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Topic Review
Primary Coenzyme Q10 Deficiency
Primary coenzyme Q10 deficiency is a disorder that can affect many parts of the body, especially the brain, muscles, and kidneys. As its name suggests, the disorder involves a shortage (deficiency) of a substance called coenzyme Q10.
  • 1.2K
  • 24 Dec 2020
Topic Review
Stereotactic Arrhythmia Radioablation
Ventricular tachycardia is a type of arrhythmia (heart rhythm disorder) characterized by fast heart rate (exceeding 100 beats per minute), originating from abnormal electrical impulse localized in heart ventricles. The electrophysiology-guided noninvasive cardiac radioablation, also known as STAR (stereotactic arrhythmia radioablation), is an emerging treatment method of non-invasive treatment for ventricular tachycardia persistent after conventional methods of ablation.
  • 1.2K
  • 10 May 2021
Topic Review
Models of Lipid-Lowering Drug-Induced Myopathies
Drug-induced myopathies are classified as acquired myopathies caused by exogenous factors. These pathological conditions develop in patients without muscle disease and are triggered by a variety of medicaments, including lipid-lowering drugs (LLDs) such as statins, fibrates, and ezetimibe. 
  • 1.2K
  • 10 Jun 2021
Topic Review
CD163
In ischemic stroke patients, a higher monocyte count is associated with disease severity and worse prognosis. The complex correlation between subset phenotypes and functions underscores the importance of clarifying the role of monocyte subpopulations. We examined the subtype-specific distribution of the CD163+ and CD80+ circulating monocytes and evaluated their association with the inflammatory status in 26 ischemic stroke patients and 16 healthy controls.
  • 1.2K
  • 15 Jul 2021
Topic Review
The Association of Gut Microbiota in Gastrointestinal-Cancer Therapies
The gut microbiome of patients with gastrointestinal cancer undergoes specific changes during different therapies such as surgery, chemotherapy and radiation. Likewise, complications of these therapies are associated with specific changes in the microbiome. 
  • 1.2K
  • 02 Nov 2021
Topic Review Peer Reviewed
Greek Honey Authentication: Botanical Approach
Honey is a functional, honeybee product with a useful role in human nutrition and several health benefits. Greece is a Mediterranean region with several types of monofloral honey. Today, Greek honey has acquired an important position in national and international markets. Due to this increased industrialization and globalization, quality control is a necessity. Mislabeling constitutes one of the most notable types of fraudulence, while most consumers are looking for authentic honey. Moreover, producers and suppliers are searching for rapid and analytical methodologies to secure Greek honey in a competitive environment. In this entry, the classical (melissopalynological, physicochemical) and analytical (chromatographic, spectrometric, and spectroscopic) methods for the standardization of the botanical origin of Greek honey will be described. 
  • 1.2K
  • 13 Apr 2022
Topic Review
JmjC Domain-Containing Proteins
Histone methylation tightly regulates chromatin accessibility, transcription, proliferation, and cell differentiation, and its perturbation contributes to oncogenic reprogramming of cells. In particular, many myeloid malignancies show evidence of epigenetic dysregulation.
  • 1.2K
  • 13 Jan 2022
Topic Review
Enhancing the Decision-Making Process through Industry 4.0 Technologies
In order to meet the increasingly complex expectations of customers, many companies must increase efficiency and agility. In this sense, Industry 4.0 technologies offer significant opportunities for improving both operational and decision-making processes. These developments make it possible to consider an increase in the level of operational systems and teams’ autonomy. However, the potential for strengthening the decision-making process by means of these new technologies remains unclear in the current literature. To fill this gap, a Delphi study using the Régnier Abacus technique was conducted with a representative panel of 24 experts. The novelty of this study was to identify and characterize the potential for enhancing the overall decision-making process with the main Industry 4.0 groups of technologies. Our results show that cloud computing appears as a backbone to enhance the entire decision-making process. However, certain technologies, such as IoT and simulation, have a strong potential for only specific steps within the decision-making process. This research also provides a first vision of the manager’s perspectives, expectations, and risks associated with implementing new modes of decision-making and cyber-autonomy supported by Industry 4.0 technologies.
  • 1.2K
  • 20 Jan 2022
Topic Review
Recent Advances in the Development of Fire-Resistant Biocomposites
Biocomposites reinforced with natural fibers represent an eco-friendly and inexpensive alternative to conventional petroleum-based materials and have been increasingly utilized in a wide variety of industrial applications due to their numerous advantages, such as their good mechanical properties, low production costs, renewability, and biodegradability. However, these engineered composite materials have inherent downsides, such as their increased flammability when subjected to heat flux or flame initiators, which can limit their range of applications. As a result, certain attempts are still being made to reduce the flammability of biocomposites. The combustion of biobased composites can potentially create life-threatening conditions in buildings, resulting in substantial human and material losses. Additives known as flame-retardants (FRs) have been commonly used to improve the fire protection of wood and biocomposite materials, textiles, and other fields for the purpose of widening their application areas. At present, this practice is very common in the construction sector due to stringent fire safety regulations on residential and public buildings. 
  • 1.2K
  • 28 Jan 2022
Topic Review
Effect of Nutrition on Aging
Choosing low carbohydrate diets or diets rich in vegetables, fruits, nuts, cereals, fish, and unsaturated fats, containing antioxidants, potassium, and omega-3 decreased cardiovascular diseases and obesity risk, protected the brain from aging, reduced the risk of telomere shortening, and promoted an overall healthier life. Since the biological processes of aging cannot be controlled, changing one’s nutritional patterns is crucial to prevent the emergence and development of diseases, boost longevity, and, mostly, to enhance one’s quality of life and promote healthy aging.
