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Topic Review
Pilomatricoma
Pilomatricoma, also known as pilomatrixoma, is a type of noncancerous (benign) skin tumor associated with hair follicles.
  • 1.1K
  • 24 Dec 2020
Topic Review
Technological Aspects for Pleasant Learning
The teaching–learning process, at each educational level, is often an open problem for educators and researchers related to the stated topic. Researchers combine emerging technologies to formulate learning tools in order to understand the abstract contents of the subjects; however, the problem still persists. A technological learning tool would be effective when projected into an educational model that looks at motivation, usability, engagement, and technological acceptability. Some of these aspects could be attributed through the use of augmented reality and games. 
  • 1.1K
  • 22 Apr 2021
Topic Review
ABC-Type Linear Triblock Terpolymers
This entry aims to cover the most recent advances regarding the synthesis of linear ABC-type triblock terpolymers by RAFT polymerization, as well as their self-assembly properties in aqueous solutions. RAFT polymerization has received extensive attention, as it is a versatile technique, compatible with a great variety of functional monomers and reaction conditions, while providing exceptional and precise control over the final structure, with well-defined side-groups and post-polymerization engineering potential. Linear triblock terpolymers synthesis can lead to very interesting novel ideas, since there are countless combinations of stimuli/non-stimuli and hydrophilic/hydrophobic monomers that someone can use. One of their most interesting features is their ubiquitous ability to self-assemble in different nanostructures depending on their degree of polymerization (DP), block composition, solubilization protocol, internal and external stimuli. 
  • 1.1K
  • 26 May 2021
Topic Review
Injectable Cryogels
Cryogels are interconnected macroporous materials that are synthesized from a monomer solution at sub-zero temperatures. 
  • 1.1K
  • 01 Jun 2021
Topic Review
Triple-Negative Breast Cancer
Triple negative breast cancer (TNBC) is a heterogeneous tumor characterized by early recurrence, high invasion, and poor prognosis. Currently, its treatment includes chemotherapy, which shows a suboptimal efficacy. However, with the increasing studies on TNBC subtypes and tumor molecular biology, great progress has been made in targeted therapy for TNBC. The new developments in the treatment of breast cancer include targeted therapy, which has the advantages of accurate positioning, high efficiency, and low toxicity, as compared to surgery, radiotherapy, and chemotherapy. Given its importance as cancer treatment, we review the latest research on the subtypes of TNBC and relevant targeted therapies. 
  • 1.1K
  • 30 Jun 2021
Topic Review
Linear IgA Disease
Linear IgA disease (LAD) is an autoimmune mucocutaneous disease characterized by linear deposits of IgA at the basement membrane zone on immunopathology. It is also known as linear IgA bullous dermatosis (LABD), but LAD is preferred because it is inclusive of patients without bullous lesions. In the pediatric population, it is known as chronic bullous disease of childhood (CBDC).
  • 1.1K
  • 22 Sep 2021
Topic Review
SARS-CoV-2 and Acute Cerebrovascular Events
Since the coronavirus disease 2019 (COVID-19) pandemic, due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, accumulating evidence indicates that SARS-CoV-2 infection may be associated with various neurological manifestations, including acute cerebrovascular events (i.e., stroke and cerebral venous thrombosis). These events can occur prior to, during and even after the onset of COVID-19's general symptoms. Although the mechanisms underlying the cerebrovascular complications in patients with COVID-19 are yet to be fully elucidated, the hypercoagulability state, inflammation and altered angiotensin-converting enzyme 2 (ACE-2) signaling in association with SARS-CoV-2 may play key roles. ACE-2 plays a critical role in preserving heart and brain homeostasis. As the number of published COVID-19 cases with cerebrovascular events is growing, prospective studies would help gather more valuable insights into the pathophysiology of cerebrovascular events, effective therapies, and the factors predicting poor functional outcomes related to such events in COVID-19 patients.
