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Topic Review
Assessment of Gastrointestinal Autonomic Dysfunction
The autonomic nervous system delicately regulates the function of several target organs, including the gastrointestinal tract. Thus, nerve lesions or other nerve pathologies may cause autonomic dysfunction (AD). Some of the most common causes of AD are diabetes mellitus and α-synucleinopathies such as Parkinson’s disease. Widespread dysmotility throughout the gastrointestinal tract is a common finding in AD, but no commercially available method exists for direct verification of enteric dysfunction. Thus, assessing segmental enteric physiological function is recommended to aid diagnostics and guide treatment.
  • 3.9K
  • 24 Apr 2021
Topic Review
Interferometric Fiber Optic Sensors
Due to the improvement of living standards, people’s attention to health has gradually increased. More and more people are willing to spend money and time on health management. The vital signs monitoring system based on fiber optic interferometers, including the design of sensor structures, signal demodulation methods and data analysis. After a large number of trials, the system can achieve long-term stable heart rate (HR), respiration rate (RR) and body temperature monitoring, and the collected data can be used for health analysis. Due to the high sensitivity, low cost, and light weight of the interferometric fiber optic sensor, it can be integrated under a mattress or a cushion, which is very suitable for daily use. The system has great application prospects in the field of healthcare. 
  • 3.9K
  • 26 Jan 2022
Topic Review
Water Cooler
A water cooler or water dispenser is a device that cools and dispenses water. Water coolers come in a variety of form factors, ranging from wall-mounted to bottle filler water cooler combination units, to bi-level units and other formats. They are generally broken up in two categories: point-of use (POU) water coolers and bottled water coolers. POU Water coolers are connected to a water supply, while bottled water coolers require delivery (or self-pick-up) of water in large bottles from vendors. Bottled water coolers can be top-mounted or bottom-loaded, depending on the design of the model. Bottled water coolers typically use 5 or 10-gallon dispensers commonly found on top of the unit. Pressure coolers are a subcategory of water coolers encompassing water fountains and direct-piping water dispensers. Water cooler may also refer to a primitive device for keeping water cool. Water coolers are a common metonym referring to workplace socialization.
  • 3.9K
  • 18 Oct 2022
Topic Review
Bodhisattva Precepts
The Bodhisattva Precepts (traditional Chinese: 菩薩戒; ; pinyin: Púsà Jiè, Japanese: bosatsukai) are a set of moral codes used in Mahayana Buddhism to advance a practitioner along the path to becoming a Bodhisattva. Traditionally, monastics observed the basic moral code in Buddhism, the Prātimokṣa (such as that of the Dharmaguptaka), but in the Mahayana tradition, monks may observe the Bodhisattva Precepts as well.
  • 3.9K
  • 16 Nov 2022
Topic Review
Stellar Aberration (Derivation from Lorentz Transformation)
Stellar aberration is an astronomical phenomenon "which produces an apparent motion of celestial objects". It can be proven mathematically that stellar aberration is due to the change of the astronomer's inertial frame of reference. The formula is derived with the use of Lorentz transformation of the star's coordinates. As the astronomer John Herschel has already explained in 1844, the stellar aberration does not depend on the relative velocity of the star towards Earth. Otherwise eclipsing binary stars would appear to be separated, in stark contrast to observation: both stars are rotating with high speed —and ever changing and different velocity vectors— around each other, but they appear as one spot all the time.
