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Topic Review
Application of CRISPR/Cas9 in Rapeseed
Brassica napus L. provides high-quality edible oil and clean energy for humans. For a long time, rapeseed breeders have tried to breed improved varieties through traditional breeding strategies. However, B. napus is an allotetraploid species containing many repetitive sequences. It is very inefficient to change traits through traditional genetic methods such as hybridization and random mutagenesis due to gene redundancy. Today, the burgeoning CRISPR/Cas9 technology has been applied in polyploid rapeseed for gene function research and targeted genetic improvement because of its unique advantages of high efficiency and simplicity. 
  • 1.2K
  • 25 Apr 2022
Topic Review
Nitroaromatic Hypoxia-Activated Prodrugs for Cancer Therapy
The presence of “hypoxic” tissue (with O2 levels of <0.1 mmHg) in solid tumours, resulting in quiescent tumour cells distant from blood vessels, but capable of being reactivated by reoxygenation following conventional therapy (radiation or drugs), have long been known as a limitation to successful cancer chemotherapy. This has resulted in a sustained effort to develop nitroaromatic “hypoxia-activated prodrugs” designed to undergo enzyme-based nitro group reduction selectively in these hypoxic regions, to generate active drugs. Such nitro-based prodrugs can be classified into two major groups; those activated either by electron redistribution or by fragmentation following nitro group reduction, relying on the extraordinary difference in electron demand between an aromatic nitro group and its reduction products. 
  • 1.2K
  • 22 Apr 2022
Topic Review
Two Faces of Vitamin C: AA vs. DHA
Historically, vitamin C has been associated with many regulatory processes that involve specific signaling pathways. Among the most studied signaling pathways are those involved in the regulation of aging, differentiation, neurotransmission, proliferation, and cell death processes in cancer. This wide variety of regulatory effects is due to the fact that vitamin C has a dual mechanism of action. The reduced form of vitamin C (ascorbic acid, AA) is an essential micronutrient of small size; it is soluble in water and has two dissociable protons with pKa values of 4.2 and 11.8. At physiological pH, its reduced form predominates as the monovalent ascorbate anion (AA); when it loses the second proton, it is oxidized to dehydroascorbic acid (DHA).
  • 1.2K
  • 14 Jun 2022
Topic Review
Borreliaceae Diagnostics
The acceleration of climate change has been associated with an alarming increase in the prevalence and geographic range of tick-borne diseases (TBD), many of which have severe and long-lasting effects—particularly when treatment is delayed principally due to inadequate diagnostics and lack of physician suspicion. Moreover, there is a paucity of treatment options for many TBDs that are complicated by diagnostic limitations for correctly identifying the offending pathogens. 
  • 1.2K
  • 30 Sep 2022
Topic Review
Transcriptional Regulation of Wnt/β-Catenin Pathway in Colorectal Cancer
The Wnt/β-catenin signaling pathway exerts integral roles in embryogenesis and adult homeostasis. Aberrant activation of the pathway is implicated in growth-associated diseases and cancers, especially as a key driver in the initiation and progression of colorectal cancer (CRC). 
  • 1.2K
  • 14 Oct 2022
Topic Review
MOST (Satellite)
The Microvariability and Oscillations of Stars telescope, better known simply as MOST, was Canada 's first space telescope. Up until nearly 10 years after its launch it was also the smallest space telescope in orbit (for which its creators nicknamed it the "Humble Space Telescope", in reference to one of the largest, the Hubble). MOST was the first spacecraft dedicated to the study of asteroseismology, subsequently followed by the now-completed CoRoT and Kepler missions. It was also the first Canadian science satellite launched since ISIS II, 32 years previously.
  • 1.2K
  • 02 Nov 2022
Topic Review
Galvanic Anode
A galvanic anode, or sacrificial anode, is the main component of a galvanic cathodic protection (CP) system used to protect buried or submerged metal structures from corrosion. They are made from a metal alloy with a more "active" voltage (more negative reduction potential / more positive electrode potential) than the metal of the structure. The difference in potential between the two metals means that the galvanic anode corrodes, so that the anode material is consumed in preference to the structure. The loss (or sacrifice) of the anode material gives rise to the alternative name of sacrificial anode.
