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Topic Review
Enzymatic Paper-Based Point-of-Care Testing for Type-2 Diabetes
A point-of-care (POC) can be defined as an in vitro diagnostic test that can provide results within minutes. It has gained enormous attention as a promising tool for biomarkers detection and diagnosis, as well as for screening of chronic noncommunicable diseases such as diabetes mellitus. Diabetes mellitus type 2 is one of the metabolic disorders that has grown exponentially in recent years, becoming one of the greatest challenges to health systems. Early detection and accurate diagnosis of this disorder are essential to provide adequate treatments. Diabetes-monitoring tools must be accessible and affordable; thus, POC platforms are attractive, especially paper-based ones. Paper-based POCs are simple and portable, can use different matrixes, do not require highly trained staff, and are less expensive than other platforms. These advantages enhance the viability of its application in low-income countries and hard-to-reach zones.
  • 704
  • 15 Dec 2021
Topic Review
Modeling Immune Checkpoint Inhibitors
Immune checkpoint inhibitors are revolutionizing the treatment of cancer, but models that accurately predict their efficacy before administering them to humans are badly needed.  This entry presents the application of a microfluidic tumor model that simulates the interactions between immune cells and tumors in a dynamic microenvironment, utilizing real-time imaging and image analytic algorithms to demonstrate excellent correlations between the laboratory model and animal studies.  Future applications of the system in precision medicine will explore the use of the device for selecting patient-specific therapies for cancer.
  • 703
  • 26 Oct 2020
Topic Review
Breast Cancer Detection
Breast cancer is one the main death causes for women worldwide, as 16% of the diagnosed malignant lesions worldwide are its consequence. In this sense, it is of paramount importance to diagnose these lesions in the earliest stage possible, in order to have the highest chances of survival. While there are several works that present selected topics in this area, none of them present a complete panorama, that is, from the image generation to its interpretation.
  • 699
  • 27 Jul 2022
Topic Review
Synchrotron X-ray Radiation in Medical Imaging
Synchrotron X-ray radiation (SXR) has been widely studied to explore the structure of matter. Recently, there has been an intense focus on the medical application of SXR in imaging. Synchrotron X-ray radiation source provides many useful features (e.g., high intensity and collimation, a wide range of energy spectrum, option to use monochromator to select narrow beam of the desired energy, etc.). However, because of its high cost, it has still found limited applications in routine clinical and laboratory uses. With the advancement in other disciplines, specifically, the advancement in generating synthetic images from one modality to another modality using deep learning could be adapted to generate SXR images provided that a conventional X-ray image of the object is available. A photon-counting detector (PCD) can further improve the signal-to-noise ratio and soft tissue contrast by detecting scattered photons while using the monochromatic energy provided by the SXR. A combination of the computational advancement of different disciplines with the physical capabilities of the SXR can make high-resolution SXR-based medical imaging affordable and cost-effective, especially for in vivo microstructure and cellular level studies.
  • 698
  • 24 Apr 2022
Topic Review
Design Parameters of Power Amplifiers for Ultrasound Applications
A design analysis of the power amplifiers developed for ultrasound applications was conducted because ultrasound applications require different types of power amplifiers, which are one of the most critical electronic components in ultrasound systems. To generate acoustic signals using transducers, which are among the most important mechanical devices in ultrasound systems, an appropriate output voltage, current, or power signal must be produced by a power amplifier.
  • 694
  • 11 Jul 2023
Topic Review
Mechanical Properties of Animal Tendons
In medical and bioengineering research, animal tendons are commonly utilized as surrogates for human ones for mechanical testing. Due to the differences among human tendons of different anatomical districts, different animal species can be better suited for specific purposes. Indeed, the mechanical response of animal tendons to an external load is strictly related to its complex and highly organized hierarchical structure, which ranges from nano- to macroscale. In a broader sense, the mechanical properties of tendons during tensile tests are affected by several distinct factors, due in part to tendon nature (anatomical site, age, training, injury, etc.) but also depending on the experimental setup and settings. Thus, there are similarities between animal and human tendons that should be considered in the biomechanical evaluation. 
