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Topic Review
Extrapulmonary Tuberculosis
Pathogenic Mycobacterium tuberculosis complex organisms (MTBC) primarily cause pulmonary tuberculosis (PTB); however, MTBC are also capable of causing disease in extrapulmonary (EP) organs, which pose a significant threat to human health worldwide. Extrapulmonary tuberculosis (EPTB) accounts for about 20–30% of all active TB cases and affects mainly children and adults with compromised immune systems. EPTB can occur through hematogenous, lymphatic, or localized bacillary dissemination from a primary source, such as PTB, and affects the brain, eye, mouth, tongue, lymph nodes of neck, spine, bones, muscles, skin, pleura, pericardium, gastrointestinal, peritoneum, and the genitourinary system as primary and/or disseminated disease. EPTB diagnosis involves clinical, radiological, microbiological, histopathological, biochemical/immunological, and molecular methods. However, only culture and molecular techniques are considered confirmatory to differentiate MTBC from any non-tuberculous mycobacteria (NTM) species. While EPTB due to MTBC responds to first-line anti-TB drugs (ATD), drug susceptibility profiling is an essential criterion for addressing drug-resistant EPTB cases (DR-EPTB). Besides antibiotics, adjuvant therapy with corticosteroids has also been used to treat specific EPTB cases. Occasionally, surgical intervention is recommended, mainly when organ damage is debilitating to the patient. 
  • 1.3K
  • 03 Jun 2021
Topic Review
Insect Pest and Disease Threats to Forest Plantations
The planted forest area in Vietnam increased from 3.0 to 4.4 million hectares in the period 2010–2020, but the loss of productivity from pests and diseases continues to be a problem. During this period, frequent and systematic plantation forest health surveys were conducted on 12 native and 4 exotic genera of trees as well as bamboo across eight forest geographic regions of Vietnam. Damage caused by insects and pathogens was quantified in the field and laboratory in Hanoi. 
  • 1.3K
  • 23 Nov 2021
Topic Review
Cancer Therapy Targeting CD47
The interaction between cluster of differentiation 47 (CD47) on cancer cells and signal regulatory protein alpha (SIRPα) on immune cells, such as macrophages and dendritic cells, generates a “don’t eat me” signal. This is a common mechanism that provides cancer cells an escape from the innate immune system. Several therapeutics directed to CD47 or SIRPα have entered early clinical trials in recent years.
  • 1.3K
  • 29 Mar 2022
Topic Review
Graphene Oxide Thin Films with Drug Delivery Function
Graphene oxide has been used in different fields of nanomedicine as a manager of drug delivery due to its inherent physical and chemical properties that allow its use in thin films with biomedical applications. Several studies demonstrated its efficacy in the control of the amount and the timely delivery of drugs when it is incorporated in multilayer films. It has been demonstrated that graphene oxide layers incorporated in drug delivery systems are able to work either as a nanocarrier, transporting the drugs to their targets or as a barrier delaying the release of drugs to accommodate the treatment schedules. This allows for the development of structured ,sophisticated and time-controlled systems.
  • 1.3K
  • 22 Apr 2022
Topic Review
Classification of the Fish Inspired Robots
Compared with traditional underwater vehicles, bio-inspired fish robots have the advantages of high efficiency, high maneuverability, low noise, and minor fluid disturbance. The propulsion ability of fish comes from the coordination between muscle groups, which gives its body uniform weight distribution and a more space-saving motion structure. A body that has evolved over billions of years also has an excellent hydrodynamic shape and a reasonable structural elastic modulus. At the same time, the organic combination of movement between muscle groups is also the reason to improve the overall efficiency of movement. Finally, fish have unique fluid sensing systems. A body and (or) caudal fin (BCF) swimmer bends its body into a backward propulsive wave that extends up to its caudal fin, while median and paired fin (MPF) swimmers use the median and paired fins to gain thrust. Similar to the classification of the biological systems, fish-inspired robots can also be divided into BCF-based and MPF-based robotic fish with a series of subcategories.
  • 1.3K
  • 10 Jun 2022
Topic Review
Prenylated Flavonoids in Topical Infections and Wound Healing
Flavonoids have been shown to be excellent natural agents useful in the treatment of various skin lesions with minimal side effects. Topical application is the best option for targeted use due to their lipophilic nature. On the other hand, the polyhydroxyl structure determines their antibacterial, antifibrotic, antioxidant, and anti-inflammatory properties. Prenylated Flavonoids are a subclass of flavonoids modified with at least one lipophilic side chain of varying length. They attract the attention of scientists because of their promising biological activities, such as antibacterial, antifungal, estrogenic, immunosuppressive, anticancer, anti-inflammatory, antioxidant, antiviral, larvicidal, osteogenic, antiallergic, and cytotoxic.