  • 1.2K
  • 03 Mar 2022
Topic Review
Drug Repurposing in Prostate Cancer
Prostate cancer (PCa) is the second most common cancer in men. Common treatments include active surveillance, surgery, or radiation. Androgen deprivation therapy and chemotherapy are usually reserved for advanced disease or biochemical recurrence, such as castration-resistant prostate cancer (CRPC), but they are not considered curative because PCa cells eventually develop drug resistance. The need for novel therapeutic approaches is necessary under these circumstances. An alternative way to treat PCa is by repurposing of existing drugs that were initially intended for other conditions.
  • 1.2K
  • 02 Mar 2022
Topic Review
Chitosan and Its Derivatives in Promoting Drug Permeation
Chitosan is the product of N-deacetylation of chitin. Due to the simultaneous presence of amino, acetamido, and hydroxyl groups in the molecule, chitosan is quite active in nature and can be modified, activated, and coupled, showing rich functionality and modifiability in biological applications. As the only polycationic polymer of natural origin, chitosan is capable of interacting with negatively charged cell membranes to assist the loading of drugs across the cell membrane.
  • 1.2K
  • 21 Apr 2022
Topic Review
Bilberry Supplementation on Metabolic and Cardiovascular Disease Risk
Bilberry (Vaccinium myrtillus L.) is one of the richest natural sources of anthocyanins which give berries their red/purple/blue coloration. Anthocyanins are powerful antioxidants and are reported to play an important role in the prevention of metabolic disease and CVD as well as cancer and other conditions. 
  • 1.2K
  • 15 Jul 2022
Topic Review
ANNEXIN A1
ANXA1 is found in the plasma membrane, cytoplasm, and nucleus, being described at low levels in the nuclear and cytoplasmic compartments of placental cells related to gestational diabetic diseases, and its translocation from the cytoplasm to the nucleus has been associated with a response to DNA damage. The human ANXA1 gene is located on chromosome 19q24, and encodes a 37-kDa protein. ANXA1 has a central domain (C-terminal), consisting of four repeats of 70 to 80 amino acids, which are highly conserved and responsible for calcium affinity and binding to phospholipids.
  • 1.2K
  • 20 Jul 2022
Topic Review
Food-Borne Chemical Carcinogens
Food-borne carcinogens span a range of chemical classes and can arise from natural or anthropogenic sources, as well as form endogenously.
  • 1.2K
  • 11 Oct 2022
Topic Review
Growler (Vehicle)
The M1161 Growler is officially the Internally Transportable Light Strike Vehicle (ITV-LSV) designed specifically for use with the V-22 Osprey tiltrotor aircraft. The M1161 and M1163 are the only tactical vehicles certified to fly in the V-22. Fulfilling multiple roles of light utility, light strike and fast attack vehicle, the M1161 Growler is smaller than most international vehicles in the same role. It has taken over duties of the M151 jeep-type variants and replaced the Interim Fast Attack Vehicle (IFAV). A separate US Marine Corps variant, the shorter two-seat M1163 prime mover is combined with the M327 towed 120mm heavy mortar, and also became its ammunition hauler after the M1162 trailer was cancelled.
  • 1.2K
  • 08 Nov 2022
Topic Review
Comparison of File Verification Software
The following tables compare file verification software that typically use checksums to confirm the integrity or authenticity of a file.
  • 1.2K
  • 11 Nov 2022
Topic Review
North African Climate Cycles
North African climate cycles have a unique history that can be traced back millions of years. The cyclic climate pattern of the Sahara is characterized by significant shifts in the strength of the North African Monsoon. When the North African Monsoon is at its strongest, annual precipitation and consequently vegetation in the Sahara region increase, resulting in conditions commonly referred to as the "green Sahara". For a relatively weak North African Monsoon, the opposite is true, with decreased annual precipitation and less vegetation resulting in a phase of the Sahara climate cycle known as the "desert Sahara". Variations in the climate of the Sahara region can, at the simplest level, be attributed to the changes in insolation because of slow shifts in Earth's orbital parameters. The parameters include the precession of the equinoxes, obliquity, and eccentricity as put forth by the Milankovitch theory. The precession of the equinoxes is regarded as the most important orbital parameter in the formation of the "green Sahara" and "desert Sahara" cycle. A January 2019 MIT paper in Science Advances shows a cycle from wet to dry approximately every 20,000 years.
  • 1.2K
  • 11 Nov 2022
Topic Review
Read
In DNA sequencing, a read is an inferred sequence of base pairs (or base pair probabilities) corresponding to all or part of a single DNA fragment. A typical sequencing experiment involves fragmentation of the genome into millions of molecules, which are size-selected and ligated to adapters. The set of fragments is referred to as a sequencing library, which is sequenced to produce a set of reads.
  • 1.2K
  • 24 Nov 2022
Topic Review
The Gut Microbiome and Female Health
Given that females may be more likely to be affected by some ailments such as osteoarthritis, heart disease, cancer, and anxiety, it is imperative to study the effect of the gut microbiome and its role in female health. It is evident that the presence/ratio of microbial species is altered in polycystic ovarian syndrome, cancer, pregnancy, and menopause. Thus, potential probiotics should be developed and the administration of certain bacterial species should be considered, as novel independent or adjunct therapies for various female-related pathologies.
  • 1.2K
  • 30 Nov 2022
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