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Topic Review
Respiratory Syncytial Virus Passive Immunoprophylaxis
Respiratory syncytial virus (RSV) is a non-segmented, single-stranded, negative-sense RNA virus belonging to the Pneumoviridae family. It represents the leading cause of acute respiratory tract infections in children worldwide. Treatment of RSV infections is primarily supportive, including hydration and oxygen supplementation.
  • 1.1K
  • 28 Apr 2021
Topic Review
Electrospun Nanofiber Mats
Air pollution is one of the biggest health and environmental problems in the world and a huge threat to human health on a global scale. Due to the great impact of respiratory viral infections, chronic obstructive pulmonary disease, asthma, emphysema, lung disease, and heart disease, respiratory allergies are increasing significantly every year. Because of the special properties of electrospun nanofiber mats, e.g., large surface-to-volume ratio and low basis weight, uniform size, and nanoporous structure, nanofiber mats are the preferred choice for use in large-scale air filtration applications. 
  • 1.1K
  • 07 May 2021
Topic Review
Materials for Agricultural Gas Sensors
A sensing material employed as a gas sensor will react with multiple gases, and for this reason, multiple sensing materials are employed in a network of gas sensors known as an electronic nose (eNose) system. By recording the response of this network of gas sensors, a signature which relates to the target analyte is detected, mitigating the issue of selectivity. 
  • 1.1K
  • 21 May 2021
Topic Review
Sesquiterpene Essential Oil from Jungia rugosa Less
As part of a project devoted to the phytochemical study of Ecuadorian biodiversity, new essential oils are systematically distilled and analysed. In the present work, Jungia rugosa Less (Asteraceae) has been selected and some wild specimens collected to investigate the volatile fraction. The essential oil, obtained from fresh leaves, was analysed for the first time in the present study. The chemical composition was determined by gas chromatography, coupled to mass spectrometry (GC-MS) for qualitative analysis, and to flame ionization detector (GC-FID) for quantitation. The calculation of relative response factors (RRF), based on combustion enthalpy, was carried out for each quantified component. Fifty-six compounds were identified and quantified in a 5% phenyl-polydimethylsiloxane non-polar column and 53 compounds in a polyethylene glycol polar column, including four undetermined compounds. The main feature of this essential oil was the exclusive sesquiterpenes content, both hydrocarbons (74.7% and 80.4%) and oxygenated (8.3% and 9.6%). Major constituents were: γ-curcumene (47.1% and 49.7%) and β-sesquiphellandrene (17.0% and 17.9%), together with two abundant undetermined oxygenated sesquiterpenes, whose abundance was 6.7–7.2% and 4.7–3.3%, respectively. 
  • 1.1K
  • 21 Oct 2021
Topic Review
Peimine, an Anti-Inflammatory Compound from Chinese Herbal Extracts
Fritillaria bulbs are used in Traditional Chinese Medicine to treat several illnesses. Peimine (Pm), an anti-inflammatory compound from Fritillaria, is known to inhibit some voltage-dependent ion channels and muscarinic receptors, but its interaction with ligand-gated ion channels remains unexplored.
  • 1.1K
  • 29 Mar 2022
Topic Review
Protected Areas in Lebanon
Protected areas (PA) play a significant role in the conservation of the world’s habitats and the protection of biodiversity that have become highly threatened by devastating anthropocentric practices. In addition, protected areas, especially biosphere reserves (BR), are considered effective instruments for both nature conservation and rural development. However, their impact on rural communities constitutes the most controversial debate in conservation policy and practice.
  • 1.1K
  • 01 Dec 2021
Topic Review
Circular Economy within Geotechnical Engineering
The construction industry currently relies heavily on primary aggregates which is unsustainable. There are many recycled and secondary aggregates which may be adopted as an alternative to primary aggregates, offering the potential for reducing reliance on a finite resource and diverting waste from landfill.