  • 1.3K
  • 22 Jul 2022
Topic Review
Redox-Responsive Drug Delivery Systems
With the widespread global impact of cancer on humans and the extensive side effects associated with current cancer treatments, a novel, effective, and safe treatment is needed. Redox-responsive drug delivery systems (DDSs) have emerged as a potential cancer treatment with minimal side effects and enhanced site-specific targeted delivery. 
  • 1.3K
  • 30 Sep 2022
Topic Review
HP OmniGo 120 Organizer Plus
The HP 200LX Palmtop PC (F1060A, F1061A, F1216A), also known as project Felix, is a personal digital assistant introduced by Hewlett-Packard in August 1994. It was often called a Palmtop PC, and it was notable that it was, with some minor exceptions, a MS-DOS-compatible computer in a palmtop format, complete with a monochrome graphic display, QWERTY keyboard, serial port, and PCMCIA expansion slot.
  • 1.3K
  • 30 Oct 2022
Topic Review
Off-Road Detection Analysis for Autonomous Ground Vehicles
When it comes to some essential abilities of autonomous ground vehicles (AGV), detection is one of them. In order to safely navigate through any known or unknown environment, AGV must be able to detect important elements on the path. Detection is applicable both on-road and off-road, but they are much different in each environment. The key elements of any environment that AGV must identify are the drivable pathway and whether there are any obstacles around it. Many works have been published focusing on different detection components in various ways.
  • 1.3K
  • 17 Nov 2022
Topic Review
Angiogenesis and Inflammation in Neovascular Age-Related Macular Degeneration
Age-related macular degeneration (AMD) is the leading cause of visual impairment in the aging population with a limited understanding of its pathogenesis and the number of patients are all the time increasing. AMD is classified into two main forms: dry and neovascular AMD (nAMD). Dry AMD is the most prevalent form (80–90%) of AMD cases. Neovascular AMD (10–20% of AMD cases) is treated with monthly or more sparsely given intravitreal anti-vascular endothelial growth factor inhibitors, but unfortunately, not all patients respond to the current treatments. A clinical hallmark of nAMD is choroidal neovascularization. The progression of AMD is initially characterized by atrophic alterations in the retinal pigment epithelium, as well as the formation of lysosomal lipofuscin and extracellular drusen deposits. Cellular damage caused by chronic oxidative stress, protein aggregation and inflammatory processes may lead to advanced geographic atrophy and/or choroidal neovascularization and fibrosis.
  • 1.3K
  • 02 Feb 2023
Topic Review
Delivery Systems for Mitochondrial Gene Therapy
Mitochondria are membrane-bound cellular organelles of high relevance responsible for the chemical energy production used in most of the biochemical reactions of cells. Mitochondria have their own genome, the mitochondrial DNA (mtDNA). Inherited solely from the mother, this genome is quite susceptible to mutations, mainly due to the absence of an effective repair system. Mutations in mtDNA are associated with endocrine, metabolic, neurodegenerative diseases, and even cancer. Mitochondrial gene therapy emerges as a promising strategy as it deeply focuses on the cause of mitochondrial disorder. The development of suitable mtDNA-based delivery systems to target and transfect mammalian mitochondria represents an exciting field of research, leading to progress in the challenging task of restoring mitochondria’s normal function. 
  • 1.3K
  • 20 Apr 2023
Topic Review
Amygdalin as a Promising Anticancer Agent
Amygdalin, also known as vitamin B17 (and laetrile, a synthetic compound), is a cyanogenic glycoside compound that is mainly found in the kernels and pulps of fruits. This compound has been proposed for decades as a promising naturally occurring substance which may provide anticancer effects.
