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Topic Review
Cognitive Decline in Rheumatoid Arthritis
Cognitive decline refers to a deterioration of intellectual and learning abilities and related memory problems, and is often associated with behavioral alterations, which prevents sufferers from carrying out the most common daily activities, such as maintaining normal productive interpersonal relationships, communicating, and leading an autonomous life. Numerous studies have highlighted the association between cognitive decline and autoimmune disorders, including rheumatoid arthritis (RA). RA is a chronic, inflammatory, autoimmune disease that involves systems and organs other than the bones and joints, with varying severity among patients.
  • 1.1K
  • 10 Mar 2021
Topic Review
Intestinal Cell Plasticity
Under constant barrage from chemical, pathogenic, and mechanical stresses, the intestinal epithelium is homeostatically replenished by a pool of Lgr5⁺ intestinal stem cells (ISCs), residing at the bottom of submucosal invaginations termed crypts. Decorated with the RSPO-receptor LGR5, which potentiates canonical Wnt/β-catenin signalling, these actively cycling cells can both self-renew and give rise to short-lived transit-amplifying cells. In turn, transit-amplifying cells undergo successive rounds of cell division and differentiation to generate the full gamut of terminally differentiated intestinal cell types tasked with performing pleiotropic absorptive, secretory, immune, and barrier functions. The self-renewal capabilities and multipotency of Lgr5⁺ ISCs are tightly controlled by instructive cues emanating from epithelial and stromal components of the ISC niche in the vicinity of the lower crypt.  The intestinal epithelium displays a remarkable ability to regenerate following demise of homeostatic Lgr5⁺ ISCs post injury. Plasticity—the ability of lineage-restricted cells to regain self-renewal capacity and multi-lineage differentiation potential in response to environmental cues—is pervasive among multiple intestinal cell populations. Reserve stem-like cells, lineage-committed progenitors, and/or fully differentiated cell types can all contribute to regeneration and repair through dedifferentiation and reversion to an Lgr5⁺ stem-like state. In line with the pervasive plasticity of the intestinal epithelium, accumulating evidence supports both “bottom-up” and “top-down” histogenesis of colorectal tumours whereby the cells-of-origin comprise either ISCs at the crypt base or differentiated cells at the crypt apex, respectively. 
  • 1.1K
  • 30 Mar 2021
Topic Review
Data-Driven Decision-Making
Decision-making for manufacturing and maintenance operations is benefiting from the advanced sensor infrastructure of Industry 4.0, enabling the use of algorithms that analyze data, predict emerging situations, and recommend mitigating actions. 
  • 1.1K
  • 22 Apr 2021
Topic Review
Metal-Promoted Heterocyclization
The recent formulation, production, and ongoing administration of vaccines represent a starting point in the battle against SARS-CoV-2, but they cannot be the only aid available. In this regard, the use of drugs capable to mitigate and fight the virus is a crucial aspect of the pharmacological strategy. Among the plethora of approved drugs, a consistent element is a heterocyclic framework inside its skeleton. Heterocycles have played a pivotal role for decades in the pharmaceutical industry due to their high bioactivity derived from anticancer, antiviral, and anti-inflammatory capabilities. In this context, the development of new performing and sustainable synthetic strategies to obtain heterocyclic molecules has become a key focus of scientists.
  • 1.1K
  • 09 Jul 2021
Topic Review
Reliable Internet of Things
The Internet of Things (IoT) is a vital component of many future industries. By intelligent integration of sensors, wireless communications, computing techniques, and data analytics, IoT can increase productivity and efficiency of industries. Reliability of data transmission is key to realize several applications offered by IoT.
  • 1.1K
  • 27 Oct 2021
Topic Review
Web Axillary Pain Syndrome: Novel Rehabilitative Suggestions
Axillary web syndrome (AWS) is defined as a visible and palpable network of cords in the skin of the axillary cavity that are tensed by shoulder abduction following surgery for breast cancer, causing significant functional limits of the ipsilateral upper limb (UL) and pain. The purpose of this narrative review is to discuss rehabilitation approaches for greater efficacy with respect to pain and novel suggestions. AWS is a frequent complication of axillary lymphadenectomy that necessitates a thorough follow-up in the medium to long term. Physiotherapy is effective in the treatment of functional limb deficits, the management of pain, and the treatment of upper limb disability. The best management approach involves the use of soft tissue techniques to slow the natural course of the syndrome, in association with therapeutic exercises for functional recovery and muscle strengthening. AWS is linked secondary lymphedema, requiring integration with manual lymphatic drainage. The physiotherapy management of AWS is currently fragmented, and insufficient information is available on the nature of the disease. Thus, randomized and controlled studies that compare rehabilitation approaches in AWS are desirable, including the possibility of using mesotherapy in the treatment of axillary and upper limb pain
  • 1.1K
  • 05 Nov 2021
Topic Review
Bacteriophages and Lytic Enzymes
Both phages and their lytic enzymes are now widely considered as safe and have now progressed to clinical phase II to show clinical efficacy as pharmaceutical.
