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Topic Review
Environmental DNA Based Methods (Sensu Stricto)
Worldwide biodiversity loss points to a necessity of upgrading to a fast and effective monitoring method that can provide quick conservation action. Newly developed environmental DNA (eDNA) based method found to be more cost-effective, non-invasive, quick, and accurate than traditional monitoring (spot identification, camera trapping). 
  • 1.2K
  • 06 Dec 2021
Topic Review
Corporate Social Responsibility on Earnings Management
As it evidences the need to promote research on responsible business practices in order to formulate policies that enable the implementation of CSR (Corporate Social Responsibility) practices that favor EM (Earnings Management), therefore, researchers should follow the recommended directions and fill the existing knowledge gaps, thus extending the body in this field, developing better and more precise hypotheses and research questions, and, therefore, increasing the quality of research on the influence of CSR on EM.
  • 1.2K
  • 20 Dec 2021
Topic Review
Lacticaseibacillus casei ATCC 393
Lactic acid bacteria (LAB) are commonly applied to fish as a means of growth promotion and disease prevention. However, evidence regarding whether LAB colonize the gastrointestinal (GI) tract of fish remains sparse and controversial.
  • 1.2K
  • 28 Dec 2021
Topic Review
Attention Deficit Hyperactivity Disorder
Attention-deficit Hyperactivity Disorder is one of the most common childhood mental health disorders, affecting about 5.6% of the population worldwide.
  • 1.2K
  • 15 Jan 2022
Topic Review
Advances on Smart Cities and Smart Buildings
Modern cities are facing the challenge of combining competitiveness on a global city scale and sustainable urban development to become smart cities. A smart city is a high-tech intensive and advanced city that connects people, information, and city elements using new technologies in order to create a sustainable, greener city; competitive and innovative commerce; and an increased quality of life. This Special Issue collects the recent advancements on smart cities and covers different topics and aspects.
  • 1.2K
  • 25 Jan 2022
Topic Review
Novel Treatment Approaches to Combat Trichomoniasis
Trichomoniasis is a neglected sexually transmitted infection (STI) caused by Trichomonas vaginalis, a flagellate protozoan responsible for a prevalence of 110.4 million cases and 156.0 million rate of incidence. The last estimative from the World Health Organization (WHO) demonstrated the incidence rate for trichomoniasis across the globe, highlighting the African Region with the highest rates, followed by America, Western Pacific, Eastern Mediterranean, South-East Asia, and last, the European region. Although most cases are asymptomatic, complaints such as pruritus, vaginal discharge, irritation, and odor are still reported. The long-lasting infection of T. vaginalis, which can persist for months to years, may lead to severe complications such as the premature delivery and low weight of newborns, infertility, pelvic inflammatory disease, and a positive association with the onset of cervical and prostate cancer. 
  • 1.2K
  • 23 Feb 2022
Topic Review
Nucleic Acid Nanotechnology in Acute Kidney Injury
Acute kidney injury (AKI) is a clinical syndrome characterized by an abrupted decline in renal function due to miscellaneous factors, such as rapid volume depletion, acute infection, nephrotoxic medicines and so on, leading to a retention of nitrogen wastes and creatinine accompanied by electrolyte disturbances and acid-base imbalance. Owing to the predictable base-pairing rule and highly modifiable characteristics, nucleic acids have already become significant biomaterials for nanostructure and nanodevice fabrication, which is known as nucleic acid nanotechnology. In particular, its excellent programmability and biocompatibility have further promoted its intersection with medical challenges. Lately, there have been an influx of research connecting nucleic acid nanotechnology with the clinical needs for renal diseases, especially AKI.
  • 1.2K
  • 23 Mar 2022
Topic Review
Freight Transport Decarbonization
Freight transport decarbonization is currently an urgent challenge. Decarbonization strategies have a specific time to take effect, and it is essential to consider their time dependence. The system dynamics approach is well suited to represent feedback, lagged responses, and the time dependence of decarbonization strategies. 
  • 1.2K
  • 31 Mar 2022
Topic Review
Cholestatic Diseases
Cholestatic diseases are based on bile dysfunction due to defects affecting bile synthesis or secretion. These processes involve a wide range of enzymes and membrane transporters involved in hepatobiliary circulation. According to its origin, cholestasis can be classified into two main groups: acquired cholestasis and genetic cholestasis.
