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Topic Review
DKK1 in Hair Regeneration
Dickkopf-related protein 1 (DKK1) is distinctly identified as an inhibitor of canonical Wnt/β-catenin signaling.
  • 4.4K
  • 22 Nov 2021
Topic Review
Euro
The euro (sign: €; code: EUR) is the official currency of 19 of 27 member states of the European Union, as well as some of the territories of the EU. This group of states is known as the eurozone or euro area. It is the second largest and second most traded currency in the foreign exchange market after the United States dollar . The euro is subdivided into 100 cents. The currency is also officially used by the institutions of the European Union and its territories, four other European countries, as well as unilaterally by two others, and is consequently used daily by some 343 million Europeans (As of 2018). Outside Europe, a number of overseas territories of EU members also use the euro as their currency. Additionally, 240 million people worldwide (As of 2018) use currencies pegged to the euro. The euro is the second largest reserve currency as well as the second most traded currency in the world after the United States dollar. (As of August 2018), with more than €1.2 trillion in circulation, the euro has one of the highest combined values of banknotes and coins in circulation in the world, having surpassed the U.S. dollar.[note 14] The name euro was officially adopted on 16 December 1995 in Madrid. The euro was introduced to world financial markets as an accounting currency on 1 January 1999, replacing the former European Currency Unit (ECU) at a ratio of 1:1 (US$1.1743). Physical euro coins and banknotes entered into circulation on 1 January 2002, making it the day-to-day operating currency of its original members, and by May 2002 it had completely replaced the former currencies. While the euro dropped subsequently to US$0.83 within two years (26 October 2000), it has traded above the U.S. dollar since the end of 2002, peaking at US$1.60 on 18 July 2008. In late 2009, the euro became immersed in the European sovereign-debt crisis, which led to the creation of the European Financial Stability Facility as well as other reforms aimed at stabilising and strengthing the currency.
  • 4.4K
  • 23 Nov 2022
Topic Review
Epidemiology and Consequences of ARFID
Avoidant/Restrictive Food Intake Disorder (ARFID) is an avoidant/restrictive food intake disorder identified in the DSM V (Diagnostic and Statistical Manual of Mental Disorders) diagnostic criteria for mental disorders in 2013, which replaced feeding disorder of infancy and early childhood (FEDIC), among others.
  • 4.4K
  • 28 Apr 2022
Topic Review
Power-System Protection
Power-system protection is a branch of electrical power engineering that deals with the protection of electrical power systems from faults through the disconnection of faulted parts from the rest of the electrical network. The objective of a protection scheme is to keep the power system stable by isolating only the components that are under fault, whilst leaving as much of the network as possible still in operation. Thus, protection schemes must apply a very pragmatic and pessimistic approach to clearing system faults. The devices that are used to protect the power systems from faults are called protection devices.
  • 4.4K
  • 16 Nov 2022
Topic Review
Infrared Spectroscopy in Biological Studies
Infrared (IR) radiation is electromagnetic radiation with wavenumbers ranges of 12,500–10 cm−1. The IR region in the electromagnetic spectrum can be subdivided into three spectral regions, namely near-IR (NIR, 12,500–4000 cm−1), mid-IR (MIR, 4,000–400 cm−1), and far-IR (FIR, 400–10 cm−1). Accumulating evidence has shown that IR radiation has been widely investigated for biological studies and effects. The interaction between IR radiation and biomolecules enables to study the specific molecular vibrations of the sample constituents. IR spectroscopy, specifically MIR, has been used to investigate large numbers of biological samples such as cells, tissues, organ, and biofluids, providing qualitative and quantitative information that could be used for detection and classification. Notably, FTIR spectroscopy is considered a promising tool to study and analyze biological samples using MIR radiation. 
  • 4.4K
  • 09 Jan 2023
Topic Review
Stereotype Embodiment Theory
Stereotype embodiment theory (SET) is a theoretical model first posited by psychologist Becca Levy to explain the process by which age stereotypes influence the health of older adults. There are multiple well-documented effects of age stereotypes on a number of cognitive and physical outcomes (including memory, cardiovascular reactivity, and longevity). SET explains these findings according to a three-step process: Underlying these three steps are SET's four main theoretical premises. According to Levy (2009): "The theory has four components: The stereotypes (a) become internalized across the lifespan, (b) can operate unconsciously, (c) gain salience from self-relevance, and (d) utilize multiple pathways." Although this theory was developed to explain the operation of age stereotypes across the lifespan, it may also explain how other types of self-stereotypes operate, such as race stereotypes among African Americans and gender stereotypes among women.