  • 3.9K
  • 27 Oct 2022
Topic Review
Environmental Intelligence, A Holistic Approach
The human beings intrinsically, intensively, and strongly guard their life and soul. This instinctive protection is also supported by the social, cultural, religious, and legal principles and regulations, too. If we consider the means of realizing this phenomenon to be the instinctive intelligence of man in preserving its life and health, we must admit that humans do not have such intelligence about their environment and this is a rare paradox. So, why cannot humans understand that the destruction of the environment will ultimately cause the destruction of the human race, while these same humans are incredibly industrious, active, and confident in guarding their own lives? This apparent and dangerous contradiction can be attributed to the lack of intelligence which historical experiences show it has been clearly prominent among individuals and human groups in the traditional world, and more likely in prehistoric man and has been badly damaged and destroyed in modern times and with the acceptance of the duet between man and nature. This is the intelligence that has to be revitalized again in an acceptable manner for the modern human beings. The mental relationship between people and the environment comes from a chain of experiences and knowledge, and the meaning of the environment derives from its functions. This intelligence, which we call "Environmental Intelligence", is the power of calculation, analysis, and presupposition that can help humans establish an organic and immediate relationship between their own partial actions and the large and subtle environmental effects that would immediately and undoubtedly influence the whole society and the entire environment and eventually every individual members of the society. This is the intelligence that has to have an individual and collective aspect and be learnt and transferred in a holistic connection of the individual and society and it is the intelligence that can establish a systematic and nonlinear relationship between the individual, society, environment and the bioenvironmental data. The acquisition and deepening of such intelligence can bridge the gaps that are existent in the human community and are dangerously growing on a daily basis even with the extensive and unprecedented instructions and notifications.
  • 3.9K
  • 28 Sep 2021
Topic Review
Tire Pyrolysis Oil
Energy is essential for the nature of life and the development of countries. The main demand for the 21st century is to fulfill growing energy needs. Pakistan, through the use of fossil fuels, meets energy demands. There is pressure on the economy of the country due to the massive reliance on fossil fuels, and this tendency is influenced by various environmental impacts. To overcome the burden on fossil fuels, more attention has been drawn to provide fossil fuel substitution. Tire pyrolysis is among the effective substitutes of the fuel technology that generates useful products of liquid oil, char, and pyro gas.
  • 3.9K
  • 30 Sep 2021
Topic Review
Subscriber Identity Module
A subscriber identity module or subscriber identification module (SIM), widely known as a SIM card, is an integrated circuit that is intended to securely store the international mobile subscriber identity (IMSI) number and its related key, which are used to identify and authenticate subscribers on mobile telephony devices (such as mobile phones and computers). It is also possible to store contact information on many SIM cards. SIM cards are always used on GSM phones; for CDMA phones, they are only needed for newer LTE-capable handsets. SIM cards can also be used in satellite phones, smart watches, computers, or cameras. The SIM circuit is part of the function of a universal integrated circuit card (UICC) physical smart card, which is usually made of PVC with embedded contacts and semiconductors. SIM cards are transferable between different mobile devices. The first UICC smart cards were the size of credit and bank cards; sizes were reduced several times over the years, usually keeping electrical contacts the same, so that a larger card could be cut down to a smaller size. A SIM card contains its unique serial number (ICCID), international mobile subscriber identity (IMSI) number, security authentication and ciphering information, temporary information related to the local network, a list of the services the user has access to, and two passwords: a personal identification number (PIN) for ordinary use, and a personal unblocking code (PUC) for PIN unlocking.
  • 3.9K
  • 25 Oct 2022
Topic Review
ECM decellularization methods
The extracellular matrix (ECM) is a complex network with multiple functions, including specific functions during tissue regeneration. Precisely, the properties of the ECM have been thoroughly used in tissue engineering and regenerative medicine research, aiming to restore the function of damaged or dysfunctional tissues. Tissue decellularization is gaining momentum as a technique to obtain potentially implantable decellularized extracellular matrix (dECM) with well-preserved key components. Interestingly, the tissue-specific dECM is becoming a feasible option to carry out regenerative medicine research, with multiple advantages compared to other approaches. We recently published an overview of the most common methods used to obtain the dECM from specific tissues[1]. Here we provide a summary from that report as a helpful guide for future research development.
