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Topic Review
Microorganisms as a Source of Antioxidant Compounds
Microorganisms are a diverse group of microscopic organisms including archaea, bacteria, fungi, protozoa, algae, and viruses. Microbial diversity produces a massive pool of unique chemicals, which have become a valuable source for innovative biotechnology. Microorganisms can be used as a source of antioxidants with the advantage of fast growth under controlled conditions. 
  • 1.3K
  • 02 Jun 2023
Topic Review
Ancient Urban Land-Use Based on Geographic Information System
As ancient cities are spaces that represent the development of civilization, it is worth exploring and studying their characteristics and conceptions of land use. The city plan was calibrated with the help of satellite remote sensing images and sites. By constructing the “urban element area acquisition and analysis model”, various operations for areas in the city plan were realized, including an area value calculation, land use structure calculation, area modulus analysis, area ratio analysis between areas, and determination of the cultural significance of numbers and ratios. Taking the Sui and Tang dynasties capital city of Chang'an as an example, it will be described in detail below.
  • 1.3K
  • 15 Jun 2023
Topic Review
Carbon Emission Mitigation in the Food Industry
The food system plays a significant role in anthropogenic greenhouse gas (GHG) emissions, contributing to over one-third of these emissions. There has been limited attention given in the literature on how the food industry can effectively address the carbon issue.
  • 1.3K
  • 05 Jul 2023
Topic Review
Influencing Factors of Digital Village Development in China
Digital rural construction is an important strategy for rural revitalization. In terms of dynamic evolution, the core density curve of China’s digital rural construction shifted to the right between 2011 and 2021, accompanied by gradient influence and a multipolar development trend; local general budget revenue, the per capita disposable income of rural residents, rural infrastructure investment, computer ownership per 100 rural residents, added value of primary industry, education level, and rural power generation are some of the factors that affect the development level of China’s digital countryside. 
  • 1.3K
  • 04 Aug 2023
Topic Review
Visceral Hypersensitivity Association with  Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is a severe problem in the health service. It is estimated that it accounts for 3% of all medical consultations. Moreover, this diagnosis is made in the case of about 40% of all outpatient gastroenterological referrals. The visceral stimuli from the digestive tract are transmitted via afferent nerves through the spinal cord to the brain, where they are felt as pain. The overreaction observed in the brain of irritable bowel syndrome (IBS) patients may be due to increased peripheral sensitivity to stimuli from the gastrointestinal tract.
  • 1.3K
  • 11 Oct 2023
Topic Review
Individuals with High Metacognitive Ability
To clarify whether this relationship exists, the current study used eye tracking techniques and vocal thinking reports to explore creativity differences in individuals with different levels of metacognitive ability.
  • 1.3K
  • 04 Sep 2023
Topic Review
Cell-Penetrable Peptide-Conjugated FADD protein
Peptide mediated intracellular delivery of FADD protein, efficiently expressed in the cytosol and target core pro-tumorigenic NFκB signaling to restrict cancer cells proliferation. This approach has the potential to design strategies for targeted delivery of proteins inside the cells, which might be useful in cancer therapeutics.
  • 1.3K
  • 26 Oct 2020
Topic Review
Blepharocheilodontic Syndrome
Blepharocheilodontic (BCD) syndrome is a disorder that is present at birth. It mainly affects the eyelids (blepharo-), upper lip (-cheilo-), and teeth (-dontic).
  • 1.3K
  • 24 Dec 2020
Topic Review
The NFX1 Gene
The official name of the gene NFX1 in humans (Gene ID 4799 at NCBI) is Nuclear Transcription Factor, X-box binding 1. It is also known as NF-X1, NFX-1, NF.X1, NFX2, Tex42, and TEG-42 in the literature. For clarity, we will use the italicized term NFX1 for the human gene, and we will use NFX1 or isoform-specific names when discussing the human gene products. Regardless of this nomenclature, NFX1 has homologs across species. 
  • 1.3K
  • 05 May 2021
Topic Review
Retrotransposition of Protein Coding Genes
Retrotransposition of protein coding genes is RNA-based gene duplication leading to the creation of single exon nonfunctional copies. Nevertheless, over time, many of these duplicates acquire transcriptional capabilities. In human in most cases, these so-called retrogenes do not code for proteins but function as regulatory long noncoding RNAs (lncRNAs). The mechanisms by which they can regulate other genes include microRNA sponging, modulation of alternative splicing, epigenetic regulation and competition for stabilizing factors, among others.