  • 1.2K
  • 10 Jun 2022
Topic Review
Immunopathogenesis of Vitiligo
Vitiligo is an acquired immune-mediated disorder of pigmentation clinically characterized by well-defined depigmented or chalk-white macules and patches on the skin. The prevalence of vitiligo varies by geographical area, affecting 0.5% to 2% of the population. The disease imposes a significant psychological burden due to its major impact on patients’ social and emotional aspects of life. Given its autoimmune background, vitiligo is frequently associated with other autoimmune diseases or immune-mediated diseases. Vitiligo is a multifaceted disorder that involves both genetic predisposition and environmental triggers. In recent years, major predisposing genetic loci for the development of vitiligo have been discovered. Oxidative-stress-mediated activation of innate immunity cells such as dendritic cells, natural killer, and ILC-1 cells is thought to be a key event in the early onset of vitiligo. Innate immunity cells serve as a bridge to adaptive immunity cells including T helper 1 cells, cytotoxic T cells and resident memory T cells. IFN-γ is the primary cytokine mediator that activates the JAK/STAT pathway, causing keratinocytes to produce the key chemokines CXCL9 and CXCL10. Complex interactions between immune and non-immune cells finally result in apoptosis of melanocytes.
  • 1.2K
  • 15 Jul 2022
Topic Review
Blood Culture-Negative Infective Endocarditis by Mycoplasma hominis
Mycoplasma hominis is a habitual colonizing microorganism of the lower genital tract but can exceptionally be the causal agent of blood culture-negative infective endocarditis (IE). 
  • 1.2K
  • 21 Jul 2022
Topic Review
Woody Plant Growth and Development under Elevated CO2
Climate change is mainly driven by the accumulation of carbon dioxide (CO2) in the atmosphere in the last century. Plant growth is constantly challenged by environmental fluctuations including heat waves, severe drought and salinity, along with ozone accumulation in the atmosphere. The effects of the predicted environment scenario of elevated CO2 concentration (e[CO2]) and more severe abiotic stresses have been scarcely investigated in woody plants, and an integrated view involving physiological, biochemical and molecular data is missing.
  • 1.2K
  • 12 Aug 2022
Topic Review
Biopolymer Based Prodrugs as Potential Antineoplastic Therapy
Cancer represents a major public health issue, a substantial economic issue, and a burden for society. Limited by numerous disadvantages, conventional chemotherapy is being replaced by new strategies targeting tumor cells. In this context, therapies based on biopolymer prodrug systems represent a promising alternative for improving the pharmacokinetic and pharmacologic properties of drugs and reducing their toxicity. The polymer-directed enzyme prodrug therapy is based on tumor cell targeting and release of the drug using polymer–drug and polymer–enzyme conjugates. In addition, current trends are oriented towards natural sources. They are biocompatible, biodegradable, and represent a valuable and renewable source. Drug–polymer conjugates based on natural polymers such as chitosan (CTS), hyaluronic acid (HA), dextran (DEX), pullulan (PL), silk fibroin (SF), centyrins (CTR), heparin (HEP), and polysaccharides from Auricularia auricula (AAP) are presented. 
  • 1.2K
  • 19 Sep 2022
Topic Review
Strategies to Improve Drug Strength in Nasal Preparations
Intranasal administration is a promising route for brain drug delivery. However, it can be difficult to formulate drugs that have low water solubility into high strength intranasal solutions.
  • 1.2K
  • 08 Nov 2022
Topic Review
Canadian Internet Registration Authority
The Canadian Internet Registration Authority (CIRA) (French: Autorité canadienne pour les enregistrements Internet ACEI) is the organization that manages the .ca country code top-level domain (ccTLD) for Canada. Its offices are located at 979 Bank Street in Ottawa, Ontario, Canada. CIRA sets the policies and agendas that support Canada's Internet community and Canada's involvement in international Internet governance. It is a member-driven organization with membership open to all that hold a .ca domain. As of May 2020, there were more than 2.9 million active .ca domains.
