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Topic Review
Infectious Agents in Celiac Disease
The ingestion of wheat gliadin (alcohol-soluble proteins, an integral part of wheat gluten) and re-lated proteins induce, in genetically predisposed individuals, celiac disease (CD), which is charac-terized by immune-mediated impairment of the small intestinal mucosa. The lifelong omission of gluten and related grain proteins, i.e., a gluten-free diet (GFD), is at present the only therapy for CD. Although a GFD usually reduces CD symptoms, it does not entirely restore the small intesti-nal mucosa to a fully healthy state. Recently, the participation of microbial components in patho-genetic mechanisms of celiac disease was suggested.
  • 1.2K
  • 17 Mar 2021
Topic Review
IoT and Machine Learning
Machine learning (ML) is a powerful tool that delivers insights hidden in Internet of Things (IoT) data. These hybrid technologies work smartly to improve the decision-making process in different areas such as education, security, business, and the healthcare industry. ML empowers the IoT to demystify hidden patterns in bulk data for optimal prediction and recommendation systems. Healthcare has embraced IoT and ML so that automated machines make medical records, predict disease diagnoses, and, most importantly, conduct real-time monitoring of patients. Individual ML algorithms perform differently on different datasets. Due to the predictive results varying, this might impact the overall results. The variation in prediction results looms large in the clinical decision-making process. Therefore, it is essential to understand the different ML algorithms used to handle IoT data in the healthcare sector.
  • 1.2K
  • 16 Jun 2021
Topic Review
Therapy of the Rheumatic Knee
In rheumatoid arthritis, the joints of the lower extremities are almost always affected. This is most conspicuous in the knee joint. In rheumatics, inflammatory osteoarthritis manifests itself comparably earlier than in patients with osteoarthritis. The focus of attention was primarily on the synovia with its destruction process and secondary changes. Now, driven by experimental research, dendritic cells and fibroblasts and molecular features are moving into the clinician’s field of vision. Even in joints that appear to be in remission with no swelling or pain, the activity of these cells leads to changes in the capsule-ligaments. The complex deformities and instabilities caused by this, in conjunction with atrophy of the inter-articular musculature, have an impact on the activities of daily life (ADL). If these biomechanical aspects of the knee joint are not taken into account early on in therapy, the frequency of primary and secondary surgical treatment increases. The timely recognition of biomechanical pathologies and consistent treatment can contribute to improving the patient situation in addition to adequate medication therapy. 
  • 1.2K
  • 07 Apr 2021
Topic Review
Smart Nanoparticles in Dental Applications
A strong trend in dental applications is to apply nanotechnology and smart nanomaterials such as nanoclays, nanofibers, nanocomposites, nanobubbles, nanocapsules, solid-lipid nanoparticles, nanospheres, metallic nanoparticles, nanotubes, and nanocrystals.
  • 1.2K
  • 30 Apr 2021
Topic Review
Custard Apple (Annona squamosa L.)
Annona squamosa L. (custard apple) belongs to the family Annonaceae and is an important tropical fruit cultivated in the West Indies, South and Central America, Ecuador, Peru, Brazil, India, Mexico, the Bahamas, Bermuda, and Egypt. Leaves of custard apple plants have been studied for their health benefits, which are attributed to a considerable diversity of phytochemicals. These compounds include phenol-based compounds, e.g., proanthocyanidins, comprising 18 different phenolic compounds, mainly alkaloids and flavonoids. Extracts from Annona squamosa leaves (ASLs) have been studied for their biological activities, including anticancer, antidiabetic, antioxidant, antimicrobial, antiobesity, lipid-lowering, and hepatoprotective functions.
  • 1.2K
  • 05 May 2021
Topic Review
Fault Tolerant Techniques in USNs
Sensor networks provide services to a broad range of applications ranging from intelligence service surveillance to weather forecasting. While most of the sensor networks are terrestrial, Underwater Sensor Networks (USN) are an emerging area. One of the unavoidable and increasing challenges for modern USN technology is tolerating faults, i.e., accepting that hardware is imperfect, and coping with it. Fault Tolerance tends to have more impact in underwater than in terrestrial environment as the latter is generally more forgiving. Moreover, reaching the malfunctioning devices for replacement and maintenance under water is harder and more costly.
