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Topic Review
Melatonin in Cancer Treatment
Melatonin is a pleotropic molecule with numerous biological activities. Epidemiological and experimental studies have documented that melatonin could inhibit different types of cancer in vitro and in vivo.
  • 1.2K
  • 02 Jul 2021
Topic Review
ALA against COVID-19-Induced Cardiovascular Diseases
Cardiovascular complications are rapidly emerging as a major peril in COVID-19 in addition to respiratory disease. The mechanisms underlying the excessive effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on patients with cardiovascular comorbidities remain only partly understood. SARS-CoV-2 infection is caused by binding of the viral surface spike (S) protein to the human angiotensin-converting enzyme 2 (ACE2), followed by the activation of the S protein by transmembrane protease serine 2 (TMPRSS2). ACE2 is expressed in the lung (mainly in type II alveolar cells), heart, blood vessels, small intestine, etc., and appears to be the predominant portal to the cellular entry of the virus. Based on current information, most people infected with SARS-CoV-2 virus have a good prognosis, while a few patients reach critical condition, especially the elderly and those with chronic underlying diseases. The “cytokine storm” observed in patients with severe COVID-19 contributes to the destruction of the endothelium, leading to “acute respiratory distress syndrome” (ARDS), multiorgan failure, and death. At the origin of the general proinflammatory state may be the SARS-CoV-2-mediated redox status in endothelial cells via the upregulation of ACE/Ang II/AT1 receptors pathway or the increased mitochondrial reactive oxygen species (mtROS) production. Furthermore, this vicious circle between oxidative stress (OS) and inflammation induces endothelial dysfunction, endothelial senescence, high risk of thrombosis and coagulopathy. The microvascular dysfunction and the formation of microthrombi in a way differentiate the SARS-CoV-2 infection from the other respiratory diseases and bring it closer to cardiovascular diseases like myocardial infarction and stroke. Due the role played by OS in the evolution of viral infection and in the development of COVID-19 complications, the use of antioxidants as adjuvant therapy seems appropriate in this new pathology. Alpha-lipoic acid (ALA) could be a promising candidate that, through its wide tissue distribution and versatile antioxidant properties, interferes with several signaling pathways.
  • 1.2K
  • 12 Aug 2021
Topic Review
RNA-Mediated Control in Polyhydroxyalkanoates Synthesis
The large production of non-degradable petrol-based plastics has become a major global issue due to its environmental pollution. Biopolymers produced by microorganisms such as polyhydroxyalkanoates (PHAs) are gaining potential as a sustainable alternative, but the high cost associated to their industrial production has been a limiting factor. Post-transcriptional regulation is a key step to control gene expression in changing environments and has been reported to play a major role in numerous cellular processes. However, limited reports are available concerning the regulation of PHA accumulation in bacteria, and many essential regulatory factors still need to be identified. Here, we review studies where the synthesis of PHA has been reported to be regulated at the post-transcriptional level, and we analyze the RNA-mediated networks involved. Finally, we discuss the forthcoming research on riboregulation, synthetic and metabolic engineering which could lead to improved strategies for PHAs synthesis in industrial production, thereby reducing the costs currently associated with this procedure.
  • 1.2K
  • 10 Sep 2021
Topic Review
Nitrosative Stress in Retinal Pathologies
Nitric oxide (NO) is a gas molecule with diverse physiological and cellular functions. In the eye, NO is used to maintain normal visual function as it is involved in photoreceptor light transduction. In addition, NO acts as a rapid vascular endothelial relaxant, is involved in the control of retinal blood flow under basal conditions and mediates the vasodilator responses of different substances such as acetylcholine, bradykinin, histamine, substance P or insulin. However, the retina is rich in polyunsaturated lipid membranes and is sensitive to the action of reactive oxygen and nitrogen species. Products generated from NO (i.e., dinitrogen trioxide (N2O3) and peroxynitrite) have great oxidative damaging effects. Oxygen and nitrogen species can react with biomolecules (lipids, proteins and DNA), potentially leading to cell death, and this is particularly important in the retina.
  • 1.2K
  • 22 Sep 2021
Topic Review
Astaxanthin Delivery Systems for Skin
Astaxanthin (AST) is a biomolecule known for its powerful antioxidant effect, which is considered of great importance in biochemical research and has great potential for application in cosmetics, as well as food products that are beneficial to human health and medicines. Unfortunately, its poor solubility in water, chemical instability, and low oral bioavailability make its applications in the cosmetic and pharmaceutical field a major challenge for the development of new products. To favor the search for alternatives to enhance and make possible the use of AST in formulations, this article aimed to review the scientific data on its application in delivery systems.
