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Topic Review
Bioactive Agent-Loaded Electrospun Nanofiber Membranes
Despite the advances that have been achieved in developing wound dressings to date, wound healing still remains a challenge in the healthcare system. None of the wound dressings currently used clinically can mimic all the properties of normal and healthy skin. Electrospinning has gained remarkable attention in wound healing applications because of its excellent ability to form nanostructures similar to natural extracellular matrix (ECM). Electrospun dressing accelerates the wound healing process by transferring drugs or active agents to the wound site sooner.
  • 1.2K
  • 09 Oct 2021
Topic Review
Mechanisms of Immunothrombosis by SARS-CoV-2
During COVID-19 infection, SARS-Cov-2 interacts with Angiotensin-Converting Enzyme 2 (ACE2), NRP1, endothelial cells, platelets, neutrophil extracellular traps (NETs), thrombin, extracellular DNA (eDNA), and histones, inducing heterogeneous clinical manifestations characterized by endothelial damage, microthrombosis, and inflammation.
  • 1.2K
  • 22 Nov 2021
Topic Review
Evaluation Index System for Mine Ventilation System
The mine ventilation system is an indispensable component to improve coal mining efficiency and ensure the safety production. Only by clearly grasping the comprehensive evaluation quality of ventilation system can effective countermeasures be formulated. This paper establishes an evaluation index system for mine ventilation system by combining qualitative survey with quantitative research. Specifically, the primary indicators are screened through R-type clustering and coefficient of variation method. The weight of each index is determined by the entropy weight method. Moreover, the TOPSIS method are used to evaluate the quality of the mine ventilation system. Finally, this evaluation system is used to evaluate the ventilation renovation project in the production mining area of the Sihe mine. The evaluation results verify the effectiveness of the establishment of mine ventilation evaluation index system and evaluation methods.
  • 1.2K
  • 28 Mar 2022
Topic Review
Green Hydrogen Economy in Southern Africa
Green hydrogen energy is significant in decarbonizing the entire hydrogen value chain network from its generation to the end-user sectors. It can help achieve the UN Sustainable Development Goals (SDGs), especially the UNSDG 7, and regional sustainability. Further, the public sector (especially governments) are recognized to have a pivotal role in hydrogen energy deployment because it can enhance or drive the transition from a fossil fuel-based economy to a green economy, especially if the hydrogen energy ploicies are clearly articulated or translated into hydrogen energy statute in each Southern African Development Communities (SADC) country. To ensure that communities and SADC nations appreciate the hydrogen energy economy, there is need to also communicate the benefits that come with green hydrogen, alongside the global pursuit to reduce GHG emissions that cause climate change.
  • 1.2K
  • 10 Dec 2021
Topic Review
Activin B - Biomaker of ME/CFS
Reliable serum biomarkers are of immense need for diagnostic purposes of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)—a disabling and complex disease for which diagnosis is mainly based on clinical symptoms. The aim of this study was to evaluate a possible diagnostic potential of activin B by directly comparing 134 cases of ME/CFS with 54 healthy controls. Analyses of human activin B level in plasma samples were performed using a validated human activin B ELISA assay. 
  • 1.2K
  • 17 Dec 2021
Topic Review
Heart Failure with Preserved Ejection Fraction: Microvascular Dysfunction
Heart failure with preserved ejection fraction (HFpEF) is a condition with increasing incidence, leading to a health care problem of epidemic proportions for which no curative treatments exist. Consequently, an urge exists to better understand the pathophysiology of HFpEF. Accumulating evidence suggests a key pathophysiological role for coronary microvascular dysfunction (MVD), with an underlying mechanism of low-grade pro-inflammatory state caused by systemic comorbidities.