  • 1.2K
  • 17 May 2021
Topic Review
Adenosine Signaling in Mast Cells
Adenosine is a nucleoside involved in the pathogenesis of allergic diseases. Its effects are mediated through its binding to G protein-coupled receptors: A1, A2a, A2b and A3. The receptors differ in the type of G protein they recruit, in the effect on adenylyl cyclase (AC) activity and the downstream signaling pathway triggered. Adenosine can produce both an enhancement and an inhibition of mast cell degranulation, indicating that adenosine effects on these receptors is controversial and remains to be clarified.
  • 1.2K
  • 01 Jul 2021
Topic Review
Dietary Intake of Selenium
Se is taken with the diet in the form of organic (SeMet and Sec) and inorganic compounds (selenites, selenides). The absorption of these compounds mostly occurs in the duodenum and cecum, and their absorption mechanism depends on the chemical form of ingested Se. Inorganic compounds are absorbed by simple diffusion (selenites) or by secondary active transport, the so-called cotransport (selenides). In turn, organic compounds (SeMet, Sec, methylselenocysteine (MSC)) are absorbed by active transport in the same way as amino acids.
  • 1.2K
  • 23 Jun 2021
Topic Review
Manual Therapy in Cervical/Lumbar Radiculopathy
A comprehensive literature review was conducted using PubMed and Web of Science databases up to April 2020. The following inclusion criteria were used: (1) presence of radiculopathy; (2) treatment defined as manual therapy (i.e., traction, manipulation, mobilization); and (3) publication defined as a Randomized Controlled Trial. The electronic literature search resulted in 473 potentially relevant articles. Finally, 27 articles were accepted: 21 on cervical (CR) and 6 in lumbar radiculopathy (LR). The mean PEDro score for CR was 6.6 (SD 1.3), and for LR 6.7 (SD 1.6). Traction-oriented techniques are the most frequently chosen treatment form for CR and are efficient in reducing pain and improving functional outcomes. In LR, each of the included publications used a different form of manual therapy, which makes it challenging to summarize knowledge in this group. Of included publications, 93% were either of moderate or low quality, which indicates that quality improvement is necessary for this type of research. 
  • 1.2K
  • 22 Jun 2021
Topic Review
Epithelial–Mesenchymal Transition & prostate cancer
Epithelial–mesenchymal transition (EMT) is a dynamic, reversible cellular process which is essential in normal embryonic morphogenesis and wound healing. However this multifaceted process is also implicated in cancer progression and metastasis in many tumors, including prostate cancer. Moreover, recent evidence suggests that EMT-induced cell plasticity is involved in the development of therapy resistance in prostate cancer cells.
  • 1.2K
  • 02 Jul 2021
Topic Review
Formins in Human Monogenic Disease
Almost 25 years have passed since a mutation of a formin gene, DIAPH1, was identified as being responsible for a human inherited disorder: a form of sensorineural hearing loss. Since then, our knowledge of the links between formins and disease has deepened considerably. Mutations of DIAPH1 and six other formin genes (DAAM2, DIAPH2, DIAPH3, FMN2, INF2 and FHOD3) have been identified as the genetic cause of a variety of inherited human disorders, including intellectual disability, renal disease, peripheral neuropathy, thrombocytopenia, primary ovarian insufficiency, hearing loss and cardiomyopathy.
  • 1.2K
  • 18 Oct 2021
Topic Review
PD-1 and Its Ligands in Allergy
Programmed cell death 1 (PD-1) and its ligands PD-L1 and PD-L2 are receptors that act in co-stimulatory and coinhibitory immune responses. Signaling the PD-1/PD-L1 or PD-L2 pathway is essential to regulate the inflammatory responses to infections, autoimmunity, and allergies, and it has been extensively studied in cancer.
  • 1.2K
  • 13 Jun 2022
Topic Review
Surface Attached Mortar for Recycled Coarse Aggregate
Due to the large amount of old hardened cement mortar attached to the surface of aggregate and the internal micro-cracks formed by the crushing process, the water absorption, apparent density, and crushing index of recycled coarse aggregate are still far behind those of natural coarse aggregate. The results showed that the physical strengthening technique can remove old hardened mortar and micro powder attached to the surface of recycled coarse aggregate by mechanical action, which can effectively improve the quality of recycled coarse aggregate. 
  • 1.2K
  • 04 Jan 2022
Topic Review
Effects of Delivery Attributes on E-Shopping Consumer Behaviour
E-consumer behaviour plays a vital role in e-commerce worldwide. This entry addresses the importance of delivery time, delivery fee, and delivery reception, and the influence of delivery fee and reception on e-consumers’ behaviour by analysing the following hypotheses: delivery attributes affect e-shopping behaviour, and delivery attributes affect e-consumers’ behaviour according to their sociodemographic characteristics. Data were obtained from a web-based survey with Brazilian e-consumers, and logistic regression and artificial neural network models were estimated to assess consumer behaviour. 