  • 1.2K
  • 26 Sep 2021
Topic Review
Iberian Peninsula under Climate Change
This entry presents the results of a systematic review of temperature and precipitation extremes over the Iberian Peninsula, focusing on observed changes in temperature and precipitation during the past years and what are the projected changes by the end of the 21st century. The purpose of this entry is to assess the current literature about extreme events and their change under global warming. Observational and climate modeling studies from the past decade were considered in this entry.
  • 1.2K
  • 18 Feb 2022
Topic Review
Thrombin-Gelatin Matrix in Breast Tumor Hemostasis
Improved hemostasis during acute bleeding and a trend to prevent hematoma were observed after the TGM injection. TGM could be an alternative method to achieve better post-VABB hemostasis.
  • 1.2K
  • 02 Mar 2022
Topic Review
Deep Learning Algorithms in Oral Cancer
Oral cancer is a dangerous and extensive cancer with a high death ratio. Oral cancer is the most usual cancer in the world, with more than 300,335 deaths every year. The cancerous tumor appears in the neck, oral glands, face, and mouth. To overcome this dangerous cancer, there are many ways to detect like a biopsy, in which small chunks of tissues are taken from the mouth and tested under a secure and hygienic microscope. However, microscope results of tissues to detect oral cancer are not up to the mark, a microscope cannot easily identify the cancerous cells and normal cells. Detection of cancerous cells using microscopic biopsy images helps in allaying and predicting the issues and gives better results if biologically approaches apply accurately for the prediction of cancerous cells, but during the physical examinations microscopic biopsy images for cancer detection there are major chances for human error and mistake. So, with the development of technology deep learning algorithms plays a major role in medical image diagnosing. Deep learning algorithms are efficiently developed to predict breast cancer, oral cancer, lung cancer, or any other type of medical image.
  • 1.2K
  • 27 Jun 2022
Topic Review
Graphene Oxide Action Mechanisms
Graphene oxide (GO), an oxidized form of graphene, is regarded to be more superior to graphene with regards to application in drug delivery due to the presence of functional groups that could allow the binding of different compounds, especially water-insoluble drugs. 
  • 1.2K
  • 23 Aug 2022
Topic Review
TXA2 Signaling in Cancer
Several processes involved in cancer development, such as cell growth, migration, and angiogenesis, are regulated by the arachidonic acid derivative thromboxane A2 (TXA2). Higher levels of circulating TXA2 are observed in patients with multiple cancers, and this is accompanied by overexpression of TXA2 synthase (TBXAS1, TXA2S) and/or TXA2 receptors (TBXA2R, TP). Overexpression of TXA2S or TP in tumor cells is generally associated with poor prognosis, reduced survival, and metastatic disease. However, the role of TXA2 signaling in the stroma during oncogenesis has been underappreciated. TXA2 signaling regulates the tumor microenvironment by modulating angiogenic potential, tumor ECM stiffness, and host immune response. 
  • 1.2K
  • 26 Oct 2022
Topic Review
Reservoir Modeling
In the oil and gas industry, reservoir modeling involves the construction of a computer model of a petroleum reservoir, for the purposes of improving estimation of reserves and making decisions regarding the development of the field, predicting future production, placing additional wells, and evaluating alternative reservoir management scenarios. A reservoir model represents the physical space of the reservoir by an array of discrete cells, delineated by a grid which may be regular or irregular. The array of cells is usually three-dimensional, although 1D and 2D models are sometimes used. Values for attributes such as porosity, permeability and water saturation are associated with each cell. The value of each attribute is implicitly deemed to apply uniformly throughout the volume of the reservoir represented by the cell.
  • 1.2K
  • 15 Nov 2022
Topic Review
Fiber Optic Sensor
A fiber optic sensor is a sensor that uses optical fiber either as the sensing element ("intrinsic sensors"), or as a means of relaying signals from a remote sensor to the electronics that process the signals ("extrinsic sensors"). Fibers have many uses in remote sensing. Depending on the application, fiber may be used because of its small size, or because no electrical power is needed at the remote location, or because many sensors can be multiplexed along the length of a fiber by using light wavelength shift for each sensor, or by sensing the time delay as light passes along the fiber through each sensor. Time delay can be determined using a device such as an optical time-domain reflectometer and wavelength shift can be calculated using an instrument implementing optical frequency domain reflectometry. Fiber optic sensors are also immune to electromagnetic interference, and do not conduct electricity so they can be used in places where there is high voltage electricity or flammable material such as jet fuel. Fiber optic sensors can be designed to withstand high temperatures as well.
