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Topic Review
Senescent Microglia
Microglia, far from being simply ‘brain glue’, play an important role as the brain’s resident immune cells. Their roles include phagocytic clearance of debris, pruning of synapses, and possibly even contributing to synaptic activity, being of critical importance from early development to ageing. Despite being such long-lived cells, microglia have been relatively understudied for their role in the ageing process. Reliably identifying aged microglia has proven challenging, not least due to the diversity of cell populations, and the limitations of available models, further complicated by differences between human and rodent cells.
  • 1.1K
  • 07 May 2021
Topic Review
Ubiquitylation of ABA Receptors/PP2Cs
Post-translational modifications play a fundamental role in regulating protein function and stability. In particular, protein ubiquitylation is a multifaceted modification involved in numerous aspects of plant biology.  Regarding proteolytic functions of Ub, Lys-48-linked branched chains are the most common chain type for proteasomal degradation, whereas promotion of endocytosis and vacuolar degradation is triggered through monoubiquitylation or Lys63-linked chains introduced in integral or peripheral plasma membrane proteins. Hormone signaling relies on regulated protein turnover, and specifically the half-life of ABA signaling components is regulated both through the ubiquitin-26S proteasome system and the endocytic/vacuolar degradation pathway. 
  • 1.1K
  • 22 Jul 2021
Topic Review
Diagnosis of Helicobacter pylori Infection
Helicobacter pylori (H. pylori) infects approximately 50% of the world population. Its infection is associated with gastropathies, extra-gastric digestive diseases, and diseases of other systems. There is a canonical process from acute-on-chronic inflammation, chronic atrophic gastritis (CAG), intestinal metaplasia (IM), dysplasia, and intraepithelial neoplasia, eventually to gastric cancer (GC). H. pylori eradication abolishes the inflammatory response and early treatment prevents the progression to preneoplastic lesions.
  • 1.1K
  • 03 Aug 2021
Topic Review
Mexican Propolis
Propolis is a resinous substance collected by bees from plants and its natural product is available as a safe therapeutic option easily administered orally and readily available as a natural supplement and functional food.
  • 1.1K
  • 13 Dec 2021
Topic Review
Human Malformation Syndromes and SHH Pathway
Human hereditary malformation syndromes are caused by mutations in the genes of the signal transduction molecules involved in fetal development. Among them, the Sonic hedgehog (SHH) signaling pathway is the most important, and many syndromes result from its disruption. The output of the SHH pathway is shown as GLI activity, which is generated by SHH in a concentration-dependent manner, i.e., the sum of activating form of GLI (GLIA) and repressive form of GLI (GLIR). Which gene is mutated and whether the mutation is loss-of-function or gain-of-function determine in which concentration range of SHH the imbalance occurs. In human malformation syndromes, too much or too little GLI activity produces symmetric phenotypes affecting brain size, craniofacial (midface) dysmorphism, and orientation of polydactyly with respect to the axis of the limb. 
  • 1.1K
  • 17 Dec 2021
Topic Review
Chemotherapy-Induced Neuropathic Pain
Chemotherapy-induced peripheral neuropathy (CIPN) is a side effect of chemotherapics such as taxanes, vinca alkaloids, and platinum compounds. The pathways described so far are diverse and target various components of the peripheral Nervous System (PNS). Among the contributors to neuropathic pain, inflammation has been indicated as a powerful driver of CIPN.
  • 1.1K
  • 28 Mar 2022
Topic Review
Neutrophils and Platelets: Immune Soldiers
Neutrophils and platelets exhibit a diverse repertoire of functions in thromboinflammatory conditions such as stroke. Neutrophils can enable, as well as resolve, cerebrovascular inflammation via many effector functions including neutrophil extracellular traps, serine proteases and reactive oxygen species, and pro-resolving endogenous molecules such as Annexin A1. Like neutrophils, platelets also engage in pro- as well as anti-inflammatory roles in regulating cerebrovascular inflammation. These anucleated cells are at the core of stroke pathogenesis and can trigger an ischemic event via adherence to the hypoxic cerebral endothelial cells culminating in aggregation and clot formation.
  • 1.1K
  • 06 Jan 2022
Topic Review
Curcumin and Ethanol Effects in Trembler-J Schwann
Charcot-Marie-Tooth (CMT) syndrome is the most common progressive human motor and sensory peripheral neuropathy. CMT type 1E is a demyelinating neuropathy affecting Schwann cells due to peripheral-myelin-protein-22 (PMP22) mutations, modelized by Trembler-J mice. Curcumin, a natural polyphenol compound obtained from turmeric (Curcuma longa), exhibits dose- and time-varying antitumor, antioxidant and neuroprotective properties, however, the neurotherapeutic actions of curcumin remain elusive. Here, the researchers propose curcumin as a possible natural treatment capable of enhancing cellular detoxification mechanisms, resulting in an improvement of the neurodegenerative Trembler-J phenotype. 
