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Topic Review
Cinema Therapy
Cinema therapy or movie therapy is a form of expressive therapy - like art, music and dance therapy - for medical and mental health issues. It is also used as a form of self-help. Cinema therapy was created and popularized by Dr. Gary Solomon, the first to write on using movies as therapy. The movement started to catch up again in 2019 with the featured documentary "Calypsonians" by director Anghelo Taylor, unlike the creation of Dr. Gary Solomon, Anghelo Taylor wrote the CinemaTherapy Manifesto, that starts with one simple principle "In order for cinema therapy truly exist the filmmaker must have an internal search, question or problem to solve inside himself but that relates with the rest of humanity or with specific community. Once the filmmaker and his crew engage in the process of filmmaking, they start healing by the revelation and situations that happen along the process of making a film. In the end, the result of that process will be a medicine for all the viewers as human beings. But everything starts with the deep intention that the filmmaker has when making the film"
  • 1.8K
  • 23 Nov 2022
Topic Review
Eye Movement Desensitization and Reprocessing
Eye movement desensitization and reprocessing (EMDR) is a form of psychotherapy in which the person being treated is asked to recall distressing images; the therapist then directs the patient in one type of bilateral stimulation, such as side-to-side eye rapid movement or hand tapping. EMDR was developed by Francine Shapiro starting in 1988. According to the 2013 World Health Organization (WHO) practice guideline: "This therapy [EMDR] is based on the idea that negative thoughts, feelings and behaviours are the result of unprocessed memories. The treatment involves standardized procedures that include focusing simultaneously on (a) spontaneous associations of traumatic images, thoughts, emotions and bodily sensations and (b) bilateral stimulation that is most commonly in the form of repeated eye movements." EMDR is included in several evidence-based guidelines for the treatment of post-traumatic stress disorder (PTSD), with varying levels of recommendation and evidence (very low to moderate per WHO stress guidelines). As of 2020, the American Psychological Association lists EMDR as an evidence-based treatment for PTSD but stresses that "the available evidence can be interpreted in several ways" and notes there is debate about the precise mechanism by which EMDR appears to relieve PTSD symptoms with some evidence EMDR may simply be a variety of exposure therapy. Even though EMDR is effective, critics call it a pseudoscience because only the desensitization component has scientific support.
  • 1.8K
  • 22 Nov 2022
Topic Review
Attachment Therapy
Attachment therapy (also called "the Evergreen model," "holding time," "rage-reduction," "compression therapy," "rebirthing," "corrective attachment therapy," and Coercive Restraint Therapy) is a pseudoscientific child mental health intervention intended to treat attachment disorders. It is found primarily in the United States, and much of it is centered in about a dozen clinics in Evergreen, Colorado, where Foster Cline, one of the founders, established his clinic in the 1970s. The practice has resulted in adverse outcomes for children, including at least six documented child fatalities. Since the 1990s there have been a number of prosecutions for deaths or serious maltreatment of children at the hands of "attachment therapists" or parents following their instructions. Two of the most well-known cases are those of Candace Newmaker in 2000 and the Gravelles in 2003. Following the associated publicity, some advocates of attachment therapy began to alter views and practices to be less potentially dangerous to children. This change may have been hastened by the publication of a Task Force Report on the subject in January 2006, commissioned by the American Professional Society on the Abuse of Children (APSAC) which was largely critical of attachment therapy. In April 2007, ATTACh, an organization originally set up by attachment therapists, formally adopted a White Paper stating its unequivocal opposition to the use of coercive practices in therapy and parenting, promoting instead newer techniques of attunement, sensitivity and regulation. Attachment therapy is primarily based on Robert Zaslow's rage-reduction therapy from the 1960s and '70s and on psychoanalytic theories about suppressed rage, catharsis, regression, breaking down of resistance and defence mechanisms. Zaslow, Tinbergen, Martha Welch and other early proponents used it as a treatment for autism, based on the now discredited belief that autism was the result of failures in the attachment relationship with the mother. This form of treatment differs significantly from evidence-based attachment-based therapies, talking psychotherapies such as attachment-based psychotherapy and relational psychoanalysis.
