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Topic Review
Sepsis and HMGB1 Release
Sepsis remains a common cause of death in intensive care units, accounting for approximately 20% of total deaths worldwide. Its pathogenesis is partly attributable to dysregulated inflammatory responses to bacterial endotoxins (such as lipopolysaccharide, LPS), which stimulate innate immune cells to sequentially release early cytokines (such as tumor necrosis factor (TNF) and interferons (IFNs)) and late mediators (such as high-mobility group box 1, HMGB1).  Below is a brief summary of the intricate mechanisms underlying the regulation of bacterial endotoxin-induced HMGB1 release.
  • 1.1K
  • 13 Sep 2021
Topic Review
Cognitive Decline in Rheumatoid Arthritis
Cognitive decline refers to a deterioration of intellectual and learning abilities and related memory problems, and is often associated with behavioral alterations, which prevents sufferers from carrying out the most common daily activities, such as maintaining normal productive interpersonal relationships, communicating, and leading an autonomous life. Numerous studies have highlighted the association between cognitive decline and autoimmune disorders, including rheumatoid arthritis (RA). RA is a chronic, inflammatory, autoimmune disease that involves systems and organs other than the bones and joints, with varying severity among patients.
  • 1.1K
  • 10 Mar 2021
Topic Review
Autoimmune Gut Diseases and COVID-19 Vaccines
The SARS-CoV-2 pandemic raised many challenges for all patients with chronic conditions and those with autoimmune diseases, both adults and children. Autoimmune diseases are characterized by hyperreactivity of the immune system and loss of immune tolerance, which damage and destroy healthy tissues, cells, and organs.
  • 1.1K
  • 26 Dec 2022
Topic Review
Tumor Necrosis Factor-Alpha
Tumor necrosis factor-alpha (TNF-α) is a multifunctional Th1 cytokine and one of the most important inflammatory cytokines.
  • 1.1K
  • 22 Jun 2021
Topic Review
Immunotherapy in Lung Cancer
Immuno-oncology has redefined the treatment of lung cancer, with the ultimate goal being the reactivation of the anti-tumor immune response. However, a high percentage of lung cancer patients do not respond to these therapies or their responses are transient. Here, we summarized the impact of immunotherapy on lung cancer patients in the latest clinical trials conducted on this disease. As well as the mechanisms of primary and acquired resistance to immunotherapy in this disease.
  • 1.1K
  • 17 Dec 2020
Topic Review
The Innate Immune System in Cardiovascular Diseases
Innate immune cells are the early responders to infection and tissue damage. They play a critical role in the initiation and resolution of inflammation in response to insult as well as tissue repair. Following ischemic or non-ischemic cardiac injury, a strong inflammatory response plays a critical role in the removal of cell debris and tissue remodeling. However, persistent inflammation could be detrimental to the heart. Studies suggest that cardiac inflammation and tissue repair needs to be tightly regulated such that the timely resolution of the inflammation may prevent adverse cardiac damage. This involves the recognition of damage; activation and release of soluble mediators such as cytokines, chemokines, and proteases; and immune cells such as monocytes, macrophages, and neutrophils. This is important in the context of doxorubicin-induced cardiotoxicity as well. Doxorubicin (Dox) is an effective chemotherapy against multiple cancers but at the cost of cardiotoxicity. The innate immune system has emerged as a contributor to exacerbate the disease.
  • 1.1K
  • 30 Nov 2022
Topic Review
Gene Circuits for Cancer Immunotherapy
Engineered mammalian cells for medical purposes are becoming a clinically relevant reality thanks to advances in synthetic biology that allow enhanced reliability and safety of cell-based therapies. However, their application is still hampered by challenges including time-consuming design-and-test cycle iterations and costs. For example, in the field of cancer immunotherapy, CAR-T cells targeting CD19 have already been clinically approved to treat several types of leukemia, but their use in the context of solid tumors is still quite inefficient, with additional issues related to the adequate quality control for clinical use.
  • 1.1K
  • 17 Jan 2021
Topic Review
Immune-Targeting Nanomaterials
Cancer immunotherapy is a treatment method in which the immune system is stimulated to communicate with the tumor at the tumor microenvironment (TME) to detect, target, and destroy the growth of the cancer cells or malignancy.