  • 1.2K
  • 17 Nov 2022
Topic Review
Regenerated Keratin-Based Biofilms
The recycling, development, and application of keratin-containing waste (e.g., hair, wool, feather, and so on) provide an important means to address related environmental pollution and energy shortage issues. The extraction of keratin and the development of keratin-based functional materials are key to solving keratin-containing waste pollution. Keratin-based biofilms are gaining substantial interest due to their excellent characteristics, such as good biocompatibility, high biodegradability, appropriate adsorption, and rich renewable sources, among others. At present, keratin-based biofilms are a good option for various applications, and the development of keratin-based biofilms from keratin-containing waste is considered crucial for sustainable development. 
  • 1.2K
  • 28 Nov 2022
Topic Review
Energy Efficiency of Tall Buildings
Design priorities for tall and supertall buildings have for some time shifted to achieving more energy efficiency to address the energy needs of the increasing global population. Engineers and architects aim to achieve energy conservation through active and passive approaches, pursuing technological innovations and adopting climate-responsive design. The advent of recent building technologies in facade design, mechanical and electrical systems, new materials including smart materials, and computer-based intelligent systems has greatly impacted the design of tall buildings. It is expected that the incorporation of newer and more sophisticated technologies into the design process in the future will result in novel solutions mitigating the challenge of achieving optimal energy efficiency of tall buildings.
  • 1.2K
  • 13 Mar 2023
Topic Review
Materials of Woven Textiles
Fabrics have been recognized as a necessary component of daily life due to their involvement in garments, home textiles, and industrial textiles. The mechanical performance of textiles was considered essential to meet the end-user requirements for strength and durability.
  • 1.2K
  • 26 Sep 2023
Topic Review
Mars In Situ Resource Utilization Technologies
Exploration of Mars with a human crew is widely viewed as the ultimate culmination of planetary exploration. Initial human landing on Mars would be limited to the simple in situ resource utilization (ISRU) based on atmosphere only, which is immediately accessible without the challenge of remote, autonomous mining of regolith, transporting regolith, and processing regolith. In a second generation of missions, it might be possible to include processing regolith, either for hydrated minerals or for imbedded ice.
  • 1.2K
  • 22 Jan 2024
Topic Review
Design of Supply Chain in Perishable Products
A perishable product (PP) is defined as one that, by natural consequence, deteriorates in terms of its quality and/or organoleptic properties. The design of supply chains for products of all kinds is a classic problem of Industrial and Manufacturing Engineering as well as Cold Technology Engineering in order to provide the producer and customer with the optimal means for the manufacturing, packaging, loading, transport and download of the product with time windows.
  • 1.2K
  • 25 Jan 2024
Topic Review
Systemic Alternative in Psychiatry
The alternative systemic approach to mental health issues and of a more humane mental health care system suggests focusing on understanding mental distress as stemming from problems in living, using medications as agents facilitating psychotherapy, or as a last resort and short-term help, according to the principles of harm reduction. It argues that understanding drugs as psychoactive substances and studying the subjective effects they produce could lead to better utilization of medications and improvements in terms of conceptualizing and assessing treatment effects. Qualitative research could be particularly useful in that regard. It also advocates a radical departure from current diagnostic systems and proposes a synthesis of already existing alternatives to be used for both research and clinical purposes.
  • 1.2K
  • 13 Jul 2021
Topic Review
Intangible Mosaic of Sacred Soundscapes in Medieval Serbia
The sacred art and architecture of medieval Serbia developed under the influence of both the Byzantine East and Latin West ever since the adoption of Christianity.  Here, the focuses are particularly on the period from the late 12th century when the Nemanjić dynasty came to the throne until the fall of Serbia under Ottoman rule in the mid-15th century, because this period was fundamental for the development of the Serbian Orthodox Church as well as sacred architecture. It is argued that the archaeoacoustic studies of medieval sacred soundscapes should not be limited to church acoustics but also include open-air sacred sites to provide a complete analysis of the aural environment of religious practice and thus contribute to understanding the acoustic intention of medieval builders, as well as the aural experience of both clergy and laity. 
  • 1.2K
  • 16 Jan 2023
Topic Review
Yvelines
Yvelines (/iːvlɪnz/, /iːvlaɪnz/; French: [ivlin] (listen)) is a department in the western part of the Île-de-France region in Northern France. In 2016, it had a population of 1,431,808. Its prefecture is Versailles, home to the Palace of Versailles, the principal residence of the King of France from 1682 until 1789, a UNESCO World Heritage Site since 1979. Yvelines' subprefectures are Saint-Germain-en-Laye, Mantes-la-Jolie and Rambouillet.
  • 1.2K
  • 11 Oct 2022
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