  • 3.9K
  • 25 Aug 2020
Topic Review
Potato Proteins
About 35-45 % of all soluble potato proteins are fractions of albumin and globulin characterised by high molecular weight in the range of 40-45 kDa and high nutritive value, comparable to proteins of animal origin. They are soluble in water and in water and salt solutions, respectively; these are patatin glycoproteins, with a pIs in the range of 4.8–5.2. The second large group of potato proteins comprise fractions of protease inhibitors with a molecular weight in the range of 7–21 kDa, mostly acid soluble; they are often heat-resistant, showing a wide spectrum of healthpromoting effects, such as antimicrobial or antitumor, as well as antioxidant and antiradical. Properties of potato proteins depend strictly on the method of isolation and the applied factors, such as pH, ionic strength and temperature.
  • 3.9K
  • 26 Apr 2021
Topic Review
Sol-gel Technology for Commercial Coatings
The commercial availability of inorganic/organic precursors for sol-gel formulation is very high and increase day by day. By using the sol-gel technology, it is possible to provide materials with functional/multi-functional characteristics including flame retardant, anti-mosquito, water-repellent oil-repellent, anti-bacterial, anti-wrinkle, ultraviolet (UV) protection, self-cleaning and other properties. Some of these properties are discussed here, describing basic chemistry, factors affecting the sol-gel process, as well as progress and parameters controlling sol-gel technology for thin coatings.
  • 3.9K
  • 29 Apr 2021
Topic Review
Visible-Light-Promoted Carbonylation Reactions
The abundant and inexpensive carbon monoxide (CO) is widely exploited as a C1 source for the synthesis of both fine and bulk chemicals. In this context, photochemical carbonylation reactions have emerged as a powerful tool for the sustainable synthesis of carbonyl-containing compounds (esters, amides, ketones, etc.).
  • 3.9K
  • 11 Aug 2021
Topic Review
Ischemic Stroke Pathophysiology and Preclinical Models
Ischemic stroke is a leading cause of death worldwide, mainly in western countries. So far, approved therapies rely mainly on reperfusion of the affected brain area, by intravenous thrombolysis or mechanical thrombectomy. The combination of pharmacological brain-protective strategies with reperfusion is the future of stroke therapy, aiming to reduce brain cell death and decrease patients’ disabilities. The success of new therapies relies on bringing preclinical studies and clinical practice close together. Recent upgrades of in vitro and in vivo stroke models for accurate and effective evaluation of therapeutic strategies are described.
  • 3.9K
  • 20 Oct 2022
Topic Review
Wild Vigna Legumes
Legumes (family Fabaceae) represent the third largest family among flowering plants, consisting of approximately 650 genera and 20, 000 species which possess an undeniable vital nutritional value for both humans and animals due to their protein content. The genus Vigna is a huge and important set of legumes consisting of more than 200 species. The term under-exploited wild Vigna species has been attributed to some Vigna species of legumes that have not yet been domesticated. They do not possess commercial names since they have not got a common popular use by people or groups of people. Very few domesticated legumes species exist with more than one hundred (100) wild species under-exploited despite global food demand. A recent study explored farmers’ perceptions, preferences, and possible utilization of some wild Vigna species of legumes through quantitative and qualitative surveys conducted in a mid and high altitude agro-ecological zones in Tanzania to obtain the opinion of 150 farmers about wild legumes and their uses.