  • 1.1K
  • 26 Aug 2021
Topic Review
Thin Asphalt Layers as a Traffic Noise Intervention
Low-noise thin asphalt layers (TALs) are a feasible solution to mitigate road traffic noise in urban environments. Nevertheless, the impacts of this type of noise intervention are reported mostly regarding noise levels, while non-acoustic aspects influencing the population perception are still little-known. This study investigates the implementation of TALs in two streets of Antwerp, Belgium. The effectiveness of the intervention was measured via noise modelling and acoustic measurements of road traffic noise. A reduction of 2.8 dB in noise exposure was observed in Lden and Lnight, while SPB measurements showed decreases up to 5.2 dB on the roadside. The subjective impacts of the TALs were evaluated via self-administered surveys and compared to results from control streets. The annoyance indicators were positively impacted by the TALs implementation, resulting in annoyance levels similar or lower than in the control streets. The TALs did not impact the reported physical complaints, sleep quality, and comfort level to perform activities. 
  • 1.1K
  • 23 Nov 2021
Topic Review
Protein-Based Systems for Translational Regulation of synthetic mRNAs
Synthetic mRNAs, which are produced by in vitro transcription, have been recently attracting attention because they can express any transgenes without the risk of insertional mutagenesis. Protein-based translational regulation systems enable the context-dependent production of therapeutic proteins and have the potential to further improve the efficacy and safety of synthetic mRNAs.
  • 1.1K
  • 17 Dec 2021
Topic Review
Sexually Transmitted Infections (STIs)
Recent estimates of 8 common bacterial, viral, and parasitic sexually-transmitted infections in the United States (chlamydia, gonorrhea, trichomoniasis, syphilis, herpes simplex virus type 2, human papillomavirus, hepatitis B virus, and human immunodeficiency virus) found them to have a combined prevalence of 67.6 million and incidence of 26.2 million. Though preventative health guidelines have clarified screening recommendations for some populations, many bacterial sexually-transmitted infections (STIs) are asymptomatic, leading to missed opportunities for diagnosis and underreporting of disease prevalence and incidence. The best available estimates, published in early 2021, are from 2018. Overall, it is thought that 1 in 5 people in the United States has an STI, with 45.5% of all new STIs occurring in adolescents and young adults. New infections amount to $16 billion in direct medical costs.
  • 1.1K
  • 24 Jan 2022
Topic Review
Oxidative Crosslinking of Peptides and Proteins
Covalent crosslinks within or between proteins play a key role in determining the structure and function of proteins. Some of these are formed intentionally by either enzymatic or molecular reactions and are critical to normal physiological function. Others are generated as a consequence of exposure to oxidants (radicals, excited states or two-electron species) and other endogenous or external stimuli, or as a result of the actions of a number of enzymes (e.g., oxidases and peroxidases). Increasing evidence indicates that the accumulation of unwanted crosslinks, as is seen in ageing and multiple pathologies, has adverse effects on biological function.
  • 1.1K
  • 24 Feb 2022
Topic Review
Kynurenine 3-Monooxygenase
Kynurenine 3-monooxygenase (KMO), a key player in the kynurenine pathway (KP) of tryptophan degradation, regulates the synthesis of the neuroactive metabolites 3-hydroxykynurenine (3-HK) and kynurenic acid (KYNA). KMO activity has been implicated in several major brain diseases including Huntington’s disease (HD) and schizophrenia. In the brain, KMO is widely believed to be predominantly localized in microglial cells, but verification in vivo has not been provided so far.
  • 1.1K
  • 01 Mar 2022
Topic Review
Sweet Boron
Boron neutron capture therapy (BNCT) is a binary type of radiotherapy for the treatment of cancer. Due to recent developments of neutron accelerators and their installation in some hospitals, BNCT is on the rise worldwide and is expected to have a significant impact on patient treatments. Therefore, there is an increasing need for improved boron delivery agents. 
  • 1.1K
  • 03 Mar 2022
Topic Review
Gene Sequencing for Lactiplantibacillus plantarum
Lactiplantibacillus plantarum (formerly Lactobacillus plantarum) is one of the Gram-positive lactic acid bacteria (LAB) species. Lb. plantarum has high ecological and metabolic adaptability that exists widely in a range of habitats including fermented dairy products, sourdoughs, fruits, vegetables, cereals, meat, fish, and the mammalian gastrointestinal tract.
