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Topic Review
Clinical and Histopathological Features of Scleroderma-like Disorders
Scleroderma-like disorders include a set of entities involving cutis, subcutis and, sometimes, even muscular tissue, caused by several pathogenetic mechanisms responsible for different clinical–pathological pictures. The absence of antinuclear antibodies (ANA), Raynaud’s phenomenon and capillaroscopic anomalies constitutes an important element of differential diagnosis with systemic sclerosis.
  • 1.2K
  • 03 Dec 2021
Topic Review
Offsite Construction Typology
Offsite construction (OSC) delivers multiple products that vary in design and building complexity. Considering the growing prevalence of OSC, a systematic categorization of OSC types can offer operational and macroeconomic benefits to the construction industry.
  • 1.2K
  • 28 Mar 2022
Topic Review
Genome Editing with DSBs
Genome editing requires gRNA, the Cas9 protein, donor template, and repairing mechanism for the editing of the genome, while base editing uses the reprogrammable deaminase intending to introduce the bases at the targeted sites without any cleavage and induction of Double-Stranded DNA breaks (DSBs). In the CRISPR/Cas9 mechanism, DSBs are generated that are associated with some complex off-target effects, including p53 activation and translocations.
  • 1.2K
  • 27 Apr 2022
Topic Review
GPCR Reconstitution and Labeling for Solution NMR
G protein-coupled receptors (GPCRs) are a large membrane protein family found in higher organisms, including the human body. GPCRs mediate cellular responses to diverse extracellular stimuli and thus control key physiological functions, which makes them important targets for drug design. Signaling by GPCRs is related to the structure and dynamics of these proteins, which are modulated by extrinsic ligands as well as by intracellular binding partners such as G proteins and arrestins. 
  • 1.2K
  • 19 Jul 2022
Topic Review
Digital and Emergency eLearning Technologies during COVID-19 Lockdown
The pandemic disrupted all aspects of citizens’ lives—health services, the economy and educational practices. Government-mandated social distancing and stay-at-home injunctions required a drastic change in educational processes and delivery. The digital economy became the glue holding the “socially-distanced economy” together. As Bhaskar et al. (p. 6) contended, digitalization helped people to work, learn, shop, and socialize while locked down; it allowed society to cling to some semblance of normalcy.
  • 1.2K
  • 13 Oct 2022
Topic Review
Properties of Starch as Nanocomposites
Starch is one of the most abundant natural polymers globally. Starch and its nanocomposites have been extensively studied for their abundance, low cost, ease of processibility, and chemical and physical properties.
  • 1.2K
  • 01 Nov 2022
Topic Review
Caffeine in Neurodegenerative Diseases
There has been considerable research showing that coffee consumption seems to be beneficial to human health, as it contains a mixture of different bioactive compounds such as chlorogenic acids, caffeic acid, alkaloids, diterpenes and polyphenols. Neurodegenerative diseases (NDs) are debilitating, and non-curable diseases associated with impaired central, peripheral and muscle nervous systems. Several studies demonstrate that neuroinflammation mediated by glial cells—such as microglia and astrocytes—is a critical factor contributing to neurodegeneration that causes the dysfunction of brain homeostasis, resulting in a progressive loss of structure, function, and number of neuronal cells. This happens over time and leads to brain damage and physical impairment. The most known chronic NDs are represented by Alzheimer’s disease (AD), Parkinson’s disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS) and Huntington’s disease (HD). According to epidemiological studies, regular coffee consumption is associated with a lower risk of neurodegenerative diseases. 
  • 1.2K
  • 04 Nov 2022
Topic Review
Doctor of Osteopathic Medicine
Doctor of Osteopathic Medicine (DO or D.O., or in Australia DO USA) is a medical degree conferred by the 38 osteopathic medical schools in the United States. DO and Doctor of Medicine (MD) degrees are equivalent: a DO graduate may become licensed as a physician and thus have full medical and surgical practicing rights in all 50 US states. (As of 2021), there were 168,701 osteopathic physicians and medical students in DO programs across the United States. Osteopathic medicine emerged historically from osteopathy, but has become a distinct profession. (As of 2014), more than 28% of all US medical students were DO students. The curricula at DO-granting medical schools are equivalent to those at MD-granting medical schools, which focus the first two years on the biomedical and clinical sciences, then two years on core clinical training in the clinical specialties. One notable difference between DO and MD training is that DOs spend an additional 300–500 hours to study a set of hands-on manipulation (OMT) of the human musculoskeletal system along with learning conventional Western medicine and surgery like their MD peers. Upon completing osteopathic medical school, a DO graduate may enter an internship or residency training program, which may be followed by fellowship training. DO graduates attend the same graduate medical education programs as their MD counterparts.
