Topic Review
Primary Health Care Approach in Liberia
The World Health Organization (WHO) defines health policy as decisions, plans, and actions that are undertaken to achieve specific health care goals within a society. Primary health care (PHC), a holistic approach to health, was proposed at Alma-Ata  and has been the guiding principle for the health system rebuilding of Liberia, a post-conflict, low-income country.
  • 2.0K
  • 18 Feb 2022
Topic Review
Quantum Dot-Based Lateral Flow Immunoassay
Point-of-care testing (POCT) technology has exhibited an outstanding capability for the detection of several disease biomarkers owing to the fact that such techniques are fast, easy to perform, efficient, and low cost. The lateral flow immunoassay (LFIA) is one such strategy for POCT. LFIA is a well-established platform and a potent assay for fast and inexpensive testing, as this technology is instrumentation independent and allows the visualisation of test results by the naked eye. In order to enhance the sensitivity and specificity of the LFIAs, as well as to allow the quantitation of results, fluorescence immunochromatographic assays have been developed by utilising fluorescent reporters. Fluorescence immunochromatographic assays have advantages over conventional approaches in regard to sensitivity as it produces a higher intensity band on the test and control lines. One such promising fluorescent reporter is quantum dots (QDs). QDs are tiny semiconducting nanocrystals with diameters ranging from 2 to 10 nanometers. QDs have unique electronic characteristics that are intermediate between those of bulk semiconductors and discrete molecules, which is due in part to their high surface-to-volume ratios. The most visible result is fluorescence, in which the nanocrystals emit distinct colours determined by particle size.
  • 2.0K
  • 19 Sep 2022
Topic Review
Summaries of Product Characteristics
The Summary of Product Characteristics (SmPC) is a legal document, is one of the obligatory elements of the registration dossier of a medication, and is necessary to issue a marketing authorization for a medicinal product. The obligation to draw up a Summary of Product Characteristics is laid down in several European Parliament laws. The first documents were Directive 2001/83/EC of the European Parliament and the Council relating to medicinal products for human use, and Regulation 726/2004. The document was amended several times and finally replaced in 2004 by Directive 2004/27/EC.
  • 1.9K
  • 07 Mar 2022
Topic Review
Amino Acids, B Vitamins, and Choline and ASD
Autism spectrum disorder (ASD) is a developmental disorder of variable severity, characterized by difficulties in social interaction, communication, and restricted or repetitive patterns of thought and behavior. In 2018, the incidence of ASD was 2.4 times higher than estimated in 2000. Through examining plasma profiles, urine samples, and dietary intake, researchers found that low choline, abnormal amino acid, and low B vitamin levels were present in children with ASD compared to those without ASD. 
  • 1.9K
  • 25 Jul 2022
Topic Review
Red Seaweed Pigments
Algae taxa are notably diverse regarding pigment diversity and composition, red seaweeds (Rhodophyta) being a valuable source of phycobiliproteins (phycoerythrins, phycocyanin, and allophycocyanin), carotenes (carotenoids and xanthophylls), and chlorophyll a. These pigments have a considerable biotechnological potential, which has been translated into several registered patents and commercial applications. 
  • 1.9K
  • 20 Jan 2022
Topic Review
Carnitine in Mitochondrial Fatty Acid Transport and β-Oxidation
l-Carnitine is an amino acid derivative widely known for its involvement in the transport of long-chain fatty acids into the mitochondrial matrix, where fatty acid oxidation occurs. Moreover, l-Carnitine protects the cell from acyl-CoA accretion through the generation of acylcarnitines.
  • 1.9K
  • 11 Nov 2021
Topic Review
Glucose
Glucose is a major macronutrient and a vital homeostatic factor in the regulation of energy metabolism maintained in a narrow range of 4.4 to 6.1 mmol/L or about 1.0 g/L in the blood of healthy humans as measured in the fasting state. However, glucose per se is not the predominant component of mixed food, and its main source in the diet is poly- and oligosaccharides, which undergo enzymatic hydrolysis to monomers in the small intestine during luminal and membrane digestion. Depending on the food composition, the site of the gastrointestinal tract (GIT) and time of the day, the postprandial glucose concentrations in the GIT lumen can vary in a large range and can be several times higher than in the blood.
  • 1.9K
  • 14 Aug 2021
Topic Review
Side Effects of Microbial Transglutaminase
Microbial transglutaminase (mTG) is a heavily used food additive and its industrial transamidated complexes usage is rising rapidly.  It was classified as a processing aid and was granted the GRAS (generally recognized as safe) definition, thus escaping full and thorough toxic and safety evaluations. Despite the manufacturers claims, mTG or its cross-linked compounds are immunogenic, pathogenic, proinflammatory, allergenic and toxic, and pose a risk to public health. 
  • 1.9K
  • 26 Oct 2021
Topic Review
Thallium
Thallium, as a pharmaceutical cosmetic product, is applied for facial hair removal and fungal infections of the scalp. Thallium acetate is currently used as a catalyst in organic synthesis in the oxidation of olefins and hydrocarbons, and in epoxidation and polymerization reactions. Detection of Tl is a challenging task because its concentration in environmental samples may be at a nanogram per gram level or lower.
