Your browser does not fully support modern features. Please upgrade for a smoother experience.
Subject:
All Disciplines Arts & Humanities Biology & Life Sciences Business & Economics Chemistry & Materials Science Computer Science & Mathematics Engineering Environmental & Earth Sciences Medicine & Pharmacology Physical Sciences Public Health & Healthcare Social Sciences
Sort by:
Most Viewed Latest Alphabetical (A-Z) Alphabetical (Z-A)
Filter:
All Topic Review Biography Peer Reviewed Entry Video Entry
Topic Review
Dead Space (Video Game)
Dead Space is a 2008 survival horror video game developed by EA Redwood Shores and published by Electronic Arts for the PlayStation 3, Xbox 360 and Microsoft Windows. Released in October 2008, the title was the first in the Dead Space franchise and drew inspiration from other works of horror, notably Resident Evil 4 and the Silent Hill series. Set on a mining spaceship overrun by monsters called Necromorphs, the player controls engineer Isaac Clarke from the third-person perspective as he navigates the spaceship, fights Necromorphs, and struggles with increasing psychosis. The player explores areas on the station through the narrative, solving environmental puzzles while finding ammunition and equipment to survive. Isaac wields engineering equipment as weapons. Dead Space was pitched in early 2006 and fit Electronic Arts' priority of creating new intellectual properties. A prototype of the game was developed for the original Xbox console and lasted 18 months. The team aimed for realism and innovation in design. In the pursuit of these goals, the team removed set spawn points for enemies and omitted the heads-up display in favor of presenting information in the world. Immersive and frightening sound design was a large priority during production, and the score by Jason Graves was noted by critics cause of evoke tension and unease. Dead Space debuted weak in sales but eventually sold over a million copies worldwide. The game was met with universal acclaim: reviewers praised its atmosphere, gameplay and sound design. It won and was nominated for multiple industry awards and has been ranked by journalists as one of the greatest video games ever made. To following of the game success, spawned an adaptation for mobile phones, two numbered sequels (released in 2011 and 2013), several spin-off titles, and other related media, including a comic book prequel and an animated film. A remake of Dead Space is currently in development by EA's Motive Studios that set for release in early 2023.
  • 4.0K
  • 14 Oct 2022
Topic Review
Inositol Hexaphosphate (IP6)
Multiple human health-beneficial effects have been related to highly phosphorylated inositol hexaphosphate (IP6). This naturally occurring carbohydrate and its parent compound, myo-inositol (Ins), are abundantly present in plants, particularly in certain high-fiber diets, but also in mammalian cells, where they regulate important cellular functions. However, the striking and broad-spectrum anticancer activity of IP6, consistently demonstrated in different experimental models, has been in a spotlight of the scientific community dealing with the nutrition and cancer during the last several decades. First experiments were performed in colon cancer 30 years ago. Since then, it has been shown that IP6 reduces cell proliferation, induces apoptosis and differentiation of malignant cells with reversion to normal phenotype, affecting several critical molecular targets. Enhanced immunity and antioxidant properties also contribute to the tumor cell destruction. Although Ins possesses a modest anticancer potential, the best anticancer results were obtained from the combination of IP6 + Ins.
  • 4.0K
  • 07 Jan 2021
Topic Review
Synthesis of 3,4-Dihydropyrimidin(thio)one Containing Scaffold
The interest in 3,4-dihydropyrimidine-2(1H)-(thio)ones is increasing every day, mainly due to their paramount biological relevance. The Biginelli reaction is the classical approach to reaching these scaffolds, although the product diversity suffers from some limitations. In order to overcome these restrictions, two main approaches have been devised. The first one involves the modification of the conventional components of the Biginelli reaction and the second one refers to the postmodification of the Biginelli products. Both strategies have been extensively revised in this manuscript. Regarding the first one, initially, the modification of one of the components was covered. Although examples of modifications of the three of them were described, by far the modification of the keto ester counterpart was the most popular approach, and a wide variety of different enolizable carbonylic compounds were used; moreover, changes in two or the three components were also described, broadening the substitution of the final dihydropyrimidines. Together with these modifications, the use of Biginelli adducts as a starting point for further modification was also a very useful strategy to decorate the final heterocyclic structure.
