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Topic Review
Economic Burden of Stroke Disease
Globally, one of the main causes of non-communicable disease as a cause of death every year is stroke. The objective of this study was to analyze the burden in consequence of stroke. 
  • 1.2K
  • 06 Aug 2021
Topic Review
Foodborne Disease Caused by Salmonella
Foodborne disease caused by Salmonella is an important public health concern worldwide. Animal-based food, especially poultry meat, is the main source of human salmonellosis.
  • 1.2K
  • 22 Nov 2021
Topic Review
Microdosing in Business
Abusing psychoactive substances has been a popular sport in the business world since the mid-19th century. First, they were appreciated for their stimulating or tonic effects, but later with psychedelics on the scene, their importance in subculture matured. In the last decade, it has become very popular to use LSD and cocaine in subtle doses, which provides users with a high that is enough to feel their psychoactive potential, but not as high that significant behavioral changes can be seen. Unlike regular use, microdosing is usually sufficient to affect a few without undue finish and withdrawal symptoms. It allows for abuse in the regular mode of the working week with a rest phase on the weekend. The diametric difference between the abuse of standard dosing and micro-dosing is also in the decreasing tolerance of the organism.
  • 1.2K
  • 29 Mar 2022
Topic Review
Manual Therapy in Cervical/Lumbar Radiculopathy
A comprehensive literature review was conducted using PubMed and Web of Science databases up to April 2020. The following inclusion criteria were used: (1) presence of radiculopathy; (2) treatment defined as manual therapy (i.e., traction, manipulation, mobilization); and (3) publication defined as a Randomized Controlled Trial. The electronic literature search resulted in 473 potentially relevant articles. Finally, 27 articles were accepted: 21 on cervical (CR) and 6 in lumbar radiculopathy (LR). The mean PEDro score for CR was 6.6 (SD 1.3), and for LR 6.7 (SD 1.6). Traction-oriented techniques are the most frequently chosen treatment form for CR and are efficient in reducing pain and improving functional outcomes. In LR, each of the included publications used a different form of manual therapy, which makes it challenging to summarize knowledge in this group. Of included publications, 93% were either of moderate or low quality, which indicates that quality improvement is necessary for this type of research. 
  • 1.2K
  • 22 Jun 2021
Topic Review
YB1 in Triple Negative Breast Cancer
The Y Box binding protein 1 (YB1) is a multifunctional protein, found both in the cytoplasm and inside the nucleus, that belongs to the highly conserved Cold Shock Domain protein family. YB1 is highly expressed in TNBC tumors of AA origin when compared to CAs. Increased expression levels and activity of YB1 correlates with poor disease outcomes, resistance to chemotherapy, and the activation of the cancer stem cell (CSC) phenotype, with higher levels in AA than in CA TNBC tumors.
  • 1.2K
  • 23 Dec 2021
Topic Review
Therapeutic Implications of Splanchnic Vein Thrombosis
Splanchnic vein thrombosis (SVT) includes portal (portal vein thrombosis, PVT), mesenteric (mesenteric vein thrombosis, MVT) and splenic vein thrombosis, and Budd-Chiari syndrome (BCS). SVT is generally classified as secondary to an identified risk factor or primitive, unprovoked, when causative factors cannot be identified. While much rarer than common venous thromboembolism (VTE), SVT is often challenging to clinicians for both the identification of the causal disorder and for its therapeutic management. The therapeutic approach of SVT is a clinical challenge and considers the manifestations and the site of thrombosis, the risk of SVT progression, recurrence and bleeding. The decision regarding when to start, as well as the type and the duration of anticoagulant therapy is often made empirically.
  • 1.2K
  • 09 May 2023
Topic Review
AI in SARS-CoV-2 outbreak
Artificial Intelligence (AI) and Machine Learning (ML) have expanded their utilization in different fields of medicine. During the SARS-CoV-2 outbreak, AI and ML were also applied for the evaluation and/or implementation of public health interventions aimed to flatten the epidemiological curve. 
