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Topic Review
Design Parameters of Power Amplifiers for Ultrasound Applications
A design analysis of the power amplifiers developed for ultrasound applications was conducted because ultrasound applications require different types of power amplifiers, which are one of the most critical electronic components in ultrasound systems. To generate acoustic signals using transducers, which are among the most important mechanical devices in ultrasound systems, an appropriate output voltage, current, or power signal must be produced by a power amplifier.
  • 1.2K
  • 11 Jul 2023
Topic Review
Biological and Physiological Role of Oxidative Stress
Antioxidants are a class of molecules with an innate affinity to neutralize reactive oxygen species (ROS), which are known to cause oxidative stress. Oxidative stress has been associated with a wide range of diseases mediated by physiological damage to the cells.
  • 1.2K
  • 06 Jan 2022
Topic Review
Electrospinning of Biomedical Nanofibers/Nanomembranes
Nanotechnology has attracted great attention from researchers in modern science because nanomaterials have innovative and superior physical, chemical, and biological properties, and they can be altered and modified accordingly. As particles get smaller, their surface area increases compared to their volume. Electrospinning is one of the advanced techniques to produce ultrathin nanofibers and membranes, and it is one of the best ways to create continuous nanomaterials with variable biological, chemical, and physical properties. The produced fibers can be utilized in various domains such as wound dressing, drug release, enzyme immobilization, etc. 
  • 1.2K
  • 22 Sep 2022
Topic Review
Near-Infrared Spectroscopy in TBI
Traumatic brain injury (TBI) occurs when a sudden trauma causes damage to the brain. TBI can result when the head suddenly and violently impacts an object or when an object pierces the skull and enters brain tissue. Secondary injuries after traumatic brain injury (TBI) can lead to impairments on cerebral oxygenation and autoregulation. Considering that secondary brain injuries often take place within the first hours after the trauma, noninvasive monitoring might be helpful in providing early information on the brain’s condition. Near-infrared spectroscopy (NIRS) is an emerging noninvasive monitoring modality based on chromophore absorption of infrared light with the capability of monitoring perfusion of the brain. This study investigates the main applications of NIRS in TBI monitoring and presents a thorough revision of those applications on oxygenation and autoregulation monitoring. Databases such as PubMed, EMBASE, Web of Science, Scopus, and Cochrane library were utilized in identifying 72 publications spanning between 1977 and 2020 which were directly relevant to this study. The majority of the evidence found used NIRS for diagnosis applications, especially in oxygenation and autoregulation monitoring (59%).
  • 1.2K
  • 06 Apr 2021
Topic Review
Organ-on-Chip Models for Mimicking Joint Microenvironment
Osteoarthritis (OA) remains a prevalent disease affecting more than 20% of the global population, resulting in morbidity and lower quality of life for patients. The study of OA pathophysiology remains predominantly in animal models due to the complexities of mimicking the physiological environment surrounding the joint tissue. Development in microfluidic organ-on-chip (OoC) systems have demonstrated various techniques to mimic and modulate tissue physiological environments. Adaptations of these techniques have demonstrated success in capturing a joint tissue’s tissue physiology for studying the mechanism of OA. 
  • 1.2K
  • 10 Mar 2023
Topic Review
Smart Textile
The integration of electronic components in/onto conductive textile yarns without compromising textile qualities such as flexibility, conformability, heat and moisture transfer, and wash resistance is essential to ensuring acceptance of electronic textiles. One solution is creating flexible and stretchable conductive yarns that contain tiny surface-mounted electronic elements embedded at the fiber level.
  • 1.2K
  • 06 May 2022
Topic Review
Biopolymers and Bioprinting for Dental Tissue Engineering
Dental tissues are composed of multiple tissues with complex organization, such as dentin, gingiva, periodontal ligament, and alveolar bone. These tissues have different mechanical and biological properties that are essential for their functions. Therefore, dental diseases and injuries pose significant challenges for restorative dentistry, as they require innovative strategies to regenerate damaged or missing dental tissues. Biomimetic bioconstructs that can effectively integrate with native tissues and restore their functionalities are desirable for dental tissue regeneration.