  • 4.4K
  • 02 Nov 2022
Topic Review Peer Reviewed
Ladislaus II Jagiełło (1386–1434)
Ladislaus II Jagiełło (1386–1434). Ladislaus II Jagiełło is the founder of the Jagiellonian dynasty that had ruled over Poland and the Grand Duchy of Lithuania (until 1572), Bohemia (1471–1526) and Hungary (1440–1444, 1490–1526). A Grand Duke of Lithuania from 1377, and from 1386 a king of Poland and lord of Lithuania, which he ruled jointly with his cousin Witold (Vytautas), the son of Kęstutis. Five medieval portraits of Jagiełło survive, four of which date from the period of his reign in the Polish–Lithuanian state and one was executed posthumously. The earliest image, on Jagiełło’s Great Seal, was made in connection with his coronation as king of Poland (1386). Two portraits in the Holy Trinity Chapel at the Castle of Lublin (1418) are part of a wall paintings scheme commissioned by the monarch and executed by a team of painters brought from Ruthenia. Furthermore, the sumptuous tomb (before 1430) in Cracow was commissioned by the king. Its top slab bears an effigy of Jagiełło with his suggestively rendered countenance, which undoubtedly reflects the actual facial features of the elderly monarch. An image of the king represented as one of the Three Magi in a panel of an altarpiece in the tomb chapel of Casimir IV Jagiellonian, Jagiełło’s son and his successor on the Polish throne, dates from 1470. The chapel dedicated to the Holy Cross, erected at Cracow Cathedral, was in all likelihood commissioned by Casimir himself and his consort Elizabeth of Austria. 
  • 4.4K
  • 13 Apr 2022
Topic Review
F-X (Japan)
The F-X (unofficially called F-3) is a sixth-generation stealth fighter in development for the Japan Air Self-Defense Force (JASDF). It is Japan's first domestically developed stealth fighter jet and will replace the Mitsubishi F-2 by the mid–2030's. Its development is to also bolster the nation's defense industry and potentially enter the international arms market amid Japan's change in defense posture. The F-X has been nicknamed the "Godzilla" fighter owing to its large size, as well as a nod to the popular Kaiju.
  • 4.4K
  • 17 Oct 2022
Topic Review
Central African Lion
The Central African lion is a Panthera leo leo population in northern parts of Central and East Africa. This population has been fragmented into small and isolated groups since the 1950s. It is threatened by loss of habitat and prey base and trophy hunting. In 2005, a Lion Conservation Strategy was developed for West and Central Africa. Results of phylogeographic research indicate that the Central African lion clade forms a phylogenetic group with lion samples from West and North Africa, the Middle East and India . This group diverged from lions in southern parts of East and Southern Africa at least 50,000 years ago. Morphometric analysis of lion skulls corroborates the assessment of two major evolutionary lion clusters, one in Sub-Saharan Africa and the other in North Africa and Asia.
  • 4.4K
  • 31 Oct 2022
Topic Review
Neutral Powers During World War II
The neutral powers were countries that remained neutral during World War II. Some of these countries had large colonies abroad or had great economic power. Spain had just been through its civil war, which ended on 1 April 1939 (five months prior to the Invasion of Poland)—a war that involved several countries that subsequently participated in World War II. During World War II, the neutral powers took no official side, hoping to avoid attack. However, Portugal, Sweden, and Switzerland all helped the Allies by supplying "voluntary" brigades to the United Kingdom , while Spain avoided the Allies in favor of the Axis, supplying them with its own voluntary brigade, the Blue Division. Ireland generally favoured the Allied side, as with the United States. The United States remained neutral until 8 December 1941, a day following the attack by Japan on Pearl Harbor. The Lateran Treaty between Italy and the Vatican, signed in 1929, required that the Pope maintain "perpetual neutrality in international relations"—making the Vatican City a neutral state. Several countries suffered invasions in spite of their efforts to be neutral. These included Nazi Germany's invasion of Denmark and Norway on 9 April 1940—then Belgium, the Netherlands, and Luxembourg on 10 May 1940. On the same day, 10 May 1940, the British, having already invaded the Faroe Islands in April, invaded Iceland and established an occupying force (subsequently replaced by the then-neutral United States). The Soviet Union invaded Lithuania on 15 June 1940 and Latvia and Estonia on 17 June. In the Balkans, the Italo-Greek War began on 28 October 1940 and Yugoslavia was invaded in April 1941. Iran was also attacked and occupied by Britain and the Soviet Union in August 1941. See also the histories of Afghanistan, Andorra, Guatemala, Liechtenstein, Saudi Arabia and Yemen during this period.