  • 1.1K
  • 12 Apr 2022
Topic Review
Product Recycling Desirability Model
Product Recycling Desirability Model (PRDM) was coined as a competent model for prioritizing product selection for recycling due to its successful application in several international cases, including those of the United States, the United Kingdom, the European Union, China, and India. The model’s critical parameters were: (i) the ease with which the product’s components could be disassembled for recycling, (ii) the readiness of the recycling technology in place to carry out the recycling operation; and (iii) the criticality of the materials contained in end-of-life products, which make them prime candidates for recycling.
  • 1.1K
  • 13 May 2022
Topic Review
Human Monocyte Subsets and Cardiovascular Diseases
Monocytes are known for their very important role in tissue homeostasis and the innate immune system. The repartition of the circulating monocyte subsets has been identified as a predictive prognosis marker in various cardiovascular diseases caused by atherosclerosis.
  • 1.1K
  • 26 May 2022
Topic Review
Embodied CO2 in China’s Imports, Exports
Constraining the embodied CO2 from international trade is a crucial part of China’s efforts to achieve emission peak and carbon neutrality. By referring to the WIOD, researchers applies the Global Multi-Regional Input-Output (GMRIO) Model and the Value-added Trade Accounting Method to calculate the amount of embodied CO2 in China’s international trade from 2000 to 2014. Results indicate that China’s embodied CO2 in imports and exports is imbalanced in three dimensions: product, region, and industry. One direct cause of this phenomenon is China’s higher carbon emission factors compared to its trading partner. However, the real cause is the global relocation of energy-intensive industries, which leads China to undertake the production of high-carbon industries. To achieve the 3060 Dual Carbon Goal and high-quality economic development, China needs comprehensive and systematic reforms in its economic structure. 
  • 1.1K
  • 06 Jun 2022
Topic Review
Engineered Bacteria in the Detoxification of Heavy Metals
Heavy metal (HM) exposure remains a global occupational and environmental problem that creates a hazard to general health. Even low-level exposure to toxic metals contributes to the pathogenesis of various metabolic and immunological diseases, whereas, in this process, the gut microbiota serves as a major target and mediator of HM bioavailability and toxicity. Specifically, a picture is emerging from recent investigations identifying specific probiotic species to counteract the noxious effect of HM within the intestinal tract via a series of HM-resistant mechanisms. More encouragingly, aided by genetic engineering techniques, novel HM-bioremediation strategies using recombinant microorganisms have been fruitful and may provide access to promising biological medicines for HM poisoning. 
  • 1.1K
  • 12 Jul 2022
Topic Review
Clinical Strategies of CAR-T-Cell Therapy for Hematological Malignancies
Chimeric antigen receptor (CAR) T cells have been successfully used for hematological malignancies, especially for relapsed/refractory B-cell acute lymphoblastic leukemia and non-Hodgkin's lymphoma. Patients who have undergone conventional chemo-immunotherapy and have relapsed can achieve complete remission for several months with the infusion of CAR T-cells. However, side effects and short duration of response are still major barriers to further CAR T-cell therapy. To improve the efficacy, multiple targets, the discovery of new target antigens, and CAR T-cell optimization have been extensively studied.
  • 1.1K
  • 14 Oct 2022
Topic Review
Beta (Plasma Physics)
The beta of a plasma, symbolized by β, is the ratio of the plasma pressure (p = n kB T) to the magnetic pressure (pmag = B²/2μ0). The term is commonly used in studies of the Sun and Earth's magnetic field, and in the field of fusion power designs. In the fusion power field, plasma is often confined using strong magnets. Since the temperature of the fuel scales with pressure, reactors attempt to reach the highest pressures possible. The costs of large magnets roughly scales like β½. Therefore, beta can be thought of as a ratio of money out to money in for a reactor, and beta can be thought of (very approximately) as an economic indicator of reactor efficiency. For tokamaks, betas of larger than 0.05 or 5% are desired for economically viable electrical production. The same term is also used when discussing the interactions of the solar wind with various magnetic fields. For example, beta in the corona of the Sun is about 0.01.