  • 1.8K
  • 23 Nov 2021
Topic Review
Long-Term Care Facilities in Brazil
This scoping review aimed to explore the characteristics, strengths, and gaps in research conducted in Brazilian long-term care facilities (LTCFs) for older adults. Electronic searches investigating the residents (≥60 years old), their families, and the LTCF workforce in Brazil were conducted in Medline, EMBASE, LILACS, and Google Scholar, within the timescale of 1999 to 2018, limited to English, Portuguese, or Spanish. The reference lists were hand searched for additional papers. The Mixed Methods Appraisal Tool (MMAT) was used for critical appraisal of evidence. Data were reported descriptively considering the study design, using content analysis: 327 studies were included (n = 159 quantitative non-randomized, n = 82 quantitative descriptive, n = 67 qualitative, n = 11 mixed methods, n = 6 randomized controlled trials, and n = 2 translation of assessment tools). Regardless of the study design, most were conducted in a single LTCF (45.8%), in urban locations (84.3%), and in non-profit settings (38.7%). The randomized trials and descriptive studies presented the lowest methodological quality based on the MMAT. This is the first review to provide an overview of research on LTCFs for older people in Brazil. It illustrates an excess of small-scale, predominantly qualitative papers, many of which are reported in ways that do not allow the quality of the work to be assured.
  • 1.8K
  • 28 Sep 2021
Topic Review
Neurogenic Inflammation
Migraine is a primary headache disorder characterized by a unilateral, throbbing, pulsing headache, which lasts for hours to days, and the pain can interfere with daily activities. It exhibits various symptoms, such as nausea, vomiting, sensitivity to light, sound, and odors, and physical activity consistently contributes to worsening pain. 
  • 1.8K
  • 28 Mar 2022
Topic Review
Pharmacologic and Clinical Considerations of Nalmefene
Nalmefene is a pure opioid antagonist structurally similar to naltrexone that can serve as an alternative antidote for reversing respiratory depression associated with acute opioid overdose. Nalmefene is also known as 6-methylene naltrexone. Its main features of interest are its prolonged duration of action that surpasses most opioids and its ability to serve as an antidote for acute opioid overdose.
  • 1.8K
  • 29 Mar 2022
Topic Review
Conceptual Framework on Telehealth Use
This paper leverages the Macro-Meso-Micro (three-layer) conceptual framework to characterize the factors influencing telehealth use within a medical specialty. Based on this framework,  three levels of factors, including, macro (societal or policy-level), meso (group or organizational-level), and micro (individual-level) factors can help to explain behavior, e.g., telehealth use within a medical specialty.  
  • 1.8K
  • 03 Jun 2021
Topic Review
Smartphone Addiction and Associated Health Outcomes
Smartphone addiction (SA) is generally conceptualized as a behavioral addiction including mood tolerance, salience, withdrawal, modification, conflict, and relapse. Literature suggests that there are associations between SA and mental health, physical health, and neurological problems. Furthermore, tolerance, salience, withdrawal, and cravingshave been associated with excessive smartphone use.
  • 1.8K
  • 09 Dec 2021
Topic Review
Animal Foods' Lactic Acid Bacteria
A variety of lactic acid bacteria (LAB) strains, which are either part of the autochthonous microbiota or introduced into animal products, have potential beneficial applications for the preservation of such products and/or for consumer health. Many foods obtained from fermented products of animal origin, such as meat, fish, and dairy, contain living microorganisms that are phylogenetically similar to probiotic LAB as part of the microbiota that directs their fermentation process and is responsible for their unique character. Fermented foods, such as cultured milk, yogurt, cheese, fermented sausage, and certain types of wine, are obtained through enzymatic reactions resulting from controlled microbial growth, in which the main microbial effectors comprise, primarily, LAB and their metabolites.
  • 1.8K
  • 17 Jan 2022
Topic Review
Inappropriate Patient Sexual Behavior in Physiotherapy
A behavior which is increasing in prevalence is sexual harassment initiated by a client and displayed towards the healthcare professionals and students of these healthcare-related professions. This is termed inappropriate patient sexual behaviour (IPSB). The consequences of IPSB can be significant, including decreased academic and work performance, decreased attention/concentration, reductions in work satisfaction, and a loss of confidence.
  • 1.7K
  • 27 Dec 2021
Topic Review
Comparison of Different Food Classification Systems
The technological developments and the rise in highly processed food availability have introduced the concept of ultra-processed food (UPF). Food classification systems based on processing are now a new basis for epidemiological research. Different results from these classifications might influence conclusions on the population’s consumption of UPF or its association with health outcomes.
  • 1.7K
  • 25 Feb 2022
Topic Review
International Retirement Migration
Retirement, which marks the end of one’s working career, is an important phase in an individual’s life.
  • 1.7K
  • 30 Nov 2021
Topic Review
Music and Obsessive-Compulsive Disorder
Obsessive-compulsive disorder (OCD) is a severe psychiatric disorder, which can be associated with music-related symptoms. Music may also be used as an adjunct treatment for OCD. Patients with OCD might benefit from music therapy, which includes listening to music.
  • 1.7K
  • 22 Nov 2021
Topic Review
Trauma-Related Internalizing and Externalizing Behaviors in Adolescence
The adolescent brain is an open window on the environment, which is vulnerable to perturbations and the traumatic experiences occurring before or during this period have an increased saliency in affecting cognitive, emotional, and social levels. During adolescence, trauma-related effects causing significant impairment or suffering could be manifest in internalizing and externalizing behaviors. 
  • 1.6K
  • 29 Sep 2022
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