  • 1.2K
  • 08 Nov 2022
Topic Review
Phytoextracts as Crop Biostimulants and Natural Protective Agents
Plants are the basic source of food, energy and dietary fibers for mankind. However, the production of cereal crops affected due to various biotic and abiotic factors due to anthropogenic activities. Fungal pathogens are responsible for plant diseases and cause high economic losses. Synthetic fungicides, which are toxic and harmful to the environment, are used to control plant diseases caused by fungal pathogens; the trend is shifting towards healthy, safe and sound ecofriendly control of fungal pathogens. Phytoextracts of Beta vulgaris, Moringa oleifera, Citrus sinensis, Melia azedarach and Azadirachta indica significantly inhibited the fungal growth and spore germination.
  • 1.2K
  • 17 Nov 2022
Topic Review
Transition Process of Low-Head Pumping Station
The transition process of the low-lift pump mainly refers to the start–stop process. Due to the opening and closing of the gate, the sudden change in the flow velocity in the pipeline causes the water hammer phenomenon. This hydraulic process is called the transition process. Experience shows that hydraulic machinery accidents mainly occur in the transition process. Therefore, the study of the start–stop transition process of the pump has an important guiding significance for the safe operation of the pumping station.
  • 1.2K
  • 25 Nov 2022
Topic Review
Cancer Spheroids and Organoids
Spheroids and organoids are important novel players in medical and life science research. They are gradually replacing two-dimensional (2D) cell cultures. Indeed, three-dimensional (3D) cultures are closer to the in vivo reality and open promising perspectives for academic research, drug screening, and personalized medicine. A large variety of cells and tissues, including tumor cells, can be the starting material for the generation of 3D cultures, including primary tissues, stem cells, or cell lines.
  • 1.2K
  • 18 Apr 2023
Topic Review
Intestinal Barrier Dysfunction and Microbiota–Gut–Brain Axis
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with multifactorial etiology, characterized by impairment in two main functional areas: (1) communication and social interactions, and (2) skills, interests and activities. ASD patients often suffer from gastrointestinal symptoms associated with dysbiotic states and a “leaky gut.” A key role in the pathogenesis of ASD has been attributed to the gut microbiota, as it influences central nervous system development and neuropsychological and gastrointestinal homeostasis through the microbiota–gut–brain axis.
  • 1.2K
  • 30 Jun 2023
Topic Review
Presynaptic Precursor Vesicle Biogenesis
The faithful formation and, consequently, function of a synapse requires continuous and tightly controlled delivery of synaptic material. At the presynapse, a variety of proteins with unequal molecular properties are indispensable to compose and control the molecular machinery concerting neurotransmitter release through synaptic vesicle fusion with the presynaptic membrane. As presynaptic proteins are produced mainly in the neuronal soma, they are obliged to traffic along microtubules through the axon to reach the consuming presynapse. 
  • 1.2K
  • 09 Oct 2023
Topic Review
Dolomite Mineralogy
Dolomite [CaMg(CO3)2] is a rhombohedral carbonate mineral. The dolomite structure consists of an ordered arrangement of alternating layers of Ca2+ and Mg2+ cations interspersed with CO32− anion layers normal to the c-axis, which is in contrast to the disordered distribution of Ca2+ and Mg2+ in the (high-Mg) calcite structure.
  • 1.2K
  • 04 Dec 2023
Topic Review
Flight Operations on the Risk of Runway Excursions
The Quick Access Recorder (QAR), as an onboard device used for monitoring and recording flight parameters, has been extensively installed on various types of aircraft. Ensuring safety during the landing phase has always been a top priority for the civil aviation industry.