  • 1.1K
  • 08 Oct 2022
Topic Review
IMP321
IMP321 is a large molecule cancer drug being developed by the clinical stage biotechnology company Prima BioMed (Nasdaq: IMMP). The drug is Prima's lead compound. IMP321 (INN name: eftilagimod alpha) is soluble version of the immune checkpoint molecule LAG3, used to increase an immune response to tumours. The drug is administered by subcutaneous injection. IMP321 has two intended clinical settings, 'low dose' (for example 250 µg) as adjuvant to cancer vaccines and 'high dose' (such as 12 injections of 6 mg each) as first-line 'chemo-immunotherapy', that is, combined with standard chemotherapy. IMP321 has been in Phase II clinical testing. The product has been shown to be non-immunogenic, that is, no anti-IMP321 antibodies have been detected in clinical trials. Currently the main indication for the drug is metastatic breast cancer.
  • 1.1K
  • 27 Oct 2022
Topic Review
Epigenetic Changes and Chromatin Reorganization in Brain Function
Healthy brain functioning in mammals requires a continuous fine-tuning of gene expression. Accumulating evidence over the past demonstrates that epigenetic mechanisms and dynamic changes in chromatin organization are critical components during the control of gene transcription in neural cells. Genome-wide analyses show that the regulation of brain genes requires the contribution of both promoter and long-distance enhancer elements, which must functionally interact to upregulate gene expression in response to physiological cues. Hence, a deep comprehension of the mechanisms mediating these enhancer–promoter interactions (EPIs) is critical if people are to understand the processes associated with learning, memory and recall. Moreover, the onset and progression of several neurodegenerative diseases and neurological alterations are found to be strongly associated with changes in the components that support and/or modulate the dynamics of these EPIs. 
  • 1.1K
  • 28 Oct 2022
Topic Review
Compati Hero Series
The Compati Hero Series (コンパチヒーローシリーズ, Konpachi Hīrō Shirīzu) is a video game series published exclusively in Japan by Banpresto and Namco Bandai Games (formerly Bandai) that began in Template:Vgy, that serves as 16 crossover teams between Ultraman, Kamen Rider (also known as Masked Rider) and Gundam. It was the first video game series to involve a crossover between animated giant robots and live action tokusatsu heroes from different established franchises. The series makes this possible by using caricaturized versions of the characters (officially referred as "SD" or "super deformed" characters), which allowed the different heroes and villains to co-exist and interact with each other without the need to reconcile their contrasting styles, settings, or sizes. The first game in the series, SD Battle Ōzumō: Heisei Hero Basho for the Famicom, which mixed franchises that were originally licensed to Popy, was developed as a congratulatory present to Yukimasa Sugiura when he was promoted to president of Banpresto at the time, which was soon followed by series of spin-offs and related games featuring the same cast of characters that developed into the Compati Hero Series. The series was successful with children thanks to the SD Gundam craze, but after the release of Charinko Hero for the GameCube, there were no new games afterward for nearly eight years. Banpresto released a new game in the series titled Lost Heroes, for the Nintendo 3DS and the PlayStation Portable on September 2012.
  • 1.1K
  • 30 Oct 2022
Topic Review
NOAAS Okeanos Explorer
NOAAS Okeanos Explorer (R 337) is a converted United States Navy ship (formerly USNS Capable (T-AGOS-16)), now an exploratory vessel for the National Oceanic and Atmospheric Administration (NOAA), officially launched in 2010. Starting in 2010, NOAA entered into a five-year partnership with the San Francisco Exploratorium. The focus is on gathering scientific information about oceans for the public as well as for scientific uses. As much as 95% of the ocean remains unexplored, NOAA officials said. The ship is equipped with cameras and will provide real-time viewing of the ocean floor for scientists and for the public. This is a pioneering use of what NOAA calls "telepresence technology". The Okeanos Explorer is the only vessel owned by the U.S. government that is dedicated to exploring the seabed and ocean crust. The ship is named after Okeanos, the Ancient Greek god of the sea, from which also comes the word "ocean".
  • 1.1K
  • 04 Nov 2022
Topic Review
Future Proof
Future-proofing is the process of anticipating the future and developing methods of minimizing the effects of shocks and stresses of future events. Future-proofing is used in industries such as electronics, medical industry, industrial design, and more recently, in design for climate change. The principles of future-proofing are extracted from other industries and codified as a system for approaching an intervention in an historic building.
  • 1.1K
  • 11 Nov 2022
Topic Review
Visual Language
The visual language is a system of communication using visual elements. Speech as a means of communication cannot strictly be separated from the whole of human communicative activity which includes the visual and the term 'language' in relation to vision is an extension of its use to describe the perception, comprehension and production of visible signs.
  • 1.1K
  • 30 Nov 2022
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