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Topic Review
Extracellular Vesicles in ILDs
Interstitial lung diseases (ILDs) are chronic irreversible pulmonary conditions with significant morbidity and mortality. Diagnostic approaches to ILDs are complex and multifactorial. Effective therapeutic interventions are continuously investigated and explored with substantial progress, thanks to advances in basic understanding and translational efforts. Extracellular vesicles (EVs) offer a new paradigm in diagnosis and treatment.
  • 1.3K
  • 22 Jan 2021
Topic Review
Alternative Pesticide Residue Detection Methods
Pesticides have been extensively used in agriculture to protect crops and enhance their yields, indicating the need to monitor for their toxic residues in foodstuff. To achieve that, chromatographic methods coupled to mass spectrometry is the common analytical approach, combining low limits of detection, wide linear ranges, and high accuracy. However, these methods are also quite expensive, time-consuming, and require highly skilled personnel, indicating the need to seek for alternatives providing simple, low-cost, rapid, and on-site results. In this study, we critically review the available screening methods for pesticide residues on the basis of optical detection during the period 2016–2020. Optical biosensors are commonly miniaturized analytical platforms introducing the point-of-care (POC) era in the field. Various optical detection principles have been utilized, namely, colorimetry, fluorescence (FL), surface plasmon resonance (SPR), and surface enhanced Raman spectroscopy (SERS). Nanomaterials can significantly enhance optical detection performance and handheld platforms, for example, handheld SERS devices can revolutionize testing. All in all, despite being in an early stage facing several challenges, i.e., long sample preparation protocols, such POC diagnostics pave a new road into the food safety field in which analysis cost will be reduced and a more intensive testing will be achieved.
  • 1.3K
  • 20 Apr 2021
Topic Review
SARS-CoV-2 Infection and Cardioncology
The coronavirus disease-2019 (COVID-19) is a highly transmissible viral illness caused by SARS-CoV-2, which has been defined by the World Health Organization as a pandemic, considering its remarkable transmission speed worldwide. SARS-CoV-2 interacts with angiotensin-converting enzyme 2 and TMPRSS2, which is a serine protease both expressed in lungs, the gastro-intestinal tract, and cardiac myocytes. Patients with COVID-19 experienced adverse cardiac events (hypertension, venous thromboembolism, arrhythmia, myocardial injury, fulminant myocarditis), and patients with previous cardiovascular disease have a higher risk of death. Cancer patients are extremely vulnerable with a high risk of viral infection and more negative prognosis than healthy people, and the magnitude of effects depends on the type of cancer, recent chemotherapy, radiotherapy, or surgery and other concomitant comorbidities (diabetes, cardiovascular diseases, metabolic syndrome). Patients with active cancer or those treated with cardiotoxic therapies may have heart damages exacerbated by SARS-CoV-2 infection than non-cancer patients.
  • 1.3K
  • 20 Feb 2021
Topic Review
Macrophage in Pathogenesis of Osteoporosis
Osteoporosis is a systemic disease with progressive bone loss. The bone loss is associated with an imbalance between bone resorption via osteoclasts and bone formation via osteoblasts. Other cells including T cells, B cells, macrophages, and osteocytes are also involved in the pathogenesis of osteoporosis. Different cytokines from activated macrophages can regulate or stimulate the development of osteoclastogenesis-associated bone loss. The fusion of macrophages can form multinucleated osteoclasts and, thus, cause bone resorption via the expression of IL-4 and IL-13. Different cytokines, endocrines, and chemokines are also expressed that may affect the presentation of macrophages in osteoporosis.
  • 1.3K
  • 02 Jun 2021
Topic Review
Cholesterol Metabolism in Glioblastoma
Glioblastoma is a highly lethal adult brain tumor with no effective treatments. 
  • 1.3K
  • 16 Aug 2021
Topic Review
Breast Cancer Treatments
Breast cancer (BC) is the most frequent cancer diagnosed in women worldwide. This heterogeneous disease can be classified into four molecular subtypes (luminal A, luminal B, HER2 and triple-negative breast cancer (TNBC)) according to the expression of the estrogen receptor (ER) and the progesterone receptor (PR), and the overexpression of the human epidermal growth factor receptor 2 (HER2). Current BC treatments target these receptors (endocrine and anti-HER2 therapies) as a personalized treatment. Along with chemotherapy and radiotherapy, these therapies can have severe adverse effects and patients can develop resistance to these agents. Moreover, TNBC do not have standardized treatments. Hence it is essential to develop new treatments to target more effectively each BC subgroup. 