  • 1.1K
  • 10 Dec 2021
Topic Review
NF-κB and Human Cancer
Transcription factor NF-κB has been extensively studied for its varied roles in cancer since its initial characterization as a potent retroviral oncogene several decades ago. It is now clear that NF-κB plays a major role in a large variety of human cancers, including especially ones of immune cell origin. NF-κB is generally constitutively or aberrantly activated in human cancers where it is involved.
  • 1.1K
  • 25 Dec 2021
Topic Review
Diagnosis and Treatment of MODY
Maturity-Onset Diabetes of the Young (MODY) is a monogenic type of diabetes, resultant from single gene mutations. MODY is characterized by mild hyperglycemia, autosomal dominant inheritance, early onset of diabetes (<25 years), insulin resistance, and preservation of endogenous insulin secretion. The genes involved are crucial for the development, function and regulation of beta cells and can cause glucose sensing and insulin secretion disorders.
  • 1.1K
  • 24 Mar 2022
Topic Review
Cyclin-Dependent Inhibitors in Diet-Induced Obesity and Cancer
Overweight and obesity constitute the most impactful lifestyle-dependent risk factors for cancer and have been tightly linked to a higher number of tumor-related deaths nowadays. The excessive accumulation of energy can lead to an imbalance in the level of essential cellular biomolecules that may result in inflammation and cell-cycle dysregulation. Nutritional strategies and phytochemicals are gaining interest in the management of obesity-related cancers, with several ongoing and completed clinical studies that support their effectiveness. At the same time, cyclin-dependent kinases (CDKs) are becoming an important target in breast and ovarian cancer treatment, with various FDA-approved CDK4/6 inhibitors that have recently received more attention for their potential role in diet-induced obesity (DIO).
  • 1.1K
  • 10 Jun 2022
Topic Review
An Updated Classification of Cardiorenal Syndrome
Cardiorenal syndrome (CRS) is defined as progressive, combined cardiac and renal dysfunction. Here, the pathomechanisms and clinical hallmarks of both chronic heart failure and chronic kidney disease are presented, and an updated classification of CRS is proposed.
  • 1.1K
  • 10 Jun 2022
Topic Review
Bioactivities of Turmeric Oil
Curcuma longa L. (syn. Curcuma domestica), commonly known as turmeric, is a perennial herb native to Asia. After curing, drying, and milling, turmeric rhizomes are usually employed as a dye, cosmetic, and food seasoning. Most pharmacological activities of turmeric have been explained by the properties of curcumin, mainly because turmeric oil has not been as extensively studied as curcuminoids. Turmeric rhizome oil (TO) is responsible for this spice’s characteristic taste and smell.
  • 1.1K
  • 16 Aug 2022
Topic Review
Electric Vehicle Adoption in Oil-Producing Nations
Electric vehicles (EVs) are important elements in the global strategy to tackle climate change. EVs are widely considered to be more environmentally and economically efficient than internal combustion engine-based vehicles (ICEVs), and as the technology matures and availability increases, governments around the world are beginning to phase out ICEVs and promote EV adoption.
  • 1.1K
  • 30 Aug 2022
Topic Review
Digital Storytelling in Education
Digital storytelling in education can be made possible by introducing user-friendly tools into the process, representing not just a fashion of the time but mostly a renewal trend, aiming at revitalizing the course to attract and engage learners. Undoubtedly, today’s pupils have grown up with technological means, becoming familiar with their use so their implication causes undiminished interest in most daily activities, including schooling. In this high-tech generation, it is absurd to address the transmission of knowledge and values in outdated ways. Apart from adapting to the timely students’ needs, lesson plans on transmedia storytelling practices can also satisfy tutors, triggering their inspiration and co-creation potentials.
  • 1.1K
  • 13 Sep 2022
Topic Review
Nutraceuticals for Improving Sleep Quality
Functional beverages can be a valuable component of the human diet with the ability to not only provide essential hydration but to deliver important bioactive compounds that can contribute to chronic disease treatment and prevention. One area of the functional beverage market that has seen an increase in demand in recent years are beverages that promote relaxation and sleep. Sleep is an essential biological process, with optimal sleep being defined as one of adequate duration, quality and timing. It is regulated by a number of neurotransmitters which are, in turn, regulated by dietary intake of essential bioactive compounds. 