  • 1.1K
  • 30 Dec 2022
Topic Review
Cytoplasmic Functions of cIAP1
Cellular inhibitor of apoptosis 1 (cIAP1) is a cell signaling regulator of the IAP family. Through its E3-ubiquitine ligase activity, it has the ability to activate intracellular signaling pathways, modify signal transduction pathways by changing protein-protein interaction networks, and stop signal transduction by promoting the degradation of critical components of signaling pathways. Thus, cIAP1 appears to be a potent determinant of the response of cells, enabling their rapid adaptation to changing environmental conditions or intra- or extracellular stresses. It is expressed in almost all tissues, found in the cytoplasm, membrane and/or nucleus of cells. cIAP1 regulates innate immunity by controlling signaling pathways mediated by tumor necrosis factor receptor superfamily (TNFRs), some cytokine receptors and pattern recognition-receptors (PRRs). Although less documented, cIAP1 has also been involved in the regulation of cell migration and in the control of transcriptional programs. 
  • 1.1K
  • 18 Mar 2022
Topic Review
mRNA Vaccines against SARS-CoV-2
Coronaviruses are single-stranded positive-sense RNA (+ssRNA) viruses belonging to the Coronaviridae family. Their genome encodes replicase/transcriptase proteins, structural proteins and a set of non-structural proteins linked to their virulence and proofreading activities of the replicase complex. 
  • 1.1K
  • 06 Apr 2023
Topic Review
Epidemiological and Clinical Factors Modulating COVID-19
Addressing factors modulating COVID-19 is crucial since abundant clinical evidence shows that outcomes are markedly heterogeneous between patients. This requires identifying the factors and understanding how they mechanistically influence COVID-19. While there is a multitude of factors modulating COVID-19. These modulating factors (MFs) were selected based on epidemiological and/or clinical studies to be representative of different categories: intrinsic (age, sex and genetic factors), co-morbidities (history of dyslipidemia, obesity, pre-existing heart failure and gut dysbiosis), lifestyle-related (vitamin D deficiency and diet) and environmental (air pollution and exposure to chemicals). 
  • 1.1K
  • 09 Sep 2022
Topic Review
Adipokines
Adipokines are adipose tissue-derived factors not only playing an important role in metabolism but also influencing other central processes of the body, such as inflammation.
  • 1.1K
  • 03 Mar 2021
Topic Review
Nanoparticle- and Microparticle-Based Vaccines against Orbiviruses
Bluetongue virus (BTV) and African horse sickness virus (AHSV) are widespread arboviruses that cause important economic losses in the livestock and equine industries, respectively. In addition to these, another arthropod-transmitted orbivirus known as epizootic hemorrhagic disease virus (EHDV) entails a major threat as there is a conducive landscape that nurtures its emergence in non-endemic countries. To date, only vaccinations with live attenuated or inactivated vaccines permit the control of these three viral diseases, although important drawbacks, e.g., low safety profile and effectiveness, and lack of DIVA (differentiation of infected from vaccinated animals) properties, constrain their usage as prophylactic measures. Moreover, a substantial number of serotypes of BTV, AHSV and EHDV have been described, with poor induction of cross-protective immune responses among serotypes. In the context of next-generation vaccine development, antigen delivery systems based on nano- or microparticles have gathered significant attention. A diversity of technologies, such as virus-like particles or self-assembled protein complexes, have been implemented for vaccine design against these viruses.
  • 1.1K
  • 19 Jul 2022
Topic Review
CAR T-Cells in the Treatment of Solid Tumors
Chimeric antigen receptor (CAR) T-cell therapy is a newly designed adoptive immunotherapy that is able to target and further eliminate cancer cells by engaging with MHC-independent tumor-antigens. CAR T-cell therapy has exhibited conspicuous clinical efficacy in hematological malignancies, but more than half of patients will relapse.  