  • 4.4K
  • 28 Nov 2022
Biography
Frank Macfarlane Burnet
Sir Frank Macfarlane Burnet, OM AK KBE FRS FAA FRSNZ[1] (3 September 1899 – 31 August 1985[2]), usually known as Macfarlane or Mac Burnet, was an Australian virologist best known for his contributions to immunology. He won a Nobel Prize in 1960 for predicting acquired immune tolerance and was best known for developing the theory of clonal selection. Burnet received his Doctor of Medicine degr
  • 4.4K
  • 30 Dec 2022
Topic Review
Corporate Social Responsibility Reporting
Corporate Social Responsibility (CSR) Reporting is an essential mechanism for ensuring the transparency and accountability of companies towards sustainability performance. To further promote that sustainable development agenda, CSR-related regulations and policies have emerged worldwide.
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  • 22 Oct 2021
Topic Review
Crackle (Streaming Service)
Crackle is an over-the-top video streaming platform that is a joint venture between Chicken Soup for the Soul Entertainment, Sony Pictures Television and Columbia Pictures. Its library consists of original content as well as programming acquired from other companies. The service is available in 21 countries on connected devices including mobile, tablets, smart TVs, desktop, and gaming consoles. Crackle is also available as in-flight entertainment and in selected hotel chains. Founded as an independent company and originally known as Grouper, the streaming service was purchased by Sony Pictures in 2006 who renamed it to Crackle in July 2007, then to Sony Crackle in January 2018. Sony then sold majority of it to Chicken Soup for the Soul in March 2019, which immediately renamed it back to Crackle.
  • 4.4K
  • 11 Oct 2022
Biography
Dave Rubin
David Joshua Rubin (born June 26, 1976)[1] is an American political commentator and talk show host. He is the creator and host of The Rubin Report, a political talk show and podcast currently airing on YouTube and formerly part of The Young Turks Network[2] and Ora TV.[3] He previously hosted The Ben and Dave Show and The Six Pack, a podcast and radio show on Sirius XM Radio.[4] Topics Rubin fr
  • 4.4K
  • 22 Nov 2022
Topic Review
Runx2 and Osteoblasts
Runx2 is essential for osteoblast differentiation, chondrocyte maturation, and transdifferentiation of terminally differentiated chondrocytes into osteoblasts. During osteoblast differentiation, Runx2 is weakly expressed in uncommitted mesenchymal cells, and its expression is upregulated in preosteoblasts, reaches the maximal level in immature osteoblasts, and is down-regulated in mature osteoblasts. Runx2 enhances the proliferation of osteoblast progenitors by directly regulating Fgfr2 and Fgfr3. Runx2 enhances the proliferation of suture mesenchymal cells and induces their commitment into osteoblast lineage cells through the direct regulation of hedgehog (Ihh, Gli1, and Ptch1), Fgf (Fgfr2 and Fgfr3), Wnt (Tcf7, Wnt10b, and Wnt1), and Pthlh (Pthr1) signaling pathway genes, and Dlx5. Runx2 heterozygous mutation causes open fontanelle and sutures because more than half of the Runx2 gene dosage is required for the induction of these genes in suture mesenchymal cells. Runx2 induces the proliferation of osteoblast progenitors and their differentiation into osteoblasts through reciprocal regulation via major signaling pathways, including Fgf, hedgehog, Wnt, and Pthlh, and transcription factors, including Sp7 and Dlx5. Runx2 also regulates the expression of bone matrix protein genes, including Col1a1, Col1a2, Spp1, and Bglap/Bglap2. Bglap/Bglap2 (osteocalcin) aligns biological apatite parallel to the collagen fibrils, which is important for bone strength, but osteocalcin does not play a role as a hormone in the pancreas, testis, and muscle. 