  • 1.2K
  • 24 Feb 2022
Topic Review
Fts-Z Inhibition
Fts-Z is being explored as potent target for inhibiting emerging microbes due to its central role in Z-ring formation and conserved nature in nearly all bacterial species and absence in higher eukaryotes. Its absence in bacteria induces filamentation and cell death occurs. Antimicrobial resistance (AMR) is a pressing issue worldwide that must be addressed swiftly. It is driven by spontaneous evolution, bacterial mutation, and the dissemination of resistant genes via horizontal gene transfer. Researchers are working on many novel targets, which can become a pathway to inhibit harmful bacteria. Filamentous Thermosensitive mutant-Z (Fts-Z) is one such bacterial target that has gained popularity amongst scientists due to its conserved nature in bacteria and absence in eukaryotes.
  • 1.2K
  • 22 Jun 2022
Topic Review
Determination of Anti-Neurodegenerative Disease Activity of Plant Compounds
Neurodegenerative diseases, among which one of the most common is Alzheimer’s disease, are a multifactorial disease and therefore demand multiple therapeutic approaches.  In the last few years, different active constituents from plants have been tested as potential drugs in neurodegenerative disease therapy. The availability, lower price and less toxic effects of herbal medicines compared with synthetic agents make them a simple and excellent choice in the treatment of neurodegenerative diseases. The empirical approach to discovering new drugs from the systematic screening of plant extracts or plant-derived compounds is still an important strategy when it comes to finding new biologically active substances.
  • 1.2K
  • 30 Jul 2022
Topic Review
Regulation of Amylin and Secretases on Alzheimer’s Disease
Alzheimer’s disease remains a prevailing neurodegenerative condition which has an array physical, emotional, and financial consequences to patients and society. Among these biomolecules, there are four modulatory mechanisms of interest: alpha-, beta-, gamma-secretases, and amylin. Thus, regulation of these might have a potential therapeutic function for treatment of AD.
  • 1.2K
  • 29 Jul 2022
Topic Review
The Proteasome Activator PA200/PSME4
Proteasomes comprise a family of proteasomal complexes essential for maintaining protein homeostasis. Accordingly, proteasomes represent promising therapeutic targets in multiple human diseases. Several proteasome inhibitors are approved for treating hematological cancers. Their side effects impede their efficacy and broader therapeutic applications. Therefore, understanding the biology of the different proteasome complexes present in the cell is crucial for developing tailor-made inhibitors against specific proteasome complexes. 
  • 1.2K
  • 09 Sep 2022
Topic Review
Gestalt Practice
Gestalt Practice is a contemporary form of personal exploration and integration developed by Dick Price at the Esalen Institute. The objective of the practice is to become more fully aware of the process of living within a unified field of body, mind, relationship, earth and spirit. Gestalt is a German word that denotes form, shape or configuration, and connotes wholeness. Practice is an ongoing program or process of development. Gestalt Practice is an ongoing process of integrating human awareness across a broad spectrum of consciousness. Initially, Gestalt was used as a psychological term in Gestalt psychology. Then Fritz Perls, Laura Perls and Paul Goodman applied it to psychotherapy when they developed Gestalt therapy, upon which Gestalt Practice was partially based. Alan Watts, who was a mentor of Dick Price, suggested combining practices from the cultures of East and West. The writings of Nyanaponika Thera and the nearby presence of Zen Roshi Shunryu Suzuki[notes 1] were sources of Buddhist meditation practice for Price. Gestalt Practice was the term he used to describe his combination of these Eastern and Western traditions. This term distinguished the practice Price taught from both Gestalt therapy and Buddhist practice.:172
  • 1.2K
  • 03 Nov 2022
Topic Review
Nanoparticle–Biomolecule Conjugate
A nanoparticle–biomolecule conjugate is a nanoparticle with biomolecules attached to its surface. Nanoparticles are minuscule particles, typically measured in nanometers (nm), that are used in nanobiotechnology to explore the functions of biomolecules. Properties of the ultrafine particles are characterized by the components on their surfaces more so than larger structures, such as cells, due to large surface area-to-volume ratios. Large surface area-to-volume-ratios of nanoparticles optimize the potential for interactions with biomolecules.
