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Topic Review
Fall Prevention for Pediatric Inpatients
Falls account for a high proportion of the safety accidents experienced by hospitalized children. This entry aims to analyze the contents and effects of fall prevention programs for pediatric inpatients to develop more adaptable fall prevention programs.
  • 1.3K
  • 09 Jun 2021
Topic Review
Masks
Face masks can protect humans through their filtration function. They include different types and mechanisms of filtration whose performance depends on the texture of the fabric, the latter of which is strongly related to the manufacturing method. 
  • 1.3K
  • 24 Jan 2022
Topic Review
Real-World Evidence
Real-world evidence (RWE) is increasingly involved in the early benefit assessment of medicinal drugs. It is expected that RWE will help to speed up approval processes comparable to RWE developments in vaccine research during the COVID-19 pandemic. Definitions of RWE are diverse, marking the highly fluid status in this field. So far, RWE comprises information produced from data routinely collected on patient’s health status and/or delivery of health care from various sources other than traditional clinical trials. These sources can include electronic health records, claims, patient-generated data including in home-use settings, data from mobile devices, as well as patient, product, and disease registries. RWE has already been included in various approval procedures of regulatory authorities, reflecting its actual acceptance and growing importance in evaluating and accelerating new therapies. Since RWE research is still in a transition process, and since a number of gaps in this field have been explored, more guidance and a consented definition are necessary to increase the implementation of real-world data.
  • 1.3K
  • 02 Sep 2022
Topic Review
The COVID-19 and Autism-Spectrum Experience (CASE) Parent Survey
The COVID-19 outbreak represented a challenging period, especially for people suffering from pre-existing mental health related issues. Individuals with Autism Spectrum Disorders (ASD) are among this patient population and thus particularly at risk due to their vulnerability and difficulties with adapting to changes and complex situations. The CASE parent survey was developed by a group of physicians, psychologists, and child life specialists, in order to assess the impact of the COVID-19 emergency on children and adolescents with ASD. It consists of 40 questions (20 yes/no questions, 18 multiple choice questions and 2 open-response questions), subdivided into three categories investigating Autism Spectrum Disorder's subjects socio-demographic and clinical characteristics, the impact the COVID-19 outbreak had on their physical and mental wellbeing, and the needs to deal with the ongoing emergency.
  • 1.3K
  • 08 Nov 2022
Topic Review
Driver's age and road crash
It has been widely reported that younger and older drivers have an excess risk of causing a road crash. Two casual hypotheses may coexist: the riskier driving behaviors and age-related mechanisms in extreme age groups (direct path) and the different environmental and vehicle circumstances (indirect path). Our aim was to quantify, through a mediation analysis, the percentage contribution of both paths. A case-control study was designed from the Spanish Register of Road Crashes with victims from 2014 to 2017. Assuming a quasi-induced exposure approach, controls were non-responsible drivers involved in clean collisions between two or more vehicles (n = 52,131). Responsible drivers for these collisions plus drivers involved in single crashes constituted the case group (n = 82,071). A logit model in which the outcome was the log (odds) of causing a road crash and the exposure was age groups was adjusted for driver, vehicle and environmental factors. The highest crash risk was observed in extreme age groups, compared to the 35-44 year old age group: the youngest (18-24 years old, odds ratio = 2.14, 95% confidence interval: 2.06-2.24) and the oldest drivers (>74 years old, odds ratio = 3.30, 95% confidence interval: 3.04-2.58). The mediation analysis identified the direct path as the main explanatory mechanism for these increases: 89% in the youngest and 93% in the oldest drivers. These data support the hypothesis that the excess crash risk observed for younger and older drivers is mainly related to their higher frequency of risky driving behaviors and age-related loss of capabilities. Preventive strategies in extreme-aged drivers should focus on decreasing these behaviors.
  • 1.3K
  • 05 Oct 2021
Topic Review
Macrolide Resistance in Bordetella pertussis
Pertussis is a highly contagious respiratory infection caused by Bordetella pertussis bacterium. The mainstay of treatment is macrolide antibiotics that reduce transmissibility, shorten the duration of symptoms and decrease mortality in infants. 