  • 1.7K
  • 14 Oct 2022
Topic Review
Pyrimidine Derivatives as Anticancer Agents
In this entry, new pyrimidine derivatives were designed, synthesized and analyzed in terms of their anticancer properties. The tested compounds were evaluated in vitro for their antitumor activity. The cytotoxic effect on normal human dermal fibroblasts (NHDF) was also determined. According to the results, all the tested compounds exhibited inhibitory activity on the proliferation of all lines of cancer cells (colon adenocarcinoma (LoVo), resistant colon adenocarcinoma (LoVo/DX), breast cancer (MCF-7), lung cancer (A549), cervical cancer (HeLa), human leukemic lymphoblasts (CCRF-CEM) and human monocytic (THP-1)).
  • 1.7K
  • 23 Apr 2021
Topic Review
Integrative Body Psychotherapy
Integrative body psychotherapy (IBP) is a psychotherapy that recognizes and treats the somatic (physical), psychological/emotional, and spiritual nature of a human being. It is based on the premise that the body, mind, and spirit are not separate, but rather integrated parts of a whole person. Every experience has a physical, mental, emotional, and spiritual aspect, which manifests internally within the body and externally in relationship to others. IBP was first developed by Jack Lee Rosenberg starting in the late 1970s (see § History, below).
  • 1.7K
  • 14 Oct 2022
Topic Review
Scorpion Venom
Scorpion venom may cause severe medical complications and untimely death if injected into the human body. A wide range of bioactive molecules can be found in scorpion venoms. Advances in separation, characterization, and biotechnological approaches have enabled not only the development of more effective treatments against scorpion envenomings, but have also led to the discovery of several scorpion venom peptides with interesting therapeutic properties. Thus, scorpion venom may not only be a medical threat to human health, but could prove to be a valuable source of bioactive molecules that may serve as leads for the development of new therapies against current and emerging diseases. 
  • 1.7K
  • 25 Jun 2021
Topic Review
Process Analytical Technology
Various frameworks and methods, such as quality by design (QbD), real time release test (RTRT), and continuous process verification (CPV), have been introduced to improve drug product quality in the pharmaceutical industry. The methods recognize that an appropriate combination of process controls and predefined material attributes and intermediate quality attributes (IQAs) during processing may provide greater assurance of product quality than end-product testing. The efficient analysis method to monitor the relationship between process and quality should be used. Process analytical technology (PAT) was introduced to analyze IQAs during the process of establishing regulatory specifications and facilitating continuous manufacturing improvement. Although PAT was introduced in the pharmaceutical industry in the early 21st century, new PAT tools have been introduced during the last 20 years.
  • 1.6K
  • 22 Jul 2021
Topic Review
Sotai
Sotai or Sotai-hō (操体法, Sōtai-hō) is a Japan ese form of muscular or movement therapy invented by Keizo Hashimoto (1897–1993), a Japanese medical doctor from Sendai. The term So-tai (操体) is actually the opposite of the Japanese word for exercise: Tai-so (体操). Dr. Hashimoto conceived Sotai as an antidote to the forceful and regimented exercises of Japan, that anyone could practice easily to restore balance and health. Sotai is different from regular exercise because it distinguishes between balanced movements that are natural and beneficial and those that are unnatural and cause strains and physical distortions. The aim of Sotai is to help the body restore and maintain its natural balance. Dr. Hashimoto developed a model of treatment based on restoring structural balance that is claimed to work with the breath and movements toward comfort (or away from pain). He developed Sotai Therapy from traditional East Asian medicine (acupuncture, moxibustion, bone setting (Sekkotsu), Seitai Jutsu) in concert with his knowledge of modern medicine. Sotai Therapy is intended to be a method of neuromuscular reeducation and unwinding muscular holding patterns. According practitioners, Sotai Therapy balances the nervous and muscular systems. Its central principle is backtracking movement or "reverse-motion" treatment. The idea is that structural distortions can be returned to a more normal condition by moving the body in the comfortable direction. Using the effects of an isometric contraction followed by a sudden relaxation (post-isometric relaxation) can normalise the strained condition.
  • 1.5K
  • 21 Nov 2022
Topic Review
Drama Therapy
Drama therapy is the use of theatre techniques to facilitate personal growth and promote mental health. Drama therapy is used in a wide variety of settings, including hospitals, schools, mental health centers, prisons, and businesses. Drama therapy, as a modality of the creative arts therapies, exists in many forms and can apply to individuals, couples, families, and various groups.