  • 1.2K
  • 15 Nov 2022
Topic Review
Citrus hystrix DC for Metabolic Disorders
Metabolic disorder, which includes hypertension, diabetes mellitus, dyslipidemia, and obesity, represents a major global health concern due to increased morbidity and mortality. It occurs due to disturbance in normal metabolic process leading to redox and energy imbalance. Metabolic disorder, which includes hypertension, diabetes mellitus, dyslipidemia, and obesity, represents a major global health concern due to increased morbidity and mortality. It occurs due to disturbance in normal metabolic process leading to redox and energy imbalance.
  • 1.2K
  • 10 Feb 2023
Topic Review
OCA on Different Physiological Processes through FXR Activation
Obeticholic acid (OCA) or 6-alpha-ethyl-chenodeoxycholic acid is a semisynthetic modified bile acid derivative that acts on the farnesoid X receptor (FXR) as an agonist with a higher potency than bile acid. The FXR is a nuclear receptor highly expressed in the liver and small intestine and regulates bile acid, cholesterol, glucose metabolism, inflammation, and apoptosis. 
  • 1.2K
  • 08 Mar 2023
Topic Review
DNA Damage and Repair Pathway
DNA injuries occur as a result of intrinsic or extrinsic agents and can include modifications to bases and sugars, single- and double-strand breaks (SSBs, DSBs), DNA-protein crosslinks, and base-free sites. While some specific DNA lesions can lead to mutations that cause cancer, the main consequence of DNA injuries is the threat they pose to DNA integrity and stability. To prevent accumulated DNA lesions from causing irreversible harm, cells initiate DDR, which senses the DNA damage, signals its presence, and mediates its repair.
  • 1.2K
  • 06 Apr 2023
Topic Review
Impact of Herbal Therapies on COVID-19 and Influenza
Synthetic antivirals and corticosteroids have been used to treat both influenza and the SARS-CoV-2 disease named COVID-19. However, these medications are not always effective, produce several adverse effects, and are associated with high costs. Medicinal plants and their constituents act on several different targets and signaling pathways involved in the pathophysiology of influenza and COVID-19. Medicinal plants, in different formulations, can help to decrease viral spread and the time until full recovery. Plants reduced the incidence of acute respiratory syndromes and the symptom scores of the illnesses. Moreover, plants are related to few adverse effects and have low costs. In addition to their significance as natural antiviral agents, medicinal plants and their bioactive compounds may exhibit low bioavailability. 
  • 1.2K
  • 25 Jul 2023
Topic Review
Targeted Therapy for EWS-FLI1 in Ewing Sarcoma
Ewing sarcoma (EwS) is a highly aggressive and metastatic cancer in children and adolescents. Canonical therapy mainly comprises the combination of intensive chemotherapy, radiation, and local surgery, which give rise to acute and chronic adverse effects. Drugs targeting EwS without side effects are in urgent demand. Genetically, EwS is characterized by chromosomal translocations with a low mutation burden. As a result, the chimeric protein EWS-ETS, mainly EWS-FLI1(85%), is critical for the malignancy of EwS. EWS-FLI1 directly binds to GGAA microsatellites in enhancers and promotors of the target genes and recruits multiple transcription factors or epigenetic regulators to reprogramme the epigenome.
  • 1.2K
  • 17 Aug 2023
Topic Review
Crack Analysis in Structures Using Image Processing Technique
Structural health monitoring (SHM) involves the control and analysis of mechanical systems to monitor the variation of geometric features of engineering structures. Damage processing is one of the issues that can be addressed by using several techniques derived from image processing. There are two types of SHM: contact-based and non-contact methods. Sensors, cameras, and accelerometers are examples of contact-based SHM, whereas photogrammetry, infrared thermography, and laser imaging are non-contact SHM techniques. 
  • 1.2K
  • 22 Sep 2023
Topic Review
Pousargues's Mongoose
Pousargues's mongoose (Dologale dybowskii) is a small carnivorous mammal found in the wetlands and forests of central Africa, particularly in the Congo Basin. With a sleek body, short legs, and a long tail, it navigates its habitat with agility, preying on small vertebrates, insects, and occasionally, fruits. Despite its elusive nature and limited research, Pousargues's mongoose plays a vital role in its ecosystem, contributing to the regulation of prey populations and biodiversity maintenance in its range.