  • 1.2K
  • 29 May 2021
Topic Review
Child and Adolescent Obesity
Child and adolescent obesity constitute one of the greatest contemporary public health menaces. The enduring disproportion between calorie intake and energy consumption, determined by a complex interaction of genetic, epigenetic, and environmental factors, finally leads to the development of overweight and obesity. Child and adolescent overweight/obesity promotes smoldering systemic inflammation (“para-inflammation”) and increases the likelihood of later metabolic and cardiovascular complications, including metabolic syndrome and its components, which progressively deteriorate during adulthood. Exosomes are endosome-derived extracellular vesicles that are secreted by a variety of cells, are naturally taken-up by target cells, and may be involved in many physiological and pathological processes. Over the last decade, intensive research has been conducted regarding the special role of exosomes and the non-coding (nc) RNAs they contain (primarily micro (mi) RNAs, long (l) non-coding RNAs, messenger (m) RNAs and other molecules) in inter-cellular communications. Through their action as communication mediators, exosomes may contribute to the pathogenesis of obesity and associated disorders. There is increasing evidence that exosomal miRNAs and lncRNAs are involved in pivotal processes of adipocyte biology and that, possibly, play important roles in gene regulation linked to human obesity. 
  • 1.2K
  • 14 Apr 2021
Topic Review
Violence Prevention Education in Healthcare
Violence from patients and visitors towards healthcare workers is a serious international issue affecting the safety and health of workers, quality of care, and healthcare system sustainability. The main intervention is violence prevention (VP) education for healthcare workers. Both the healthcare environment and reasons for patient violence are complex, making it challenging to evaluate VP education using traditional methods. An alternative realist evaluation approach offers the ability to understand how, why and for whom VP education is effective to prevent violence and related injuries.
  • 1.2K
  • 27 May 2021
Topic Review
Short Vestibular and Cognitive Training for Dyslexia
Dyslexia is a common learning difficulty that does not compromise oral or nonverbal reasoning skills, and it is reported in 5–10% of school-aged children. In the literature, different theories have tried to explain the etiology of this disorder. Phonological impairment is the most known hypothesis for dyslexia; however, others researchers suggested that dyslexia could be due to cerebellar impairments. Interestingly, reading performance and arithmetic skills have been suggested to also be related to cerebellar activity. Several subsequent studies from our group and others examining postural performances in the dyslexia population supported this hypothesis, even if other researchers suggested that such an impairment occurred not only in dyslexia but also in subjects having other types of developmental disorders. A visual attentional deficit has also been reported by Facoetti et al.  and our group showed an abnormal oculomotor pattern in children with dyslexia. Based on these different theories, several researchers have tried to develop different training types in order to improve the reading abilities in children with dyslexia. 
  • 1.2K
  • 05 Nov 2021
Topic Review
Healthcare Waste Management
Healthcare waste (HCW) disposal includes a multitude of disposal methods, including incineration, landfilling and chemical treatments. These rudimentary methods and their growing use present their own problems that negatively impact both the environment and, in turn, damage public health, thus contributing to a global healthcare crisis.
  • 1.2K
  • 28 Apr 2021
Topic Review
Bruxism in Down Syndrome Children
Bruxism is defined as “a repetitive jaw-muscle activity that is characterized by clenching or grinding of the teeth and/or by bracing or thrusting of the mandible,” and is distinguished into sleep bruxism (SB) or awake bruxism (AB), depending on its circadian phenotype. Its role in children and adolescents with Down syndrome is still unclear. Therefore, this study aims to conduct a narrative review of the literature about bruxism in children and adolescents with Down syndrome to identify the prevalence, risk factors, and possible treatments of this disorder. 
  • 1.2K
  • 01 Apr 2021
Topic Review
Assistive Technologies for Supporting Older Adults' Wellbeing
As people age, they are more likely to develop multiple chronic diseases and experience a decline in some of their physical and cognitive functions, leading to the decrease in their ability to live independently. Innovative technology-based interventions tailored to older adults’ functional levels and focused on healthy lifestyles are considered imperative. 