  • 4.4K
  • 22 Apr 2021
Topic Review
Flocculation Harvesting Techniques for Microalgae
Microalgae have been considered as one of the most promising biomass feedstocks for various industrial applications such as biofuels, animal/aquaculture feeds, food supplements, nutraceuticals, and pharmaceuticals. Several biotechnological challenges associated with algae cultivation, including the small size and negative surface charge of algal cells as well as the dilution of its cultures, need to be circumvented, which increases the cost and labor. Therefore, efficient biomass recovery or harvesting of diverse algal species represents a critical bottleneck for large-scale algal biorefinery process. Among different algae harvesting techniques (e.g., centrifugation, gravity sedimentation, screening, filtration, and air flotation), the flocculation-based processes have acquired much attention due to their promising efficiency and scalability. 
  • 4.4K
  • 13 Sep 2020
Topic Review
Collectivism
Collectivism is a cultural value that is characterized by emphasis on cohesiveness among individuals and prioritization of the group over self. Individuals or groups that subscribe to a collectivistic worldview tend to find common values and goals as particularly salient and demonstrate greater orientation toward in-group than toward out-group. The term “in-group” is thought to be more diffusely defined for collectivistic individuals to include societal units ranging from the nuclear family to a religious or racial/ethnic group. Meta-analytic findings support that collectivism shows a consistent association with discrete values, interpersonal patterns of interaction, cognition, perception and self-construal. Collectivism is often discussed alongside the cultural value of individualism, but these are two distinct concepts and are not considered to be opposites.
  • 4.4K
  • 22 Nov 2022
Topic Review
DEFLATE
In computing, Deflate is a lossless data compression file format that uses a combination of LZSS and Huffman coding. It was designed by Phil Katz, for version 2 of his PKZIP archiving tool. Deflate was later specified in RFC 1951 (1996). Katz also designed the original algorithm used to construct Deflate streams. This algorithm was patented as U.S. Patent 5,051,745, and assigned to PKWARE, Inc. As stated in the RFC document, an algorithm producing Deflate files was widely thought to be implementable in a manner not covered by patents. This led to its widespread use, for example in gzip compressed files and PNG image files, in addition to the ZIP file format for which Katz originally designed it. The patent has since expired.
  • 4.4K
  • 11 Oct 2022
Topic Review
LinkedIn
LinkedIn (/lɪŋktˈɪn/) is a business and employment-oriented service that operates via websites and mobile apps. Founded on December 28, 2002, and launched on May 5, 2003, it is mainly used for professional networking, including employers posting jobs and job seekers posting their CVs. As of 2015, most of the company's revenue came from selling access to information about its members to recruiters and sales professionals. As of April 2017, LinkedIn had 500 million members in 200 countries, out of which more than 106 million members are active. LinkedIn allows members (both workers and employers) to create profiles and "connections" to each other in an online social network which may represent real-world professional relationships. Members can invite anyone (whether an existing member or not) to become a connection. The "gated-access approach" (where contact with any professional requires either an existing relationship or an introduction through a contact of theirs) is intended to build trust among the service's members. LinkedIn participated in the EU's International Safe Harbor Privacy Principles. The site has an Alexa Internet ranking as the 34th most popular website ((As of June 2018)). According to the New York Times, US high school students are now creating LinkedIn profiles to include with their college applications. Based in the United States, the site is, as of 2013, available in 24 languages, including Arabic, Chinese, English, French, German, Italian, Portuguese, Spanish, Dutch, Swedish, Danish, Romanian, Russian, Turkish, Japanese, Czech, Polish, Korean, Indonesian, Malay, and Tagalog. LinkedIn filed for an initial public offering in January 2011 and traded its first shares on May 19, 2011, under the NYSE symbol "LNKD". On June 13, 2016, Microsoft announced plans to acquire LinkedIn for $26.2 billion. The acquisition was completed on December 8, 2016. According to the SEC filing, "The transaction resulted in the payment of approximately $26.4 billion in cash merger consideration."
  • 4.4K
  • 04 Nov 2022
Topic Review Video
Classification of Energy Storage Technologies
The intensive exploitation and usage of fossil fuels has led to serious environmental consequences, including soil, water, and air pollution and climate changes, and it has compromised the natural resources available for future generations. In this context, identifying new energy storage technologies can be considered a sustainable solution to these problems, with potential long-term effects.
  • 4.4K
  • 19 Jan 2024
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