  • 1.3K
  • 30 Nov 2022
Topic Review
Lhia as A Chatbot for Breastfeeding Education
Human milk is the most important way to feed and protect newborns as it has the components to ensure human health. Human Milk Banks (HMBs) form a network that offers essential services to ensure that newborns and mothers can take advantage of the benefits of human milk.
  • 1.3K
  • 16 Jun 2023
Topic Review
Vascular Smooth Muscle Cells Model
Vascular remodeling is a prominent feature of pulmonary hypertension. This process involves increased muscularization of already muscularized vessels as well as neo-muscularization of non-muscularized vessels. The cell-of-origin of the newly formed vascular smooth muscle cells has been a subject of intense debate in recent years. Identifying these cells may have important clinical implications since it opens the door for attempts to therapeutically target the progenitor cells and/or reverse the differentiation of their progeny. 
  • 1.3K
  • 24 Aug 2021
Topic Review
Impact of COVID-19 on Young People's Mental Health
There is increasing evidence of the psychological impact of COVID-19 on various population groups, with concern particularly focused on young people’s mental health. Yet to date little research has explored the views of young people themselves on the impact of living through the pandemic on their mental health. Young people's discussions on social media have highlighted the complexities of this impact and how socially embedded it has been. Forging appropriate support for young people post-pandemic will necessitate looking beyond an individualised conceptualisation of their mental health that sets this apart from broader societal concerns. Instead, both research and practice need to take a systemic approach, recognising young people’s societal belonging and social contexts.
  • 1.3K
  • 13 Jan 2022
Topic Review
Artificial Intelligence in COVID-19 Pandemic
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which caused coronavirus diseases (COVID-19) in late 2019 in China created a devastating economical loss and loss of human lives.11 variants have been identified with minimum to maximum severity of infection and surges in cases. Bacterial co-infection/secondary infection is identified during viral respiratory infection, which is a vital reason for morbidity and mortality. The occurrence of secondary infections is an additional burden to the healthcare system; therefore, the quick diagnosis of both COVID-19 and secondary infections will reduce work pressure on healthcare workers. Therefore, well-established support from Artificial Intelligence (AI) could reduce the stress in healthcare and even help in creating novel products to defend against the coronavirus. AI is one of the rapidly growing fields with numerous applications for the healthcare sector. 
  • 1.3K
  • 25 May 2023
Topic Review
Zearalenone and the Immune Response
Zearalenone (ZEA) is an estrogenic fusariotoxin, being classified as a phytoestrogen, or as a mycoestrogen. ZEA and its metabolites are able to bind to estrogen receptors, 17β-estradiol specific receptors, leading to reproductive disorders which include low fertility, abnormal fetal development, reduced litter size and modification at the level of reproductive hormones especially in female pigs. ZEA has also significant effects on immune response with immunostimulatory or immunosuppressive results. This review presents the effects of ZEA and its derivatives on all levels of the immune response such as innate immunity with its principal component inflammatory response as well as the acquired immunity with two components, humoral and cellular immune response. The mechanisms involved by ZEA in triggering its effects are addressed. 
  • 1.3K
  • 26 Apr 2021
Topic Review
Pulmonary Arterial Hypertension (PAH)
Pulmonary arterial hypertension (PAH) is a progressive disease characterized by elevated pulmonary arterial pressure due to increased pulmonary vascular resistance, secondary to sustained pulmonary vasoconstriction and excessive obliterative pulmonary vascular remodeling. Work over the last decade has led to the identification of a critical role for metabolic reprogramming in the PAH pathogenesis. It is becoming clear that in addition to its role in ATP generation, the mitochondrion is an important organelle that regulates complex and integrative metabolic- and signal transduction pathways.