  • 1.3K
  • 11 Oct 2023
Topic Review
Aerobic Glycolysis in Cancer Cells
Aerobic glycolysis in cancer cells, which involves the production of lactate as the end product of glucose breakdown even in the presence of adequate oxygen, is the foundation for the current interest in the cancer-cell-specific reprograming of metabolic pathways. The renewed interest in cancer cell metabolism has now gone well beyond the original Warburg effect related to glycolysis to other metabolic pathways that include amino acid metabolism, one-carbon metabolism, the pentose phosphate pathway, nucleotide synthesis, antioxidant machinery, etc. Since glucose and amino acids constitute the primary nutrients that fuel the altered metabolic pathways in cancer cells, the transporters that mediate the transfer of these nutrients and their metabolites not only across the plasma membrane but also across the mitochondrial and lysosomal membranes have become an integral component of the expansion of the Warburg effect.
  • 1.3K
  • 31 Jan 2024
Topic Review
Electrolyte Filling and Wetting in Lithium-Ion Battery Production
Electrolyte filling and wetting is a quality-critical and cost-intensive process step of battery cell production. Due to the importance of this process, a steadily increasing number of publications is emerging for its different influences and factors. 
  • 1.3K
  • 24 Mar 2023
Topic Review
Enhanced Recovery after Surgery
Enhanced recovery after surgery (ERAS) aims to improve patient outcomes by controlling specific aspects of perioperative care.
  • 1.3K
  • 17 May 2021
Topic Review
Nutritional Interventions for COVID-19
The coronavirus infection (COVID‐19) conveys a serious threat globally to health and economy because of lack of vaccines and specific treatments. A common factor for conditions that predispose for serious progress is a low-grade inflammation, as seen e.g. in metabolic syndrome, diabetes and heart failure to which micronutrient deficiencies may contribute.  The aim of the present article is to explore the usefulness of early micronutrient intervention, with focus on zinc, selenium and vitamin D, to relieve escalation of COVID-19.  Methods: We have conducted an online search for articles published in the period 2010-2020 on zinc, selenium and vitamin D and corona and related virus infections.  Results: There were a few studies providing direct evidence on association between zinc, selenium and vitamin D and COVID-19.  Adequate supply of zinc, selenium, and vitamin D, is essential for resistance to other viral infections, immune function and reduced inflammation. Hence, it is suggested that nutrition intervention securing an adequate status might protect against SARS-CoV2, and  mitigate the course of COVID‐19.  Conclusion: We recommend initiation of adequate supplementation in high risk areas and/or soon after the time of suspected infection with SARS-CoV-2. Subjects in high-risk groups should have high priority as regards this nutritive adjuvant therapy, which should be started prior to administration of specific and supportive medical measures. 
  • 1.3K
  • 24 Aug 2020
Topic Review
Newcastle Disease Viruses
Newcastle disease viruses (NDVs), also known as avian paramyxoviruses type 1, are members of the genus Orthoavulavirus, species Avian orthoavulavirus 1 in the family Paramyxoviridae. They are negative-sense, single-stranded, non-fragmented RNA viruses, distributed worldwide, and they are able to infect wild, peridomestic and domestic avian species.
  • 1.3K
  • 27 Jan 2021
Topic Review
Potassium Control of Plant Functions
Potassium, mostly as a cation (K+), together with calcium (Ca2+) are the most abundant inorganic chemicals in plant cellular media, but they are rarely discussed. K+ is not a component of molecular or macromolecular plant structures, thus it is more difficult to link it to concrete metabolic pathways than nitrogen or phosphorus. Over the last two decades, many studies have reported on the role of K+ in several physiological functions, including controlling cellular growth and wood formation, xylem–phloem water content and movement, nutrient and metabolite transport, and stress responses. In this paper, we present an overview of contemporary findings associating K+ with various plant functions, emphasizing plant-mediated responses to environmental abiotic and biotic shifts and stresses by controlling transmembrane potentials and water, nutrient, and metabolite transport. These essential roles of K+ account for its high concentrations in the most active plant organs, such as leaves, and are consistent with the increasing number of ecological and agricultural studies that report K+ as a key element in the function and structure of terrestrial ecosystems, crop production, and global food security. 
  • 1.3K
  • 12 Mar 2021
Topic Review
Solar Concentration for Wastewaters Remediation
As the effectiveness of conventional wastewater treatment processes is increasingly challenged by the growth of industrial activities, a demand for low-cost and low-impact treatments is emerging. A possible solution is represented by systems coupling solar concentration technology with advanced oxidation processes (AOP).
  • 1.3K
  • 17 Jun 2021
Topic Review
Marine Actinomycetes
Actinomycetales is an order of Gram-positive bacteria consisting of both benign and pathogenic bacteria belonging to the phylum Actinobacteria.
  • 1.3K
  • 14 Jul 2021
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