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Topic Review
Thermal properties and applications of nanofluids
The nanofluids (NFs) are known as a colloidal suspension where nanoparticles (NPs) are dispersed in conventional base fluids (BFs). This suspension has been frequently used to improve the heat transfer (HT) capacity of a fluid by studying their thermophysical properties. The NFs thermal properties and their applications are being used in different fields of engineering, ranging from machining to renewable energies. In machining, NFs play a prominent role in the processes of turning, milling, drilling, and grinding, being responsible for their optimization as well as improving the useful life of the tools and reducing costs. In the solar energy field, NFs have been used in the thermal management of the panels, controlling and homogenizing the operating temperature of these systems. In the biomedical area, the advantages of using NFs come from the treatment of cancer cells, the development of vaccines before the improvement of diagnostic imaging, and many others.
  • 1.2K
  • 08 Feb 2022
Topic Review
Protein Tyrosine Phosphatase Receptor Gamma
Protein tyrosine phosphatase gamma (PTPRG) is an enzyme that remove phosphate groups from phosphotyrosine residues of specific intracellular targets. It belongs to the tyrosine phosphatase (PTP) family of proteins and it is widely expressed in human tissues. 
  • 1.2K
  • 23 Feb 2022
Topic Review
Data Quality Supporting Marine Mineral Oil Spill Assessments
Spilled mineral oils in the marine environment pose a number of challenges to sampling and analysis. Mineral oils are complex assemblages of hydrocarbons and additives, the composition of which can vary considerably depending on the source oil and product specifications. Further, the marine microbial and chemical environment can be harsh and variable over short times and distances, producing a rigorous source of hydrocarbon degradation of a mineral oil assemblage. Researchers must ensure that any measurements used to determine the nature and extent of the oil release, the fate and transport of the mineral oil constituents, and any resultant toxicological effects are derived using representative data that adhere to the study’s data quality objectives (DQOs).
  • 1.2K
  • 11 Mar 2022
Topic Review
Machine Learning in Agricultural Big Data
Agricultural Big Data is a set of technologies that allows responding to the challenges of the new data era. In conjunction with machine learning, farmers can use data to address problems such as farmers’ decision making, water management, soil management, crop management, and livestock management. Crop management includes yield prediction, disease detection, weed detection, crop quality, and species recognition. On the other hand, livestock management considers animal welfare and livestock production. 
  • 1.2K
  • 08 Apr 2022
Topic Review
Improvement of Agricultural Product Traceability with Blockchain
In recent years, agricultural product safety accidents have raised public concern, jeopardizing people’s dietary safety and health. In order to keep track of specific information through the entire supply chain, including the production, logistics, processing, and sales processes, as well as to quickly find and prevent agricultural product safety problems, it is important to build a trusted traceability system. Traditional centralized traceability systems exist with the issues of insecure data storage, low traceability reliability, and single-point attack vulnerability. Blockchain technology has the characteristics of being data tamper-proof, distributed, decentralized, and traceable, which makes it a promising technology for agricultural product traceability.
  • 1.2K
  • 16 May 2022
Topic Review
Reconstructive Surgery in Distal Tubal Disease
Tubal factor infertility is one of the most frequent causes of female infertility. Despite the rising usage of artificial reproductive technologies, surgery remains an important therapy option among this group of patients. However, the effectiveness of tubal reconstructive surgery against another treatment approaches has not been appropriately evaluated. There are no randomized controlled trials that compare surgery versus IVF or expectant management. Clinical practice is guided on the basis of observational studies. Researchers use different classifications and inclusion criteria. Surgical techniques are not uniform. As a result, published data differ substantially and interpreting of outcomes is consequently made more difficult. 
  • 1.2K
  • 21 Jun 2022
Topic Review
Severe Acute Respiratory Syndrome
Severe acute respiratory syndrome (SARS) is a viral respiratory disease of zoonotic origin caused by the SARS coronavirus (SARS-CoV). Between November 2002 and July 2003, an outbreak of SARS in southern China caused an eventual 8,098 cases, resulting in 774 deaths reported in 37 countries, with the majority of cases in China and Hong Kong (9.6% fatality rate) according to the World Health Organization (WHO). No cases of SARS have been reported worldwide since 2004. In late 2017, Chinese scientists traced the virus through the intermediary of civets to cave-dwelling horseshoe bats in Yunnan province.