  • 1.3K
  • 16 Feb 2022
Topic Review
Post-Traumatic Stress Disorder in People with Visual Impairment
People with a visual impairment appear to have an increased risk of experiencing potentially traumatizing life events and possibly also subsequently developing post-traumatic stress disorder (PTSD). 
  • 1.3K
  • 21 Feb 2022
Topic Review
SCD and Genetic Propensity for Dementia beyond Apolipoproteinε4
Subjective cognitive decline (SCD) has been described as a probable early stage of dementia, as it has consistently appeared to precede the onset of objective cognitive impairment. SCD is related to many risk factors, including genetic predisposition for dementia. The Apolipoprotein (APOE) ε4 allele, which has been thoroughly studied, seems to explain genetic risk for SCD only partially.
  • 1.3K
  • 14 Mar 2024
Topic Review
Saliva in SARS-COV-2 Detection
In the wake of the COVID-19 pandemic, it is crucial to assess the application of a multitude of effective diagnostic specimens for conducting mass testing, for accurate diagnosis and to formulate strategies for its prevention and control. As one of the most versatile and amenable specimen options, saliva offers great advantages for widespread screening strategies due to its non-invasive properties, cost-effectiveness, excellent stability and minimal risk of cross-infection. 
  • 1.3K
  • 01 Jun 2021
Topic Review
The Molecular Hydrogen Hypothesis
Since the late 18th century, molecular hydrogen (H2) has been shown to be well tolerated, firstly in animals, and then in humans. However, although research into the beneficial effects of molecular hydrogen in both plant and mammalian physiology is gaining momentum, the idea of utilising this electrochemically neutral and non-polar diatomic compound for the benefit of health has yet to be widely accepted by regulatory bodies worldwide. Due to the precise mechanisms of H2 activity being as yet undefined, the lack of primary target identification, coupled with difficulties regarding administration methods (e.g., dosage and dosage frequencies, long-term effects of treatment, and the patient’s innate antioxidant profile), there is a requirement for H2 research to evidence how it can reasonably and most effectively be incorporated into medical practice.
  • 1.3K
  • 28 Jan 2022
Topic Review
Glycosaminoglycans in Mucopolysaccharidosis
Mucopolysaccharidosis (MPS) consists of a group of inherited lysosomal storage disorders that are caused by a defect of certain enzymes that participate in the metabolism of glycosaminoglycans (GAGs). The abnormal accumulation of GAGs leads to progressive dysfunctions in various tissues and organs during childhood, contributing to premature death.
  • 1.2K
  • 23 Mar 2023
Topic Review
Bio-Preservation of Meat by Lactic Acid Bacteria Strains
Meat and some meat products are highly perishable due to their high-water content, pH, and high content of nutrients. Therefore, spoilage control in these products is one of the critical challenges in the food industry. On the other hand, the increasing widespread awareness about the undesirable effects of synthetic preservatives has promoted the breakthrough of the use of natural compounds or bio-preservation technology. Bio-preservation implies the application of microorganisms or their metabolites to extend the shelf life of food products. In this regard, according to the ancient and safe use of fermentation by lactic acid bacteria (LAB), their application in the bio-preservation of meat and meat products is gaining more attention.
  • 1.2K
  • 11 Jul 2023
Topic Review
Safety Training
The purpose of safety training in acquiring knowledge about safety at work is to obtain information about the hazards present in the workplace and the necessary measures worn or kept by employees to protect him/her from one or more hazards associated with the presence of dangerous or harmful factors in the work environment (types of PPE). 
  • 1.2K
  • 27 Oct 2021
Topic Review
Pulmonary Ultrasound during COVID 19
In practical terms, lung ultrasound (LUS) can be considered as an equally accurate alternative for CT in many situations where CT is not easily accessible or when molecular tests are not available. The use of lung ultrasound (LUS) as a triage tool has been proposed since the beginning of the COVID-19 pandemicand subsequent studies have confirmed its role. The high sensitivity of ultrasound for the superficial lesions of the lung from the interstitial stages represents its great value.
  • 1.2K
  • 15 Apr 2022
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