  • 1.1K
  • 16 Dec 2022
Topic Review
Trypanosoma cruzi Congenital Transmission
Chagas disease, initiated by the etiological agent Trypanosoma cruzi, is an endemic infection in the American continent. Although vectorial transmission of T. cruzi is recognized as the main mode of infection, other routes such as congenital and blood transfusion are also documented as important methods of transmission. T. cruzi maternal–fetal transmission has been recorded in humans and examined by some investigators in naturally and experimentally infected mammals. 
  • 1.0K
  • 08 Nov 2022
Topic Review
Endothelial Dysfunction in Diabetes
Diabetes and its vascular complications affect an increasing number of people. This disease of epidemic proportion nowadays involves abnormalities of large and small blood vessels, all commencing with alterations of the endothelial cell (EC) functions. 
  • 1.0K
  • 15 Jan 2021
Topic Review
Circulating Tumor Cells in Metastatic Cascade
Circulating tumor cells (CTCs) are a heterogeneous population of tumor cells that have shed from a tumor into the lymphatics and vasculature, ultimately disseminating into blood circulation. Circulating tumor cells are a key player in cancer metastasis, a multi-step and complex process that involves (1) local invasion of primary tumor cells into adjacent tissue; (2) intravasation (trans-endothelial migration into nearby blood vessels); (3) circulation (transient travel and survival in the circulatory system as CTCs); (4) extravasation; (5) colonization. To successfully metastasize, CTCs must evade immune surveillance at every step once they leave the immunosuppressive tumor microenvironment. On the other hand, immune cells can promote or inhibit tumorigenesis, depending on the cell type and context.
  • 1.0K
  • 04 Mar 2022
Topic Review
DIHS/DRESS
Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DIHS/DRESS) is a severe type of adverse drug eruption associated with multiorgan involvement and the reactivation of human herpesvirus 6, which arises after prolonged exposure to a limited number of drugs. Severe complications, some of which are related to cytomegalovirus reactivation, can be fatal. DIHS/DRESS is distinct from other drug reactions, as it involves herpes virus reactivation and can lead to the subsequent development of autoimmune diseases. The current consensus on the pathogenesis of DIHS/DRESS is that it occurs as a result of complex interactions between several herpesviruses and comprehensive immune responses, including drug-specific immune responses and antiviral immune responses. Although our understanding of the pathophysiology of DIHS/DRESS has evolved considerably over the last decade, the precise pathomechanisms of this complex disease remain largely unknown. This entry describes the clinical features of DIHS/DRESS, including the associated complications and sequelae.
  • 1.0K
  • 18 May 2021
Topic Review
Annelid Immune Response to Nanoparticles
Earthworms and leeches are sentinel animals that represent the annelid phylum within terrestrial and freshwater ecosystems, respectively. One early stress signal in these organisms is related to innate immunity, but how nanomaterials affect it is poorly characterized. In this survey, we compare the latest literature on earthworm and leeches with examples of their molecular/cellular responses to inorganic (silver nanoparticles) and organic (carbon nanotubes) nanomaterials. A special focus is placed on the role of annelid immunocytes in the evolutionarily conserved antioxidant and immune mechanisms and protein corona formation and probable endocytosis pathways involved in nanomaterial uptake. Our summary helps to realize why these environmental sentinels are beneficial to study the potential detrimental effects of nanomaterials.
  • 1.0K
  • 07 Dec 2020
Topic Review
Efficacy of Vaccines
Vaccination is one of the most effective medical procedures with a significant impact on quality of life. The elderly and the immune-suppressed people are at risk to develop side effects or not respond. Elderly people present an altered immune response, known as immunosenescence. Immunosenescence involves mainly the adaptive immune system, with a reduced ability to respond to new antigens, accumulation of memory T cells and the constant presence of low-grade inflammation, known as inflammaging. Many alterations of adaptive immunity system have been observed and are probably central in the development of immunosenescence and possibly in the deficient response to vaccines in the elderly population. In this review, we discuss the role of immunosenescence as the result of alterations in the function of all the branches of the human immune response, which causes a defect in the normal homeostasis of the immune system, resulting probably in a major susceptibility of infections and a poorer response to vaccinations.
  • 1.0K
  • 27 Nov 2020
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