  • 1.3K
  • 06 Sep 2021
Topic Review
Capsule-Based Dry Powder Inhalers
Capsule-based dry powder inhalers (cDPIs) are widely utilized in the delivery of pharmaceutical powders to the lungs. In these systems, the fundamental nature of the interactions between the drug/formulation powder, the capsules, the inhaler device, and the patient must be fully elucidated in order to develop robust manufacturing procedures and provide reproducible lung deposition of the drug payload. 
  • 1.3K
  • 23 Sep 2021
Topic Review
The Role of Curcumin in Chronic Disorders
Curcumin is the primary polyphenol in turmeric’s curcuminoid class. It has a wide range of therapeutic applications, such as anti-inflammatory, antioxidant, antidiabetic, hepatoprotective, antibacterial, and anticancer effects against various cancers, but has poor solubility and low bioavailability.
  • 1.3K
  • 30 Nov 2021
Topic Review
Defining Blood Plasma and Serum Metabolome by GC-MS
Metabolomics uses advanced analytical chemistry methods to analyze metabolites in biological samples. The most intensively studied samples are blood and its liquid components: plasma and serum. Armed with advanced equipment and progressive software solutions, the scientific community has shown that small molecules’ roles in living systems are not limited to traditional “building blocks” or “just fuel” for cellular energy. 
  • 1.3K
  • 06 Jan 2022
Topic Review
CREB Protein Family Members in Radioresistance Mechanisms
In the framework of space flight, the risk of radiation carcinogenesis is considered a “red” risk due to the high likelihood of occurrence as well as the high potential impact on the quality of life in terms of disease-free survival after space missions. The cyclic AMP response element-binding protein (CREB) is overexpressed both in haematological malignancies and solid tumours and its expression and function are modulated following irradiation. The CREB protein is a transcription factor and member of the CREB/activating transcription factor (ATF) family. As such, it has an essential role in a wide range of cell processes, including cell survival, proliferation, and differentiation. Among the CREB-related nuclear transcription factors, NF-κB and p53 have a relevant role in cell response to ionising radiation. Their expression and function can decide the fate of the cell by choosing between death or survival. 
  • 1.3K
  • 09 Jan 2022
Topic Review
Bauxite Residue as Eco-Friendly Cementitious Materials
Bauxite residue (red mud) is a solid waste resulting from the aluminum production industry. Disposal or landfill of the red mud (RM) poses irreversible environmental problems; therefore, it is compelling to find practical solutions that can mitigate the negative environmental problems of RM stacking storage. In the past decades, although the recycling of RM has achieved significant progress, challenges remain from both academic and practical perspectives. Previous studies have demonstrated that all the aluminosilicate-based solid wastes have pozzolanic activity, and thus can be considered as resources to manufacture eco-friendly cementitious materials to relieve the carbon emission burden. Therefore, combining RM and other solid wastes to manufacture green cementitious materials has become a promising route to alleviate the burden of environmental pollution. However, challenges from the fluctuation of the chemical compositions, inert activity, heavy metals stabilization, efflorescence, the side effects of the second pollutions from solid wastes, the hydration process, and mutual interaction mechanisms between the various types of solid wastes are still unclear, especially for multi-components RM-based cementitious materials.
  • 1.3K
  • 06 Apr 2022
Topic Review
Ultrafast Laser in Orthopedic Surgery
The potential of ultrafast lasers (pico- to femtosecond) in orthopedics-related procedures has been studied extensively for clinical adoption. As compared to conventional laser systems with continuous wave or longer wave pulse, ultrafast lasers provide advantages such as higher precision and minimal collateral thermal damages. Translation to surgical applications in the clinic has been restrained by limitations of material removal rate and pulse average power, whereas the use in surface texturing of implants has become more refined to greatly improve bioactivation and osteointegration within bone matrices.
  • 1.3K
  • 07 May 2022
Topic Review
The Sustainability Potential of Upcycling
The upcycling trend has received renewed attention in the past few years due to growing concerns for the environment related to increased resource consumption and waste volumes. Indeed, cities across the world are supporting resource upcycling initiatives by establishing do-it-yourself (DIY) repair cafes and makerspaces as a means to transform societies towards sustainable development. However, the sustainability potential of such upcycling initiatives is unknown due to the lack of theoretical frameworks.