  • 693
  • 12 Mar 2022
Topic Review
Collagen in Airway Mechanics
Collagen is the most abundant airway extracellular matrix component and is the primary determinant of mechanical airway properties. Abnormal airway collagen deposition is associated with the pathogenesis and progression of airway disease.
  • 690
  • 20 Feb 2021
Topic Review
Pap Smear Images Classification with Machine Learning
Cervical cancer is regularly diagnosed in women all over the world. This cancer is the seventh most frequent cancer globally and the fourth most prevalent cancer among women. Automated and higher accuracy of cervical cancer classification methods are needed for the early diagnosis of cancer. In addition, routine Pap smears could enhance clinical outcomes by facilitating the early diagnosis of cervical cancer. Liquid-based cytology (LBC)/Pap smears for advanced cervical screening is a highly effective precancerous cell detection technology based on cell image analysis, where cells are classed as normal or abnormal. Computer-aided systems in medical imaging have benefited greatly from extraordinary developments in artificial intelligence (AI) technology.
  • 684
  • 02 Dec 2022
Topic Review
Biocidal Action of Hydrogen Peroxide Vapour and Mechanism
Disinfection is described as a process that eliminates many or all pathogenic microorganisms on inanimate objects, with the exception of bacterial endospores. Disinfection is usually carried out by chemical or physical means. Among other settings, disinfection is of utmost importance in hospital environments due to pathogens living on hospital surfaces being the direct cause for hospital-acquired infections (HAIs). However, the presence of a wide range of pathogens and biofilms, combined with the indiscriminate use of antibiotics, presents infection control teams in healthcare facilities with ongoing challenges in the selection of biocides and application methods. This necessitates the development of biocides and innovative disinfection methods that overcome the shortcomings of conventional methods. The use of hydrogen peroxide vapour to be a superior alternative to conventional methods. Hydrogen peroxide vapour to be very close to an ideal disinfectant due to its proven efficacy against a wide range of microorganisms, safety to use, lack of toxicity concerns and good material compatibility.
  • 683
  • 14 Mar 2024
Topic Review
Computational Simulations of Heart Valves
Computational methods are a cost-effective tool that can be used to evaluate the flow parameters of heart valves. Valve repair and replacement have long-term stability and biocompatibility issues, highlighting the need for a more robust method for resolving valvular disease. For example, while fluid–structure interaction analyses are still scarcely utilized to study aortic valves, computational fluid dynamics is used to assess the effect of different aortic valve morphologies on velocity profiles, flow patterns, helicity, wall shear stress, and oscillatory shear index in the thoracic aorta. It has been analyzed that computational flow dynamic analyses can be integrated with other methods to create a superior, more compatible method of understanding risk and compatibility.
  • 681
  • 10 May 2022
Topic Review
A Unique Marine-Derived Collagen
To provide the conditions for the mechanical and structural properties needed for the restored tissue and its appropriate functioning, the scaffold requires specific biochemical properties in order to ensure a correct healing process. The scaffold creates a support system and requires a suitable material that will transduce the appropriate signals for the regenerative process to take place. A scaffold composed of material that mimics natural tissue, rather than a synthetic material, will achieve better results.
  • 675
  • 30 Aug 2021
Topic Review
Biopolymers and Bioprinting for Dental Tissue Engineering
Dental tissues are composed of multiple tissues with complex organization, such as dentin, gingiva, periodontal ligament, and alveolar bone. These tissues have different mechanical and biological properties that are essential for their functions. Therefore, dental diseases and injuries pose significant challenges for restorative dentistry, as they require innovative strategies to regenerate damaged or missing dental tissues. Biomimetic bioconstructs that can effectively integrate with native tissues and restore their functionalities are desirable for dental tissue regeneration.
  • 675
  • 23 Aug 2023
Topic Review
Post-Stroke Movement with Motion Capture and Musculoskeletal Modeling
Research of post-stroke locomotion via musculoskeletal (MSK) modeling has offered an unprecedented insight into pathological muscle function and its interplay with skeletal geometry and external stimuli. Advances in solving the dynamical system of post-stroke effort and the generic MSK models used have triggered noticeable improvements in simulating muscle activation dynamics of stroke populations.