  • 1.2K
  • 24 Nov 2022
Topic Review
Artemisia Armeniaca
Artemisia /ˌɑːrtɪˈmiːziə/ is a large, diverse genus of plants with between 200 and 400 species belonging to the daisy family Asteraceae. Common names for various species in the genus include mugwort, wormwood, and sagebrush. Artemisia comprises hardy herbaceous plants and shrubs, which are known for the powerful chemical constituents in their essential oils. Artemisia species grow in temperate climates of both hemispheres, usually in dry or semiarid habitats. Notable species include A. vulgaris (common mugwort), A. tridentata (big sagebrush), A. annua (sagewort), A. absinthium (wormwood), A. dracunculus (tarragon), and A. abrotanum (southernwood). The leaves of many species are covered with white hairs. Most species have strong aromas and bitter tastes from terpenoids and sesquiterpene lactones, which discourage herbivory, and may have had a selective advantage. The small flowers are wind-pollinated. Artemisia species are used as food plants by the larvae of a number of Lepidoptera species. Some botanists split the genus into several genera, but DNA analysis does not support the maintenance of the genera Crossostephium, Filifolium, Neopallasia, Seriphidium, and Sphaeromeria; three other segregate genera -- Stilnolepis, Elachanthemum, and Kaschgaria -- are maintained by this evidence. Occasionally, some of the species are called sages, causing confusion with the Salvia sages in the family Lamiaceae.
  • 1.2K
  • 02 Dec 2022
Topic Review
Metal and Metal Oxide Nanomaterials
The misuse and mismanagement of antibiotics have made the treatment of bacterial infections a challenge. This challenge is magnified when bacteria form biofilms, which can increase bacterial resistance up to 1000 times. It is desirable to develop anti-infective materials with antibacterial activity and no resistance to drugs. With the rapid development of nanotechnology, anti-infective strategies based on metal and metal oxide nanomaterials have been widely used in antibacterial and antibiofilm treatments.
  • 1.2K
  • 02 Feb 2023
Topic Review
Physiologic Effects of Natriuretic Peptides
Natriuretic peptides are a complex and interesting network of molecules playing pleiotropic effects on many organs and tissues, ensuring the maintenance of homeostasis mainly in the cardiovascular system and regulating the water–salt balance. Natriuretic peptides (NPs) and their receptors play several physiological roles in maintaining and ensuring homeostasis in the human body by performing pleiotropic actions on multiple organs and target sites. Various other mechanisms have been characterized in other organs, which were made possible by the specific and individual interactions between each natriuretic peptide and the corresponding receptor in a particular site of action.
  • 1.2K
  • 08 Jun 2023
Topic Review
Machine Learning-Based Text Classification Comparison
The growth in textual data associated with the increased usage of online services and the simplicity of having access to these data has resulted in a rise in the number of text classification research papers. Text classification has a significant influence on several domains such as news categorization, the detection of spam content, and sentiment analysis. The classification of Turkish text is the research focus since only a few studies have been conducted in this context. Researchers utilize data obtained from customers’ inquiries that come to an institution to evaluate the proposed techniques. Classes are assigned to such inquiries specified in the institution’s internal procedures. The Support Vector Machine, Naïve Bayes, Long Term-Short Memory, Random Forest, and Logistic Regression algorithms were used to classify the data. The performance of the various techniques was then analyzed after and before data preparation, and the results were compared. The Long Term-Short Memory technique demonstrated superior effectiveness in terms of accuracy, achieving an 84% accuracy rate, surpassing the best accuracy record of traditional techniques, which was 78% accuracy for the Support Vector Machine technique. The techniques performed better once the number of categories in the dataset was reduced. Moreover, the findings show that data preparation and coherence between the classes’ number and the number of training sets are significant variables influencing the techniques’ performance.
  • 1.2K
  • 01 Sep 2023
Topic Review
Deep Learning Models to Predict Prosthetic Ankle Torque
Inverse dynamics from motion capture is the most common technique for acquiring biomechanical kinetic data. However, this method is time-intensive, limited to a gait laboratory setting, and requires a large array of reflective markers to be attached to the body. A practical alternative must be developed to provide biomechanical information to high-bandwidth prosthesis control systems to enable predictive controllers.
  • 1.2K
  • 25 Sep 2023
Topic Review
Thermal Characteristics of Lithium-Ion Batteries
The interaction between temperature regulation and lithium-ion batteries is pivotal due to the intrinsic heat generation within these energy storage systems. A profound understanding of the thermal behaviors exhibited by lithium-ion batteries, along with the implementation of advanced temperature control strategies for battery packs, remains a critical pursuit. Utilizing tailored models to dissect the thermal dynamics of lithium-ion batteries significantly enhances our comprehension of their thermal management across a wide range of operational scenarios. 
  • 1.2K
  • 25 Oct 2023
Topic Review
An Underutilized Food “Miwu”
Miwu (“蘼芜” in Chinese), the stems and leaves of Ligusticum chuanxiong Hort. has been used in China as a food for least 800 years. Modern research has shown that Miwu has a high dietary fibre content, is rich in iron and low in sodium, and has a similar aroma to celery but more than 4 times the dietary fibre content. At the same time, the wide cultivation of this herb, in combination with the use of the root as medicine, can better enhance the utilisation of this plant.