  • 3.9K
  • 30 Oct 2020
Topic Review
Geology of the Himalaya
The geology of the Himalayas is a record of the most dramatic and visible creations of the immense mountain range formed by plate tectonic forces and sculpted by weathering and erosion. The Himalayas, which stretch over 2400 km between the Namcha Barwa syntaxis at the eastern end of the mountain range and the Nanga Parbat syntaxis at the western end, are the result of an ongoing orogeny — the collision of the continental crust of two tectonic plates, namely, the Indian Plate thrusting into the Eurasian Plate. The Himalaya-Tibet region supplies fresh water for more than one-fifth of the world population, and accounts for a quarter of the global sedimentary budget. Topographically, the belt has many superlatives: the highest rate of uplift (nearly 10 mm/year at Nanga Parbat), the highest relief (8848 m at Mt. Everest Chomolangma), among the highest erosion rates at 2–12 mm/yr, the source of some of the greatest rivers and the highest concentration of glaciers outside of the polar regions. This last feature earned the Himalaya its name, originating from the Sanskrit for "the abode of the snow". From south to north the Himalaya (Himalaya orogen) is divided into 4 parallel tectonostratigraphic zones and 5 thrust faults which extend across the length of Himalaya orogen. Each zone, flanked by the thrust faults on its north and south, has stratigraphy (type of rocks and their layering) different from the adjacent zones. From south to north, the zones and the major faults separating them are the Main Frontal Thrust (MFT), Subhimalaya Zone (also called Sivalik), Main Boundary Thrust (MBT), Lesser Himalaya (further subdivided into the "Lesser Himalayan Sedimentary Zone (LHSZ) and the Lesser Himalayan Crystalline Nappes (LHCN)), Main Central thrust (MCT), Higher (or Greater) Himalayan crystallines (HHC), South Tibetan detachment system (STD), Tethys Himalaya (TH), and the Indus‐Tsangpo Suture Zone (ISZ). North of this lies the transhimalaya in Tibet which is outside the Himalayas. Himalaya has Indo-Gangetic Plain in south, Pamir Mountains in west in Central Asia, and Hengduan Mountains in east on China–Myanmar border. From east to west the Himalayas are divided into 3 regions, Eastern Himalaya, Central Himalaya, and Western Himalaya, which collectively house several nations and states.
  • 3.9K
  • 05 Dec 2022
Topic Review
Various Protein Kinase Inhibitors as Anticancer Agents
Protein kinases (PTKs) are enzymes that regulate the biological activity of proteins by phosphorylation of certain amino acid residues. This reaction causes a conformational change from an inactive to an active form of the protein, which is one of the most important regulatory mechanisms of the cell cycle and transduction of external signals. Dysregulation of protein kinases activity is implicated in the processes of carcinogenesis and the progression of various solid cancers. Therefore, protein kinases are prime targets for the development of selective anticancer drugs.
  • 3.9K
  • 22 Apr 2022
Topic Review
Alginate-Based Biomaterials
Alginates are naturally occurring polysaccharides extracted from brown marine algae and bacteria. Being biocompatible, biodegradable, non-toxic and easy to gel, alginates can be processed into various forms, such as hydrogels, microspheres, fibers and sponges, and have been widely applied in biomedical field.
  • 3.9K
  • 31 May 2021
Topic Review
Autonomy as a Social Role
Personal autonomy is a crucial philosophical topic which is of great relevance for different disciplines. First I would present an introduction to the contemporary debate. Second,I’ll follow a line of thought that suggests to intend "personal autonomy" in a social sense. The urgency to undertake this move arises because of the wide variety of informational sources we are exposed which influence our behavior. Social background represents the basis for autonomy; at the same time, interaction with others (real or virtual) enlarges the possibility for autonomous judgements.
  • 3.9K
  • 01 Nov 2020
Topic Review
Pseudomonas aeruginosa
Pseudomonas aeruginosa is the most frequent cause of infection among non-fermenting Gram-negative bacteria, predominantly affecting immunocompromised patients, but its pathogenic role should not be disregarded in immunocompetent patients. seudomonas aeruginosa is the most frequent cause of infection among non-fermenting Gram-negative bacteria, predominantly affecting immunocompromised patients, but its pathogenic role should not be disregarded in immunocompetent patients.
  • 3.9K
  • 21 Jan 2021
Topic Review
The All
The All (also called The One, The Absolute, The Great One, The Creator, The Supreme Mind, The Supreme Good, The Father, and The All Mother) is the Hermetic, pantheistic, pandeistic or panentheistic (and thus also panpsychism/monopsychism/unus mundus/anima mundi) view of God, which is that everything that is, or at least that can be experienced, collectively makes up The All. One Hermetic maxim states, "While All is in The All, it is equally true that The All is in All." The All can also be seen to be androgynous, possessing both masculine and feminine qualities in equal part.
  • 3.9K
  • 18 Oct 2022
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