  • 1.1K
  • 05 May 2022
Topic Review
Deep Learning and Non-Orthogonal Multiple Access System
In a non-orthogonal multiple access (NOMA) system, the successive interference cancellation (SIC) procedure is typically employed at the receiver side, where several user’s signals are decoded in a subsequent manner. Fading channels may disperse the transmitted signal and originate dependencies among its samples, which may affect the channel estimation procedure and consequently affect the SIC process and signal detection accuracy. Machine learning (ML) algorithms have the capability to adapt to variations in channel between user and base station (BS); therefore, ML is regarded as a strong contender for future radio networks.
  • 1.1K
  • 13 Jun 2022
Topic Review
Arsenic Exposure via Contaminated Water and Food Sources
Arsenic poisoning constitutes a major threat to humans, causing various health problems. The presence of arsenic in ecosystems can originate from several natural or anthropogenic activities. Arsenic can be then gradually accumulated in different food sources, such as vegetables, rice and other crops, but also in seafood, etc., and in water sources (mainly in groundwater, but also to a lesser extent in surface water), potentially used as drinking-water supplies, provoking their contamination and therefore potential health problems to the consumers. 
  • 1.1K
  • 24 Jun 2022
Topic Review
Blue Streak (Missile)
The de Havilland Propellers Blue Streak was a British medium-range ballistic missile (MRBM), and later the first stage of the Europa satellite launch vehicle. Blue Streak was cancelled without entering full production. The project was intended to maintain an independent British nuclear deterrent, replacing the V bomber fleet which would become obsolete by 1965. The operational requirement for the missile was issued in 1955 and the design was complete by 1957. However, during development it became clear that the missile system was too expensive and too vulnerable to a pre-emptive strike. The missile project was cancelled in 1960, with US-led Skybolt the preferred replacement. Partly to avoid political embarrassment from the cancellation, the UK Government proposed that the rocket be used as the first stage of a civilian satellite launcher called Black Prince. However, the cost was thought to be too great for the UK alone, and international collaboration was sought. This led to the formation of the European Launcher Development Organisation (ELDO), with Blue Streak used as the first stage of a carrier rocket named Europa. Europa was tested at Woomera Test Range, Australia, and later at Kourou in French Guiana. Following launch failures, the ELDO project was cancelled in 1972 and development of Blue Streak was halted.
  • 1.1K
  • 11 Oct 2022
Topic Review
Partially Substitutions of Silica Fume for Sustainable Concrete
Self-compacting concrete (SCC) uses a lot of natural resources, much like regular concrete, which results in unsustainable construction. Slump flow, slump T50, L-box, and V-funnel tests were used to investigate fresh SCC properties, such as filling and passing capabilities. Mechanical properties were examined using compressive, tensile, and flexure strength, while the durability characteristics of SCC were examined through water absorption, porosity, sorptivity, and chloride resistance. The internal structure of SCC, with and without SF, is reviewed through scan electronic microscopy (SEM). Silica fume (SF) lacked the filling and passing ability of SCC, but is still within the limit defined by the technical specification for SCC. Improvements in SCC’s strength and durability were also seen; however, greater doses had a negative impact on these attributes due to an absence of flowability. Researchers recommended the ideal SF dosage ranges from 10 to 15% by volume of cement. 
  • 1.1K
  • 12 Oct 2022
Topic Review
Comparison of Document Markup Languages
The following tables compare general and technical information for a number of document markup languages. Please see the individual markup languages' articles for further information.
  • 1.1K
  • 23 Oct 2022
Topic Review
Respiratory Syncytial Virus and Air Pollution Interaction
Respiratory syncytial virus (RSV) is one of the major infectious agents in paediatrics, and its relationship with air pollution is frequently observed. A relationship between lower air quality and RSV infections was observed mainly in hospital-based and some community-based studies, with particular interest in PM2.5, PM10, nitric dioxide (NO2), ozone, carbon monoxide (CO), and benzene. Exposure to another pollutant, cigarette smoke, is a well-described risk factor for a more severe RSV infection in children, an increased RSV LRTI prevalence, and chronic obstructive pulmonary disease (COPD); in the latter case, the RSV can be persistently present, escaping an immune response.
  • 1.1K
  • 01 Nov 2022
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