  • 1.2K
  • 11 Jan 2022
Topic Review
Protein-Bound Uremic Toxins (PBUTs) and Cellular Transporters
Uremic toxins are a heterogeneous group of molecules that accumulate in the body due to the progression of chronic kidney disease (CKD), being only partially eliminated by dialysis therapies. Several uremic toxins bind to albumin and also enter cells via membrane transporters, triggering pathophysiological processes.
  • 1.2K
  • 04 Mar 2022
Topic Review
Therapeutic Potential of Certain Terpenoids as Anticancer Agents
Cancer is a life-threatening disease and is considered to be among the leading causes of death worldwide. Chemoresistance, severe toxicity, relapse and metastasis are the major obstacles in cancer therapy. Therefore, introducing new therapeutic agents for cancer remains a priority to increase the range of effective treatments. Terpenoids, a large group of secondary metabolites, are derived from plant sources and are composed of several isoprene units. The high diversity of terpenoids has drawn attention to their potential anticancer and pharmacological activities. Some terpenoids exhibit an anticancer effect by triggering various stages of cancer progression, for example, suppressing the early stage of tumorigenesis via induction of cell cycle arrest, inhibiting cancer cell differentiation and activating apoptosis. At the late stage of cancer development, certain terpenoids are able to inhibit angiogenesis and metastasis via modulation of different intracellular signaling pathways. Significant progress in the identification of the mechanism of action and signaling pathways through which terpenoids exert their anticancer effects has been highlighted. 
  • 1.2K
  • 07 Mar 2022
Topic Review
Intelligent Sensor arrays for Early Detection of Diabetes
At present, it is unquestionable that machine learning (ML) modeling is one of the most promising and powerful tools for the development of diagnosis methods and technologies. It permits the fast cribbage and analysis of huge amounts of data from overwhelmingly complex biological matrices which, applied to diagnostics, can be translated into valuable support technologies that would ease rapid decision-making in early diagnosis and screening programs. It has been seen that one can find a great number of colorimetric and electrochemical sensing methods for the detection of biomarkers related to diabetes mellitus (DM) and diabetic rethinopathy (DR), including some recent efforts towards the development of sensor-array technologies exploiting or not ML models for the sensing of diverse biomarkers and for diagnose purposes (including DM). 
  • 1.2K
  • 14 Mar 2022
Topic Review
Edge Computing in Manufacturing Industry
The primary goal of edge computing (EC) is to reduce the time required to transfer large amounts of data. With the ability to analyze data at the edge, it is possible to obtain immediate feedback and use it in the decision-making process. However, the implementation of EC requires investments not only in infrastructure, but also in the development of employee knowledge related to modern computing methods based on artificial intelligence. Future research in EC should particularly cover areas where actions require immediate decision making and the processing of big data, such as autonomous control of robots, vehicles, or entire factories. The second area of research should be technologies related to mobile edge computing, for example, telecommunications and all issues related to 5G technology.
  • 1.2K
  • 11 Apr 2022
Topic Review
Ukrainian Migrants in Poland during COVID-19 Pandemic
Economic and political crises have significant impacts on the situation of foreigners in their host country. Some of these impacts of such crises can be predicted, while others appear unexpectedly. Particularly challenging are those characterised by extreme unusualness and the absence of warning signs that suggest the possibility of their occurrence. The pandemic as an emergency situation entailing restrictions on mobility between countries did not significantly affect the migration decisions of Ukrainians. Disregarding the difficult epidemiological situation, they continued to make decisions on immigration to Poland, guided by individual profit and loss calculations. Others remained in Poland to wait out the crisis. The pandemic has exposed the dependence of the Polish economy on migrant labour and has also shown the deficiencies in migration policy.
  • 1.2K
  • 23 May 2022
Topic Review
Carbon Nanotubes in Nanocomposite Mixed-Matrix Membranes
Carbon nanotubes (CNTs) are a popular material for gas separation because their walls are naturally smooth, allowing for faster gas transit than other inorganic fillers. It also has excellent mechanical strength, allowing membranes to work under high pressure. Although CNTs have superior qualities to other inorganic fillers, incorporating them into a polymer matrix is difficult due to CNTs' strong van der Waals forces, which cause agglomeration. CNT dispersion must be addressed if the full potential of CNTs is to be realized.
  • 1.2K
  • 17 Jun 2022
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