  • 4.0K
  • 15 Aug 2022
Topic Review
GLP-1 Receptor Agonists
GLP-1 receptor agonists stimulate GLP-1R to promote insulin secretion, whereas DPP4 inhibitors slow GLP-1 degradation. Both approaches are incretin-based therapies for T2D. In addition to GLP-1 analogs, small nonpeptide GLP-1RAs such as LY3502970, TT-OAD2, and PF-06882961 have been considered as possible therapeutic alternatives.
  • 4.0K
  • 23 Jun 2022
Topic Review
Current Sensing Methods in Power Electronics Applications
A current sensor is a device exploited to measure electric currents, either alternating current (AC) or direct current (DC). These devices are used in various applications, including detecting faults, monitoring performance (for control or prognostics), and detecting changes in system behavior. Power applications employ various current-monitoring products to control, characterize, and monitor the current flow. Current sensors, for example, are used in power lines to measure the flow of the current, for controlling current flow, or detect overcurrent or excess currents.
  • 4.0K
  • 10 Aug 2023
Topic Review
Inflammatory Pain Study in Animal-Models
Pain is an easily recognized sensation that is experienced by humans and animals alike. However, the process behind the production of the pain experience is a complex pathway that requires parallel integration of both the emotional and sensory experiences together with noxious perceptual information registered by multiple layers of our brain structure with the purpose of defending our body from harm’s way. Here, the complete protocol that is being adapted for inflammatory pain study in animals induced by different phlogogenic agents and different assessment methods were elaborated along with the underlying mechanism of actions. This provides a concise idea and improves our scientists’ understanding of inflammatory pain management in future research.
  • 4.0K
  • 05 Nov 2020
Topic Review
Synthesis of Conducting Polymers
Conductive polymers (CPs) are a class of organic compounds that belong to a large group of electrochemically active polymers. They have been actively studied for more than 40 years, beginning with the discovery of the conductive properties of halogen-substituted polyacetylene and the preparation of polypyrrole.
  • 4.0K
  • 26 Sep 2023
Topic Review
Social Constructionism
Social constructionism is a theoretical approach in sociology that posits that reality is socially constructed through language, discourse, and social interactions. It asserts that knowledge and meaning are not inherent in objects or phenomena but are instead created and maintained by individuals and societies through shared beliefs, cultural norms, and power dynamics. Social constructionism emphasizes the role of language, symbols, and social context in shaping our understanding of reality and social phenomena.
  • 4.0K
  • 26 Jan 2024
Topic Review
Electrochemical Glucose Sensing
The research field of glucose biosensing has shown remarkable growth and development since the first reported enzyme electrode in 1962. Extensive research on various immobilization methods and the improvement of electron transfer efficiency between the enzyme and the electrode have led to the development of various sensing platforms that have been constantly evolving with the invention of advanced nanostructures and their nano-composites. Examples of such nanomaterials or composites include gold nanoparticles, carbon nanotubes, carbon/graphene quantum dots and chitosan hydrogel composites, all of which have been exploited due to their contributions as components of a biosensor either for improving the immobilization process or for their electrocatalytic activity towards glucose. This review aims to summarize the evolution of the biosensing aspect of these glucose sensors in terms of the various generations and recent trends based on the use of applied nanostructures for glucose detection in the presence and absence of the enzyme.
  • 4.0K
  • 13 Nov 2020
Topic Review
Monotreme
Monotremes (/ˈmɒnətriːmz/) are prototherian mammals of the order Monotremata. They are one of the three groups of living mammals, along with placentals (Eutheria) and marsupials (Metatheria). Monotremes are typified by structural differences in their brains, jaws, digestive tract, reproductive tract, and other body parts, compared to the more common mammalian types. In addition, they lay eggs rather than bearing live young, but, like all mammals, the female monotremes nurse their young with milk. Monotremes have been considered members of Australosphenida, a clade that contains extinct mammals from the Jurassic and Cretaceous of Madagascar, South America, and Australia, though this is disputed. The only surviving examples of monotremes are all indigenous to Australia and New Guinea, although there is evidence that they were once more widespread, as Monotrematum is known from the Paleocene of South America. The extant monotreme species are the platypus and four species of echidnas. There is currently some debate regarding monotreme taxonomy. The name monotreme derives from the Greek words μονός (monós 'single') and τρῆμα (trêma 'hole'), referring to the cloaca.