  • 1.1K
  • 06 Dec 2021
Topic Review
Mesoscale Dielectric Particles: Unusual Optical Effects
Mesoscale dielectric particles are mesostructures comprising both wavelength-scaled (i.e. dimensions comparable to wavelength) particles and particle chains or arrays. These particles are made of low loss dielectric materials having relatively low refractive index, namely the refractive index less than two. The main unusual optical effects in such structures are discussed below.
  • 1.1K
  • 01 Jan 2022
Topic Review
Hand Pose Recognition Using Parallel Multi Stream CNN
Recently, several computer applications provided operating mode through pointing fingers, waving hands, and with body movement instead of a mouse, keyboard, audio, or touch input such as sign language recognition, robot control, games, appliances control, and smart surveillance. With the increase of hand-pose-based applications, new challenges in this domain have also emerged. Support vector machines and neural networks have been extensively used in this domain using conventional RGB data, which are not very effective for adequate performance.
  • 1.1K
  • 12 Jan 2022
Topic Review
Carbon-Coated SiO2 for Li-Ion Batteries
Li-ion battery technology is at the core of the imminent massive vehicle electrification due to the forecast growth penetration rate of electrified vehicles. In this cutting-edge Li-ion battery technology, silicon seems to be the most promising candidate for next-generation Li-ion battery technology due to its high theoretical capacity of 4200 mAh·g−1 (compared to 372 mAh·g−1 for graphite). Shifting to silicon as an anode material has the potential to deliver higher energy density for the batteries. The anode of a Li-ion battery should operate at low potentials and offer high specific energy capacity and density.
  • 1.1K
  • 07 Feb 2022
Topic Review
Carcinoid Crisis Management
Carcinoid Crisis represents a rare and extremely dangerous manifestation that can occur in patients with Neuroendocrine Tumors (NETs). It is characterized by a sudden onset of hemodynamic instability, sometimes associated with the classical symptoms of carcinoid syndrome, such as bronchospasm and flushing. Carcinoid Crisis seems to be caused by a massive release of vasoactive substances, typically produced by neuroendocrine cells, and can emerge after abdominal procedures, but also spontaneously in rare instances. To date, there are no empirically derived guidelines for the management of this cancer-related medical emergency, and the available evidence essentially comes from single-case reports or dated small retrospective series. A transfer to the Intensive Care Unit may be necessary during the acute setting, when the severe hypotension becomes unresponsive to standard practices, such as volemic filling and the infusion of vasopressor therapy. The only effective strategy is represented by prevention. The administration of octreotide, anxiolytic and antihistaminic agents represents the current treatment approach to avoid hormone release and prevent major complications. 
  • 1.1K
  • 21 Feb 2022
Topic Review
Composting of Coffee By-Products
Coffee is a worldwide used product and of the most valued commodities in trade, being one of the most important agricultural exports in Costa Rica.
  • 1.1K
  • 28 Feb 2022
Topic Review
Computational Simulation Methods in Ship Broken Ice
The majority of sea ice in polar regions can be generalized into two types, (a) level ice that exists as a continuous form, and (b) broken ice that consists of discontinuous ice blocks. Broken ice includes brash ice that normally accumulates in ice channels, sliding ice pieces that form from breaking continuous ice, unconsolidated ice ridges generated by compression between ice floes, and ice floe fields (the most common broken ice condition in the polar region) that appear and evolve with natural processes. In recent years, computational simulation models have increasingly been used for the evaluation of ship operability under broken ice conditions, presenting some challenging issues. A ship’s response in broken ice is divided into two categories: resistance, which relates to the overall ship performance, and local loads, which relates to structural safety. 
  • 1.1K
  • 22 Mar 2022
Topic Review
Categories and Characteristics of Extracellular Vesicles
Extracellular vesicles (EVs) are heterogeneous small membrane structures that originate from plasma membranes. Although most EVs have a diameter of 50–200 nm, larger ones are also observed. Generally, particles up to a diameter of 1000 nm are regarded as EVs. They are typically isolated from the conditioned media of cultured cells. The contents of EVs include proteins, mRNA, microRNA (miRNA), and nucleic acids. Each vesicle performs a specific function in transferring biological material(s) to induce biological processes, such as replication, growth, apoptosis, and necrosis.