  • 1.2K
  • 07 Feb 2024
Topic Review
Impact of Autonomous Navigation in Short Sea Shipping
Short sea shipping (SSS) is a concept created in the European Union (EU), building upon the traditional concept of cabotage, but expanding it to an EU scale and adding maritime connections to countries across seas surrounding Europe. In spite of being a European concept, the fact is that it applies very well to other areas of the world, often under other designations such as coastal shipping or international cabotage.
  • 1.2K
  • 27 Feb 2024
Topic Review Peer Reviewed
Phosphatidyl Inositol 4-Kinases
In recent decades, phosphoinositides (or PIs) have emerged as essential signaling molecules. Despite their low cellular abundance, PIs are found to be involved in various cellular processes, including cell migration, vesicular trafficking, cell cycle regulation, metabolism, cytoskeletal remodeling, autophagy, aging, apoptosis, and cell signaling. Recent studies have shown that aberrant activity of either lipid kinases or phosphatases leads to various medical implications like cancer, diabetes, and microbial infections, suggesting an essential role for these lipid molecules and enzymes in their metabolism. This entry focused on one of the critical enzymes involved in phosphoinositide metabolism: phosphatidyl inositol 4-kinase (PI4-Kinase).
  • 1.2K
  • 02 Jul 2024
Topic Review
Membrane-Based Environmental Remediation
During the last century, industrialization has grown very fast and as a result heavy metals have contaminated many water sources. Due to their high toxicity, these pollutants are hazardous for humans, fish, and aquatic flora. Traditional techniques for their removal are adsorption, electro-dialysis, precipitation, and ion exchange, but they all present various drawbacks. Membrane technology represents an exciting alternative to the traditional ones characterized by high efficiency, low energy consumption and waste production, mild operating conditions, and easy scale-up. In this review, the attention has been focused on applying driven-pressure membrane processes for heavy metal removal, highlighting each of the positive and negative aspects. Advantages and disadvantages, and recent progress on the production of nanocomposite membranes and electrospun nanofiber membranes for the adsorption of heavy metal ions have also been reported and critically discussed. Finally, future prospective research activities and the key steps required to make their use effective on an industrial scale have been presented
  • 1.2K
  • 02 Jul 2021
Topic Review
Missing-Digit Sum
Missing-digit sums are integer numbers that are equal to the sum of numbers created by deleting one or more digits at a time from the original number. For example, the OEIS lists these two integers as missing-digit sums in base ten: Missing-digit sums are therefore a subset of narcissistic numbers, when these are defined as numbers that are equal to some manipulation of their own digits (for example, 153 and 132 are narcissistic numbers in base ten because 153 = 13 + 53 + 33 and 132 = 13 + 32 + 12 + 31 + 23 + 21).
  • 1.2K
  • 27 Oct 2022
Topic Review
DNA Homeostasis and Senescence
As we age, our bodies accrue damage in the form of DNA mutations. These mutations lead to the generation of sub-optimal proteins, resulting in inadequate cellular homeostasis and senescence. The build-up of senescent cells negatively affects the local cellular micro-environment and drives ageing associated disease, including neurodegeneration. Therefore, limiting the accumulation of DNA damage is essential for healthy neuronal populations.  
  • 1.2K
  • 17 Jun 2021
Topic Review
Oncolytic Viruses: Applications of Adenoviruses
Cancer is a major health problem. Most of the treatments exhibit systemic toxicity, as they are not targeted or specific to cancerous cells and tumors. Specific and targeted therapy can be designed using specific functional modifiers/inhibitors like antibodies, peptides, nanobodies and soluble ligands etc. Another novel therapeutic strategy is by using Oncolytic viruses. These are viruses, which can specifically infect or enter into cancer cells and kill them. Since viruses have evolved natural affinity towards some receptors, their affinity needs to be re-targeted towards cancer cells and de-targeted from their natural receptors. Adenoviruses are very promising gene delivery vectors and have shown immense potential in delivering targeted therapy. Here, we review a wide range of strategies that have been tried, tested, and demonstrated to enhance the specificity of oncolytic viruses towards specific cancer cells. A combination of these strategies and other conventional therapies may be more effective than any of those strategies alone.
  • 1.2K
  • 10 Oct 2020
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