goleman’s research later confirmed an 85% relationship between emotional intelligence and leader effectiveness. It may be the most critical area for current and aspiring leaders to develop. While leadership scholars accept the importance of emotional intelligence for leadership and the fact that emotional intelligence can be developed, there appears to be some uncertainty around how emotional intelligence can be developed. The authors shed light on that area and provide current and aspiring leaders with some proven strategies for developing the four predominant components of emotional intelligence. The importance of emotional intelligence to leadership is well documented, and leaders would be well served by working to heighten their levels of emotional intelligence and, in doing so, increase their leadership potential, efficacy, and impact.
  • 3.5K
  • 19 Mar 2024
Topic Review
Swyer Syndrome
Swyer syndrome is a condition that affects sexual development. Sexual development is usually determined by an individual's chromosomes; however, in Swyer syndrome, sexual development does not match the affected individual's chromosomal makeup.  
  • 3.5K
  • 23 Dec 2020
Topic Review
β-Ionone
β-Ionone is a natural plant volatile compound, and it is the 9,10 and 9′,10′ cleavage product of β-carotene by the carotenoid cleavage dioxygenase. β-Ionone is widely distributed in flowers, fruits, and vegetables. β-Ionone and other apocarotenoids comprise flavors, aromas, pigments, growth regulators, and defense compounds; serve as ecological cues; have roles as insect attractants or repellants, and have antibacterial and fungicidal properties. In recent years, β-ionone has also received increased attention from the biomedical community for its potential as an anticancer treatment and for other human health benefits. However, β-ionone is typically produced at relatively low levels in plants. Thus, expressing plant biosynthetic pathway genes in microbial hosts and engineering the metabolic pathway/host to increase metabolite production is an appealing alternative.
  • 3.5K
  • 26 Apr 2021
Topic Review
Fabrication of Organ-on-Chip
Organ-on-chips (OOCs) are microfluidic devices used for creating physiological organ biomimetic systems. OOC technology brings numerous advantages in the current landscape of preclinical models, capable of recapitulating the multicellular assemblage, tissue–tissue interaction, and replicating numerous human pathologies.
  • 3.5K
  • 26 Apr 2022
Biography
Ravi Shankar
Ravi Shankar (born 13 May 1956) is an Indian yoga guru,[1] a spiritual leader. He is frequently referred to as "Sri Sri" (honorific), Guru ji, or Gurudev.[2] From around the mid 1970s, he worked as an apprentice under Mahesh Yogi, the founder of Transcendental Meditation. In 1981, he split from the Transcendental Meditation (TM) and founded the Art of Living Foundation.[3] Ravi Shankar was bo
  • 3.5K
  • 30 Nov 2022
Topic Review
Imagined Interaction
Imagined interactions (IIs) are a type of social cognition and mental imagery grounded in symbolic interactionism in which individuals imagine conversations with significant others for a variety of purposes (Honeycutt, 2003; 2015). The research program was founded and created by James M. Honeycutt in 1987, who was designated an LSU Distinguished Professor in 2012. He provided a keynote address at the American Association for the Study of Mental Imagery at Yale University in 1987 discussing the functions of imagined interactions and mental imagery. In 2006, Honeycutt's book, "Imagined Interactions: Daydreaming about Communication" (2003), was awarded Distinguished Book of the Year by the National Communication Association for developing the original formulations and the II construct which has provided a beneficial mechanism for operationalizing the study of intrapersonal communication, social cognition, daydreaming, and mental imagery. Furthermore, imagined interactions can be used in sports imagery as athletes "imagine" positive outcomes of their executions on specific plays or formations (Keaton, Gearhart, & Honeycutt, 2014).
  • 3.5K
  • 15 Nov 2022
Topic Review
3D Printing in Organ-on-a-Chip Platforms
Three-dimensional (3D) in vitro models, such as organ-on-a-chip platforms, are an emerging and effective technology that allows the replication of the function of tissues and organs, bridging the gap amid the conventional models based on planar cell cultures or animals and the complex human system. Hence, they have been increasingly used for biomedical research, such as drug discovery and personalized healthcare. A promising strategy for their fabrication is 3D printing, a layer-by-layer fabrication process that allows the construction of complex 3D structures.
  • 3.5K
  • 21 May 2021
Topic Review Peer Reviewed
Gross Pathology in COVID-19
The global infectious disease COVID-19 is caused by SARS-CoV-2, a new member of the Coronaviridae family. Though presented as a novel disease that primarily affects the respiratory system, multi-organ involvement has been well-noticed and documented since the beginning of the pandemic. When performed properly with adequate safety measures, autopsy provides the most valuable information to decipher the pathogenesis of this novel disease, therefore providing a basis for clinical management. In addition to reviewing the macroscopic changes in organs and tissues involved in COVID-19, the relevant microscopic alterations and possible pathogenesis are also discussed.
  • 3.5K
  • 31 Oct 2022
Topic Review
FoxO1
FoxO1 is a conserved transcription factor involved in energy metabolism. It is tightly regulated by modifications on its mRNA and protein and responds to environmental nutrient signals. FoxO1 controls the transcription of downstream genes mediating metabolic regulation. Dysfunction of FoxO1 pathways results in several metabolic diseases, including diabetes, obesity, non-alcoholic fatty liver disease, and atherosclerosis.
  • 3.5K
  • 07 Jun 2021
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