  • 1.5K
  • 23 Nov 2022
Topic Review
Syndrome of Undifferentiated Recurrent Fever
Syndrome of undifferentiated recurrent fever (SURF) is a heterogeneous group of autoinflammatory diseases (AID) characterized by self-limiting episodes of systemic inflammation without a confirmed molecular diagnosis, not fulfilling the criteria for periodic fever, aphthous stomatitis, pharyngitis and adenopathy (PFAPA) syndrome.
  • 1.5K
  • 13 May 2021
Topic Review
Eidetic Imagery
An eidetic image is a type of vivid mental image, not necessarily derived from an actual external event or memory. It was identified in the early twentieth century as a distinct phenomenon by psychologists including E.R. Jaensch, Heinrich Klüver, Gordon Allport and Frederic Bartlett. Later, Akhter Ahsen located eidetic imagery in a structuralist context, and explored its therapeutic applications: psychotherapists sometimes encourage their clients to create and explore eidetic images as a way of coming to terms with past life events. Eidetic imagery has also been studied in relation to the creative arts.
  • 1.5K
  • 21 Oct 2022
Topic Review
Hyperferritinemia
Ferritin is one of the most frequently requested laboratory tests in primary and secondary care, and levels often deviate from reference ranges. Serving as an indirect marker for total body iron stores, low ferritin is highly specific for iron deficiency. Hyperferritinemia is, however, a non-specific finding, which is frequently overlooked in general practice. In routine medical practice, only 10% of cases are related to an iron overload, whilst the rest is seen as a result of acute phase reactions and reactive increases in ferritin due to underlying conditions. Differentiation of the presence or absence of an associated iron overload upon hyperferritinemia is essential, although often proves to be complex.
  • 1.5K
  • 27 May 2021
Topic Review
Tocotrienols: Stroke and Myocardial Infarction
Although the current treatments for stroke and myocardial infarction contribute to an improvement in mortality rates, the consequences of reperfusion therapy have remained a challenge. Tocotrienols have been shown to exert beneficial effects on the brain and heart.  We retrieved articles from Scopus, MEDLINE and PubMed from inception to June 2021, and included any studies using tocotrienols as a treatment for cerebral or myocardial I/R injury therapy. Observational studies and review articles were excluded, and the risk of bias was conducted using a specific tool for animal study (SYRCLE). The data were analyzed qualitatively. Twelve articles met the eligibility criteria. Tocotrienols significantly improved the structural, functional, and biochemical parameters in both cerebral and myocardial I/R injury models. In contrast, oxidative stress, inflammation, and apoptosis were markedly attenuated by tocotrienol treatment. Limitations to the analysis included marked differences in animal models, disease inductions, forms of tocotrienols, and an unclear risk of bias in certain types of bias. However, tocotrienols have the potential to serve as a supplement for reducing the impact of reperfusion injury. 
  • 1.5K
  • 10 Sep 2021
Topic Review
Anticancer Plants
The rising burden of cancer worldwide calls for an alternative treatment solution. Herbal medicine provides a very feasible alternative to western medicine against cancer. This entry reviews the selected plant species with active phytochemicals, the animal models used for these studies, and their regulatory aspects. This study is based on a meticulous literature review conducted through the search of relevant keywords in databases, Web of Science, Scopus, PubMed, and Google Scholar. Twenty plants were selected based on defined selection criteria for their potent anticancer compounds. The detailed analysis of the research studies revealed that plants play an indispensable role in fighting different cancers such as breast, stomach, oral, colon, lung, hepatic, cervical, and blood cancer cell lines. The in vitro studies showed cancer cell inhibition through DNA damage and activation of apoptosis-inducing enzymes by the secondary metabolites in the plant extracts. Studies that reported in vivo activities of these plants showed remarkable results in the inhibition of cancer in animal models. 
  • 1.5K
  • 26 Jul 2021
Topic Review
Oral Hypoglycemic Agents
Diabetes mellitus (DM) is a chronic illness with an increasing global prevalence. More than 537 million cases of diabetes were reported worldwide in 2021, and the number is steadily increasing. The worldwide number of people suffering from DM is projected to reach 783 million in 2045. In 2021 alone, more than USD 966 billion was spent on the management of DM. Reduced physical activity due to urbanization is believed to be the major cause of the increase in the incidence of the disease, as it is associated with higher rates of obesity. Diabetes poses a risk for chronic complications such as nephropathy, angiopathy, neuropathy and retinopathy. Hence, the successful management of blood glucose is the cornerstone of DM therapy. The effective management of the hyperglycemia associated with type 2 diabetes includes physical exercise, diet and therapeutic interventions (insulin, biguanides, second generation sulfonylureas, glucagon-like peptide 1 agonists, dipeptidyl-peptidase 4 inhibitors, thiazolidinediones, amylin mimetics, meglitinides, α-glucosidase inhibitors, sodium-glucose cotransporter-2 inhibitors and bile acid sequestrants).