  • 1.2K
  • 23 Aug 2023
Topic Review
Drowning Behaviour and Signs
Drowning poses a significant threat, resulting in unexpected injuries and fatalities. To promote water sports activities, it is crucial to develop surveillance systems that enhance safety around pools and waterways. 
  • 1.2K
  • 18 Jan 2024
Topic Review
Biofunctionalization of the Tissue Engineered Heart Valves
Valve replacement is the mainstay of treatment for end-stage valvular heart disease, but varying degrees of defects exist in clinically applied valve implants. A mechanical heart valve requires long-term anti-coagulation, but the formation of blood clots is still inevitable. A biological heart valve eventually decays following calcification due to glutaraldehyde cross-linking toxicity and a lack of regenerative capacity. The goal of tissue-engineered heart valves is to replace normal heart valves and overcome the shortcomings of heart valve replacement commonly used in clinical practice. Surface biofunctionalization has been widely used in various fields of research to achieve functionalization and optimize mechanical properties.
  • 1.2K
  • 28 Sep 2022
Topic Review
Stem Cell Niche Microenvironment
Limbal epithelial stem cells (LESCs), which live in a specialized stem cell niche (SCN), are crucial for the survival of the human corneal epithelium. They live at the bottom of the limbal crypts, in a physically enclosed microenvironment with a number of neighboring niche cells. Scientists also simplified features of these diverse microenvironments for more analysis in situ by designing and recreating features of different SCNs. 
  • 1.1K
  • 22 Sep 2021
Topic Review
Synchrotron X-ray Radiation in Medical Imaging
Synchrotron X-ray radiation (SXR) has been widely studied to explore the structure of matter. Recently, there has been an intense focus on the medical application of SXR in imaging. Synchrotron X-ray radiation source provides many useful features (e.g., high intensity and collimation, a wide range of energy spectrum, option to use monochromator to select narrow beam of the desired energy, etc.). However, because of its high cost, it has still found limited applications in routine clinical and laboratory uses. With the advancement in other disciplines, specifically, the advancement in generating synthetic images from one modality to another modality using deep learning could be adapted to generate SXR images provided that a conventional X-ray image of the object is available. A photon-counting detector (PCD) can further improve the signal-to-noise ratio and soft tissue contrast by detecting scattered photons while using the monochromatic energy provided by the SXR. A combination of the computational advancement of different disciplines with the physical capabilities of the SXR can make high-resolution SXR-based medical imaging affordable and cost-effective, especially for in vivo microstructure and cellular level studies.
  • 1.1K
  • 24 Apr 2022
Topic Review
Machine Learning in Fetal Anomaly Detection
Fetal development is a critical phase in prenatal care, demanding the timely identification of anomalies in ultrasound images to safeguard the well-being of both the unborn child and the mother. Medical imaging has played a pivotal role in detecting fetal abnormalities and malformations. However, despite significant advances in ultrasound technology, the accurate identification of irregularities in prenatal images continues to pose considerable challenges, often necessitating substantial time and expertise from medical professionals. 
  • 1.1K
  • 18 Dec 2023
Topic Review
Advancements in Noble Metal Nanoparticles-Based Point-of-Care Testing
Noble metal nanoparticles (NM NPs) have been used for POC testing for decades. The most known example might be the lateral flow assay (LFA, or test strip), where Au NPs are usually utilized as colorimetric labels owing to their outstanding optical properties. Over-the-counter pregnancy tests and the recent COVID-19 antigen rapid tests are representative examples of the lateral flow assays (LFA). Over the last couple of decades, engineered NM NPs have been extensively used for the point-of-care (POC) tests of various platforms beyond the LFA, despite most of them being in early stages of commercialization. This recent NM NPs-based POC testing techniques with innovative designs are discussed.