  • 1.2K
  • 15 Feb 2022
Topic Review
The Ketogenic Diet and Cardiovascular Diseases
The ketogenic diet has been shown to have a multifaceted effect on the prevention and treatment of cardiovascular diseases (CVD). Among other aspects, it has a beneficial effect on the blood lipid profile, even compared to other diets. It shows strong anti-inflammatory and cardioprotective potential, which is due, among other factors, to the anti-inflammatory properties of the state of ketosis, the elimination of simple sugars, the restriction of total carbohydrates and the supply of omega-3 fatty acids. In addition, ketone bodies provide “rescue fuel” for the diseased heart by affecting its metabolism. They also have a beneficial effect on the function of the vascular endothelium, including improving its function and inhibiting premature ageing. The ketogenic diet has a beneficial effect on blood pressure and other CVD risk factors through, among other aspects, weight loss. The evidence cited is often superior to that for standard diets, making it likely that the ketogenic diet shows advantages over other dietary models in the prevention and treatment of cardiovascular diseases.
  • 1.2K
  • 07 Sep 2023
Topic Review
Natural Milk Microbiota
Profound bioactivities of raw breastmilk include benefits attributed to the dense and diverse natural microbiota, termed natural microbiota hereafter. Infants benefit from breastfeeding not just nutritionally, but by both ‘seeding and feeding’ the infant gut , providing microbes that seed the naïve gastrointestinal (GI or gut) ecosystem and nutritive components that feed both infant and microbial cells.
  • 1.2K
  • 11 Nov 2021
Topic Review
Telehealth and Artificial Intelligence during the COVID-19 Pandemic
Telemedicine enables clinical services to use information technology, video imaging, and telecommunication links to deliver healthcare services at a distance. In contrast to telemedicine, which is defined as the provision of medical services at a distance by a physician, telehealth is an umbrella word that encompasses telemedicine as well as a number of nonphysician services such as telenursing and telepharmacy. Telemedicine is often used for controlling chronic diseases such as cardiovascular diseases, diabetes mellitus, cancer, and mental disorders.
  • 1.2K
  • 07 Mar 2022
Topic Review
Innate Immunity Promotes Programmed Death of Individual Organisms
Over-activation of innate immunity in response to bacterial or viral (including COVID-19) infections, massive trauma, or ischemia/reperfusion often causes severe illness and death. We suggest that such severe outcomes may be manifestations of an altruistic suicidal strategy protecting the entire population from the spread of pathogens and from dangerous pathologies rather than aberrant hyperstimulation of defense responses. 
  • 1.2K
  • 22 Dec 2021
Topic Review
Erectile Dysfunction and Its Impact on Relationships
Explore how effective partner communication can significantly aid in the treatment of erectile dysfunction (ED) in this insightful article from ED Generic Store. Delving into the importance of emotional connection, open dialogue, and mutual support, this piece offers practical guidance for couples navigating the complexities of ED together. Learn how fostering trust, sharing concerns, and exploring lifestyle changes can enhance intimacy and improve overall relationship satisfaction. Gain valuable insights into the role of professional help and the power of celebrating progress as partners work collaboratively towards overcoming ED and revitalizing their connection.
  • 1.2K
  • 09 May 2024
Topic Review
Arboviral Disease Outbreaks in the Pacific Islands Countries
Arthropod-borne viral (arboviral) diseases are a significant global health problem accounting for >17% of all infectious disease cases and 1 million deaths worldwide annually. Arboviral diseases are infections caused by over 100 viruses belonging to the Flaviviridae, Togaviridae, Reoviridae, Bunyaviridae, Rhabdoviridae and Orthomyxoviridae families. These viruses are spread to humans through arthropods, including mosquitos, ticks, and flies.
  • 1.2K
  • 17 Jan 2022
Topic Review
Hotspots and Frontiers of Urban Floods
Current research shows that the number of papers published in the field of urban flooding is generally increasing year by year, and the research focus has shifted from exploring hydrological processes to adopting advanced management measures to solve urban flooding problems. 
  • 1.2K
  • 15 Dec 2021
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