  • 4.0K
  • 28 Nov 2022
Topic Review
Muscle Memory
Muscle memory is a form of procedural memory that involves consolidating a specific motor task into memory through repetition, which has been used synonymously with motor learning. When a movement is repeated over time, a long-term muscle memory is created for that task, eventually allowing it to be performed with little to no conscious effort. This process decreases the need for attention and creates maximum efficiency within the motor and memory systems. Muscle memory is found in many everyday activities that become automatic and improve with practice, such as riding bicycles, driving motor vehicles, playing ball sports, typing on keyboards, entering PINs, playing musical instruments, poker, martial arts, and dancing.
  • 4.0K
  • 04 Nov 2022
Topic Review
Tissue
In biology, tissue is a biological organizational level between cells and a complete organ. A tissue is an ensemble of similar cells and their extracellular matrix from the same origin that together carry out a specific function. Organs are then formed by the functional grouping together of multiple tissues. The English word "tissue" derives from the French word "tissu", the past participle of the verb tisser, "to weave". The study of tissues is known as histology or, in connection with disease, as histopathology. Xavier Bichat is considered as the "Father of Histology". Plant histology is studied in both plant anatomy and physiology. The classical tools for studying tissues are the paraffin block in which tissue is embedded and then sectioned, the histological stain, and the optical microscope. Developments in electron microscopy, immunofluorescence, and the use of frozen tissue-sections have enhanced the detail that can be observed in tissues. With these tools, the classical appearances of tissues can be examined in health and disease, enabling considerable refinement of medical diagnosis and prognosis.
  • 4.0K
  • 26 Oct 2022
Topic Review
Diagnosis and Management of Onychophagia
Onychophagia is defined as chronic biting of the nail plate, nail folds, nail bed, and/or cuticle.
  • 4.0K
  • 25 Mar 2022
Topic Review
Methicilin-Susceptible Staphylococcus aureus
Antibiotic resistance is a global health challenge nowadays, and methicillin-sensitive Staphylococcus aureus (MSSA) is a skin infection presents as pimples, boils, abscesses, or infected cuts and is not resistant to certain antibiotics. MSSA affects people of all ages and is known to cause epidemics among sports teams, families, prison inmates, and people who live and work in close quarters and is a global health challenge nowadays, creating problems in antibiotic therapy.
  • 4.0K
  • 10 Nov 2020
Topic Review
N-Butanol
n-Butanol or n-butyl alcohol or normal butanol is a primary alcohol with a 4-carbon structure and the chemical formula C4H9OH. Its isomers include isobutanol, 2-butanol, and tert-butanol. Butanol is one of the group of "fusel alcohols" (from the German for "bad liquor"), which have more than two carbon atoms and have significant solubility in water. n-Butanol occurs naturally as a minor product of the fermentation of sugars and other carbohydrates, and is present in many foods and beverages. It is also a permitted artificial flavorant in the United States, used in butter, cream, fruit, rum, whiskey, ice cream and ices, candy, baked goods and cordials. It is also used in a wide range of consumer products. The largest use of n-butanol is as an industrial intermediate, particularly for the manufacture of butyl acetate (itself an artificial flavorant and industrial solvent). It is a petrochemical, manufactured from propylene and usually used close to the point of manufacture. Estimated production figures for 1997 are: United States 784,000 tonnes; Western Europe 575,000 tonnes; Japan 225,000 tonnes.
  • 4.0K
  • 26 Oct 2022
Topic Review
O-Linked Glycosylation
O-linked glycosylation is the attachment of a sugar molecule to the oxygen atom of serine (Ser) or threonine (Thr) residues in a protein. O-glycosylation is a post-translational modification that occurs after the protein has been synthesised. In eukaryotes, it occurs in the endoplasmic reticulum, Golgi apparatus and occasionally in the cytoplasm; in prokaryotes, it occurs in the cytoplasm. Several different sugars can be added to the serine or threonine, and they affect the protein in different ways by changing protein stability and regulating protein activity. O-glycans, which are the sugars added to the serine or threonine, have numerous functions throughout the body, including trafficking of cells in the immune system, allowing recognition of foreign material, controlling cell metabolism and providing cartilage and tendon flexibility. Because of the many functions they have, changes in O-glycosylation are important in many diseases including cancer, diabetes and Alzheimer's. O-glycosylation occurs in all domains of life, including eukaryotes, archaea and a number of pathogenic bacteria including Burkholderia cenocepacia, Neisseria gonorrhoeae and Acinetobacter baumannii.