  • 1.2K
  • 15 Mar 2024
Topic Review
Stress Measures
The most commonly used measure of stress is the Cauchy stress tensor, often called simply the stress tensor or "true stress". However, several other measures of stress can be defined. Some such stress measures that are widely used in continuum mechanics, particularly in the computational context, are: The Kirchhoff stress (τ). The Nominal stress (N). The first Piola-Kirchhoff stress (P). This stress tensor is the transpose of the nominal stress (P=NT). The second Piola-Kirchhoff stress or PK2 stress (S). The Biot stress (T).
  • 1.2K
  • 06 Dec 2022
Topic Review
Erectile Dysfunction and Its Impact on Relationships
Explore how effective partner communication can significantly aid in the treatment of erectile dysfunction (ED) in this insightful article from ED Generic Store. Delving into the importance of emotional connection, open dialogue, and mutual support, this piece offers practical guidance for couples navigating the complexities of ED together. Learn how fostering trust, sharing concerns, and exploring lifestyle changes can enhance intimacy and improve overall relationship satisfaction. Gain valuable insights into the role of professional help and the power of celebrating progress as partners work collaboratively towards overcoming ED and revitalizing their connection.
  • 1.2K
  • 09 May 2024
Topic Review
Synthesis of Metabolite of Resveratrol by Beauveria bassiana
Resveratrol is a well-known dietary polyphenol because it has a variety of beneficial biological activities. The fungus Beauveria bassiana is one of the most frequently used microorganisms for the biotransformation of polyphenols. Recently, resvebassianol A (2), a glycosylated metabolite of resveratrol by B. bassiana, was isolated and structurally elucidated. It was demonstrated to exhibit antioxidant, regenerative, and anti-inflammatory activities with no cytotoxicity. Here, we report the first total synthesis of resvebassianol A, 4'-O-β-(4'"-O-methylglucopyranosyl)resveratrol (2), and its regiomer, 3-O-β-(4 -O-methylglucopyranosyl)resveratrol (3). Key reactions include (i) the construction of a stilbene core via a novel Heck reaction of aryl halides and styrenes, and (ii) glycosylation with unnatural methylglucopyranosyl bromide. The glycosylation step was carefully optimized by varying the bases and solvents. Resveratrol metabolites 2 and 3 were obtained at 7.5% and 6.3% of the overall yield, respectively.
  • 1.2K
  • 25 Oct 2021
Topic Review
Commuter Interdependence
The comprehensive research framework is divided into two phases, namely assessment and abatement, each of which involves a method that has been developed on the basis of an analytical framework. The vehicle emission estimation method, in the assessment phase, is built on the basis of the ‘Institution of Sustainability’ (IoS) framework to assess vehicle emission levels and identify all potential traffic-related sources influencing such emissions. Field experiments are designed, in the abatement phase, on the basis of the ‘Institutions and Development’ (IAD) framework to analyse the ‘near-to-real’ commuter interdependence, with respect to demand-based, non-technical measures in the experiment arrangement.
  • 1.2K
  • 27 Oct 2020
Topic Review
Recovery of phosphorus from wastewater
Mined phosphate rock is the largest source of phosphorus (P) for use in agriculture and agro-industry, but it also is a finite resource irregularly distributed around the world. Alternatively, waste water is a renewable source of P, available at the local scale. In waste water treatment, biological nitrogen (N) removal is applied according to a wide range of variants targeting the abatement of the ammonium content. Ammonium oxidation to nitrate can also be considered to mitigate ammonia emission, while enabling N recovery. Different alternatives exist for coupling biological N treatment and phosphate precipitation when treating waste water in view of producing P-rich materials easily usable as fertilisers. Phosphate precipitation can be applied before (upstream configuration), together with (concomitant configuration), and after (downstream configuration) N treatment; i.e., chemically induced as a conditioning pre-treatment, biologically induced inside the reactor, and chemically induced as a refining post-treatment. Characteristics of the recovered products differ significantly depending on the case studied. Currently (year 2020), precipitated phosphate salts are not typified in the European fertiliser regulation, and this fact limits marketability. Nonetheless, this topic is in progress according to potential requirements to be complied by these materials. Integrated approaches for waste water treatment including P recovery must consider significant needs for subsequent agronomic valorisation of the recovered phosphate salts following the paradigms of the circular economy, sustainability, and environmental protection.
  • 1.2K
  • 27 Oct 2020
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