  • 1.4K
  • 15 Jun 2023
Topic Review
Parenteral Nutrition and Sepsis
Parenteral nutrition (PN) is recommended in malnourished patients or those at risk of malnutrition in some conditions—such as gut functional unavailability or gut physical inaccessibility. The lipids are sepsis risk factors in patients receiving parenteral nutrition. 
  • 1.4K
  • 29 Jul 2022
Topic Review
Developmental Origins of Health and Disease (DOHaD) Hypothesis
The “developmental origins of health and disease” (DOHaD) hypothesis refers to the influence of early developmental exposures and fetal growth on the risk of chronic diseases in later periods. 
  • 1.4K
  • 11 Feb 2022
Topic Review
Mitochondrial Dysfunction
Mitochondrial dysfunction results in a series of defective cellular events, including decreased adenosine triphosphate (ATP) production, enhanced reactive oxygen species (ROS) output, and altered proteastasis and cellular quality control. An enhanced output of ROS may damage mitochondrial components, such as mitochondrial DNA and elements of the electron transport chain, resulting in the loss of proper electrochemical gradient across the mitochondrial inner membrane and an ensuing shutdown of mitochondrial energy production. Neurons have an increased demand for ATP and oxygen, and thus are more prone to damage induced by mitochondrial dysfunction. Mitochondrial dysfunction, damaged electron transport chains, altered membrane permeability and Ca2+ homeostasis, and impaired mitochondrial defense systems induced by oxidative stress, are pathological changes involved in neurodegenerative disorders. A growing body of evidence suggests that the use of antioxidants could stabilize mitochondria and thus may be suitable for preventing neuronal loss. Numerous natural products exhibit the potential to counter oxidative stress and mitochondrial dysfunction; however, science is still looking for a breakthrough in the treatment of neurodegenerative disorders. β-caryophyllene is a bicyclic sesquiterpene, and an active principle of essential oils derived from a large number of spices and food plants. As a selective cannabinoid receptor 2 (CB2) agonist, several studies have reported it as possessing numerous pharmacological activities such as antibacterial (e.g., Helicobacter pylori), antioxidant, anti-inflammatory, analgesic (e.g., neuropathic pain), anti-neurodegenerative and anticancer properties. The present review mainly focuses on the potential of β-caryophyllene in reducing oxidative stress and mitochondrial dysfunction, and its possible links with neuroprotection. 
  • 1.3K
  • 29 Apr 2021
Topic Review
Cationic Liposomes
Cationic liposomes (CLs) are assemblies of lipids with an overall cationic (positive) charge that is contributed by the sum of the charges of the lipid headgroups. In particular, they are spherical bilayer assemblies of cationic lipids or a mixture of neutral and cationic lipids. CLs effective carriers of a variety of therapeutics.
  • 1.3K
  • 23 Feb 2022
Topic Review
External Beam Radiotherapy
External beam radiotherapy (EBRT) is the most common form of radiotherapy (radiation therapy). The patient sits or lies on a couch and an external source of ionizing radiation is pointed at a particular part of the body. In contrast to brachytherapy (sealed source radiotherapy) and unsealed source radiotherapy, in which the radiation source is inside the body, external beam radiotherapy directs the radiation at the tumour from outside the body. Orthovoltage ("superficial") X-rays are used for treating skin cancer and superficial structures. Megavoltage X-rays are used to treat deep-seated tumours (e.g. bladder, bowel, prostate, lung, or brain), whereas megavoltage electron beams are typically used to treat superficial lesions extending to a depth of approximately 5 cm (increasing beam energy corresponds to greater penetration). X-rays and electron beams are by far the most widely used sources for external beam radiotherapy. A small number of centers operate experimental and pilot programs employing beams of heavier particles, particularly protons, owing to the rapid dropoff in absorbed dose beneath the depth of the target.
  • 1.3K
  • 19 Oct 2022
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