  • 4.0K
  • 25 Nov 2022
Topic Review
Flybuys (Australia)
flybuys is an Australia n loyalty program owned and operated by Coles, with the main participating retail outlets being Coles Supermarkets, Coles Express, Kmart, Liquorland, First Choice Liquor and Target stores. It is one of Australia's largest loyalty programs, with over 10 million flybuys cardholders in over 5.5 million Australian households. Members earn points from household consumer purchases (and through credit card use) and subsequently exchange points for gift cards, merchandise, flights and other rewards.
  • 4.0K
  • 02 Dec 2022
Topic Review
Production of Edible Films and Coatings
Generally, edible films and coatings are the primary forms of edible food packaging. The differences between edible films and coatings lie in their physical form and application process. Edible films are obtained as solid laminated sheets and then used as a food wrap that can be removed or consumed with food, whereas coatings are applied to foods in liquid form by coating, spraying, and immersion. After drying, an edible layer over the food is formed, and it can either be removed or consumed.
  • 4.0K
  • 21 Jul 2023
Topic Review
Baddeley's Model of Working Memory
Baddeley's model of working memory is a model of human memory proposed by Alan Baddeley and Graham Hitch in 1974, in an attempt to present a more accurate model of primary memory (often referred to as short-term memory). Working memory splits primary memory into multiple components, rather than considering it to be a single, unified construct. Baddeley & Hitch proposed their three-part working memory model as an alternative to the short-term store in Atkinson & Shiffrin's 'multi-store' memory model (1968). This model is later expanded upon by Baddeley and other co-workers to add a fourth component, and has become the dominant view in the field of working memory. However, alternative models are developing, providing a different perspective on the working memory system. The original model of Baddeley & Hitch was composed of three main components: the central executive which acts as a supervisory system and controls the flow of information from and to its slave systems: the phonological loop and the visuo-spatial sketchpad. The phonological loop stores verbal content, whereas the visuo-spatial sketchpad caters to visuo-spatial data. Both the slave systems only function as short-term storage centers. In 2000, Baddeley added a third slave system to his model, the episodic buffer. Baddeley & Hitch's argument for the distinction of two domain-specific slave systems in the older model was derived from experimental findings with dual-task paradigms. Performance of two simultaneous tasks requiring the use of two separate perceptual domains (i.e. a visual and a verbal task) is nearly as efficient as performance of the tasks individually. In contrast, when a person tries to carry out two tasks simultaneously that use the same perceptual domain, performance is less efficient than when performing the tasks individually. A fourth component of Baddeley's model was added 25 years later to complement the central executive system. The third slave system was designated as episodic buffer. It is considered a limited-capacity system that provides temporary storage of information by conjoining information from the subsidiary systems, and long-term memory, into a single episodic representation.
  • 4.0K
  • 04 Nov 2022
Topic Review
Arhat
In Buddhism, an arhat (Sanskrit) or arahant (Pali) is one who has gained insight into the true nature of existence and has achieved nirvana. Mahayana Buddhist traditions have used the term for people far advanced along the path of Enlightenment, but who may not have reached full Buddhahood. The understanding of the concept has changed over the centuries, and varies between different schools of Buddhism and different regions. A range of views on the attainment of arhats existed in the early Buddhist schools. The Sarvāstivāda, Kāśyapīya, Mahāsāṃghika, Ekavyāvahārika, Lokottaravāda, Bahuśrutīya, Prajñaptivāda, and Caitika schools all regarded arhats as imperfect in their attainments compared to buddhas. Mahayana Buddhist teachings urge followers to take up the path of a bodhisattva, and to not fall back to the level of arhats and śrāvakas. The arhats, or at least the senior arhats, came to be widely regarded by Theravada buddhists as "moving beyond the state of personal freedom to join the Bodhisattva enterprise in their own way". Mahayana Buddhism regarded a group of Eighteen Arhats (with names and personalities) as awaiting the return of the Buddha as Maitreya, while other groupings of 6, 8, 16, 100, and 500 also appear in tradition and Buddhist art, especially in East Asia called luohan or lohan. They may be seen as the Buddhist equivalents of the Christian saint, apostles or early disciples and leaders of the faith.
  • 4.0K
  • 28 Nov 2022
  • Page
  • of
  • 2851
Featured Entry Collections
>>

Featured Reprints

>>
Encyclopedia of Digital Society, Industry 5.0 and Smart City
Encyclopedia of Engineering
Encyclopedia of Social Sciences
Encyclopedia of Medieval Royal Iconography
Academic Video Service
Feedback