  • 1.2K
  • 29 Dec 2023
Topic Review
Durability of Recycled Fine Aggregate Concrete
In recent years, scholars around the world have worked on improving recycle aggregates in concrete and broadening the scope of applications of recycled concrete. The findings of research on the effects of recycled fine aggregates (RFAs) on the permeability, drying shrinkage, carbonation, chloride ion penetration, acid resistance, and freeze–thaw resistance of concrete has been reviewed. The results show that the content of old mortar and the quality of recycled concrete are closely related to the durability of prepared RFA concrete. 
  • 1.2K
  • 28 Mar 2022
Topic Review
Immune Checkpoint Inhibitors in Melanoma
Despite of melanoma immunogenicity, this tumor develops immune escape mechanisms that stimulate a fast melanoma progression. Such mechanisms include impaired antigen presentation by tumor cells, accumulation of dysfunctional effector T cells and generation of the immunosuppressive TME represented by MDSC, TAN, CAF, TAM, and Treg. Therefore, numerous approaches were developed to reinvigorate the anti-tumor immune response. Recently approved immunotherapies with ICI (anti-PD-1, anti-PD-L1 and anti-CTLA-4 antibodies) have revolutionized the treatment of melanoma. This treatment significantly increased the survival of melanoma patients and provided a durable control of the disease [26,27,28]. However, the response rates to ICI are still restricted. Thus, further efforts should be undertaken to maximize the efficacy of ICI treatment. This aim could be achieved by improving the selection of patients who might benefit from the ICI therapy, by applying early radiological findings and by measuring predictive markers from tumor and liquid biopsies. Furthermore, the combination of different ICI (such as ipilimumab and nivolumab), their combination with targeting of the immunosuppressive TME or with other anti-cancer therapies could significantly improve the efficacy of tumor immunotherapy. Furthermore, targeting of other immune checkpoints (such as LAG-3, TIM-3, TIGIT) and its combination with approved ICI are currently under investigation.
  • 1.2K
  • 30 Oct 2020
Topic Review
Molecular concepts in vascular disorders
In physiology and pathophysiology the molecules involved in blood cell–blood cell and blood cell–endothelium interactions have been identified. Platelet aggregation and adhesion to the walls belonging to vessels involve glycoproteins (GP), GP llb and GP llla and the GP Ib–IX–V complex. Red blood cells (RBCs) in normal situations have little interaction with the endothelium. Abnormal adhesion of RBCs was first observed in sickle cell anemia involving vascular cell adhesion molecule (VCAM)-1, α4β1, Lu/BCAM, and intercellular adhesion molecule (ICAM)-4. More recently RBC adhesion was found to be increased in retinal-vein occlusion (RVO) and in polycythemia vera (PV). The molecules which participate in this process are phosphatidylserine and annexin V in RVO, and phosphorylated Lu/BCAM and α5 laminin chain in PV. The additional adhesion in diabetes mellitus occurs due to the glycated RBC band 3 and the advanced glycation end-product receptors. The multiligand receptor binds advanced glycation end products (AGEs) or S100 calgranulins, or β-amyloid peptide. This receptor for advanced glycation end products is known as RAGE. The binding to RAGE-activated endothelial cells leads to an inflammatory reaction and a prothrombotic state via NADPH activation and altered gene expression. RAGE blockade is a potential target for drugs preventing the deleterious consequences of RAGE activation.
  • 1.2K
  • 28 Sep 2021
Topic Review
Oxidative Stress in Cardiovascular Diseases
       This entry aims to introduce the physiological roles and pathological implications of oxidative stress in cardiovascular tissues
  • 1.2K
  • 28 Sep 2021
Topic Review
EVs as Potential-Biomarkers in MS
       Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system and its pathophysiology is characterized by a progressive blood-brain barrier dysfunction accompanied by infiltration in the central nervous system of peripheral pathogenic immune cells and inflammatory mediators leading to demyelination, axonal damage, and dysfunction and/or loss of synapses. Accumulating evidence highlights blood and cerebrospinal fluid (CSF) derived extracellular vesicles (EVs) as potential biomarkers of MS disease stages and of response to treatment. In particular, EVs released from blood–brain barrier (BBB) endothelial cells, platelets, leukocytes, myeloid cells, astrocytes, and oligodendrocytes seem to be involved in the pathogenesis of MS and of its rodent model experimental autoimmune encephalomyelitis. Further research is necessary to validate these observations and the screening of specific EVs subsets based on their cargo and membrane compositions associated to specific MS pathophysiological mechanisms might help guiding MS diagnosis, prognosis, and response to therapy. 
  • 1.2K
  • 28 Sep 2021
Topic Review
The Gamma-Tubulin Meshwork
γTubulin is part of a family of GTPases called the tubulins. Due to the self-polymerizing ability of γ-tubulin, in combination with its presence in all cellular compartments, γtubulin can be organized in γ-strings, and γ-tubules, and the γ-strings associated with the centrosome. These components are interlinked to form a cellular meshwork in both the cytosol (including all cellular organelles) and the nuclear compartment.
  • 1.2K
  • 10 Nov 2020
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