  • 1.2K
  • 09 Nov 2022
Topic Review
Advanced Nuclear
Advanced nuclear is an emerging area of the energy industry focused on designing and commercializing next generation reactors for nuclear energy production. Encompassing more comprehensive and radical technological innovations and design advancements, these innovations aim to dramatically improve performance and eliminate known problems associated with the existing generation nuclear reactors (Gen I and Gen II) currently in use around the world. The earliest Gen I and Gen II nuclear reactors built utilized the light-water reactor design in one of three variants: the pressurized water reactor (PWR), the boiling water reactor (BWR), and the supercritical water reactor (SCWR). The use of the light-water design (i.e. using regular water, H2O and not heavy water, 2H2O) as both its coolant and neutron moderator but needing a plentiful supply) in all commercial reactors was a trade-off that enabled the industry to leverage the purchasing clout of Admiral Hyman G. Rickover, who was keen on procuring nuclear-powered submarines for the Navy, to grow quickly. The choice, however, imposed a riskier design that many argued was not optimized for terrestrial energy, bringing both competitive advantages as well as fateful disadvantages to the initial development and subsequent growth of the commercial nuclear power fleet. Despite operating to the military's exacting specifications and winning praise and massive contracts from government buyers, the industry quickly earned the distrust of the public. (See the Anti-nuclear movement.) Generation III reactors contain yet further incremental refinements to aspects of Generation II nuclear reactor designs but were not very popular. Improvements were developed for fuel technology, thermal efficiency, to safety systems to reduce maintenance and capital costs. The first Generation III reactor was Kashiwazaki 6 (an ABWR) in 1996 but the declining support for the underlying Generation II light-water design, caused relatively few third generation reactors to be built. Generation IV designs are the first generation where innovator in Advanced Nuclear technologies are exploring paradigm shifts in methodologies. Gen IV projects encompass not just innovative nuclear fission concepts, like the Molten salt reactor, Liquid Metal Fast Breeder Reactors, and High temperature gas cooled reactors, but also Fusion power and even Low Energy Nuclear Reactors (LENR), which generate heat through a series of controlled chemical reactions that then cause a nuclear bond to shift, which results in heat output. Gen IV is still in development as of 2017, and are not expected to start entering commercial operation until after 2020. Some of the different reactor design ideas being explored and developed for Advanced nuclear reactors, now thought of as Generation IV reactors (Gen IV) today were actually first conceived within the National Labs back in the 1960s. Several of these concepts, including Alvin M. Weinberg's Molten salt reactor (MSR) developed at the Oak Ridge National Laboratory (ORNL), even had the benefit of being prototyped and tested over a period of time. Weinberg's MSR became the first reactor to run on Uranium 233 in 1968 and logged more than 13,000 hours at "full power" before being shut down in 1969. Today, the concept of using a molten salt brew that acts both as the fuel and the "containment" of the reaction by using the ionic bonds of the salt to capture and contain the heat generated from the nuclear reaction, thereby dispensing with the need for expensive containment structures and eliminating much of risk and cost, remains of keen interest to those exploring Advanced nuclear technologies.
  • 1.2K
  • 11 Nov 2022
Topic Review
Ultrafast Laser Spectroscopy
Ultrafast laser spectroscopy is a spectroscopic technique that uses ultrashort pulse lasers for the study of dynamics on extremely short time scales (attoseconds to nanoseconds). Different methods are used to examine dynamics of charge carriers, atoms and molecules. Many different procedures have been developed spanning different time scales and photon energy ranges; some common methods are listed below.
  • 1.2K
  • 15 Nov 2022
Topic Review
Health Effects of Radiation Exposure
Computed tomography (CT) exposes patients to hazardous ionizing radiation, which carry the risk to damage the genetic material in the cells, leading to stochastic health effects in the form of heritable genetic mutations and increased cancer risk. These probabilistic, long-term carcinogenic effects of radiation can be seen over a lifetime and may sometimes take several decades to manifest. 
  • 1.2K
  • 19 Dec 2022
Topic Review
The Free Banking School
The Free Banking School is a term used for economists who study the costs and benefits of the competitive issue of currency by banks. 
  • 1.2K
  • 30 Dec 2022
Topic Review
Mobile-Hypertensive Retinopathy
Hypertensive retinopathy (HR) is a serious eye disease that causes the retinal arteries to change. This change is mainly due to the fact of high blood pressure. Cotton wool patches, bleeding in the retina, and retinal artery constriction are affected lesions of HR symptoms.
  • 1.2K
  • 29 May 2023
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