  • 1.1K
  • 27 Apr 2022
Topic Review
Applications of Coupled Bulk Acoustic Wave Resonators
There are two basic types of acoustic waves: SAW and BAW. When the acoustic wave is confined and travels at the interface between the substrate and the air, it is called a surface acoustic wave (SAW), like the ripples observed on the water surface hit by a stone. In contrast, a wave that propagates in the bulk of the material of the medium and exists in most of the volume of the media, is called a bulk acoustic wave (BAW), like a sound wave that travels through the air.
  • 1.1K
  • 16 Jun 2022
Topic Review
Metal Nanoparticles for Environmental Remediation
Environmental pollution deriving from anthropogenic activities is nowadays a serious problem that afflicts our planet and that cannot be neglected. Nanotechnologies and new performing nanomaterials, thanks to their unique features, such as high surface area (surface/volume ratio), catalytic capacity, reactivity and easy functionalization to chemically modulate their properties, represent potential for the development of sustainable, advanced and innovative products/techniques for environmental (bio)remediation. Metal nanoparticles (MNPs; related to metals or noble metals such as M = Pt, Pd, Ni, Ru, Al, Ag, Au, Cu) are nanomaterials with physical and chemical properties that differ from bulk materials due to their small size and high surface-to-volume ratio. 
  • 1.1K
  • 15 Aug 2022
Topic Review
Adult ADHD Self-Report Scale
The Adult ADHD Self-Report Scale (ASRS) Symptom Checklist is a self-reported questionnaire used to assist in the diagnosis of adult ADHD. ADHD is a neurological disorder that can present itself in adolescence and adulthood. Some individuals can outgrow ADHD but around 30% will continue to have ADHD throughout their adulthood. Adults with ADHD may experience difficulties in relation to cognitive, academic, occupational, social and economic situations. The PhenX Toolkit uses ASRS as its adult protocol for Attention-Deficit/Hyperactivity Disorder Symptoms.
  • 1.1K
  • 15 Nov 2022
Topic Review
Managing Oral Health in Context of Antimicrobial Resistance
The oral microbiome plays a major role in shaping oral health/disease state; thus, a main challenge for dental practitioners is to preserve or restore a balanced oral microbiome. Nonetheless, when pathogenic microorganisms install in the oral cavity and are incorporated into the oral biofilm, oral infections, such as gingivitis, dental caries, periodontitis, and peri-implantitis, can arise. Several prophylactic and treatment approaches are available nowadays, but most of them have been antibiotic-based. Given the actual context of antimicrobial resistance (AMR), antibiotic stewardship in dentistry would be a beneficial approach to optimize and avoid inappropriate or even unnecessary antibiotic use, representing a step towards precision medicine. 
  • 1.1K
  • 23 Dec 2022
Topic Review
Feeding Abilities in Achondroplasia Patients
Achondroplasia is an autosomal dominant genetic disease representing the most common form of human skeletal dysplasia: almost all individuals with achondroplasia have identifiable mutations in the fibroblast growth factor receptor type 3 (FGFR3) gene. The cardinal features of this condition and its inheritance have been well-established, but the occurrence of feeding and nutritional complications has received little prominence. In infancy, the presence of floppiness and neurological injury due to foramen magnum stenosis may impair the feeding function of a newborn with achondroplasia. Along with growth, the optimal development of feeding skills may be affected by variable interactions between midface hypoplasia, sleep apnea disturbance, and structural anomalies. Anterior open bite, prognathic mandible, retrognathic maxilla, and relative macroglossia may adversely impact masticatory and respiratory functions. Independence during mealtimes in achondroplasia is usually achieved later than peers. Early supervision of nutritional intake should proceed into adolescence and adulthood because of the increased risk of obesity and respiratory problems and their resulting sequelae. 
  • 1.1K
  • 29 Jan 2023
Topic Review
Tailing Covering Technology for Oxidation Prevention
Water and oxygen are the main reactants to produce Acid mine drainage (AMD), and the inhibition methods should consider controlling the availability of one or two components. Therefore, two strategies are adopted: (i) preventing oxygen from entering the tailings pile and thus reducing the rate of sulfide oxidation; and (ii) isolating the infiltration of external water and thus weakening the role of dissolved oxygen. According to different coverage principles, tailing cover systems can be divided into dry covers, wet covers, and organic covers.
  • 1.1K
  • 31 Jan 2023
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