  • 1.2K
  • 30 Nov 2022
Topic Review
Graphene and Carbon-Based Additives
Graphene exhibits remarkable and unparalleled qualities, making it highly desirable for tribological applications due to its exceptionally high mechanical strength, outstanding conductivity, low shear strength, and high surface area. The tribological properties of graphene are controlled by various techniques used for its synthesis and the presence of functional groups, such as residual oxygen functionalities, thickness and lateral dimensions of each sheet, number of atomic lamellae in a sheet, and structural flaws.
  • 1.2K
  • 17 Jan 2023
Topic Review
Artificial Intelligence in Fluorescent Nanodiamonds Biomedical Imaging
The ability to precisely monitor the intracellular temperature directly contributes to the essential understanding of biological metabolism, intracellular signaling, thermogenesis, and respiration. The intracellular heat generation and its measurement can also assist in the prediction of the pathogenesis of chronic diseases. Intracellular thermometry without altering the biochemical reactions and cellular membrane damage is challenging, requiring appropriately biocompatible, nontoxic, and efficient biosensors. Bright, photostable, and functionalized fluorescent nanodiamonds (FNDs) have emerged as excellent probes for intracellular thermometry and magnetometry with the spatial resolution on a nanometer scale. The temperature and magnetic field-dependent luminescence of naturally occurring defects in diamonds are key to high-sensitivity biosensing applications. Alterations in the surface chemistry of FNDs and conjugation with polymer, metallic, and magnetic nanoparticles have opened vast possibilities for drug delivery, diagnosis, nanomedicine, and magnetic hyperthermia. The possibilities and outcomes of using AI strategies recommended for early stage disease diagnosis and imaging are discuessed. 
  • 1.2K
  • 18 Jan 2023
Topic Review
Green and Low-Carbon Rural Development in China
Green and low-carbon rural development (GLRD) is becoming an important way to explore sustainable development in rural areas of China. It is significant for the sustainable development of the rural economy and of society to build a rural carbon sink system, advocate low-carbon emissions in rural areas, and promote the development of rural green industries and rural transformation.
  • 1.2K
  • 13 Feb 2023
Topic Review
Carbon Content in Biochar and GHG Emissions
Agricultural soils are a primary source of greenhouse gas (GHG) emissions. Biochar is commonly used as a soil amendment to prevent climate change by reducing GHG production, increasing soil carbon storage, improving soil moisture retention, and enhancing crop productivity. However, the effect of biochar’s carbon content under subsurface drip irrigation (SDI) has not been well studied.
  • 1.2K
  • 24 Mar 2023
Topic Review
Novel Adipokines and Their Role in Bone Metabolism
Adipokines secreted from white adipose tissue (WAT) and bone marrow adipose tissue (BMAT) exerts endocrine and paracrine effects on the survival and function of osteoblasts and osteoclasts.
  • 1.2K
  • 22 Mar 2023
Topic Review
Lipid-Based Nanocarrier Systems
Nanotechnology-based tools have played a major role in this. The implementation of this multifaceted nanotechnology concept encourages the advancement of innovative strategies and materials for improving patient compliance.
  • 1.2K
  • 03 Apr 2023
Topic Review
Sustainability Standards and Ecolabeling in the Textile Industry
The textile and fashion industry is a major polluter, contributing significantly to the pollution of water and air and producing solid waste. Textile manufacturing occurs in many steps, such as pretreatment, dyeing, and finishing; involves the use of several harmful chemicals that generate a significant amount of toxic waste and greenhouse gases; and consumes a large amount of water.
  • 1.2K
  • 01 Aug 2023
Topic Review
The Role of microRNAs in Neurological Pathologies
MicroRNAs (miRNAs) are small non-coding RNA molecules that are 18–25 nucleotides long (22 nucleotides on average) and involved in the transcriptional and post-transcriptional regulation of gene expression by RNA interference, which is of great interest to molecular biologists, geneticists, and biochemists. These molecules are mainly present intracellularly, but there is also an extracellular (circulating) microRNA fraction. The existence and functions of more than 2500 human miRNAs are known. 
  • 1.2K
  • 29 Aug 2023
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