  • 1.1K
  • 14 Oct 2022
Topic Review
Time Stretch Analog-to-digital Converter
The time-stretch analog-to-digital converter (TS-ADC), also known as the time stretch enhanced recorder (TiSER), is an analog-to-digital converter (ADC) system that has the capability of digitizing very high bandwidth signals that cannot be captured by conventional electronic ADCs. Alternatively, it is also known as the photonic time stretch (PTS) digitizer, since it uses an optical frontend. It relies on the process of time-stretch, which effectively slows down the analog signal in time (or compresses its bandwidth) before it can be digitized by a slow electronic ADC.
  • 1.1K
  • 20 Oct 2022
Topic Review
Nanoporous Stainless Steel Materials for Body Implants
Despite the inadequate biocompatibility, medical-grade stainless steel materials have been used as body implants for decades. The desired biological response of surfaces to specific applications in the body is a highly challenging task, and usually not all the requirements of a biomaterial can be achieved. Nanostructured surfaces have shown intriguing results as cell selectivity can be achieved by specific surface nanofeatures. Nanoporous structures can be fabricated by anodic oxidation, which has been widely studied for titanium and its alloys, while no systematic studies are available for stainless steel (SS) materials.
  • 1.1K
  • 04 Nov 2022
Topic Review
EINTR
The Unix philosophy, originated by Ken Thompson, is a set of cultural norms and philosophical approaches to minimalist, modular software development. It is based on the experience of leading developers of the Unix operating system. Early Unix developers were important in bringing the concepts of modularity and reusability into software engineering practice, spawning a "software tools" movement. Over time, the leading developers of Unix (and programs that ran on it) established a set of cultural norms for developing software; these norms became as important and influential as the technology of Unix itself, and have been termed the "Unix philosophy." The Unix philosophy emphasizes building simple, compact, clear, modular, and extensible code that can be easily maintained and repurposed by developers other than its creators. The Unix philosophy favors composability as opposed to monolithic design.
  • 1.1K
  • 04 Nov 2022
Topic Review
Crowds
Crowds is a proposed anonymity network for anonymous web browsing. The main idea behind Crowds anonymity protocol is to hide each user's communications by routing them randomly within a group of similar users. Neither the collaborating group members nor the end receiver can therefore be sure where in the group the packet originated. Crowds was designed by Michael K. Reiter and Aviel D. Rubin. It defends against internal attackers and a corrupt receiver, but provides no anonymity against a global attacker or a local eavesdropper (see "Crowds: Anonymity For Web Transactions"). Crowds is vulnerable to the predecessor attack; this was discussed in Reiter and Rubin's paper and further expanded in "The Predecessor Attack: An Analysis of a Threat to Anonymous Communications Systems" by Matthew K. Wright, Micah Adler, And Brian Neil Levine. Crowds introduced the concept of users blending into a crowd of computers.
  • 1.1K
  • 08 Nov 2022
Topic Review
Transcriptomic Harmonization
Emergence of methods interrogating gene expression at high throughput gave birth to quantitative transcriptomics, but also posed a question of inter-comparison of expression profiles obtained using different equipment and protocols and/or in different series of experiments. Addressing this issue is challenging, because all of the above variables can dramatically influence gene expression signals and, therefore, cause a plethora of peculiar features in the transcriptomic profiles. Millions of transcriptomic profiles were obtained and deposited in public databases of which the usefulness is however strongly limited due to the inter-comparison issues. Platform/protocol/batch bias can be efficiently reduced not only for the comparisons of limited transcriptomic datasets. Instead, instruments were proposed for transforming gene expression profiles into the universal, uniformly shaped format that can support multiple inter-comparisons for reasonable calculation costs. This forms a basement for universal indexing of all or most of all types of RNA sequencing and microarray hybridization profiles.
  • 1.1K
  • 02 Dec 2022
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