  • 674
  • 09 Dec 2022
Topic Review
Phenylpropanoid Biosynthetic Pathways
The MYB transcription factors (TFs) are evolving as critical role in the regulation of the phenylpropanoid and tanshinones biosynthetic pathway. MYB TFs relate to a very important gene family, which are involved in the regulation of primary and secondary metabolisms, terpenoids, bioactive compounds, plant defense against various stresses and cell morphology.
  • 672
  • 17 Sep 2021
Topic Review
Nanomaterials for Skin Cancer Photoimmunotherapy
Skin cancer is one of the most common types of cancer, and its incidence continues to increase. It is divided into two main categories, melanoma and non-melanoma. Treatments include surgery, radiation therapy, and chemotherapy. The relatively high mortality in melanoma and the existing recurrence rates, both for melanoma and non-melanoma, create the need for studying and developing new approaches for skin cancer management. Studies have focused on immunotherapy, photodynamic therapy, photothermal therapy, and photoimmunotherapy. Photoimmunotherapy has gained much attention due to its excellent potential outcomes. It combines the advantages of photodynamic and/or photothermal therapy with a systemic immune response, making it ideal for metastatic cancer. 
  • 672
  • 11 May 2023
Topic Review
Organ-on-Chip Models for Mimicking Joint Microenvironment
Osteoarthritis (OA) remains a prevalent disease affecting more than 20% of the global population, resulting in morbidity and lower quality of life for patients. The study of OA pathophysiology remains predominantly in animal models due to the complexities of mimicking the physiological environment surrounding the joint tissue. Development in microfluidic organ-on-chip (OoC) systems have demonstrated various techniques to mimic and modulate tissue physiological environments. Adaptations of these techniques have demonstrated success in capturing a joint tissue’s tissue physiology for studying the mechanism of OA. 
  • 671
  • 10 Mar 2023
Topic Review
Virus-Incorporated Biomimetic Nanocomposites
Owing to the astonishing properties of non-harmful viruses, tissue regeneration using virus-based biomimetic materials has been an emerging trend recently. The selective peptide expression and enrichment of the desired peptide on the surface, monodispersion, self-assembly, and ease of genetic and chemical modification properties have allowed viruses to take a long stride in biomedical applications. 
  • 670
  • 07 Jun 2021
Topic Review
Key Requirements for the Development of Skin-on-a-Chip Devices
The increased demand for physiologically relevant in vitro human skin models for testing pharmaceutical drugs has led to significant advancements in skin engineering. One of the most promising approaches is the use of in vitro microfluidic systems to generate advanced skin models, commonly known as skin-on-a-chip (SoC) devices. These devices allow the simulation of key mechanical, functional and structural features of the human skin, better mimicking the native microenvironment. Importantly, contrary to conventional cell culture techniques, SoC devices can perfuse the skin tissue, either by the inclusion of perfusable lumens or by the use of microfluidic channels acting as engineered vasculature. Moreover, integrating sensors on the SoC device allows real-time, non-destructive monitoring of skin function and the effect of topically and systemically applied drugs.
  • 670
  • 13 Apr 2022
Topic Review
Dielectrophoresis Studies on Protein Albumin
Research relating to dielectrophoresis (DEP) has been progressing rapidly through time as it is a strong and controllable technique for manipulation, separation, preconcentration, and partitioning of protein. Extensive studies have been carried out on protein DEP, especially on Bovine Serum Albumin (BSA).
  • 668
  • 01 Sep 2022
Topic Review
Critical MIM + SH Processing Parameters
Metal injection molding (MIM) combined with the use of a space holder (SH) is a very attractive route for the fabrication of highly porous titanium and titanium alloy components for biomedical applications. This approach allows fine control of the morphology, architecture, and purity of very complex net-shaped components.
  • 665
  • 13 May 2022
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