  • 1.3K
  • 19 May 2021
Topic Review
Albumin Nanostructures in Cancer
Albumin is a versatile protein being used widely for developing carriers for drugs and nucleic acids. It provides biocompatibility, tumor specificity, the possibility for surface modification, and reduces toxicity. 
  • 1.3K
  • 23 Jul 2021
Topic Review
Pterostilbene in Cancer Therapy
Natural polyphenols are organic chemicals which contain phenol units in their structures and possess antitumor properties. However, a key problem is their short half-life and low bioavailability under in vivo conditions. Pterostilbene (3,5-dimethoxy-4'-hydroxystilbene; PT) is a phytoalexin originally isolated from the heartwood of red sandalwood. As recently reported by our group, PT was shown to be effective in the treatment of melanoma. Counterintuitively, PT is not effective (cytotoxic) against melanoma in vitro, and only under in vivo conditions does PT display its anticancer activity. This study elucidated that PT can be effective against melanoma through the inhibition of adrenocorticotropic hormone production in the brain of a mouse, which weakens the Nrf2-dependent antioxidant defenses of melanoma and also pancreatic cancers. This results in both the inhibition of tumor growth and sensitization of the tumor to oxidative stress. Moreover, PT can promote cancer cell death via a mechanism involving lysosomal membrane permeabilization. Different grades of susceptibility were observed among the different cancer cells depending on their lysosomal heat shock protein 70 content, a known stabilizer of lysosomal membranes. In addition, the safety of PT administered i.v. has been evaluated in mice. PT was found to be pharmacologically safe because it showed no organ-specific or systemic toxicity (including tissue histopathologic examination and regular hematology and clinical chemistry data) even when administered i.v. at a high dose (30 mg/kg per day × 23 days). Moreover, new pharmacological advances are being developed to increase its bioavailability and, thereby, its bioefficacy. Therefore, although applications of PT in cancer therapy are just beginning to be explored, it represents a potential (and effective) adjuvant/sensitizing therapy which may improve the results of various oncotherapies. The aim of this review is to present and discuss the results that in our opinion best support the usefulness of PT in cancer therapy, making special emphasis on the in vivo evidence.
  • 1.3K
  • 26 Jul 2021
Topic Review
Nocturnal Bees as Crop Pollinators
Bees are typically diurnal but around 1% of described species have nocturnal activity. Nocturnal bees are still poorly studied due to bias towards studying diurnal insects. However, knowledge concerning their biology and role as crop pollinators has increased. We review the literature on nocturnal bees’ traits and their host plants, and assess the crop pollination effectiveness of this neglected group. Nocturnal bees have visual adaptations to cope with low light intensities, and floral scents are a key sensory cue used to find their host flowers. Nocturnal bees generally show high flower constancy, the ability to vibrate flowers, and high transfer rates of pollen grains to stigmas. The flowers visited by nocturnal bees range from small radial and zygomorphic flowers to large brush blossoms; moreover, they visit plants with different flowering strategies. Nocturnal bees are effective pollinators of regional fruit crops in Brazil, such as cambuci (Campomanesia phaea), guaraná (Paullinia cupana), cajá (Spondias mombin), and in North America of cultivated pumpkins (Cucurbita species). However, they most likely are pollinators of several other crops. Strategies to host high numbers of nocturnal bees around cropping areas should be taken, such as preserving adjacent native forests, restricting soil management, providing food resources beyond crop flowers, and avoiding light pollution.
  • 1.3K
  • 29 Jul 2021
Topic Review
Uremic Toxins Affect the Endothelium
Uremic toxins can induce endothelial dysfunction in patients with chronic kidney disease (CKD). Indeed, the structure of the endothelial monolayer is damaged in CKD, and studies have shown that the uremic toxins contribute to the loss of cell–cell junctions, increasing permeability. Membrane proteins, such as transporters and receptors, can mediate the interaction between uremic toxins and endothelial cells. In these cells, uremic toxins induce oxidative stress and activation of signaling pathways, including the aryl hydrocarbon receptor (AhR), nuclear factor kappa B (NF-κB), and mitogen-activated protein kinase (MAPK) pathways. The activation of these pathways leads to overexpression of proinflammatory (e.g., monocyte chemoattractant protein-1, E-selectin) and prothrombotic (e.g., tissue factor) proteins. Uremic toxins also induce the formation of endothelial microparticles (EMPs), which can lead to the activation and dysfunction of other cells, and modulate the expression of microRNAs that have an important role in the regulation of cellular processes.