  • 1.3K
  • 30 May 2022
Topic Review
Novel Biomarkers of Heart Failure in Pediatrics
Novel biomarkers of heart failure are the subject of numerous studies. Biomarkers of heart failure can be determined in the blood and in the urine. The future of biomarker use is in multimarker panels that include a combination of biomarkers with different pathophysiological mechanisms in order to improve their diagnostic and prognostic predictive value.
  • 1.3K
  • 01 Jun 2022
Topic Review
Innovative Strategies for Wound Healing
Wound healing is highly specialized dynamic multiple phase process for the repair of damaged/injured tissues through an intricate mechanism. Various emerging and innovative strategies for promoting quality wound healing have been discussed. 
  • 1.3K
  • 15 Aug 2022
Topic Review
Anhydrobiosis
Anhydrobiosis is induced by loss of water and indicates dehydration tolerance. Survival of dehydration is possible through changes at different levels of organism organization, including a remarkable reduction in metabolic activity at the cellular level. Thus, anhydrobiosis may be regarded as an anti-aging strategy.
  • 1.3K
  • 23 Aug 2022
Topic Review
Type I Photosensitizers Based on Aggregation-Induced Emission
Photodynamic therapy (PDT) is emerging as a minimally invasive therapeutic modality with precise controllability and high spatiotemporal accuracy in the field of diseases treatment. PDT mainly relies on the photosensitizers (PSs) to generate oxidative reactive oxygen species (ROS), to play the therapeutic role. Type I photosensitizers, that undergo hydrogen atom abstraction or electron transfer manner and subsequently produce superoxide radical (O2•−), hydroxyl radical (OH•), or hydrogen peroxide (H2O2), etc., is showing more and more prominent advantages, particularly in hypoxic tissues, since type I PSs-involved PDT usually exhibit distinctive hypoxia tolerance. Regarding the diverse type I PSs, aggregation-induced emission (AIE)-active type I PSs are currently arousing great research interest owing to their distinguished aggregation-induced emission and aggregation-induced generation of reactive oxygen species (AIE-ROS) features.
  • 1.3K
  • 21 Sep 2022
Topic Review
Radiography of Cultural Objects
The radiography of cultural objects is the use of radiography to understand intrinsic details about objects. Most commonly this involves X-rays of paintings to reveal underdrawing, pentimenti alterations in the course of painting or by later restorers, and sometimes previous paintings on the support. Many pigments such as lead white show well in radiographs. X-ray spectromicroscopy has also been used to analyse the reactions of pigments in paintings. For example, in analysing colour degradation in the paintings of van Gogh. These processes can reveal various details about objects that are not visible to the naked eye. This information, which includes structural elements, aids conservators as they assess object condition and consider treatment plans. For three dimensional objects, the computed tomography (CT) has become a common tool, which when combined with analysis can, for example, "digitally unroll" or unfold and make possible the reading of fragile scrolls, books, or sealed correspondence.
  • 1.3K
  • 10 Oct 2022
Topic Review
Geotechnical Investigation
Geotechnical investigations are performed by geotechnical engineers or engineering geologists to obtain information on the physical properties of soil and rock around a site to design earthworks and foundations for proposed structures and for repair of distress to earthworks and structures caused by subsurface conditions. This type of investigation is called a site investigation. Additionally, geotechnical investigations are also used to measure the thermal resistivity of soils or backfill materials required for underground transmission lines, oil and gas pipelines, radioactive waste disposal, and solar thermal storage facilities. A geotechnical investigation will include surface exploration and subsurface exploration of a site. Sometimes, geophysical methods are used to obtain data about sites. Subsurface exploration usually involves soil sampling and laboratory tests of the soil samples retrieved. Surface exploration can include geologic mapping, geophysical methods, and photogrammetry, or it can be as simple as a geotechnical professional walking around on the site to observe the physical conditions at the site. To obtain information about the soil conditions below the surface, some form of subsurface exploration is required. Methods of observing the soils below the surface, obtaining samples, and determining physical properties of the soils and rocks include test pits, trenching (particularly for locating faults and slide planes), boring, and in situ tests.
  • 1.3K
  • 24 Oct 2022
Topic Review
Spilogale
The genus Spilogale includes all skunks commonly known as spotted skunks and is composed of four extant species: S. gracilis, S. putorius, S. pygmaea, and S. angustifrons.
  • 1.3K
  • 31 Oct 2022
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