  • 1.1K
  • 29 Nov 2022
Topic Review
Peroxidase Mimetic Nanozymes in Cancer
Peroxidase (POD) mimetic nanozymes converts endogenous H2O2 to water (H2O) and reactive oxygen species (ROS) in a hypoxic tumor microenvironment is a fascinating approach.
  • 1.1K
  • 31 Aug 2021
Topic Review
Silk Protein-Based Membrane for GBR
Silk derived from the silkworm is known for its excellent biological and mechanical properties. It has been used in various fields as a biomaterial, especially in bone tissue engineering scaffolding. Recently, silk protein-based biomaterial has been used as a barrier membrane scaffolding for guided bone regeneration (GBR). GBR promotes bone regeneration in bone defect areas using special barrier membranes. GBR membranes should have biocompatibility, biodegradability, cell occlusion, the mechanical properties of space-making, and easy clinical handling. Silk-based biomaterial has excellent biologic and mechanical properties that make it a good candidate to be used as GBR membranes. 
  • 1.1K
  • 24 Jun 2021
Topic Review
Photocatalysis of COVID-19 in Wastewater
The coronavirus (COVID-19) pandemic is currently posing a significant threat to the world’s public health and social-economic growth. Despite the rigorous international lockdown and quarantine efforts, the rate of COVID-19 infectious cases remains exceptionally high. Notwithstanding, the end route of COVID-19, together with emerging contaminants’ (antibiotics, pharmaceuticals, nanoplastics, pesticide, etc.) occurrence in wastewater treatment plants (WWTPs), poses a great challenge in wastewater settings.
  • 1.1K
  • 09 Oct 2020
Topic Review
Physical Micro-Environment of Periodontal Ligament
In native periodontal ligament (PDL) development and homeostasis, mechanical loading plays a crucial role. Thus, any strategy aiming at periodontal tissue engineering should entail understanding and replicating in vitro the specific mechanical forces that guide the formation and remodeling of the PDL.
  • 1.1K
  • 21 Dec 2022
Topic Review
Nanomaterials for Skin Cancer Photoimmunotherapy
Skin cancer is one of the most common types of cancer, and its incidence continues to increase. It is divided into two main categories, melanoma and non-melanoma. Treatments include surgery, radiation therapy, and chemotherapy. The relatively high mortality in melanoma and the existing recurrence rates, both for melanoma and non-melanoma, create the need for studying and developing new approaches for skin cancer management. Studies have focused on immunotherapy, photodynamic therapy, photothermal therapy, and photoimmunotherapy. Photoimmunotherapy has gained much attention due to its excellent potential outcomes. It combines the advantages of photodynamic and/or photothermal therapy with a systemic immune response, making it ideal for metastatic cancer. 
  • 1.1K
  • 11 May 2023
Topic Review
Connectivity Analysis in EEG Data
Despite high-spatial-resolution imaging techniques such as functional magnetic resonance imaging (fMRI) being widely used to map this complex network of multiple interactions, electroencephalographic (EEG) recordings claim high temporal resolution and are thus perfectly suitable to describe either spatially distributed and temporally dynamic patterns of neural activation and connectivity.
  • 1.1K
  • 30 Jun 2023
Topic Review
Skeletal Muscle Tissue Engineering
Skeletal muscle (SKM) represents nowadays a complex and arguing tissue to be generated in vitro for tissue engineering purposes. Several attempts have been pursued to develop hydrogels with different formulations resembling in vitro the characteristics of SKM tissue in vivo. Topographical cues have been applied on the hydrogels to guide cellular orientation and facilitate myogenic differentiation of blended myocites and maturation of the constructs. 3D bioprinting technique allows controlled spatial deposition of cells into ECM based hydrogels and provide the proper SKM native-like tissue microenvironment.  
  • 1.1K
  • 27 Oct 2020
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