  • 1.3K
  • 26 Oct 2021
Topic Review
Impact of COVID-19 on Young People's Mental Health
There is increasing evidence of the psychological impact of COVID-19 on various population groups, with concern particularly focused on young people’s mental health. Yet to date little research has explored the views of young people themselves on the impact of living through the pandemic on their mental health. Young people's discussions on social media have highlighted the complexities of this impact and how socially embedded it has been. Forging appropriate support for young people post-pandemic will necessitate looking beyond an individualised conceptualisation of their mental health that sets this apart from broader societal concerns. Instead, both research and practice need to take a systemic approach, recognising young people’s societal belonging and social contexts.
  • 1.3K
  • 13 Jan 2022
Topic Review
Applications of Cubosomes on Cancers
Cancer is a group of disorders characterized by aberrant gene function and alterations in gene expression patterns. In 2020, it was anticipated that 19 million new cancer cases would be diagnosed globally, with around 10 million cancer deaths. Late diagnosis and interventions are the leading causes of cancer-related mortality. In addition, the absence of comprehensive cancer therapy adds to the burden. Many lyotropic non-lamellar liquid-crystalline-nanoparticle-mediated formulations have been developed in the last few decades, with promising results in drug delivery, therapeutics, and diagnostics. Cubosomes are nano-structured liquid-crystalline particles made of specific amphiphilic lipids in particular proportions. Their ability to encapsulate lipophilic, hydrophilic, and amphiphilic molecules within their structure makes them one of a kind. They are biocompatible, versatile drug carriers that can deliver medications through various routes of administration. Many preclinical studies on the use of cubosomes in cancer treatment and theranostic applications have been conducted. However, before cubosomes may be employed in clinical practice, significant technical advances must be accomplished. 
  • 1.3K
  • 24 Mar 2022
Topic Review
Design and Experience of Mobile Applications
With the tremendous growth in mobile phones, mobile application development is an important emerging arena. Moreover, various applications fail to serve the purpose of getting the attention of the intended users, which is determined by their User Interface (UI) and User Experience (UX). As a result, developers often find it challenging to meet the users’ expectations. Various aspects of design and the experience of mobile applications using UX/UI are explored. 
  • 1.3K
  • 20 Jul 2022
Topic Review
PPARs and the Hallmarks of Cancer
Peroxisome proliferator-activated receptors (PPARs) function as nuclear transcription factors upon the binding of physiological or pharmacological ligands and heterodimerization with retinoic X receptors. Physiological ligands include fatty acids and fatty-acid-derived compounds with low specificity for the different PPAR subtypes (alpha, beta/delta, and gamma). For each of the PPAR subtypes, specific pharmacological agonists and antagonists, as well as pan-agonists, are available. In agreement with their natural ligands, PPARs are mainly focused on as targets for the treatment of metabolic syndrome and its associated complications. Nevertheless, many publications are available that implicate PPARs in malignancies. In several instances, they are controversial for very similar models.
  • 1.3K
  • 12 Aug 2022
Topic Review
Capecitabine in Head and Neck Cancers
Head and neck cancers (HNCs) are the sixth most common malignancies in the world, with more than 500,000 new cases occurring each year. Capecitabine, an oral pro-drug that is metabolized to 5-FU, the use of capecitabine has been evaluated in many trials including cases diagnosed in recurrent or metastatic settings. Induction regimens or a combination with radiation therapy were evaluated in head and neck cancers, but 5-FU still remained the fluoropyrimidine used as a part of the current therapeutic standard.
  • 1.3K
  • 18 Oct 2022
Topic Review
2001 Massacre of Plaza de Mayo
The 2001 Massacre of Plaza de Mayo was a slaughter of people at Plaza de Mayo (May Square), Buenos Aires, Argentina, and around this area that took place on December 20, 2001. Five people were murdered. The names of the fatal victims were: Carlos Almiron, Gustavo Ariel Benedetto, Diego Lamagna, Alberto Marquez and Gaston Marcelo Riva. The perpetrators tried to kill four more people (Marcelo Dorado, Martin Galli, Sergio Ruben Sanchez, and Paula Simonetti), but they did not succeed. A total of 277 injuries was reported.These crimes were committed under Fernando de la Rua’s presidential term in which Argentina was suffering one of its deepest crises and people were rioting in different cities around the nation. These incidents left a total of 39 people that were murdered across the country, among them 7 children.The trial against the 17 defendants started on February 24, 2014.
  • 1.3K
  • 17 Oct 2022
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